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The Oral Health of Refugees and Asylum Seekers in Canada: A Mixed Methods Study Protocol.

Macdonald ME, Keboa MT, Nurelhuda NM, Lawrence HP, Carnevale F, McNally M, Singhal S, Ka K, Nicolau B.

Int J Environ Res Public Health. 2019 Feb 13;16(4). pii: E542. doi: 10.3390/ijerph16040542.


Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites.

Kedaigle AJ, Fraenkel E, Atwal RS, Wu M, Gusella JF, MacDonald ME, Kaye JA, Finkbeiner S, Mattis VB, Tom CM, Svendsen C, King AR, Chen Y, Stocksdale JT, Lim RG, Casale M, Wang PH, Thompson LM, Akimov SS, Ratovitski T, Arbez N, Ross CA.

Hum Mol Genet. 2019 Feb 15. pii: ddy430. doi: 10.1093/hmg/ddy430. [Epub ahead of print]


Dentistry and nursing working together to improve oral health care in a long-term care facility.

Keboa M, Beaudin A, Cyr J, Decoste J, Power F, Hovey R, LaFrance L, Ouellet D, Wiseman M, Macdonald ME.

Geriatr Nurs. 2018 Oct 24. pii: S0197-4572(18)30395-1. doi: 10.1016/j.gerinurse.2018.10.002. [Epub ahead of print]


Beyond bare bones: critical, theoretically engaged qualitative research in public health.

Mykhalovskiy E, Eakin J, Beagan B, Beausoleil N, Gibson BE, Macdonald ME, Rock MJ.

Can J Public Health. 2018 Dec;109(5-6):613-621. doi: 10.17269/s41997-018-0154-2. Epub 2018 Nov 21.


Of dilemmas and tensions: a qualitative study of palliative care physicians' positions regarding voluntary active euthanasia in Quebec, Canada.

Bélanger E, Towers A, Wright DK, Chen Y, Tradounsky G, Macdonald ME.

J Med Ethics. 2019 Jan;45(1):48-53. doi: 10.1136/medethics-2017-104339. Epub 2018 Oct 30.


Hyperglycemia Aggravates Diet-Induced Coronary Artery Disease and Myocardial Infarction in SR-B1-Knockout/ApoE-Hypomorphic Mice.

Gonzalez L, MacDonald ME, Deng YD, Trigatti BL.

Front Physiol. 2018 Oct 9;9:1398. doi: 10.3389/fphys.2018.01398. eCollection 2018.


Interdatabase Variability in Cortical Thickness Measurements.

MacDonald ME, Williams RJ, Forkert ND, Berman AJL, McCreary CR, Frayne R, Pike GB.

Cereb Cortex. 2018 Aug 23. doi: 10.1093/cercor/bhy197. [Epub ahead of print]


Genetic Modification of Huntington Disease Acts Early in the Prediagnosis Phase.

Long JD, Lee JM, Aylward EH, Gillis T, Mysore JS, Abu Elneel K, Chao MJ, Paulsen JS, MacDonald ME, Gusella JF.

Am J Hum Genet. 2018 Sep 6;103(3):349-357. doi: 10.1016/j.ajhg.2018.07.017. Epub 2018 Aug 16.


Health status, emergency department visits, and oncologists' feedback: An analysis of secondary endpoints from a randomized phase II geriatric assessment trial.

Sattar S, Alibhai SMH, Brennenstuhl S, Kulik M, MacDonald ME, McWatters K, Lee K, Jang R, Amir E, Krzyzanowska MK, Joshua AM, Monette J, Wan-Chow-Wah D, Puts MTE.

J Geriatr Oncol. 2019 Jan;10(1):169-174. doi: 10.1016/j.jgo.2018.06.014. Epub 2018 Jul 21.


Whole head quantitative susceptibility mapping using a least-norm direct dipole inversion method.

Sun H, Ma Y, MacDonald ME, Pike GB.

Neuroimage. 2018 Oct 1;179:166-175. doi: 10.1016/j.neuroimage.2018.06.036. Epub 2018 Jun 15.


Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity.

Shin B, Jung R, Oh H, Owens GE, Lee H, Kwak S, Lee R, Cotman SL, Lee JM, MacDonald ME, Song JJ, Vijayvargia R, Seong IS.

Mol Ther Nucleic Acids. 2018 Jun 1;11:416-428. doi: 10.1016/j.omtn.2018.03.008. Epub 2018 Mar 16.


Modeling hyperoxia-induced BOLD signal dynamics to estimate cerebral blood flow, volume and mean transit time.

MacDonald ME, Berman AJL, Mazerolle EL, Williams RJ, Pike GB.

Neuroimage. 2018 Sep;178:461-474. doi: 10.1016/j.neuroimage.2018.05.066. Epub 2018 May 29.


Population-specific genetic modification of Huntington's disease in Venezuela.

Chao MJ, Kim KH, Shin JW, Lucente D, Wheeler VC, Li H, Roach JC, Hood L, Wexler NS, Jardim LB, Holmans P, Jones L, Orth M, Kwak S, MacDonald ME, Gusella JF, Lee JM.

PLoS Genet. 2018 May 11;14(5):e1007274. doi: 10.1371/journal.pgen.1007274. eCollection 2018 May.


Assessing Dental Students' Readiness to Treat Populations That Are Underserved: A Scoping Review.

Furlini L, Noushi N, Castonguay G, Allison P, Bedos C, De Souza R, Esfandiari S, Hovey R, Macdonald ME, Morris M, Nicolau B, Power F, Feine J.

J Dent Educ. 2018 May;82(5):483-491. doi: 10.21815/JDE.018.053. Review.


Transcriptional regulatory networks underlying gene expression changes in Huntington's disease.

Ament SA, Pearl JR, Cantle JP, Bragg RM, Skene PJ, Coffey SR, Bergey DE, Wheeler VC, MacDonald ME, Baliga NS, Rosinski J, Hood LE, Carroll JB, Price ND.

Mol Syst Biol. 2018 Mar 26;14(3):e7435. doi: 10.15252/msb.20167435.


Relational ethics of delirium care: Findings from a hospice ethnography.

Wright DK, Brajtman S, Macdonald ME.

Nurs Inq. 2018 Jul;25(3):e12234. doi: 10.1111/nin.12234. Epub 2018 Mar 24.


HttQ111/+ Huntington's Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction.

Kovalenko M, Milnerwood A, Giordano J, St Claire J, Guide JR, Stromberg M, Gillis T, Sapp E, DiFiglia M, MacDonald ME, Carroll JB, Lee JM, Tappan S, Raymond L, Wheeler VC.

J Huntingtons Dis. 2018;7(1):17-33. doi: 10.3233/JHD-170282.


Gas-free calibrated fMRI with a correction for vessel-size sensitivity.

Berman AJL, Mazerolle EL, MacDonald ME, Blockley NP, Luh WM, Pike GB.

Neuroimage. 2018 Apr 1;169:176-188. doi: 10.1016/j.neuroimage.2017.12.047. Epub 2017 Dec 15.


Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.

Handley RR, Reid SJ, Brauning R, Maclean P, Mears ER, Fourie I, Patassini S, Cooper GJS, Rudiger SR, McLaughlan CJ, Verma PJ, Gusella JF, MacDonald ME, Waldvogel HJ, Bawden CS, Faull RLM, Snell RG.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11293-E11302. doi: 10.1073/pnas.1711243115. Epub 2017 Dec 11.


Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering.

Yu P, Xiong T, Tenedero CB, Lebeau P, Ni R, MacDonald ME, Gross PL, Austin RC, Trigatti BL.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):26-39. doi: 10.1161/ATVBAHA.117.305140. Epub 2017 Nov 21.


The Making of Informed Choice in Midwifery: A Feminist Experiment in Care.

MacDonald ME.

Cult Med Psychiatry. 2018 Jun;42(2):278-294. doi: 10.1007/s11013-017-9560-9.


HDL protects against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type 1-, PI3K-, and Akt-dependent manner.

Durham KK, Chathely KM, Mak KC, Momen A, Thomas CT, Zhao YY, MacDonald ME, Curtis JM, Husain M, Trigatti BL.

Am J Physiol Heart Circ Physiol. 2018 Jan 1;314(1):H31-H44. doi: 10.1152/ajpheart.00521.2016. Epub 2017 Oct 6.


A modifier of Huntington's disease onset at the MLH1 locus.

Lee JM, Chao MJ, Harold D, Abu Elneel K, Gillis T, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF.

Hum Mol Genet. 2017 Oct 1;26(19):3859-3867. doi: 10.1093/hmg/ddx286.


The conceptualization of childhood in North American pediatric dentistry texts: a discursive case study analysis.

Makansi N, Carnevale FA, Macdonald ME.

Int J Paediatr Dent. 2018 Mar;28(2):189-197. doi: 10.1111/ipd.12325. Epub 2017 Aug 25.


Haplotype-based stratification of Huntington's disease.

Chao MJ, Gillis T, Atwal RS, Mysore JS, Arjomand J, Harold D, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF, Lee JM.

Eur J Hum Genet. 2017 Nov;25(11):1202-1209. doi: 10.1038/ejhg.2017.125. Epub 2017 Aug 23.


Reconciling disparate data to determine the right answer: A grounded theory of meta analysts' reasoning in meta-analysis.

Chan L, Macdonald ME, Carnevale FA, Steele RJ, Shrier I.

Res Synth Methods. 2018 Mar;9(1):25-40. doi: 10.1002/jrsm.1258. Epub 2017 Sep 3.


A randomized phase II trial of geriatric assessment and management for older cancer patients.

Puts MTE, Sattar S, Kulik M, MacDonald ME, McWatters K, Lee K, Brennenstuhl S, Jang R, Amir E, Krzyzanowska MK, Joshua AM, Monette J, Wan-Chow-Wah D, Alibhai SMH.

Support Care Cancer. 2018 Jan;26(1):109-117. doi: 10.1007/s00520-017-3820-7. Epub 2017 Jul 25.


'I'm only dealing with the acute issues': How medical ward 'busyness' constrains care of the dying.

Chan LS, Macdonald ME, Carnevale FA, Cohen SR.

Health (London). 2018 Sep;22(5):451-468. doi: 10.1177/1363459317708822. Epub 2017 May 29.


Erratum to: The concept of 'vulnerability' in research ethics: an in-depth analysis of policies and guidelines.

Bracken-Roche D, Bell E, Macdonald ME, Racine E.

Health Res Policy Syst. 2017 Apr 3;15(1):29. doi: 10.1186/s12961-017-0186-8. No abstract available.


Corrigendum: Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease.

Bragg RM, Coffey SR, Weston RM, Ament SA, Cantle JP, Minnig S, Funk CC, Shuttleworth DD, Woods EL, Sullivan BR, Jones L, Glickenhaus A, Anderson JS, Anderson MD, Dunnett SB, Wheeler VC, MacDonald ME, Brooks SP, Price ND, Carroll JB.

Sci Rep. 2017 Mar 28;7:44960. doi: 10.1038/srep44960. No abstract available.


High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.

Ament SA, Pearl JR, Grindeland A, St Claire J, Earls JC, Kovalenko M, Gillis T, Mysore J, Gusella JF, Lee JM, Kwak S, Howland D, Lee MY, Baxter D, Scherler K, Wang K, Geman D, Carroll JB, MacDonald ME, Carlson G, Wheeler VC, Price ND, Hood LE.

Hum Mol Genet. 2017 Mar 1;26(5):913-922. doi: 10.1093/hmg/ddx006.


Inuit interpreters engaged in end-of-life care in Nunavik, Northern Quebec.

Hordyk SR, Macdonald ME, Brassard P.

Int J Circumpolar Health. 2017;76(1):1291868. doi: 10.1080/22423982.2017.1291868.


End-of-Life Care in Nunavik, Quebec: Inuit Experiences, Current Realities, and Ways Forward.

Hordyk SR, Macdonald ME, Brassard P.

J Palliat Med. 2017 Jun;20(6):647-655. doi: 10.1089/jpm.2016.0256. Epub 2017 Feb 8.


Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease.

Bragg RM, Coffey SR, Weston RM, Ament SA, Cantle JP, Minnig S, Funk CC, Shuttleworth DD, Woods EL, Sullivan BR, Jones L, Glickenhaus A, Anderson JS, Anderson MD, Dunnett SB, Wheeler VC, MacDonald ME, Brooks SP, Price ND, Carroll JB.

Sci Rep. 2017 Feb 8;7:41570. doi: 10.1038/srep41570. Erratum in: Sci Rep. 2017 Mar 28;7:44960.


The concept of 'vulnerability' in research ethics: an in-depth analysis of policies and guidelines.

Bracken-Roche D, Bell E, Macdonald ME, Racine E.

Health Res Policy Syst. 2017 Feb 7;15(1):8. doi: 10.1186/s12961-016-0164-6. Erratum in: Health Res Policy Syst. 2017 Apr 3;15(1):29.


Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9.

Shin JW, Kim KH, Chao MJ, Atwal RS, Gillis T, MacDonald ME, Gusella JF, Lee JM.

Hum Mol Genet. 2016 Oct 15;25(20):4566-4576. doi: 10.1093/hmg/ddw286.


Novel allele-specific quantification methods reveal no effects of adult onset CAG repeats on HTT mRNA and protein levels.

Shin A, Shin B, Shin JW, Kim KH, Atwal RS, Hope JM, Gillis T, Leszyk JD, Shaffer SA, Lee R, Kwak S, MacDonald ME, Gusella JF, Seong IS, Lee JM.

Hum Mol Genet. 2017 Apr 1;26(7):1258-1267. doi: 10.1093/hmg/ddx033.


Potential molecular consequences of transgene integration: The R6/2 mouse example.

Jacobsen JC, Erdin S, Chiang C, Hanscom C, Handley RR, Barker DD, Stortchevoi A, Blumenthal I, Reid SJ, Snell RG, MacDonald ME, Morton AJ, Ernst C, Gusella JF, Talkowski ME.

Sci Rep. 2017 Jan 25;7:41120. doi: 10.1038/srep41120.


Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening.

Cheng C, Fass DM, Folz-Donahue K, MacDonald ME, Haggarty SJ.

Curr Protoc Hum Genet. 2017 Jan 11;92:21.8.1-21.8.21. doi: 10.1002/cphg.33.


Patient participation in palliative care decisions: An ethnographic discourse analysis.

Bélanger E, Rodríguez C, Groleau D, Légaré F, MacDonald ME, Marchand R.

Int J Qual Stud Health Well-being. 2016 Nov 22;11:32438. doi: 10.3402/qhw.v11.32438. eCollection 2016.


Chemotherapy treatment decision-making experiences of older adults with cancer, their family members, oncologists and family physicians: a mixed methods study.

Puts MT, Sattar S, McWatters K, Lee K, Kulik M, MacDonald ME, Jang R, Amir E, Krzyzanowska MK, Leighl N, Fitch M, Joshua AM, Warde P, Tourangeau AE, Alibhai SM.

Support Care Cancer. 2017 Mar;25(3):879-886. doi: 10.1007/s00520-016-3476-8. Epub 2016 Nov 9.


Suffering and medicalization at the end of life: The case of physician-assisted dying.

Karsoho H, Fishman JR, Wright DK, Macdonald ME.

Soc Sci Med. 2016 Dec;170:188-196. doi: 10.1016/j.socscimed.2016.10.010. Epub 2016 Oct 12.


The oral health of refugees and asylum seekers: a scoping review.

Keboa MT, Hiles N, Macdonald ME.

Global Health. 2016 Oct 7;12(1):59. Review.


Flow and pressure measurements in aneurysms and arteriovenous malformations with phase contrast MR imaging.

MacDonald ME, Dolati P, Mitha AP, Wong JH, Frayne R.

Magn Reson Imaging. 2016 Nov;34(9):1322-1328. doi: 10.1016/j.mri.2016.07.007. Epub 2016 Jul 25.


Correction: RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression.

Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH.

PLoS One. 2016 Jul 25;11(7):e0160295. doi: 10.1371/journal.pone.0160295. eCollection 2016.


Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.

Alexandrov V, Brunner D, Menalled LB, Kudwa A, Watson-Johnson J, Mazzella M, Russell I, Ruiz MC, Torello J, Sabath E, Sanchez A, Gomez M, Filipov I, Cox K, Kwan M, Ghavami A, Ramboz S, Lager B, Wheeler VC, Aaronson J, Rosinski J, Gusella JF, MacDonald ME, Howland D, Kwak S.

Nat Biotechnol. 2016 Aug;34(8):838-44. doi: 10.1038/nbt.3587. Epub 2016 Jul 4.


The emergency department as a 'last resort': why parents seek care for their child's nontraumatic dental problems in the emergency room.

Mostajer Haqiqi A, Bedos C, Macdonald ME.

Community Dent Oral Epidemiol. 2016 Oct;44(5):493-503. doi: 10.1111/cdoe.12239. Epub 2016 Jun 10.


Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group.

Wickwire EM, Williams SG, Roth T, Capaldi VF, Jaffe M, Moline M, Motamedi GK, Morgan GW, Mysliwiec V, Germain A, Pazdan RM, Ferziger R, Balkin TJ, MacDonald ME, Macek TA, Yochelson MR, Scharf SM, Lettieri CJ.

Neurotherapeutics. 2016 Apr;13(2):403-17. doi: 10.1007/s13311-016-0429-3.


Low-income working immigrant families in Quebec: Exploring their challenges to well-being.

Pitt RS, Sherman J, Macdonald ME.

Can J Public Health. 2016 Mar 16;106(8):e539-45. doi: 10.17269/cjph.106.5028.


Phase Error Correction in Time-Averaged 3D Phase Contrast Magnetic Resonance Imaging of the Cerebral Vasculature.

MacDonald ME, Forkert ND, Pike GB, Frayne R.

PLoS One. 2016 Feb 24;11(2):e0149930. doi: 10.1371/journal.pone.0149930. eCollection 2016.

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