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Items: 1 to 50 of 440

1.

Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.

Chennupati V, Veiga DF, Maslowski KM, Andina N, Tardivel A, Yu EC, Stilinovic M, Simillion C, Duchosal MA, Quadroni M, Roberts I, Sankaran VG, MacDonald HR, Fasel N, Angelillo-Scherrer A, Schneider P, Hoang T, Allam R.

J Clin Invest. 2018 Apr 2;128(4):1597-1614. doi: 10.1172/JCI94956. Epub 2018 Mar 19.

2.

Developing HSCs become Notch independent by the end of maturation in the AGM region.

Souilhol C, Lendinez JG, Rybtsov S, Murphy F, Wilson H, Hills D, Batsivari A, Binagui-Casas A, McGarvey AC, MacDonald HR, Kageyama R, Siebel C, Zhao S, Medvinsky A.

Blood. 2016 Sep 22;128(12):1567-77. doi: 10.1182/blood-2016-03-708164. Epub 2016 Jul 15.

3.

Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells.

Chennupati V, Koch U, Coutaz M, Scarpellino L, Tacchini-Cottier F, Luther SA, Radtke F, Zehn D, MacDonald HR.

J Immunol. 2016 Aug 1;197(3):771-82. doi: 10.4049/jimmunol.1501675. Epub 2016 Jun 20.

4.

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes.

Preston GC, Sinclair LV, Kaskar A, Hukelmann JL, Navarro MN, Ferrero I, MacDonald HR, Cowling VH, Cantrell DA.

EMBO J. 2015 Aug 4;34(15):2008-24. doi: 10.15252/embj.201490252. Epub 2015 Jul 1.

5.

NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module.

Ludigs K, Seguín-Estévez Q, Lemeille S, Ferrero I, Rota G, Chelbi S, Mattmann C, MacDonald HR, Reith W, Guarda G.

PLoS Genet. 2015 Mar 26;11(3):e1005088. doi: 10.1371/journal.pgen.1005088. eCollection 2015 Mar.

6.

Central serous chorioretinopathy after trabeculectomy in a patient with microphthalmos and congenital rubella syndrome.

Takakura A, Haug SJ, Radhakrishnan S, Fu AD, Jumper JM, MacDonald HR, Johnson RN, Lujan BJ, Cunningham ET Jr.

Retin Cases Brief Rep. 2014 Spring;8(2):153-6. doi: 10.1097/ICB.0000000000000029.

PMID:
25372335
7.

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses.

Fasnacht N, Huang HY, Koch U, Favre S, Auderset F, Chai Q, Onder L, Kallert S, Pinschewer DD, MacDonald HR, Tacchini-Cottier F, Ludewig B, Luther SA, Radtke F.

J Exp Med. 2014 Oct 20;211(11):2265-79. doi: 10.1084/jem.20132528. Epub 2014 Oct 13.

8.

Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes.

Jiang W, Wang X, Zeng B, Liu L, Tardivel A, Wei H, Han J, MacDonald HR, Tschopp J, Tian Z, Zhou R.

J Exp Med. 2013 Oct 21;210(11):2465-76. doi: 10.1084/jem.20122490. Epub 2013 Sep 23. Erratum in: J Exp Med. 2013 Nov 18;210(12):2791.

9.

Notch signaling regulates follicular helper T cell differentiation.

Auderset F, Schuster S, Fasnacht N, Coutaz M, Charmoy M, Koch U, Favre S, Wilson A, Trottein F, Alexander J, Luther SA, MacDonald HR, Radtke F, Tacchini-Cottier F.

J Immunol. 2013 Sep 1;191(5):2344-50. doi: 10.4049/jimmunol.1300643. Epub 2013 Aug 5.

10.

DL4-mediated Notch signaling is required for the development of fetal αβ and γδ T cells.

Ferrero I, Koch U, Claudinot S, Favre S, Radtke F, Luther SA, MacDonald HR.

Eur J Immunol. 2013 Nov;43(11):2845-53. doi: 10.1002/eji.201343527. Epub 2013 Aug 25.

11.

Inducible gene expression in fetal thymic epithelium: a new BAC transgenic model.

Fiorini E, Ferrero I, Poisson C, Scarpellino L, Luther SA, MacDonald HR.

Genesis. 2013 Oct;51(10):717-24. doi: 10.1002/dvg.22414. Epub 2013 Aug 7.

PMID:
23832856
12.

Regulation of innate and adaptive immunity by Notch.

Radtke F, MacDonald HR, Tacchini-Cottier F.

Nat Rev Immunol. 2013 Jun;13(6):427-37. doi: 10.1038/nri3445. Epub 2013 May 13. Review.

PMID:
23665520
13.

Functional education of invariant NKT cells by dendritic cell tuning of SHP-1.

Napolitano A, Pittoni P, Beaudoin L, Lehuen A, Voehringer D, MacDonald HR, Dellabona P, Casorati G.

J Immunol. 2013 Apr 1;190(7):3299-308. doi: 10.4049/jimmunol.1203466. Epub 2013 Feb 20.

14.

LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance.

Lee SU, Maeda M, Ishikawa Y, Li SM, Wilson A, Jubb AM, Sakurai N, Weng L, Fiorini E, Radtke F, Yan M, Macdonald HR, Chen CC, Maeda T.

Blood. 2013 Feb 7;121(6):918-29. doi: 10.1182/blood-2012-03-418103. Epub 2012 Nov 7.

15.

Neurogenic subventricular zone stem/progenitor cells are Notch1-dependent in their active but not quiescent state.

Basak O, Giachino C, Fiorini E, Macdonald HR, Taylor V.

J Neurosci. 2012 Apr 18;32(16):5654-66. doi: 10.1523/JNEUROSCI.0455-12.2012.

16.

NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells.

Staehli F, Ludigs K, Heinz LX, Seguín-Estévez Q, Ferrero I, Braun M, Schroder K, Rebsamen M, Tardivel A, Mattmann C, MacDonald HR, Romero P, Reith W, Guarda G, Tschopp J.

J Immunol. 2012 Apr 15;188(8):3820-8. doi: 10.4049/jimmunol.1102671. Epub 2012 Mar 12.

17.

Redundant Notch1 and Notch2 signaling is necessary for IFNγ secretion by T helper 1 cells during infection with Leishmania major.

Auderset F, Schuster S, Coutaz M, Koch U, Desgranges F, Merck E, MacDonald HR, Radtke F, Tacchini-Cottier F.

PLoS Pathog. 2012;8(3):e1002560. doi: 10.1371/journal.ppat.1002560. Epub 2012 Mar 1.

18.

Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint.

Merck E, Lees RK, Voyle RB, Held W, MacDonald HR.

J Immunol. 2011 Jul 1;187(1):110-7. doi: 10.4049/jimmunol.1002755. Epub 2011 Jun 1.

19.

Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion.

Seizer P, Ochmann C, Schönberger T, Zach S, Rose M, Borst O, Klingel K, Kandolf R, MacDonald HR, Nowak RA, Engelhardt S, Lang F, Gawaz M, May AE.

Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1377-86. doi: 10.1161/ATVBAHA.111.225771. Epub 2011 Mar 24.

20.

Improved survival in non-Ashkenazi Jewish ovarian cancer patients with BRCA1 and BRCA2 gene mutations.

Lacour RA, Westin SN, Meyer LA, Wingo SN, Schorge JO, Brooks R, Mutch D, Molina A, Sutphen R, Barnes M, Elder J, Teoh D, Powell CB, Choubey V, Blank S, Macdonald HR, Brady MF, Urbauer DL, Bodurka D, Gershenson DM, Lu KH.

Gynecol Oncol. 2011 May 1;121(2):358-63. doi: 10.1016/j.ygyno.2010.12.354. Epub 2011 Jan 28.

21.

Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts.

Fortner KA, Lees RK, MacDonald HR, Budd RC.

Int Immunol. 2011 Feb;23(2):75-88. doi: 10.1093/intimm/dxq466. Epub 2011 Jan 25.

22.

Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation.

Wendorff AA, Koch U, Wunderlich FT, Wirth S, Dubey C, Brüning JC, MacDonald HR, Radtke F.

Immunity. 2010 Nov 24;33(5):671-84. doi: 10.1016/j.immuni.2010.11.014.

23.

Inducible gene and shRNA expression in resident hematopoietic stem cells in vivo.

Laurenti E, Barde I, Verp S, Offner S, Wilson A, Quenneville S, Wiznerowicz M, Macdonald HR, Trono D, Trumpp A.

Stem Cells. 2010 Aug;28(8):1390-8. doi: 10.1002/stem.460.

24.

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.

Hodson DJ, Janas ML, Galloway A, Bell SE, Andrews S, Li CM, Pannell R, Siebel CW, MacDonald HR, De Keersmaecker K, Ferrando AA, Grutz G, Turner M.

Nat Immunol. 2010 Aug;11(8):717-24. doi: 10.1038/ni.1901. Epub 2010 Jul 11. Erratum in: Nat Immunol. 2010 Oct;11(10):969.

25.

c-Myc controls the development of CD8alphaalpha TCRalphabeta intestinal intraepithelial lymphocytes from thymic precursors by regulating IL-15-dependent survival.

Jiang W, Ferrero I, Laurenti E, Trumpp A, MacDonald HR.

Blood. 2010 Jun 3;115(22):4431-8. doi: 10.1182/blood-2009-11-254698. Epub 2010 Mar 22.

26.

Notch signaling in the immune system.

Radtke F, Fasnacht N, Macdonald HR.

Immunity. 2010 Jan 29;32(1):14-27. doi: 10.1016/j.immuni.2010.01.004. Review.

27.

Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies.

Fiorini E, Merck E, Wilson A, Ferrero I, Jiang W, Koch U, Auderset F, Laurenti E, Tacchini-Cottier F, Pierres M, Radtke F, Luther SA, Macdonald HR.

J Immunol. 2009 Dec 1;183(11):7212-22. doi: 10.4049/jimmunol.0902432. Epub 2009 Nov 13.

28.

Enrichment of human CD4+ V(alpha)24/Vbeta11 invariant NKT cells in intrahepatic malignant tumors.

Bricard G, Cesson V, Devevre E, Bouzourene H, Barbey C, Rufer N, Im JS, Alves PM, Martinet O, Halkic N, Cerottini JC, Romero P, Porcelli SA, Macdonald HR, Speiser DE.

J Immunol. 2009 Apr 15;182(8):5140-51. doi: 10.4049/jimmunol.0711086.

29.

Selective requirement for c-Myc at an early stage of V(alpha)14i NKT cell development.

Mycko MP, Ferrero I, Wilson A, Jiang W, Bianchi T, Trumpp A, MacDonald HR.

J Immunol. 2009 Apr 15;182(8):4641-8. doi: 10.4049/jimmunol.0803394.

30.
31.

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.

Wilson A, Laurenti E, Oser G, van der Wath RC, Blanco-Bose W, Jaworski M, Offner S, Dunant CF, Eshkind L, Bockamp E, Lió P, Macdonald HR, Trumpp A.

Cell. 2008 Dec 12;135(6):1118-29. doi: 10.1016/j.cell.2008.10.048. Erratum in: Cell. 2009 Jul 10;138(1):209.

32.

Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells.

Fiorini E, Ferrero I, Merck E, Favre S, Pierres M, Luther SA, MacDonald HR.

J Immunol. 2008 Dec 15;181(12):8199-203.

33.

Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity.

Laurenti E, Varnum-Finney B, Wilson A, Ferrero I, Blanco-Bose WE, Ehninger A, Knoepfler PS, Cheng PF, MacDonald HR, Eisenman RN, Bernstein ID, Trumpp A.

Cell Stem Cell. 2008 Dec 4;3(6):611-24. doi: 10.1016/j.stem.2008.09.005.

34.

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

Koch U, Fiorini E, Benedito R, Besseyrias V, Schuster-Gossler K, Pierres M, Manley NR, Duarte A, Macdonald HR, Radtke F.

J Exp Med. 2008 Oct 27;205(11):2515-23. doi: 10.1084/jem.20080829. Epub 2008 Sep 29.

35.

Massive cystic degeneration of a pedunculated leiomyoma.

Dancz CE, Macdonald HR.

Fertil Steril. 2008 Oct;90(4):1180-1. doi: 10.1016/j.fertnstert.2007.12.046. Epub 2008 Feb 15.

PMID:
18279856
36.

Sustained activation and tumor targeting of NKT cells using a CD1d-anti-HER2-scFv fusion protein induce antitumor effects in mice.

Stirnemann K, Romero JF, Baldi L, Robert B, Cesson V, Besra GS, Zauderer M, Wurm F, Corradin G, Mach JP, Macdonald HR, Donda A.

J Clin Invest. 2008 Mar;118(3):994-1005. doi: 10.1172/JCI33249.

37.

NKT cells: In the beginning...

Macdonald HR.

Eur J Immunol. 2007 Nov;37 Suppl 1:S111-5.

38.

A critical lineage-nonspecific role for pTalpha in mediating allelic and isotypic exclusion in TCRbeta-transgenic mice.

Ferrero I, Grosjean F, Fiorini E, MacDonald HR.

Eur J Immunol. 2007 Nov;37(11):3220-8.

39.

Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis.

Koch U, Wilson A, Cobas M, Kemler R, Macdonald HR, Radtke F.

Blood. 2008 Jan 1;111(1):160-4. Epub 2007 Sep 13.

40.

Development and selection of Valpha l4i NKT cells.

MacDonald HR, Mycko MP.

Curr Top Microbiol Immunol. 2007;314:195-212. Review.

PMID:
17593662
41.

Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike.

Wilson A, Ardiet DL, Saner C, Vilain N, Beermann F, Aguet M, Macdonald HR, Zilian O.

J Immunol. 2007 Jun 1;178(11):6746-51.

42.

Dormant and self-renewing hematopoietic stem cells and their niches.

Wilson A, Oser GM, Jaworski M, Blanco-Bose WE, Laurenti E, Adolphe C, Essers MA, Macdonald HR, Trumpp A.

Ann N Y Acad Sci. 2007 Jun;1106:64-75. Epub 2007 Apr 18. Review.

PMID:
17442778
43.

T cell recognition of lipids: quo vadis?

De Libero G, Macdonald HR, Dellabona P.

Nat Immunol. 2007 Mar;8(3):223-7. No abstract available. Erratum in: Nat Immunol. 2007 Apr;8(4):438.

PMID:
17304228
44.

Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.

Besseyrias V, Fiorini E, Strobl LJ, Zimber-Strobl U, Dumortier A, Koch U, Arcangeli ML, Ezine S, Macdonald HR, Radtke F.

J Exp Med. 2007 Feb 19;204(2):331-43. Epub 2007 Jan 29.

45.

TCRgamma silencing during alphabeta T cell development depends upon pre-TCR-induced proliferation.

Ferrero I, Mancini SJ, Grosjean F, Wilson A, Otten L, MacDonald HR.

J Immunol. 2006 Nov 1;177(9):6038-43.

46.

Margin width as the sole determinant of local recurrence after breast conservation in patients with ductal carcinoma in situ of the breast.

Macdonald HR, Silverstein MJ, Lee LA, Ye W, Sanghavi P, Holmes DR, Silberman H, Lagios M.

Am J Surg. 2006 Oct;192(4):420-2.

PMID:
16978941
47.

TCR-alpha CDR3 loop audition regulates positive selection.

Ferreira C, Furmanski A, Millrain M, Bartok I, Guillaume P, Lees R, Simpson E, MacDonald HR, Dyson J.

J Immunol. 2006 Aug 15;177(4):2477-85.

48.

Endometrial cancer patients have a significant risk of harboring isolated tumor cells in histologically negative lymph nodes.

Amezcua CA, MacDonald HR, Lum CA, Yi W, Muderspach LI, Roman LD, Felix JC.

Int J Gynecol Cancer. 2006 May-Jun;16(3):1336-41.

PMID:
16803526
49.

LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major.

Gumy A, Aseffa A, Rachinel N, Breton M, Otten L, Tacchini-Cottier F, Röcken M, Doyen N, Acha-Orbea H, Locksley RM, MacDonald HR, Launois P, Louis J.

Eur J Immunol. 2006 Jun;36(6):1465-73.

50.

The tumor suppressor p16Ink4a regulates T lymphocyte survival.

Bianchi T, Rufer N, MacDonald HR, Migliaccio M.

Oncogene. 2006 Jul 6;25(29):4110-5. Epub 2006 Feb 20.

PMID:
16491120

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