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Subclinical Inflammation of the Ocular Surface in Soft Contact Lens Wear.

Saliman NH, Morgan PB, MacDonald AS, Maldonado-Codina C.

Cornea. 2020 Feb;39(2):146-154. doi: 10.1097/ICO.0000000000002192.


Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs.

Obieglo K, Costain A, Webb LM, Ozir-Fazalalikhan A, Brown SL, MacDonald AS, Smits HH.

Eur J Immunol. 2019 Aug;49(8):1226-1234. doi: 10.1002/eji.201847858. Epub 2019 May 29.


Corrigendum: Schistosome Egg Migration: Mechanisms, Pathogenesis and Host Immune Responses.

Costain AH, MacDonald AS, Smits HH.

Front Immunol. 2019 Apr 11;10:749. doi: 10.3389/fimmu.2019.00749. eCollection 2019.


The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation.

Svedberg FR, Brown SL, Krauss MZ, Campbell L, Sharpe C, Clausen M, Howell GJ, Clark H, Madsen J, Evans CM, Sutherland TE, Ivens AC, Thornton DJ, Grencis RK, Hussell T, Cunoosamy DM, Cook PC, MacDonald AS.

Nat Immunol. 2019 May;20(5):571-580. doi: 10.1038/s41590-019-0352-y. Epub 2019 Apr 1.


Schistosome Egg Migration: Mechanisms, Pathogenesis and Host Immune Responses.

Costain AH, MacDonald AS, Smits HH.

Front Immunol. 2018 Dec 20;9:3042. doi: 10.3389/fimmu.2018.03042. eCollection 2018. Review. Erratum in: Front Immunol. 2019 Apr 11;10:749.


Dynamics of Colon Monocyte and Macrophage Activation During Colitis.

Jones GR, Bain CC, Fenton TM, Kelly A, Brown SL, Ivens AC, Travis MA, Cook PC, MacDonald AS.

Front Immunol. 2018 Nov 27;9:2764. doi: 10.3389/fimmu.2018.02764. eCollection 2018.


Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1.

Walwyn-Brown K, Guldevall K, Saeed M, Pende D, Önfelt B, MacDonald AS, Davis DM.

J Immunol. 2018 Oct 1;201(7):2028-2041. doi: 10.4049/jimmunol.1800475. Epub 2018 Aug 17.


Schistosoma mansoni infection is associated with quantitative and qualitative modifications of the mammalian intestinal microbiota.

Jenkins TP, Peachey LE, Ajami NJ, MacDonald AS, Hsieh MH, Brindley PJ, Cantacessi C, Rinaldi G.

Sci Rep. 2018 Aug 13;8(1):12072. doi: 10.1038/s41598-018-30412-x.


Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.

May S, Owen H, Phesse TJ, Greenow KR, Jones GR, Blackwood A, Cook PC, Towers C, Gallimore AM, Williams GT, Stürzl M, Britzen-Laurent N, Sansom OJ, MacDonald AS, Bird AP, Clarke AR, Parry L.

J Pathol. 2018 Jul;245(3):270-282. doi: 10.1002/path.5074. Epub 2018 May 16.


Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner.

Melo-Gonzalez F, Fenton TM, Forss C, Smedley C, Goenka A, MacDonald AS, Thornton DJ, Travis MA.

J Biol Chem. 2018 Jun 1;293(22):8543-8553. doi: 10.1074/jbc.M117.789305. Epub 2018 Mar 26.


Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.

Pariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW.

J Clin Invest. 2018 Jun 1;128(6):2281-2296. doi: 10.1172/JCI93910. Epub 2018 Apr 30.


The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock.

Hopwood TW, Hall S, Begley N, Forman R, Brown S, Vonslow R, Saer B, Little MC, Murphy EA, Hurst RJ, Ray DW, MacDonald AS, Brass A, Bechtold DA, Gibbs JE, Loudon AS, Else KJ.

Sci Rep. 2018 Feb 28;8(1):3782. doi: 10.1038/s41598-018-22021-5.


X-ray micro-computed tomography (μCT): an emerging opportunity in parasite imaging.

O'Sullivan JDB, Behnsen J, Starborg T, MacDonald AS, Phythian-Adams AT, Else KJ, Cruickshank SM, Withers PJ.

Parasitology. 2018 Jun;145(7):848-854. doi: 10.1017/S0031182017002074. Epub 2017 Nov 28. Review.


Evaluation of a visual tool co-developed for training hospital staff on the prevention and control of the spread of healthcare associated infections.

Macdonald AS, Macduff C, Loudon D, Wan S.

Infect Dis Health. 2017 Sep;22(3):105-116. doi: 10.1016/j.idh.2017.06.002. Epub 2017 Jul 10.


Type I interferon is required for T helper (Th) 2 induction by dendritic cells.

Webb LM, Lundie RJ, Borger JG, Brown SL, Connor LM, Cartwright AN, Dougall AM, Wilbers RH, Cook PC, Jackson-Jones LH, Phythian-Adams AT, Johansson C, Davis DM, Dewals BG, Ronchese F, MacDonald AS.

EMBO J. 2017 Aug 15;36(16):2404-2418. doi: 10.15252/embj.201695345. Epub 2017 Jul 17.


Different populations of CD11b+ dendritic cells drive Th2 responses in the small intestine and colon.

Mayer JU, Demiri M, Agace WW, MacDonald AS, Svensson-Frej M, Milling SW.

Nat Commun. 2017 Jun 9;8:15820. doi: 10.1038/ncomms15820.


Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

Grabiec AM, Denny N, Doherty JA, Happonen KE, Hankinson J, Connolly E, Fife ME, Fujimori T, Fujino N, Goenka A, Holden S, Tavernier G, Shah R, Cook PC, MacDonald AS, Niven RM, Dahlbäck B, Fowler SJ, Simpson A, Hussell T.

J Allergy Clin Immunol. 2017 Oct;140(4):1144-1146.e4. doi: 10.1016/j.jaci.2017.03.024. Epub 2017 Apr 12. No abstract available.


Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota.

McFarlane AJ, McSorley HJ, Davidson DJ, Fitch PM, Errington C, Mackenzie KJ, Gollwitzer ES, Johnston CJC, MacDonald AS, Edwards MR, Harris NL, Marsland BJ, Maizels RM, Schwarze J.

J Allergy Clin Immunol. 2017 Oct;140(4):1068-1078.e6. doi: 10.1016/j.jaci.2017.01.016. Epub 2017 Feb 11.


Particles from the Echinococcus granulosus laminated layer inhibit IL-4 and growth factor-driven Akt phosphorylation and proliferative responses in macrophages.

Seoane PI, Rückerl D, Casaravilla C, Barrios AA, Pittini Á, MacDonald AS, Allen JE, Díaz A.

Sci Rep. 2016 Dec 14;6:39204. doi: 10.1038/srep39204.


IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha.

Jackson-Jones LH, Rückerl D, Svedberg F, Duncan S, Maizels RM, Sutherland TE, Jenkins SJ, McSorley HJ, Bénézech C, MacDonald AS, Allen JE.

Eur J Immunol. 2016 Oct;46(10):2311-2321. doi: 10.1002/eji.201646442.


Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells.

Kannan Y, Li Y, Coomes SM, Okoye IS, Pelly VS, Sriskantharajah S, Gückel E, Webb L, Czieso S, Nikolov N, MacDonald AS, Ley SC, Wilson MS.

J Allergy Clin Immunol. 2017 Feb;139(2):655-666.e7. doi: 10.1016/j.jaci.2016.05.031. Epub 2016 Jul 5.


Dendritic cells in lung immunopathology.

Cook PC, MacDonald AS.

Semin Immunopathol. 2016 Jul;38(4):449-60. doi: 10.1007/s00281-016-0571-3. Epub 2016 Jun 2. Review.


IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection.

Pelly VS, Kannan Y, Coomes SM, Entwistle LJ, Rückerl D, Seddon B, MacDonald AS, McKenzie A, Wilson MS.

Mucosal Immunol. 2016 Nov;9(6):1407-1417. doi: 10.1038/mi.2016.4. Epub 2016 Feb 17.


Rehabilitation professionals' perceptions of the use of new visualisation software tools with people with stroke.

Ballinger C, Taylor A, Loudon D, Macdonald AS.

Disabil Rehabil Assist Technol. 2016 Feb;11(2):139-149. doi: 10.3109/17483107.2015.1111941.


Integrin α4β1 controls G9a activity that regulates epigenetic changes and nuclear properties required for lymphocyte migration.

Zhang X, Cook PC, Zindy E, Williams CJ, Jowitt TA, Streuli CH, MacDonald AS, Redondo-Muñoz J.

Nucleic Acids Res. 2016 Apr 20;44(7):3031-44. doi: 10.1093/nar/gkv1348. Epub 2015 Dec 10.


A central role for hepatic conventional dendritic cells in supporting Th2 responses during helminth infection.

Lundie RJ, Webb LM, Marley AK, Phythian-Adams AT, Cook PC, Jackson-Jones LH, Brown S, Maizels RM, Boon L, O'Keeffe M, MacDonald AS.

Immunol Cell Biol. 2016 Apr;94(4):400-10. doi: 10.1038/icb.2015.114. Epub 2015 Dec 11.


1,25-Dihydroxyvitamin D3-Conditioned CD11c+ Dendritic Cells are Effective Initiators of CNS Autoimmune Disease.

Besusso D, Saul L, Leech MD, O'Connor RA, MacDonald AS, Anderton SM, Mellanby RJ.

Front Immunol. 2015 Nov 18;6:575. doi: 10.3389/fimmu.2015.00575. eCollection 2015.


Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase.

Redpath SA, van der Werf N, MacDonald AS, Maizels RM, Taylor MD.

Infect Immun. 2015 Oct;83(10):3881-9. doi: 10.1128/IAI.00408-15. Epub 2015 Jul 20.


A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.

Cook PC, Owen H, Deaton AM, Borger JG, Brown SL, Clouaire T, Jones GR, Jones LH, Lundie RJ, Marley AK, Morrison VL, Phythian-Adams AT, Wachter E, Webb LM, Sutherland TE, Thomas GD, Grainger JR, Selfridge J, McKenzie AN, Allen JE, Fagerholm SC, Maizels RM, Ivens AC, Bird A, MacDonald AS.

Nat Commun. 2015 Apr 24;6:6920. doi: 10.1038/ncomms7920.


Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid.

Jones LH, Cook PC, Ivens AC, Thomas GD, Phythian-Adams AT, Allen JE, MacDonald AS.

Int Immunol. 2015 Nov;27(11):589-96. doi: 10.1093/intimm/dxv020. Epub 2015 Apr 20.


The adult murine heart has a sparse, phagocytically active macrophage population that expands through monocyte recruitment and adopts an 'M2' phenotype in response to Th2 immunologic challenge.

Mylonas KJ, Jenkins SJ, Castellan RF, Ruckerl D, McGregor K, Phythian-Adams AT, Hewitson JP, Campbell SM, MacDonald AS, Allen JE, Gray GA.

Immunobiology. 2015 Jul;220(7):924-33. doi: 10.1016/j.imbio.2015.01.013. Epub 2015 Feb 7.


The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung.

Fujimori T, Grabiec AM, Kaur M, Bell TJ, Fujino N, Cook PC, Svedberg FR, MacDonald AS, Maciewicz RA, Singh D, Hussell T.

Mucosal Immunol. 2015 Sep;8(5):1021-1030. doi: 10.1038/mi.2014.129. Epub 2015 Jan 21.


Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype.

Morrison VL, James MJ, Grzes K, Cook P, Glass DG, Savinko T, Lek HS, Gawden-Bone C, Watts C, Millington OR, MacDonald AS, Fagerholm SC.

Nat Commun. 2014 Oct 28;5:5359. doi: 10.1038/ncomms6359.


MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus.

Reynolds LA, Harcus Y, Smith KA, Webb LM, Hewitson JP, Ross EA, Brown S, Uematsu S, Akira S, Gray D, Gray M, MacDonald AS, Cunningham AF, Maizels RM.

J Immunol. 2014 Sep 15;193(6):2984-93. doi: 10.4049/jimmunol.1401056. Epub 2014 Aug 11.


Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling.

Robson NC, Hidalgo L, Mc Alpine T, Wei H, Martínez VG, Entrena A, Melen GJ, MacDonald AS, Phythian-Adams A, Sacedón R, Maraskovsky E, Cebon J, Ramírez M, Vicente A, Varas A.

Cancer Res. 2014 Sep 15;74(18):5019-5031. doi: 10.1158/0008-5472.CAN-13-2845. Epub 2014 Jul 18.


Unconventional maturation of dendritic cells induced by particles from the laminated layer of larval Echinococcus granulosus.

Casaravilla C, Pittini A, Rückerl D, Seoane PI, Jenkins SJ, MacDonald AS, Ferreira AM, Allen JE, Díaz A.

Infect Immun. 2014 Aug;82(8):3164-76. doi: 10.1128/IAI.01959-14. Epub 2014 May 19.


Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection.

Hoy AM, Lundie RJ, Ivens A, Quintana JF, Nausch N, Forster T, Jones F, Kabatereine NB, Dunne DW, Mutapi F, Macdonald AS, Buck AH.

PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2701. doi: 10.1371/journal.pntd.0002701. eCollection 2014 Feb.


A unique DNA methylation signature defines a population of IFN-γ/IL-4 double-positive T cells during helminth infection.

Deaton AM, Cook PC, De Sousa D, Phythian-Adams AT, Bird A, MacDonald AS.

Eur J Immunol. 2014 Jun;44(6):1835-41. doi: 10.1002/eji.201344098. Epub 2014 Mar 25.


RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.

Rigby RE, Webb LM, Mackenzie KJ, Li Y, Leitch A, Reijns MA, Lundie RJ, Revuelta A, Davidson DJ, Diebold S, Modis Y, MacDonald AS, Jackson AP.

EMBO J. 2014 Mar 18;33(6):542-58. doi: 10.1002/embj.201386117. Epub 2014 Feb 10.


ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection.

Redpath SA, van der Werf N, Cervera AM, MacDonald AS, Gray D, Maizels RM, Taylor MD.

Eur J Immunol. 2013 Mar;43(3):705-15. doi: 10.1002/eji.201242794. Epub 2013 Jan 31.


TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis.

Mellanby RJ, Cambrook H, Turner DG, O'Connor RA, Leech MD, Kurschus FC, MacDonald AS, Arnold B, Anderton SM.

J Neuroinflammation. 2012 Oct 30;9:248. doi: 10.1186/1742-2094-9-248.


Developing visualisation software for rehabilitation: investigating the requirements of patients, therapists and the rehabilitation process.

Loudon D, Macdonald AS, Carse B, Thikey H, Jones L, Rowe PJ, Uzor S, Ayoade M, Baillie L.

Health Informatics J. 2012 Sep;18(3):171-80.


Alternative activation of macrophages by filarial nematodes is MyD88-independent.

Mylonas KJ, Hoeve MA, MacDonald AS, Allen JE.

Immunobiology. 2013 Apr;218(4):570-8. doi: 10.1016/j.imbio.2012.07.006. Epub 2012 Jul 21.


Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion.

Smith KA, Harcus Y, Garbi N, Hämmerling GJ, MacDonald AS, Maizels RM.

Infect Immun. 2012 Oct;80(10):3481-9. doi: 10.1128/IAI.00436-12. Epub 2012 Jul 30.


Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo.

Cook PC, Jones LH, Jenkins SJ, Wynn TA, Allen JE, MacDonald AS.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9977-82. doi: 10.1073/pnas.1121231109. Epub 2012 Jun 1.


An essay on agriculture and population pressure.

Macdonald AS.

Nutr Health. 2012 Jan;21(1):6-16. doi: 10.1177/0260106012437546.


Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.

Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F, Zamoyska R.

PLoS One. 2012;7(4):e35466. doi: 10.1371/journal.pone.0035466. Epub 2012 Apr 9.


Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction.

Perona-Wright G, Lundie RJ, Jenkins SJ, Webb LM, Grencis RK, MacDonald AS.

J Immunol. 2012 Mar 1;188(5):2350-8. doi: 10.4049/jimmunol.1101642. Epub 2012 Jan 27.


Plasma membrane proteomes of differentially matured dendritic cells identified by LC-MS/MS combined with iTRAQ labelling.

Ferret-Bernard S, Castro-Borges W, Dowle AA, Sanin DE, Cook PC, Turner JD, MacDonald AS, Thomas JR, Mountford AP.

J Proteomics. 2012 Jan 4;75(3):938-48. doi: 10.1016/j.jprot.2011.10.010. Epub 2011 Oct 25.

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