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The environmental stress sensitivities of pathogenic Candida species, including Candida auris, and implications for their spread in the hospital setting.

Heaney H, Laing J, Paterson L, Walker AW, Gow NAR, Johnson EM, MacCallum DM, Brown AJP.

Med Mycol. 2020 Jan 7. pii: myz127. doi: 10.1093/mmy/myz127. [Epub ahead of print]


An ex vivo Human Skin Model to Study Superficial Fungal Infections.

Corzo-León DE, Munro CA, MacCallum DM.

Front Microbiol. 2019 Jun 5;10:1172. doi: 10.3389/fmicb.2019.01172. eCollection 2019.


A Bright Future for Fluorescence Imaging of Fungi in Living Hosts.

Chapuis AF, Ballou ER, MacCallum DM.

J Fungi (Basel). 2019 Apr 3;5(2). pii: E29. doi: 10.3390/jof5020029. Review.


Inhibition of Classical and Alternative Modes of Respiration in Candida albicans Leads to Cell Wall Remodeling and Increased Macrophage Recognition.

Duvenage L, Walker LA, Bojarczuk A, Johnston SA, MacCallum DM, Munro CA, Gourlay CW.

mBio. 2019 Jan 29;10(1). pii: e02535-18. doi: 10.1128/mBio.02535-18.


Author Correction: Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis.

Rudkin FM, Raziunaite I, Workman H, Essono S, Belmonte R, MacCallum DM, Johnson EM, Silva L, Palma AS, Feizi T, Jensen A, Erwig LP, Gow NAR.

Nat Commun. 2019 Jan 18;10(1):394. doi: 10.1038/s41467-019-08392-x.


Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis.

Rudkin FM, Raziunaite I, Workman H, Essono S, Belmonte R, MacCallum DM, Johnson EM, Silva LM, Palma AS, Feizi T, Jensen A, Erwig LP, Gow NAR.

Nat Commun. 2018 Dec 11;9(1):5288. doi: 10.1038/s41467-018-07738-1. Erratum in: Nat Commun. 2019 Jan 18;10(1):394.


The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis.

Dambuza IM, Drake T, Chapuis A, Zhou X, Correia J, Taylor-Smith L, LeGrave N, Rasmussen T, Fisher MC, Bicanic T, Harrison TS, Jaspars M, May RC, Brown GD, Yuecel R, MacCallum DM, Ballou ER.

PLoS Pathog. 2018 May 18;14(5):e1006978. doi: 10.1371/journal.ppat.1006978. eCollection 2018 May.


Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen.

Day AM, Herrero-de-Dios CM, MacCallum DM, Brown AJP, Quinn J.

Sci Rep. 2017 Oct 30;7(1):14340. doi: 10.1038/s41598-017-14756-4.


Elevated catalase expression in a fungal pathogen is a double-edged sword of iron.

Pradhan A, Herrero-de-Dios C, Belmonte R, Budge S, Lopez Garcia A, Kolmogorova A, Lee KK, Martin BD, Ribeiro A, Bebes A, Yuecel R, Gow NAR, Munro CA, MacCallum DM, Quinn J, Brown AJP.

PLoS Pathog. 2017 May 22;13(5):e1006405. doi: 10.1371/journal.ppat.1006405. eCollection 2017 May.


Adaptation of Candida albicans to environmental pH induces cell wall remodelling and enhances innate immune recognition.

Sherrington SL, Sorsby E, Mahtey N, Kumwenda P, Lenardon MD, Brown I, Ballou ER, MacCallum DM, Hall RA.

PLoS Pathog. 2017 May 22;13(5):e1006403. doi: 10.1371/journal.ppat.1006403. eCollection 2017 May.


Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation.

Day AM, Smith DA, Ikeh MA, Haider M, Herrero-de-Dios CM, Brown AJ, Morgan BA, Erwig LP, MacCallum DM, Quinn J.

PLoS Pathog. 2017 Jan 30;13(1):e1006131. doi: 10.1371/journal.ppat.1006131. eCollection 2017 Jan.


Candida albicans Chitin Increases Arginase-1 Activity in Human Macrophages, with an Impact on Macrophage Antimicrobial Functions.

Wagener J, MacCallum DM, Brown GD, Gow NA.

mBio. 2017 Jan 24;8(1). pii: e01820-16. doi: 10.1128/mBio.01820-16.


Lactate signalling regulates fungal β-glucan masking and immune evasion.

Ballou ER, Avelar GM, Childers DS, Mackie J, Bain JM, Wagener J, Kastora SL, Panea MD, Hardison SE, Walker LA, Erwig LP, Munro CA, Gow NA, Brown GD, MacCallum DM, Brown AJ.

Nat Microbiol. 2016 Dec 12;2:16238. doi: 10.1038/nmicrobiol.2016.238.


Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp.

Liu Z, Moran GP, Sullivan DJ, MacCallum DM, Myers LC.

PLoS Genet. 2016 Oct 14;12(10):e1006373. doi: 10.1371/journal.pgen.1006373. eCollection 2016 Oct.


Pho4 mediates phosphate acquisition in Candida albicans and is vital for stress resistance and metal homeostasis.

Ikeh MA, Kastora SL, Day AM, Herrero-de-Dios CM, Tarrant E, Waldron KJ, Banks AP, Bain JM, Lydall D, Veal EA, MacCallum DM, Erwig LP, Brown AJ, Quinn J.

Mol Biol Cell. 2016 Sep 1;27(17):2784-801. doi: 10.1091/mbc.E16-05-0266. Epub 2016 Jul 6.


Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections.

Mackie J, Szabo EK, Urgast DS, Ballou ER, Childers DS, MacCallum DM, Feldmann J, Brown AJ.

PLoS One. 2016 Jun 30;11(6):e0158683. doi: 10.1371/journal.pone.0158683. eCollection 2016.


The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence.

Childers DS, Raziunaite I, Mol Avelar G, Mackie J, Budge S, Stead D, Gow NA, Lenardon MD, Ballou ER, MacCallum DM, Brown AJ.

PLoS Pathog. 2016 Apr 13;12(4):e1005566. doi: 10.1371/journal.ppat.1005566. eCollection 2016 Apr.


Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicans.

Tillmann AT, Strijbis K, Cameron G, Radmaneshfar E, Thiel M, Munro CA, MacCallum DM, Distel B, Gow NA, Brown AJ.

PLoS One. 2015 Jun 3;10(6):e0126940. doi: 10.1371/journal.pone.0126940. eCollection 2015.


Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity.

Vautier S, Drummond RA, Chen K, Murray GI, Kadosh D, Brown AJ, Gow NA, MacCallum DM, Kolls JK, Brown GD.

Cell Microbiol. 2015 Apr;17(4):445-50. doi: 10.1111/cmi.12388. Epub 2014 Nov 25.


Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation.

Wagener J, Malireddi RK, Lenardon MD, Köberle M, Vautier S, MacCallum DM, Biedermann T, Schaller M, Netea MG, Kanneganti TD, Brown GD, Brown AJ, Gow NA.

PLoS Pathog. 2014 Apr 10;10(4):e1004050. doi: 10.1371/journal.ppat.1004050. eCollection 2014 Apr.


Expansion of Foxp3(+) T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge.

Whibley N, Maccallum DM, Vickers MA, Zafreen S, Waldmann H, Hori S, Gaffen SL, Gow NA, Barker RN, Hall AM.

Eur J Immunol. 2014 Apr;44(4):1069-83. doi: 10.1002/eji.201343604. Epub 2014 Feb 13.


A novel renal epithelial cell in vitro assay to assess Candida albicans virulence.

Szabo EK, Maccallum DM.

Virulence. 2014 Feb 15;5(2):286-96. doi: 10.4161/viru.27046. Epub 2013 Nov 13.


Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events.

Potrykus J, Stead D, Maccallum DM, Urgast DS, Raab A, van Rooijen N, Feldmann J, Brown AJ.

PLoS Pathog. 2013;9(10):e1003676. doi: 10.1371/journal.ppat.1003676. Epub 2013 Oct 17.


Role of the Candida albicans MNN1 gene family in cell wall structure and virulence.

Bates S, Hall RA, Cheetham J, Netea MG, MacCallum DM, Brown AJ, Odds FC, Gow NA.

BMC Res Notes. 2013 Jul 26;6:294. doi: 10.1186/1756-0500-6-294.


Mouse model of invasive fungal infection.

MacCallum DM.

Methods Mol Biol. 2013;1031:145-53. doi: 10.1007/978-1-62703-481-4_17.


Ybp1 and Gpx3 signaling in Candida albicans govern hydrogen peroxide-induced oxidation of the Cap1 transcription factor and macrophage escape.

Patterson MJ, McKenzie CG, Smith DA, da Silva Dantas A, Sherston S, Veal EA, Morgan BA, MacCallum DM, Erwig LP, Quinn J.

Antioxid Redox Signal. 2013 Dec 20;19(18):2244-60. doi: 10.1089/ars.2013.5199. Epub 2013 Jul 9.


Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1.

Marakalala MJ, Vautier S, Potrykus J, Walker LA, Shepardson KM, Hopke A, Mora-Montes HM, Kerrigan A, Netea MG, Murray GI, Maccallum DM, Wheeler R, Munro CA, Gow NA, Cramer RA, Brown AJ, Brown GD.

PLoS Pathog. 2013;9(4):e1003315. doi: 10.1371/journal.ppat.1003315. Epub 2013 Apr 18.


The Mnn2 mannosyltransferase family modulates mannoprotein fibril length, immune recognition and virulence of Candida albicans.

Hall RA, Bates S, Lenardon MD, Maccallum DM, Wagener J, Lowman DW, Kruppa MD, Williams DL, Odds FC, Brown AJ, Gow NA.

PLoS Pathog. 2013;9(4):e1003276. doi: 10.1371/journal.ppat.1003276. Epub 2013 Apr 25.


Enhanced efficacy of synergistic combinations of antimicrobial peptides with caspofungin versus Candida albicans in insect and murine models of systemic infection.

MacCallum DM, Desbois AP, Coote PJ.

Eur J Clin Microbiol Infect Dis. 2013 Aug;32(8):1055-62. doi: 10.1007/s10096-013-1850-8. Epub 2013 Apr 10.


Dectin-1 is not required for controlling Candida albicans colonization of the gastrointestinal tract.

Vautier S, Drummond RA, Redelinghuys P, Murray GI, MacCallum DM, Brown GD.

Infect Immun. 2012 Dec;80(12):4216-22. doi: 10.1128/IAI.00559-12. Epub 2012 Sep 17.


Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin.

Imtiaz T, Lee KK, Munro CA, MacCallum DM, Shankland GS, Johnson EM, MacGregor MS, Bal AM.

J Med Microbiol. 2012 Sep;61(Pt 9):1330-1334. doi: 10.1099/jmm.0.045047-0. Epub 2012 May 31.


Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen.

Ene IV, Adya AK, Wehmeier S, Brand AC, MacCallum DM, Gow NA, Brown AJ.

Cell Microbiol. 2012 Sep;14(9):1319-35. doi: 10.1111/j.1462-5822.2012.01813.x. Epub 2012 Jun 5.


Mouse intravenous challenge models and applications.

MacCallum DM.

Methods Mol Biol. 2012;845:499-509. doi: 10.1007/978-1-61779-539-8_35.


Cytokine measurement using cytometric bead arrays.

Castillo L, MacCallum DM.

Methods Mol Biol. 2012;845:425-34. doi: 10.1007/978-1-61779-539-8_29.


Hosting infection: experimental models to assay Candida virulence.

Maccallum DM.

Int J Microbiol. 2012;2012:363764. doi: 10.1155/2012/363764. Epub 2011 Dec 22.


Identification of a novel response regulator, Crr1, that is required for hydrogen peroxide resistance in Candida albicans.

Bruce CR, Smith DA, Rodgers D, da Silva Dantas A, MacCallum DM, Morgan BA, Quinn J.

PLoS One. 2011;6(12):e27979. doi: 10.1371/journal.pone.0027979. Epub 2011 Dec 2.


MAPKKK-independent regulation of the Hog1 stress-activated protein kinase in Candida albicans.

Cheetham J, MacCallum DM, Doris KS, da Silva Dantas A, Scorfield S, Odds F, Smith DA, Quinn J.

J Biol Chem. 2011 Dec 9;286(49):42002-16. doi: 10.1074/jbc.M111.265231. Epub 2011 Oct 12.


Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo.

Lee KK, Maccallum DM, Jacobsen MD, Walker LA, Odds FC, Gow NA, Munro CA.

Antimicrob Agents Chemother. 2012 Jan;56(1):208-17. doi: 10.1128/AAC.00683-11. Epub 2011 Oct 10.


C-type lectin receptors and cytokines in fungal immunity.

Vautier S, MacCallum DM, Brown GD.

Cytokine. 2012 Apr;58(1):89-99. doi: 10.1016/j.cyto.2011.08.031. Epub 2011 Sep 15. Review.


Wild-type Drosophila melanogaster as an alternative model system for investigating the pathogenicity of Candida albicans.

Glittenberg MT, Silas S, MacCallum DM, Gow NA, Ligoxygakis P.

Dis Model Mech. 2011 Jul;4(4):504-14. doi: 10.1242/dmm.006619. Epub 2011 May 2.


The contribution of mouse models to our understanding of systemic candidiasis.

Szabo EK, MacCallum DM.

FEMS Microbiol Lett. 2011 Jul;320(1):1-8. doi: 10.1111/j.1574-6968.2011.02262.x. Epub 2011 Mar 24. Review.


Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans.

Leach MD, Stead DA, Argo E, MacCallum DM, Brown AJ.

Mol Microbiol. 2011 Mar;79(6):1574-93. doi: 10.1111/j.1365-2958.2011.07542.x. Epub 2011 Jan 26. Erratum in: Mol Microbiol. 2012 May;84(3):594.


CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans.

Hall RA, De Sordi L, Maccallum DM, Topal H, Eaton R, Bloor JW, Robinson GK, Levin LR, Buck J, Wang Y, Gow NA, Steegborn C, Mühlschlegel FA.

PLoS Pathog. 2010 Nov 18;6(11):e1001193. doi: 10.1371/journal.ppat.1001193.


Differential regulation of kidney and spleen cytokine responses in mice challenged with pathology-standardized doses of Candida albicans mannosylation mutants.

Castillo L, MacCallum DM, Brown AJ, Gow NA, Odds FC.

Infect Immun. 2011 Jan;79(1):146-52. doi: 10.1128/IAI.01004-10. Epub 2010 Nov 8.


Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans.

Nicholls S, MacCallum DM, Kaffarnik FA, Selway L, Peck SC, Brown AJ.

Fungal Genet Biol. 2011 Mar;48(3):297-305. doi: 10.1016/j.fgb.2010.08.010. Epub 2010 Sep 9.


Thioredoxin regulates multiple hydrogen peroxide-induced signaling pathways in Candida albicans.

da Silva Dantas A, Patterson MJ, Smith DA, Maccallum DM, Erwig LP, Morgan BA, Quinn J.

Mol Cell Biol. 2010 Oct;30(19):4550-63. doi: 10.1128/MCB.00313-10. Epub 2010 Aug 2.


Multicenter collaborative study for standardization of Candida albicans genotyping using a polymorphic microsatellite marker.

Garcia-Hermoso D, MacCallum DM, Lott TJ, Sampaio P, Serna MJ, Grenouillet F, Klaassen CH, Bretagne S.

J Clin Microbiol. 2010 Jul;48(7):2578-81. doi: 10.1128/JCM.00040-10. Epub 2010 Apr 28.


Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection.

MacCallum DM, Coste A, Ischer F, Jacobsen MD, Odds FC, Sanglard D.

Antimicrob Agents Chemother. 2010 Apr;54(4):1476-83. doi: 10.1128/AAC.01645-09. Epub 2010 Jan 19.


Comparative transcript profiling of Candida albicans and Candida dubliniensis identifies SFL2, a C. albicans gene required for virulence in a reconstituted epithelial infection model.

Spiering MJ, Moran GP, Chauvel M, Maccallum DM, Higgins J, Hokamp K, Yeomans T, d'Enfert C, Coleman DC, Sullivan DJ.

Eukaryot Cell. 2010 Feb;9(2):251-65. doi: 10.1128/EC.00291-09. Epub 2009 Dec 18.


Functional specialization and differential regulation of short-chain carboxylic acid transporters in the pathogen Candida albicans.

Vieira N, Casal M, Johansson B, MacCallum DM, Brown AJ, Paiva S.

Mol Microbiol. 2010 Mar;75(6):1337-54. doi: 10.1111/j.1365-2958.2009.07003.x. Epub 2009 Dec 4.

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