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MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.

Casaletto JB, Geddie ML, Abu-Yousif AO, Masson K, Fulgham A, Boudot A, Maiwald T, Kearns JD, Kohli N, Su S, Razlog M, Raue A, Kalra A, Håkansson M, Logan DT, Welin M, Chattopadhyay S, Harms BD, Nielsen UB, Schoeberl B, Lugovskoy AA, MacBeath G.

Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7533-7542. doi: 10.1073/pnas.1819085116. Epub 2019 Mar 21.


Estimation of immune cell content in tumour tissue using single-cell RNA-seq data.

Schelker M, Feau S, Du J, Ranu N, Klipp E, MacBeath G, Schoeberl B, Raue A.

Nat Commun. 2017 Dec 11;8(1):2032. doi: 10.1038/s41467-017-02289-3.


Predicting ligand-dependent tumors from multi-dimensional signaling features.

Hass H, Masson K, Wohlgemuth S, Paragas V, Allen JE, Sevecka M, Pace E, Timmer J, Stelling J, MacBeath G, Schoeberl B, Raue A.

NPJ Syst Biol Appl. 2017 Sep 20;3:27. doi: 10.1038/s41540-017-0030-3. eCollection 2017.


Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121).

Schoeberl B, Kudla A, Masson K, Kalra A, Curley M, Finn G, Pace E, Harms B, Kim J, Kearns J, Fulgham A, Burenkova O, Grantcharova V, Yarar D, Paragas V, Fitzgerald J, Wainszelbaum M, West K, Mathews S, Nering R, Adiwijaya B, Garcia G, Kubasek B, Moyo V, Czibere A, Nielsen UB, MacBeath G.

NPJ Syst Biol Appl. 2017 Jan 5;3:16034. doi: 10.1038/npjsba.2016.34. eCollection 2017. Review.


Randomized Phase II Trial of Seribantumab in Combination With Paclitaxel in Patients With Advanced Platinum-Resistant or -Refractory Ovarian Cancer.

Liu JF, Ray-Coquard I, Selle F, Poveda AM, Cibula D, Hirte H, Hilpert F, Raspagliesi F, Gladieff L, Harter P, Siena S, Del Campo JM, Tabah-Fisch I, Pearlberg J, Moyo V, Riahi K, Nering R, Kubasek W, Adiwijaya B, Czibere A, Naumann RW, Coleman RL, Vergote I, MacBeath G, Pujade-Lauraine E.

J Clin Oncol. 2016 Dec 20;34(36):4345-4353. Epub 2016 Oct 23.


A phase 1 study combining the HER3 antibody seribantumab (MM-121) and cetuximab with and without irinotecan.

Cleary JM, McRee AJ, Shapiro GI, Tolaney SM, O'Neil BH, Kearns JD, Mathews S, Nering R, MacBeath G, Czibere A, Sharma S, Korn WM.

Invest New Drugs. 2017 Feb;35(1):68-78. doi: 10.1007/s10637-016-0399-7. Epub 2016 Nov 16.


Seribantumab, an Anti-ERBB3 Antibody, Delays the Onset of Resistance and Restores Sensitivity to Letrozole in an Estrogen Receptor-Positive Breast Cancer Model.

Curley MD, Sabnis GJ, Wille L, Adiwijaya BS, Garcia G, Moyo V, Kazi AA, Brodie A, MacBeath G.

Mol Cancer Ther. 2015 Nov;14(11):2642-52. doi: 10.1158/1535-7163.MCT-15-0169. Epub 2015 Aug 26.


Heregulin and HER3 are prognostic biomarkers in oropharyngeal squamous cell carcinoma.

Qian G, Jiang N, Wang D, Newman S, Kim S, Chen Z, Garcia G, MacBeath G, Shin DM, Khuri FR, Chen ZG, Saba NF.

Cancer. 2015 Oct 15;121(20):3600-11. doi: 10.1002/cncr.29549. Epub 2015 Jul 20.


Heregulin-ErbB3-Driven Tumor Growth Persists in PI3 Kinase Mutant Cancer Cells.

Yarar D, Lahdenranta J, Kubasek W, Nielsen UB, MacBeath G.

Mol Cancer Ther. 2015 Sep;14(9):2072-80. doi: 10.1158/1535-7163.MCT-15-0075. Epub 2015 Jun 26.


A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.

Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G.

Cell. 2014 Nov 6;159(4):844-56. doi: 10.1016/j.cell.2014.10.032.


A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks.

AlQuraishi M, Koytiger G, Jenney A, MacBeath G, Sorger PK.

Nat Genet. 2014 Dec;46(12):1363-1371. doi: 10.1038/ng.3138. Epub 2014 Nov 2.


Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins.

Yi CR, Allen JE, Russo B, Lee SY, Heindl JE, Baxt LA, Herrera BB, Kahoud E, MacBeath G, Goldberg MB.

J Biol Chem. 2014 Oct 24;289(43):30101-13. doi: 10.1074/jbc.M114.595868. Epub 2014 Sep 8.


Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma.

Jiang N, Wang D, Hu Z, Shin HJ, Qian G, Rahman MA, Zhang H, Amin AR, Nannapaneni S, Wang X, Chen Z, Garcia G, MacBeath G, Shin DM, Khuri FR, Ma J, Chen ZG, Saba NF.

Mol Cancer Ther. 2014 Jul;13(7):1826-36. doi: 10.1158/1535-7163.MCT-13-1093. Epub 2014 Apr 18.


Single-cell quantitative HER2 measurement identifies heterogeneity and distinct subgroups within traditionally defined HER2-positive patients.

Onsum MD, Geretti E, Paragas V, Kudla AJ, Moulis SP, Luus L, Wickham TJ, McDonagh CF, MacBeath G, Hendriks BS.

Am J Pathol. 2013 Nov;183(5):1446-1460. doi: 10.1016/j.ajpath.2013.07.015. Epub 2013 Sep 11.


Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks.

Wagner JP, Wolf-Yadlin A, Sevecka M, Grenier JK, Root DE, Lauffenburger DA, MacBeath G.

Sci Signal. 2013 Jul 16;6(284):ra58. doi: 10.1126/scisignal.2003994.


Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates β-catenin in maintaining the integrity of tight junctions.

Gujral TS, Karp ES, Chan M, Chang BH, MacBeath G.

Chem Biol. 2013 Jun 20;20(6):816-27. doi: 10.1016/j.chembiol.2013.04.021.


Suppression of host p53 is critical for Plasmodium liver-stage infection.

Kaushansky A, Ye AS, Austin LS, Mikolajczak SA, Vaughan AM, Camargo N, Metzger PG, Douglass AN, MacBeath G, Kappe SH.

Cell Rep. 2013 Mar 28;3(3):630-7. doi: 10.1016/j.celrep.2013.02.010. Epub 2013 Mar 7.


Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected.

Koytiger G, Kaushansky A, Gordus A, Rush J, Sorger PK, MacBeath G.

Mol Cell Proteomics. 2013 May;12(5):1204-13. doi: 10.1074/mcp.M112.025858. Epub 2013 Jan 28.


Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays.

Gujral TS, Karp RL, Finski A, Chan M, Schwartz PE, MacBeath G, Sorger P.

Oncogene. 2013 Jul 18;32(29):3470-6. doi: 10.1038/onc.2012.378. Epub 2012 Sep 3.


Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks.

Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB.

Cell. 2012 May 11;149(4):780-94. doi: 10.1016/j.cell.2012.03.031.


Cross-talk between receptor tyrosine kinase and tumor necrosis factor-α signaling networks regulates apoptosis but not proliferation.

Beyer EM, MacBeath G.

Mol Cell Proteomics. 2012 Jun;11(6):M111.013292. doi: 10.1074/mcp.M111.013292. Epub 2012 Feb 8.


A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins.

Luckert K, Gujral TS, Chan M, Sevecka M, Joos TO, Sorger PK, Macbeath G, Pötz O.

Sci Signal. 2012 Jan 10;5(206):pl1. doi: 10.1126/scisignal.2002372. Erratum in: Sci Signal. 2012 Aug 21;5(238):er5. Sevecka, Mark [added].


A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactions.

Chang BH, Gujral TS, Karp ES, BuKhalid R, Grantcharova VP, MacBeath G.

Chem Biol. 2011 Sep 23;18(9):1143-52. doi: 10.1016/j.chembiol.2011.06.013.


Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling.

Jung AS, Kaushansky A, Macbeath G, Kaushansky K.

Cell Cycle. 2011 Jun 1;10(11):1838-44. Epub 2011 Jun 1.


Detecting and quantifying multiple proteins in clinical samples in high-throughput using antibody microarrays.

Knickerbocker T, MacBeath G.

Methods Mol Biol. 2011;723:3-13. doi: 10.1007/978-1-61779-043-0_1.


Lysate microarrays enable high-throughput, quantitative investigations of cellular signaling.

Sevecka M, Wolf-Yadlin A, MacBeath G.

Mol Cell Proteomics. 2011 Apr;10(4):M110.005363. doi: 10.1074/mcp.M110.005363. Epub 2011 Feb 4.


High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways.

Krall JA, Beyer EM, MacBeath G.

PLoS One. 2011 Jan 10;6(1):e15945. doi: 10.1371/journal.pone.0015945.


Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements.

Boettcher JP, Kirchner M, Churin Y, Kaushansky A, Pompaiah M, Thorn H, Brinkmann V, Macbeath G, Meyer TF.

PLoS Biol. 2010 Aug 24;8(8). pii: e1000457. doi: 10.1371/journal.pbio.1000457.


Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.

Mehlitz A, Banhart S, Mäurer AP, Kaushansky A, Gordus AG, Zielecki J, Macbeath G, Meyer TF.

J Cell Biol. 2010 Jul 12;190(1):143-57. doi: 10.1083/jcb.200909095.


A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation.

Gujral TS, MacBeath G.

PLoS One. 2010 Apr 7;5(4):e10024. doi: 10.1371/journal.pone.0010024.


Quantifying protein-protein interactions in high throughput using protein domain microarrays.

Kaushansky A, Allen JE, Gordus A, Stiffler MA, Karp ES, Chang BH, MacBeath G.

Nat Protoc. 2010 Apr;5(4):773-90. doi: 10.1038/nprot.2010.36. Epub 2010 Apr 1.


Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells.

Shalek AK, Robinson JT, Karp ES, Lee JS, Ahn DR, Yoon MH, Sutton A, Jorgolli M, Gertner RS, Gujral TS, MacBeath G, Yang EG, Park H.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1870-5. doi: 10.1073/pnas.0909350107. Epub 2010 Jan 11.


The promise and challenge of '-omic' approaches.

MacBeath G, Saghatelian A.

Curr Opin Chem Biol. 2009 Dec;13(5-6):501-2. doi: 10.1016/j.cbpa.2009.10.008. Epub 2009 Oct 23. No abstract available.


Emerging miniaturized proteomic technologies to study cell signaling in clinical samples.

Gujral TS, MacBeath G.

Sci Signal. 2009 Oct 20;2(93):pe65. doi: 10.1126/scisignal.293pe64. Erratum in: Sci Signal. 2009 Oct 27;2(94):er9.


Dissecting protein function and signaling using protein microarrays.

Wolf-Yadlin A, Sevecka M, MacBeath G.

Curr Opin Chem Biol. 2009 Oct;13(4):398-405. doi: 10.1016/j.cbpa.2009.06.027. Epub 2009 Aug 5. Review.


Linear combinations of docking affinities explain quantitative differences in RTK signaling.

Gordus A, Krall JA, Beyer EM, Kaushansky A, Wolf-Yadlin A, Sevecka M, Chang BH, Rush J, MacBeath G.

Mol Syst Biol. 2009;5:235. doi: 10.1038/msb.2008.72. Epub 2009 Jan 20.


System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.

Kaushansky A, Gordus A, Budnik BA, Lane WS, Rush J, MacBeath G.

Chem Biol. 2008 Aug 25;15(8):808-17. doi: 10.1016/j.chembiol.2008.07.006.


Predicting PDZ domain-peptide interactions from primary sequences.

Chen JR, Chang BH, Allen JE, Stiffler MA, MacBeath G.

Nat Biotechnol. 2008 Sep;26(9):1041-5. doi: 10.1038/nbt.1489. Erratum in: Nat Biotechnol. 2008 Oct;26(10):1193.


A quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R.

Kaushansky A, Gordus A, Chang B, Rush J, MacBeath G.

Mol Biosyst. 2008 Jun;4(6):643-53. doi: 10.1039/b801018h. Epub 2008 Apr 8.


PDZ domain binding selectivity is optimized across the mouse proteome.

Stiffler MA, Chen JR, Grantcharova VP, Lei Y, Fuchs D, Allen JE, Zaslavskaia LA, MacBeath G.

Science. 2007 Jul 20;317(5836):364-9. Erratum in: Science. 2007 Oct 19;318(5849):393.


An integrated approach to prognosis using protein microarrays and nonparametric methods.

Knickerbocker T, Chen JR, Thadhani R, MacBeath G.

Mol Syst Biol. 2007;3:123. Epub 2007 Jun 26.


Protein arrays: sandwich approach for analyzing complex solutions.

Macbeath G.

CSH Protoc. 2007 Mar 1;2007:pdb.prot4633. doi: 10.1101/pdb.prot4633.


Protein arrays: probing the array and detecting radioactive spots for kinase-substrate interactions.

Macbeath G.

CSH Protoc. 2007 Mar 1;2007:pdb.prot4632. doi: 10.1101/pdb.prot4632.


Protein arrays: labeling the compounds and probing the array for protein-small molecule interactions.

Macbeath G.

CSH Protoc. 2007 Mar 1;2007:pdb.prot4631. doi: 10.1101/pdb.prot4631.


Protein arrays: labeling the protein and probing the array for protein-protein interactions.

Macbeath G.

CSH Protoc. 2007 Mar 1;2007:pdb.prot4630. doi: 10.1101/pdb.prot4630.


Protein arrays: preparation of microscope slides.

Macbeath G.

CSH Protoc. 2007 Mar 1;2007:pdb.prot4629. doi: 10.1101/pdb.prot4629.


Collecting and organizing systematic sets of protein data.

Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S.

Nat Rev Mol Cell Biol. 2006 Nov;7(11):803-12. Review.


Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.

Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G.

J Am Chem Soc. 2006 May 3;128(17):5913-22.

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