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Characterisation of a human antibody that potentially links cytomegalovirus infection with systemic lupus erythematosus.

Neo JYJ, Wee SYK, Bonne I, Tay SH, Raida M, Jovanovic V, Fairhurst AM, Lu J, Hanson BJ, MacAry PA.

Sci Rep. 2019 Jul 10;9(1):9998. doi: 10.1038/s41598-019-46329-y.


Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation.

Zhao X, Hamidinia M, Choo JAL, Too CT, Ho ZZ, Ren EC, Bertoletti A, MacAry PA, Gould KG, Brzostek J, Gascoigne NRJ.

J Vis Exp. 2019 Feb 28;(144). doi: 10.3791/59126.


Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01.

Gu Y, Wong YH, Liew CW, Chan CEZ, Murali TM, Yap J, Too CT, Purushotorman K, Hamidinia M, El Sahili A, Goh ATH, Teo RZC, Wood KJ, Hanson BJ, Gascoigne NRJ, Lescar J, Vathsala A, MacAry PA.

Nat Commun. 2019 Feb 21;10(1):893. doi: 10.1038/s41467-019-08790-1.


A Flow Cytometry-Based Assay for High-Throughput Detection and Quantification of Neutrophil Extracellular Traps in Mixed Cell Populations.

Zharkova O, Tay SH, Lee HY, Shubhita T, Ong WY, Lateef A, MacAry PA, Lim LHK, Connolly JE, Fairhurst AM.

Cytometry A. 2019 Mar;95(3):268-278. doi: 10.1002/cyto.a.23672. Epub 2018 Dec 14.


Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus.

Lim MQ, Kumaran EAP, Tan HC, Lye DC, Leo YS, Ooi EE, MacAry PA, Bertoletti A, Rivino L.

Front Immunol. 2018 Oct 1;9:2225. doi: 10.3389/fimmu.2018.02225. eCollection 2018.


Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.

Zhao X, Sankaran S, Yap J, Too CT, Ho ZZ, Dolton G, Legut M, Ren EC, Sewell AK, Bertoletti A, MacAry PA, Brzostek J, Gascoigne NRJ.

Nat Commun. 2018 Jul 13;9(1):2716. doi: 10.1038/s41467-018-05288-0.


Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells.

Park HY, Tan PS, Kavishna R, Ker A, Lu J, Chan CEZ, Hanson BJ, MacAry PA, Caminschi I, Shortman K, Alonso S, Lahoud MH.

NPJ Vaccines. 2017 Nov 6;2:31. doi: 10.1038/s41541-017-0033-5. eCollection 2017.


Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas.

Grifoni A, Angelo MA, Lopez B, O'Rourke PH, Sidney J, Cerpas C, Balmaseda A, Silveira CGT, Maestri A, Costa PR, Durbin AP, Diehl SA, Phillips E, Mallal S, De Silva AD, Nchinda G, Nkenfou C, Collins MH, de Silva AM, Lim MQ, Macary PA, Tatullo F, Solomon T, Satchidanandam V, Desai A, Ravi V, Coloma J, Turtle L, Rivino L, Kallas EG, Peters B, Harris E, Sette A, Weiskopf D.

Front Immunol. 2017 Oct 13;8:1309. doi: 10.3389/fimmu.2017.01309. eCollection 2017.


TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants.

Lai J, Choo JAL, Tan WJ, Too CT, Oo MZ, Suter MA, Mustafa FB, Srinivasan N, Chan CEZ, Lim AGX, Zhong Y, Chan SH, Hanson BJ, Gascoigne NRJ, MacAry PA.

Sci Rep. 2017 Aug 30;7(1):9923. doi: 10.1038/s41598-017-10265-6.


Structural Mimicry of the Dengue Virus Envelope Glycoprotein Revealed by the Crystallographic Study of an Idiotype-Anti-idiotype Fab Complex.

Wong YH, Goh BC, Lim SY, Teo EW, Lim APC, Dedon PC, Hanson BJ, MacAry PA, Lescar J.

J Virol. 2017 Aug 10;91(17). pii: e00406-17. doi: 10.1128/JVI.00406-17. Print 2017 Sep 1.


Molecular engineering of a therapeutic antibody for Blo t 5-induced allergic asthma.

Chan JHS, Chua YL, Peh HY, Jovanovic V, Gascoigne NRJ, Wong WSF, Chew FT, Hanson BJ, Kemeny DM, MacAry PA.

J Allergy Clin Immunol. 2017 May;139(5):1705-1708.e6. doi: 10.1016/j.jaci.2016.10.028. Epub 2016 Dec 5. No abstract available.


Blomia tropicalis-Specific TCR Transgenic Th2 Cells Induce Inducible BALT and Severe Asthma in Mice by an IL-4/IL-13-Dependent Mechanism.

Chua YL, Liong KH, Huang CH, Wong HS, Zhou Q, Ler SS, Tang Y, Low CP, Koh HY, Kuo IC, Zhang Y, Wong WS, Peh HY, Lim HY, Ge MQ, Haczku A, Angeli V, MacAry PA, Chua KY, Kemeny DM.

J Immunol. 2016 Nov 15;197(10):3771-3781. Epub 2016 Oct 12.


The other side of the coin: Leveraging Epstein-Barr virus in research and therapy.

Yu F, Tan WJ, Lu Y, MacAry PA, Loh KS.

Oral Oncol. 2016 Sep;60:112-7. doi: 10.1016/j.oraloncology.2016.07.010. Epub 2016 Jul 21. Review.


Targeting Epstein-Barr virus-transformed B lymphoblastoid cells using antibodies with T-cell receptor-like specificities.

Lai J, Tan WJ, Too CT, Choo JA, Wong LH, Mustafa FB, Srinivasan N, Lim AP, Zhong Y, Gascoigne NR, Hanson BJ, Chan SH, Chen J, MacAry PA.

Blood. 2016 Sep 8;128(10):1396-407. doi: 10.1182/blood-2016-03-707836. Epub 2016 Jun 23.


The Molecular Engineering of an Anti-Idiotypic Antibody for Pharmacokinetic Analysis of a Fully Human Anti-Infective.

Lim SY, Chan CE, Lisowska MM, Hanson BJ, MacAry PA.

PLoS One. 2015 Dec 23;10(12):e0145381. doi: 10.1371/journal.pone.0145381. eCollection 2015.


The diagnostic targeting of a carbohydrate virulence factor from M.Tuberculosis.

Chan CE, Götze S, Seah GT, Seeberger PH, Tukvadze N, Wenk MR, Hanson BJ, MacAry PA.

Sci Rep. 2015 May 15;5:10281. doi: 10.1038/srep10281.


Virus-specific T lymphocytes home to the skin during natural dengue infection.

Rivino L, Kumaran EA, Thein TL, Too CT, Gan VC, Hanson BJ, Wilder-Smith A, Bertoletti A, Gascoigne NR, Lye DC, Leo YS, Akbar AN, Kemeny DM, MacAry PA.

Sci Transl Med. 2015 Mar 11;7(278):278ra35. doi: 10.1126/scitranslmed.aaa0526.


Type I IFNs and IL-18 regulate the antiviral response of primary human γδ T cells against dendritic cells infected with Dengue virus.

Tsai CY, Liong KH, Gunalan MG, Li N, Lim DS, Fisher DA, MacAry PA, Leo YS, Wong SC, Puan KJ, Wong SB.

J Immunol. 2015 Apr 15;194(8):3890-900. doi: 10.4049/jimmunol.1303343. Epub 2015 Mar 2.


Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomallei.

Lim YT, Jobichen C, Wong J, Limmathurotsakul D, Li S, Chen Y, Raida M, Srinivasan N, MacAry PA, Sivaraman J, Gan YH.

Sci Rep. 2015 Feb 4;5:8235. doi: 10.1038/srep08235.


Multifunctional cytomegalovirus (CMV)-specific CD8(+) T cells are not restricted by telomere-related senescence in young or old adults.

Riddell NE, Griffiths SJ, Rivino L, King DC, Teo GH, Henson SM, Cantisan S, Solana R, Kemeny DM, MacAry PA, Larbi A, Akbar AN.

Immunology. 2015 Apr;144(4):549-60. doi: 10.1111/imm.12409.


The role of phage display in therapeutic antibody discovery.

Chan CE, Lim AP, MacAry PA, Hanson BJ.

Int Immunol. 2014 Dec;26(12):649-57. doi: 10.1093/intimm/dxu082. Epub 2014 Aug 18. Review.


Pleiotropic effects of Blastocystis spp. Subtypes 4 and 7 on ligand-specific toll-like receptor signaling and NF-κB activation in a human monocyte cell line.

Teo JD, Macary PA, Tan KS.

PLoS One. 2014 Feb 14;9(2):e89036. doi: 10.1371/journal.pone.0089036. eCollection 2014.


CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses.

Harfuddin Z, Kwajah S, Chong Nyi Sim A, Macary PA, Schwarz H.

Oncoimmunology. 2013 Nov 1;2(11):e26859. Epub 2013 Nov 11.


Defining the expression hierarchy of latent T-cell epitopes in Epstein-Barr virus infection with TCR-like antibodies.

Sim AC, Too CT, Oo MZ, Lai J, Eio MY, Song Z, Srinivasan N, Tan DA, Pang SW, Gan SU, Lee KO, Loh TK, Chen J, Chan SH, MacAry PA.

Sci Rep. 2013 Nov 18;3:3232. doi: 10.1038/srep03232.


Defining CD8+ T cell determinants during human viral infection in populations of Asian ethnicity.

Rivino L, Tan AT, Chia A, Kumaran EA, Grotenbreg GM, MacAry PA, Bertoletti A.

J Immunol. 2013 Oct 15;191(8):4010-9. doi: 10.4049/jimmunol.1301507. Epub 2013 Sep 20.


Impact of partial sleep deprivation on immune markers.

Wilder-Smith A, Mustafa FB, Earnest A, Gen L, Macary PA.

Sleep Med. 2013 Oct;14(10):1031-4. doi: 10.1016/j.sleep.2013.07.001. Epub 2013 Aug 28.


Novel phage display-derived mycolic acid-specific antibodies with potential for tuberculosis diagnosis.

Chan CE, Zhao BZ, Cazenave-Gassiot A, Pang SW, Bendt AK, Wenk MR, MacAry PA, Hanson BJ.

J Lipid Res. 2013 Oct;54(10):2924-32. doi: 10.1194/jlr.D036137. Epub 2013 Jun 24.


Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.

Jovanović V, Abdul Aziz N, Lim YT, Ng Ai Poh A, Jin Hui Chan S, Ho Xin Pei E, Lew FC, Shui G, Jenner AM, Bowen L, McKinney EF, Lyons PA, Kemeny MD, Smith KG, Wenk MR, Macary PA.

PLoS One. 2013;8(2):e55639. doi: 10.1371/journal.pone.0055639. Epub 2013 Feb 7.


Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection.

Rivino L, Kumaran EA, Jovanovic V, Nadua K, Teo EW, Pang SW, Teo GH, Gan VC, Lye DC, Leo YS, Hanson BJ, Smith KG, Bertoletti A, Kemeny DM, MacAry PA.

J Virol. 2013 Mar;87(5):2693-706. doi: 10.1128/JVI.02675-12. Epub 2012 Dec 19.


Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1.

Zou G, Kukkaro P, Lok SM, Ng JK, Tan GK, Hanson BJ, Alonso S, MacAry PA, Shi PY.

Antiviral Res. 2012 Sep;95(3):216-23. doi: 10.1016/j.antiviral.2012.06.010. Epub 2012 Jul 4.


The structural basis for serotype-specific neutralization of dengue virus by a human antibody.

Teoh EP, Kukkaro P, Teo EW, Lim AP, Tan TT, Yip A, Schul W, Aung M, Kostyuchenko VA, Leo YS, Chan SH, Smith KG, Chan AH, Zou G, Ooi EE, Kemeny DM, Tan GK, Ng JK, Ng ML, Alonso S, Fisher D, Shi PY, Hanson BJ, Lok SM, MacAry PA.

Sci Transl Med. 2012 Jun 20;4(139):139ra83. doi: 10.1126/scitranslmed.3003888.


Targeted delivery of interferon-α to hepatitis B virus-infected cells using T-cell receptor-like antibodies.

Ji C, Sastry KS, Tiefenthaler G, Cano J, Tang T, Ho ZZ, Teoh D, Bohini S, Chen A, Sankuratri S, Macary PA, Kennedy P, Ma H, Ries S, Klumpp K, Kopetzki E, Bertoletti A.

Hepatology. 2012 Dec;56(6):2027-38. doi: 10.1002/hep.25875. Epub 2012 Jul 12.


Generation and characterization of a novel recombinant antibody against 15-ketocholestane isolated by phage-display.

Islam MO, Lim YT, Chan CE, Cazenave-Gassiot A, Croxford JL, Wenk MR, Macary PA, Hanson BJ.

Int J Mol Sci. 2012;13(4):4937-48. doi: 10.3390/ijms13044937. Epub 2012 Apr 19.


A human PrM antibody that recognizes a novel cryptic epitope on dengue E glycoprotein.

Chan AH, Tan HC, Chow AY, Lim AP, Lok SM, Moreland NJ, Vasudevan SG, MacAry PA, Ooi EE, Hanson BJ.

PLoS One. 2012;7(4):e33451. doi: 10.1371/journal.pone.0033451. Epub 2012 Apr 3.


Transient immune impairment after a simulated long-haul flight.

Wilder-Smith A, Mustafa FB, Peng CM, Earnest A, Koh D, Lin G, Hossain I, MacAry PA.

Aviat Space Environ Med. 2012 Apr;83(4):418-23.


Soluble molecules are key in maintaining the immunomodulatory activity of murine mesenchymal stromal cells.

Liu H, Lu K, MacAry PA, Wong KL, Heng A, Cao T, Kemeny DM.

J Cell Sci. 2012 Jan 1;125(Pt 1):200-8. doi: 10.1242/jcs.093070. Epub 2012 Jan 16.


Influenza A virus infection results in a robust, antigen-responsive, and widely disseminated Foxp3+ regulatory T cell response.

Betts RJ, Prabhu N, Ho AW, Lew FC, Hutchinson PE, Rotzschke O, Macary PA, Kemeny DM.

J Virol. 2012 Mar;86(5):2817-25. doi: 10.1128/JVI.05685-11. Epub 2011 Dec 28.


Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells.

Ho AW, Prabhu N, Betts RJ, Ge MQ, Dai X, Hutchinson PE, Lew FC, Wong KL, Hanson BJ, Macary PA, Kemeny DM.

J Immunol. 2011 Dec 1;187(11):6011-21. doi: 10.4049/jimmunol.1100987. Epub 2011 Oct 31.


Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation.

Ang SF, Sio SW, Moochhala SM, MacAry PA, Bhatia M.

J Immunol. 2011 Nov 1;187(9):4778-87. doi: 10.4049/jimmunol.1101559. Epub 2011 Sep 28.


Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-κB signaling.

Ang SF, Moochhala SM, MacAry PA, Bhatia M.

PLoS One. 2011;6(9):e24535. doi: 10.1371/journal.pone.0024535. Epub 2011 Sep 12.


Human CD8⁺ T cells drive Th1 responses through the differentiation of TNF/iNOS-producing dendritic cells.

Chong SZ, Wong KL, Lin G, Yang CM, Wong SC, Angeli V, Macary PA, Kemeny DM.

Eur J Immunol. 2011 Jun;41(6):1639-51. doi: 10.1002/eji.201041022. Epub 2011 May 9.


Characterization of human umbilical cord lining-derived epithelial cells and transplantation potential.

Zhou Y, Gan SU, Lin G, Lim YT, Masilamani J, Mustafa FB, Phua ML, Rivino L, Phan TT, Lee KO, Calne R, MacAry PA.

Cell Transplant. 2011;20(11-12):1827-41. doi: 10.3727/096368910X564085. Epub 2011 Mar 24.


Current Views on the Clinical Relevance of Blastocystis spp.

Tan KS, Mirza H, Teo JD, Wu B, Macary PA.

Curr Infect Dis Rep. 2010 Jan;12(1):28-35. doi: 10.1007/s11908-009-0073-8.


Targeting hepatitis B virus-infected cells with a T-cell receptor-like antibody.

Sastry KS, Too CT, Kaur K, Gehring AJ, Low L, Javiad A, Pollicino T, Li L, Kennedy PT, Lopatin U, Macary PA, Bertoletti A.

J Virol. 2011 Mar;85(5):1935-42. doi: 10.1128/JVI.01990-10. Epub 2010 Dec 15.


Optimized expression of full-length IgG1 antibody in a common E. coli strain.

Chan CE, Lim AP, Chan AH, MacAry PA, Hanson BJ.

PLoS One. 2010 Apr 20;5(4):e10261. doi: 10.1371/journal.pone.0010261.


A CD8+ T cell transcription signature predicts prognosis in autoimmune disease.

McKinney EF, Lyons PA, Carr EJ, Hollis JL, Jayne DR, Willcocks LC, Koukoulaki M, Brazma A, Jovanovic V, Kemeny DM, Pollard AJ, Macary PA, Chaudhry AN, Smith KG.

Nat Med. 2010 May;16(5):586-91, 1p following 591. doi: 10.1038/nm.2130. Epub 2010 Apr 18.


Fc gamma receptor biology and systemic lupus erythematosus.

Jovanovic V, Dai X, Lim YT, Kemeny DM, MacAry PA.

Int J Rheum Dis. 2009 Dec;12(4):293-8. doi: 10.1111/j.1756-185X.2009.01426.x. Review.


Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides.

Song HY, Ngai MH, Song ZY, MacAry PA, Hobley J, Lear MJ.

Org Biomol Chem. 2009 Sep 7;7(17):3400-6. doi: 10.1039/b904060a. Epub 2009 Jul 3.


CD44high memory CD8 T cells synergize with CpG DNA to activate dendritic cell IL-12p70 production.

Wong KL, Tang LF, Lew FC, Wong HS, Chua YL, MacAry PA, Kemeny DM.

J Immunol. 2009 Jul 1;183(1):41-50. doi: 10.4049/jimmunol.0803473. Epub 2009 Jun 17.


A subpopulation of mesenchymal stromal cells with high osteogenic potential.

Liu H, Toh WS, Lu K, MacAry PA, Kemeny DM, Cao T.

J Cell Mol Med. 2009 Aug;13(8B):2436-47. doi: 10.1111/j.1582-4934.2009.00793.x. Epub 2009 Jun 5.

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