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Type I interferon induces CXCL13 to support ectopic germinal center formation.

Denton AE, Innocentin S, Carr EJ, Bradford BM, Lafouresse F, Mabbott NA, Mörbe U, Ludewig B, Groom JR, Good-Jacobson KL, Linterman MA.

J Exp Med. 2019 Feb 5. pii: jem.20181216. doi: 10.1084/jem.20181216. [Epub ahead of print]


Effects of host-derived chemokines on the motility and viability of Trypanosoma brucei.

Alfituri OA, Ajibola O, Brewer JM, Garside P, Benson RA, Peel T, Morrison LJ, Mabbott NA.

Parasite Immunol. 2019 Feb;41(2):e12609. doi: 10.1111/pim.12609. Epub 2018 Dec 27.


The Influence of Parasite Infections on Host Immunity to Co-infection With Other Pathogens.

Mabbott NA.

Front Immunol. 2018 Nov 8;9:2579. doi: 10.3389/fimmu.2018.02579. eCollection 2018. Review.


Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus.

Pridans C, Raper A, Davis GM, Alves J, Sauter KA, Lefevre L, Regan T, Meek S, Sutherland L, Thomson AJ, Clohisey S, Bush SJ, Rojo R, Lisowski ZM, Wallace R, Grabert K, Upton KR, Tsai YT, Brown D, Smith LB, Summers KM, Mabbott NA, Piccardo P, Cheeseman MT, Burdon T, Hume DA.

J Immunol. 2018 Nov 1;201(9):2683-2699. doi: 10.4049/jimmunol.1701783. Epub 2018 Sep 24.


Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge.

Patel NP, Vukmanovic-Stejic M, Suarez-Farinas M, Chambers ES, Sandhu D, Fuentes-Duculan J, Mabbott NA, Rustin MHA, Krueger J, Akbar AN.

J Infect Dis. 2018 Sep 22;218(suppl_2):S88-S98. doi: 10.1093/infdis/jiy420.


Oral Prion Neuroinvasion Occurs Independently of PrPC Expression in the Gut Epithelium.

Marshall A, Bradford BM, Clarke AR, Manson JC, Mabbott NA.

J Virol. 2018 Sep 12;92(19). pii: e01010-18. doi: 10.1128/JVI.01010-18. Print 2018 Oct 1.


Development of in vitro enteroids derived from bovine small intestinal crypts.

Hamilton CA, Young R, Jayaraman S, Sehgal A, Paxton E, Thomson S, Katzer F, Hope J, Innes E, Morrison LJ, Mabbott NA.

Vet Res. 2018 Jul 3;49(1):54. doi: 10.1186/s13567-018-0547-5.


Increased susceptibility to oral Trichuris muris infection in the specific absence of CXCR5+ CD11c+ cells.

Bradford BM, Donaldson DS, Forman R, Else KJ, Mabbott NA.

Parasite Immunol. 2018 Aug;40(8):e12566. doi: 10.1111/pim.12566.


The role of the immune system in prion infection.

Mabbott NA, Alibhai JD, Manson J.

Handb Clin Neurol. 2018;153:85-107. doi: 10.1016/B978-0-444-63945-5.00005-2. Review.


The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche.

Sehgal A, Donaldson DS, Pridans C, Sauter KA, Hume DA, Mabbott NA.

Nat Commun. 2018 Mar 28;9(1):1272. doi: 10.1038/s41467-018-03638-6.


How do PrPSc Prions Spread between Host Species, and within Hosts?

Mabbott NA.

Pathogens. 2017 Nov 24;6(4). pii: E60. doi: 10.3390/pathogens6040060. Review.


Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation.

Vukmanovic-Stejic M, Chambers ES, Suárez-Fariñas M, Sandhu D, Fuentes-Duculan J, Patel N, Agius E, Lacy KE, Turner CT, Larbi A, Birault V, Noursadeghi M, Mabbott NA, Rustin MHA, Krueger JG, Akbar AN.

J Allergy Clin Immunol. 2018 Sep;142(3):844-856. doi: 10.1016/j.jaci.2017.10.032. Epub 2017 Nov 17.


Immunology of Prion Protein and Prions.

Mabbott NA.

Prog Mol Biol Transl Sci. 2017;150:203-240. doi: 10.1016/bs.pmbts.2017.06.004. Epub 2017 Jul 31. Review.


Bovine cryptosporidiosis: impact, host-parasite interaction and control strategies.

Thomson S, Hamilton CA, Hope JC, Katzer F, Mabbott NA, Morrison LJ, Innes EA.

Vet Res. 2017 Aug 11;48(1):42. doi: 10.1186/s13567-017-0447-0. Review.


Prion disease pathogenesis in the absence of the commensal microbiota.

Bradford BM, Tetlow L, Mabbott NA.

J Gen Virol. 2017 Jul;98(7):1943-1952. doi: 10.1099/jgv.0.000860. Epub 2017 Jul 15.


Influence of ageing on the microarchitecture of the spleen and lymph nodes.

Turner VM, Mabbott NA.

Biogerontology. 2017 Oct;18(5):723-738. doi: 10.1007/s10522-017-9707-7. Epub 2017 May 13. Review.


Pre/pro-B cells generate macrophage populations during homeostasis and inflammation.

Audzevich T, Bashford-Rogers R, Mabbott NA, Frampton D, Freeman TC, Potocnik A, Kellam P, Gilroy DW.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):E3954-E3963. doi: 10.1073/pnas.1616417114. Epub 2017 May 1.


Ageing adversely affects the migration and function of marginal zone B cells.

Turner VM, Mabbott NA.

Immunology. 2017 Jul;151(3):349-362. doi: 10.1111/imm.12737. Epub 2017 May 4.


Oral Prion Disease Pathogenesis Is Impeded in the Specific Absence of CXCR5-Expressing Dendritic Cells.

Bradford BM, Reizis B, Mabbott NA.

J Virol. 2017 Apr 28;91(10). pii: e00124-17. doi: 10.1128/JVI.00124-17. Print 2017 May 15.


Structural and functional changes to lymph nodes in ageing mice.

Turner VM, Mabbott NA.

Immunology. 2017 Jun;151(2):239-247. doi: 10.1111/imm.12727. Epub 2017 Mar 16.


Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders.

Shih BB, Nirmal AJ, Headon DJ, Akbar AN, Mabbott NA, Freeman TC.

J Pathol. 2017 Apr;241(5):600-613. doi: 10.1002/path.4864. Epub 2017 Feb 24.


Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility.

Donaldson DS, Sehgal A, Rios D, Williams IR, Mabbott NA.

PLoS Pathog. 2016 Dec 14;12(12):e1006075. doi: 10.1371/journal.ppat.1006075. eCollection 2016 Dec. Erratum in: PLoS Pathog. 2017 Feb 17;13(2):e1006222.


c-Rel is dispensable for the differentiation and functional maturation of M cells in the follicle-associated epithelium.

Sehgal A, Kobayashi A, Donaldson DS, Mabbott NA.

Immunobiology. 2017 Feb;222(2):316-326. doi: 10.1016/j.imbio.2016.09.008. Epub 2016 Sep 18.


Prion pathogenesis is unaltered following down-regulation of SIGN-R1.

Bradford BM, Brown KL, Mabbott NA.

Virology. 2016 Oct;497:337-345. doi: 10.1016/j.virol.2016.08.005. Epub 2016 Aug 11.


Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs.

Sauter KA, Waddell LA, Lisowski ZM, Young R, Lefevre L, Davis GM, Clohisey SM, McCulloch M, Magowan E, Mabbott NA, Summers KM, Hume DA.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G533-47. doi: 10.1152/ajpgi.00116.2016. Epub 2016 Jul 21.


The influence of the commensal and pathogenic gut microbiota on prion disease pathogenesis.

Donaldson DS, Mabbott NA.

J Gen Virol. 2016 Aug;97(8):1725-38. doi: 10.1099/jgv.0.000507. Epub 2016 May 18. Review.


From Scientific Curiosity to Public Enemy Number One in Six Short Months.

Mabbott NA.

PLoS Pathog. 2016 Apr 14;12(4):e1005371. doi: 10.1371/journal.ppat.1005371. eCollection 2016 Apr. Review. No abstract available.


The Good, the Bad, and the Ugly of Dendritic Cells during Prion Disease.

Mabbott NA, Bradford BM.

J Immunol Res. 2015;2015:168574. doi: 10.1155/2015/168574. Epub 2015 Nov 30. Review.


A breakdown in communication? Understanding the effects of aging on the human small intestine epithelium.

Mabbott NA.

Clin Sci (Lond). 2015 Oct;129(7):529-31. doi: 10.1042/CS20150364. Epub 2015 Jun 11.


The Gut-Associated Lymphoid Tissues in the Small Intestine, Not the Large Intestine, Play a Major Role in Oral Prion Disease Pathogenesis.

Donaldson DS, Else KJ, Mabbott NA.

J Virol. 2015 Sep;89(18):9532-47. doi: 10.1128/JVI.01544-15. Epub 2015 Jul 8.


An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells.

Powell JJ, Thomas-McKay E, Thoree V, Robertson J, Hewitt RE, Skepper JN, Brown A, Hernandez-Garrido JC, Midgley PA, Gomez-Morilla I, Grime GW, Kirkby KJ, Mabbott NA, Donaldson DS, Williams IR, Rios D, Girardin SE, Haas CT, Bruggraber SF, Laman JD, Tanriver Y, Lombardi G, Lechler R, Thompson RP, Pele LC.

Nat Nanotechnol. 2015 Apr;10(4):361-9. doi: 10.1038/nnano.2015.19. Epub 2015 Mar 9.


The Characterization of Varicella Zoster Virus-Specific T Cells in Skin and Blood during Aging.

Vukmanovic-Stejic M, Sandhu D, Seidel JA, Patel N, Sobande TO, Agius E, Jackson SE, Fuentes-Duculan J, Suárez-Fariñas M, Mabbott NA, Lacy KE, Ogg G, Nestle FO, Krueger JG, Rustin MHA, Akbar AN.

J Invest Dermatol. 2015 Jul;135(7):1752-1762. doi: 10.1038/jid.2015.63. Epub 2015 Mar 3.


Prospects for safe and effective vaccines against prion diseases.

Mabbott NA.

Expert Rev Vaccines. 2015 Jan;14(1):1-4. doi: 10.1586/14760584.2015.965691. Epub 2014 Sep 30.


Reciprocal regulation of lymphoid tissue development in the large intestine by IL-25 and IL-23.

Donaldson DS, Bradford BM, Artis D, Mabbott NA.

Mucosal Immunol. 2015 May;8(3):582-95. doi: 10.1038/mi.2014.90. Epub 2014 Sep 24.


The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration.

Sauter KA, Pridans C, Sehgal A, Bain CC, Scott C, Moffat L, Rojo R, Stutchfield BM, Davies CL, Donaldson DS, Renault K, McColl BW, Mowat AM, Serrels A, Frame MC, Mabbott NA, Hume DA.

PLoS One. 2014 Aug 19;9(8):e105429. doi: 10.1371/journal.pone.0105429. eCollection 2014.


Characterisation of a novel Fc conjugate of macrophage colony-stimulating factor.

Gow DJ, Sauter KA, Pridans C, Moffat L, Sehgal A, Stutchfield BM, Raza S, Beard PM, Tsai YT, Bainbridge G, Boner PL, Fici G, Garcia-Tapia D, Martin RA, Oliphant T, Shelly JA, Tiwari R, Wilson TL, Smith LB, Mabbott NA, Hume DA.

Mol Ther. 2014 Sep;22(9):1580-92. doi: 10.1038/mt.2014.112. Epub 2014 Jun 25.


MicroRNA-100-5p indirectly modulates the expression of Il6, Ptgs1/2 and Tlr4 mRNA in the mouse follicular dendritic cell-like cell line, FL-Y.

Aungier SR, Ohmori H, Clinton M, Mabbott NA.

Immunology. 2015 Jan;144(1):34-44. doi: 10.1111/imm.12342.


Human prion diseases and the risk of their transmission during anatomical dissection.

Bradford BM, Piccardo P, Ironside JW, Mabbott NA.

Clin Anat. 2014 Sep;27(6):821-32. doi: 10.1002/ca.22403. Epub 2014 Apr 17. Review.


Aging and the mucosal immune system in the intestine.

Mabbott NA, Kobayashi A, Sehgal A, Bradford BM, Pattison M, Donaldson DS.

Biogerontology. 2015 Apr;16(2):133-45. doi: 10.1007/s10522-014-9498-z. Epub 2014 Apr 5. Review.


Peripheral prion disease pathogenesis is unaltered in the absence of sialoadhesin (Siglec-1/CD169).

Bradford BM, Crocker PR, Mabbott NA.

Immunology. 2014 Sep;143(1):120-9. doi: 10.1111/imm.12294.


Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.

Sauter KA, Pridans C, Sehgal A, Tsai YT, Bradford BM, Raza S, Moffat L, Gow DJ, Beard PM, Mabbott NA, Smith LB, Hume DA.

J Leukoc Biol. 2014 Aug;96(2):265-74. doi: 10.1189/jlb.2A0114-006R. Epub 2014 Mar 20.


Evidence of subclinical prion disease in aged mice following exposure to bovine spongiform encephalopathy.

Brown KL, Mabbott NA.

J Gen Virol. 2014 Jan;95(Pt 1):231-43. doi: 10.1099/vir.0.058958-0. Epub 2013 Oct 15.


An expression atlas of human primary cells: inference of gene function from coexpression networks.

Mabbott NA, Baillie JK, Brown H, Freeman TC, Hume DA.

BMC Genomics. 2013 Sep 20;14:632. doi: 10.1186/1471-2164-14-632.


CSF-1 receptor-mediated differentiation of a new type of monocytic cell with B cell-stimulating activity: its selective dependence on IL-34.

Yamane F, Nishikawa Y, Matsui K, Asakura M, Iwasaki E, Watanabe K, Tanimoto H, Sano H, Fujiwara Y, Stanley ER, Kanayama N, Mabbott NA, Magari M, Ohmori H.

J Leukoc Biol. 2014 Jan;95(1):19-31. doi: 10.1189/jlb.0613311. Epub 2013 Sep 19.


Identification of co-expressed gene signatures in mouse B1, marginal zone and B2 B-cell populations.

Mabbott NA, Gray D.

Immunology. 2014 Jan;141(1):79-95. doi: 10.1111/imm.12171.


Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium.

Mabbott NA, Donaldson DS, Ohno H, Williams IR, Mahajan A.

Mucosal Immunol. 2013 Jul;6(4):666-77. doi: 10.1038/mi.2013.30. Epub 2013 May 22. Review.


The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice.

Kobayashi A, Donaldson DS, Erridge C, Kanaya T, Williams IR, Ohno H, Mahajan A, Mabbott NA.

Mucosal Immunol. 2013 Sep;6(5):1027-37. doi: 10.1038/mi.2012.141. Epub 2013 Jan 30.


Prion disease and the innate immune system.

Bradford BM, Mabbott NA.

Viruses. 2012 Dec;4(12):3389-419. Review.


Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion.

Tahoun A, Mahajan S, Paxton E, Malterer G, Donaldson DS, Wang D, Tan A, Gillespie TL, O'Shea M, Roe AJ, Shaw DJ, Gally DL, Lengeling A, Mabbott NA, Haas J, Mahajan A.

Cell Host Microbe. 2012 Nov 15;12(5):645-56. doi: 10.1016/j.chom.2012.10.009.


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