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Items: 1 to 50 of 51

1.

Investigation of biaryl heterocycles as inhibitors of Wee1 kinase.

Mastracchio A, Lai C, Torrent M, Bromberg K, Buchanan FG, Ferguson D, Bontcheva V, Johnson EF, Lasko L, Maag D, Soni N, Shoemaker AR, Penning TD.

Bioorg Med Chem Lett. 2019 Jun 15;29(12):1481-1486. doi: 10.1016/j.bmcl.2019.04.017. Epub 2019 Apr 9.

PMID:
31014911
2.

Comparison of Biomarker Assays for EGFR: Implications for Precision Medicine in Patients with Glioblastoma.

Lassman AB, Roberts-Rapp L, Sokolova I, Song M, Pestova E, Kular R, Mullen C, Zha Z, Lu X, Gomez E, Bhathena A, Maag D, Kumthekar P, Gan HK, Scott AM, Guseva M, Holen KD, Ansell PJ, van den Bent MJ.

Clin Cancer Res. 2019 Jun 1;25(11):3259-3265. doi: 10.1158/1078-0432.CCR-18-3034. Epub 2019 Feb 22.

PMID:
30796037
3.

PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow.

Hopkins TA, Ainsworth WB, Ellis PA, Donawho CK, DiGiammarino EL, Panchal SC, Abraham VC, Algire MA, Shi Y, Olson AM, Johnson EF, Wilsbacher JL, Maag D.

Mol Cancer Res. 2019 Feb;17(2):409-419. doi: 10.1158/1541-7786.MCR-18-0138. Epub 2018 Nov 14.

PMID:
30429212
4.

Safety and efficacy of depatuxizumab mafodotin + temozolomide in patients with EGFR-amplified, recurrent glioblastoma: results from an international phase I multicenter trial.

Lassman AB, van den Bent MJ, Gan HK, Reardon DA, Kumthekar P, Butowski N, Lwin Z, Mikkelsen T, Nabors LB, Papadopoulos KP, Penas-Prado M, Simes J, Wheeler H, Walbert T, Scott AM, Gomez E, Lee HJ, Roberts-Rapp L, Xiong H, Ansell PJ, Bain E, Holen KD, Maag D, Merrell R.

Neuro Oncol. 2019 Jan 1;21(1):106-114. doi: 10.1093/neuonc/noy091.

5.

Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in triple-negative breast cancer (BrighTNess): a randomised, phase 3 trial.

Loibl S, O'Shaughnessy J, Untch M, Sikov WM, Rugo HS, McKee MD, Huober J, Golshan M, von Minckwitz G, Maag D, Sullivan D, Wolmark N, McIntyre K, Ponce Lorenzo JJ, Metzger Filho O, Rastogi P, Symmans WF, Liu X, Geyer CE Jr.

Lancet Oncol. 2018 Apr;19(4):497-509. doi: 10.1016/S1470-2045(18)30111-6. Epub 2018 Feb 28.

PMID:
29501363
6.

Efficacy of depatuxizumab mafodotin (ABT-414) monotherapy in patients with EGFR-amplified, recurrent glioblastoma: results from a multi-center, international study.

van den Bent M, Gan HK, Lassman AB, Kumthekar P, Merrell R, Butowski N, Lwin Z, Mikkelsen T, Nabors LB, Papadopoulos KP, Penas-Prado M, Simes J, Wheeler H, Walbert T, Scott AM, Gomez E, Lee HJ, Roberts-Rapp L, Xiong H, Bain E, Ansell PJ, Holen KD, Maag D, Reardon DA.

Cancer Chemother Pharmacol. 2017 Dec;80(6):1209-1217. doi: 10.1007/s00280-017-3451-1. Epub 2017 Oct 26.

7.

The spitting image of plant defenses: Effects of plant secondary chemistry on the efficacy of caterpillar regurgitant as an anti-predator defense.

Desurmont GA, Köhler A, Maag D, Laplanche D, Xu H, Baumann J, Demairé C, Devenoges D, Glavan M, Mann L, Turlings TCJ.

Ecol Evol. 2017 Jul 5;7(16):6304-6313. doi: 10.1002/ece3.3174. eCollection 2017 Aug.

8.

Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM, Cheng D, Klinge KL, Li HQ, Pliushchev M, Algire MA, Maag D, Guo J, Dietrich J, Panchal SC, Petros AM, Sweis RF, Torrent M, Bigelow LJ, Senisterra G, Li F, Kennedy S, Wu Q, Osterling DJ, Lindley DJ, Gao W, Galasinski S, Barsyte-Lovejoy D, Vedadi M, Buchanan FG, Arrowsmith CH, Chiang GG, Sun C, Pappano WN.

Nat Chem Biol. 2017 Jul 18;13(8):922. doi: 10.1038/nchembio0817-922b. No abstract available.

PMID:
28853738
9.

SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).

Curtin ML, Heyman HR, Clark RF, Sorensen BK, Doherty GA, Hansen TM, Frey RR, Sarris KA, Aguirre AL, Shrestha A, Tu N, Woller K, Pliushchev MA, Sweis RF, Cheng M, Wilsbacher JL, Kovar PJ, Guo J, Cheng D, Longenecker KL, Raich D, Korepanova AV, Soni NB, Algire MA, Richardson PL, Marin VL, Badagnani I, Vasudevan A, Buchanan FG, Maag D, Chiang GG, Tse C, Michaelides MR.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3317-3325. doi: 10.1016/j.bmcl.2017.06.018. Epub 2017 Jun 14.

PMID:
28610984
10.

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.

Wilsbacher JL, Cheng M, Cheng D, Trammell SAJ, Shi Y, Guo J, Koeniger SL, Kovar PJ, He Y, Selvaraju S, Heyman HR, Sorensen BK, Clark RF, Hansen TM, Longenecker KL, Raich D, Korepanova AV, Cepa S, Towne DL, Abraham VC, Tang H, Richardson PL, McLoughlin SM, Badagnani I, Curtin ML, Michaelides MR, Maag D, Buchanan FG, Chiang GG, Gao W, Rosenberg SH, Brenner C, Tse C.

Mol Cancer Ther. 2017 Jul;16(7):1236-1245. doi: 10.1158/1535-7163.MCT-16-0819. Epub 2017 May 3.

11.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM, Cheng D, Klinge KL, Li HQ, Pliushchev M, Algire MA, Maag D, Guo J, Dietrich J, Panchal SC, Petros AM, Sweis RF, Torrent M, Bigelow LJ, Senisterra G, Li F, Kennedy S, Wu Q, Osterling DJ, Lindley DJ, Gao W, Galasinski S, Barsyte-Lovejoy D, Vedadi M, Buchanan FG, Arrowsmith CH, Chiang GG, Sun C, Pappano WN.

Nat Chem Biol. 2017 Apr;13(4):389-395. doi: 10.1038/nchembio.2306. Epub 2017 Jan 30. Erratum in: Nat Chem Biol. 2017 Jul 18;13(8):922.

PMID:
28135237
12.

Highly localized and persistent induction of Bx1-dependent herbivore resistance factors in maize.

Maag D, Köhler A, Robert CA, Frey M, Wolfender JL, Turlings TC, Glauser G, Erb M.

Plant J. 2016 Dec;88(6):976-991. doi: 10.1111/tpj.13308. Epub 2016 Oct 18.

13.

A randomized Phase II study of veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in BRCA1/2 metastatic breast cancer: design and rationale.

Isakoff SJ, Puhalla S, Domchek SM, Friedlander M, Kaufman B, Robson M, Telli ML, Diéras V, Han HS, Garber JE, Johnson EF, Maag D, Qin Q, Giranda VL, Shepherd SP.

Future Oncol. 2017 Feb;13(4):307-320. doi: 10.2217/fon-2016-0412. Epub 2016 Oct 14.

14.

Biosynthesis of 8-O-Methylated Benzoxazinoid Defense Compounds in Maize.

Handrick V, Robert CA, Ahern KR, Zhou S, Machado RA, Maag D, Glauser G, Fernandez-Penny FE, Chandran JN, Rodgers-Melnik E, Schneider B, Buckler ES, Boland W, Gershenzon J, Jander G, Erb M, Köllner TG.

Plant Cell. 2016 Jul;28(7):1682-700. doi: 10.1105/tpc.16.00065. Epub 2016 Jun 17.

15.

Maize Domestication and Anti-Herbivore Defences: Leaf-Specific Dynamics during Early Ontogeny of Maize and Its Wild Ancestors.

Maag D, Erb M, Bernal JS, Wolfender JL, Turlings TC, Glauser G.

PLoS One. 2015 Aug 12;10(8):e0135722. doi: 10.1371/journal.pone.0135722. eCollection 2015.

16.

Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors.

Hopkins TA, Shi Y, Rodriguez LE, Solomon LR, Donawho CK, DiGiammarino EL, Panchal SC, Wilsbacher JL, Gao W, Olson AM, Stolarik DF, Osterling DJ, Johnson EF, Maag D.

Mol Cancer Res. 2015 Nov;13(11):1465-77. doi: 10.1158/1541-7786.MCR-15-0191-T. Epub 2015 Jul 27.

17.

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.

Sweis RF, Wang Z, Algire M, Arrowsmith CH, Brown PJ, Chiang GG, Guo J, Jakob CG, Kennedy S, Li F, Maag D, Shaw B, Soni NB, Vedadi M, Pappano WN.

ACS Med Chem Lett. 2015 Apr 29;6(6):695-700. doi: 10.1021/acsmedchemlett.5b00124. eCollection 2015 Jun 11.

18.

Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase.

Tong Y, Torrent M, Florjancic AS, Bromberg KD, Buchanan FG, Ferguson DC, Johnson EF, Lasko LM, Maag D, Merta PJ, Olson AM, Osterling DJ, Soni N, Shoemaker AR, Penning TD.

ACS Med Chem Lett. 2014 Aug 6;6(1):58-62. doi: 10.1021/ml5002745. eCollection 2015 Jan 8.

19.

Defensive weapons and defense signals in plants: some metabolites serve both roles.

Maag D, Erb M, Köllner TG, Gershenzon J.

Bioessays. 2015 Feb;37(2):167-74. doi: 10.1002/bies.201400124. Epub 2014 Nov 12.

PMID:
25389065
20.

Within-plant distribution of 1,4-benzoxazin-3-ones contributes to herbivore niche differentiation in maize.

Köhler A, Maag D, Veyrat N, Glauser G, Wolfender JL, Turlings TC, Erb M.

Plant Cell Environ. 2015 Jun;38(6):1081-93. doi: 10.1111/pce.12464. Epub 2014 Nov 28.

21.

Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.

Sweis RF, Pliushchev M, Brown PJ, Guo J, Li F, Maag D, Petros AM, Soni NB, Tse C, Vedadi M, Michaelides MR, Chiang GG, Pappano WN.

ACS Med Chem Lett. 2014 Jan 2;5(2):205-9. doi: 10.1021/ml400496h. eCollection 2014 Feb 13.

22.

3-β-D-Glucopyranosyl-6-methoxy-2-benzoxazolinone (MBOA-N-Glc) is an insect detoxification product of maize 1,4-benzoxazin-3-ones.

Maag D, Dalvit C, Thevenet D, Köhler A, Wouters FC, Vassão DG, Gershenzon J, Wolfender JL, Turlings TC, Erb M, Glauser G.

Phytochemistry. 2014 Jun;102:97-105. doi: 10.1016/j.phytochem.2014.03.018. Epub 2014 Apr 5.

PMID:
24713572
23.

Gall volatiles defend aphids against a browsing mammal.

Rostás M, Maag D, Ikegami M, Inbar M.

BMC Evol Biol. 2013 Sep 11;13:193. doi: 10.1186/1471-2148-13-193.

24.

PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner.

Summermatter S, Shui G, Maag D, Santos G, Wenk MR, Handschin C.

Diabetes. 2013 Jan;62(1):85-95. doi: 10.2337/db12-0291. Epub 2012 Oct 18.

25.

Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.

Liu X, Shi Y, Maag DX, Palma JP, Patterson MJ, Ellis PA, Surber BW, Ready DB, Soni NB, Ladror US, Xu AJ, Iyer R, Harlan JE, Solomon LR, Donawho CK, Penning TD, Johnson EF, Shoemaker AR.

Clin Cancer Res. 2012 Jan 15;18(2):510-23. doi: 10.1158/1078-0432.CCR-11-1973. Epub 2011 Nov 29.

26.

Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase.

Kim S, Kim SF, Maag D, Maxwell MJ, Resnick AC, Juluri KR, Chakraborty A, Koldobskiy MA, Cha SH, Barrow R, Snowman AM, Snyder SH.

Cell Metab. 2011 Feb 2;13(2):215-21. doi: 10.1016/j.cmet.2011.01.007.

27.

Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.

Maag D, Maxwell MJ, Hardesty DA, Boucher KL, Choudhari N, Hanno AG, Ma JF, Snowman AS, Pietropaoli JW, Xu R, Storm PB, Saiardi A, Snyder SH, Resnick AC.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1391-6. doi: 10.1073/pnas.1017831108. Epub 2011 Jan 10.

28.

Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.

Chakraborty A, Koldobskiy MA, Bello NT, Maxwell M, Potter JJ, Juluri KR, Maag D, Kim S, Huang AS, Dailey MJ, Saleh M, Snowman AM, Moran TH, Mezey E, Snyder SH.

Cell. 2010 Dec 10;143(6):897-910. doi: 10.1016/j.cell.2010.11.032.

29.

Synthesis of monodisperse oligo(1,4-phenyleneethynylene-alt-1,4-triptycyleneethynylene)s.

Maag D, Kottke T, Schulte M, Godt A.

J Org Chem. 2009 Oct 16;74(20):7733-42. doi: 10.1021/jo9009744.

PMID:
19761236
30.

Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition.

Mustafa AK, van Rossum DB, Patterson RL, Maag D, Ehmsen JT, Gazi SK, Chakraborty A, Barrow RK, Amzel LM, Snyder SH.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2921-6. doi: 10.1073/pnas.0813105106. Epub 2009 Feb 4.

31.

Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1.

Kim AY, Tang Z, Liu Q, Patel KN, Maag D, Geng Y, Dong X.

Cell. 2008 May 2;133(3):475-85. doi: 10.1016/j.cell.2008.02.053.

32.

Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.

Cheung YN, Maag D, Mitchell SF, Fekete CA, Algire MA, Takacs JE, Shirokikh N, Pestova T, Lorsch JR, Hinnebusch AG.

Genes Dev. 2007 May 15;21(10):1217-30.

33.

The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome.

Passmore LA, Schmeing TM, Maag D, Applefield DJ, Acker MG, Algire MA, Lorsch JR, Ramakrishnan V.

Mol Cell. 2007 Apr 13;26(1):41-50.

34.

N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection.

Fekete CA, Mitchell SF, Cherkasova VA, Applefield D, Algire MA, Maag D, Saini AK, Lorsch JR, Hinnebusch AG.

EMBO J. 2007 Mar 21;26(6):1602-14. Epub 2007 Mar 1.

35.

Intragenic suppressor mutations restore GTPase and translation functions of a eukaryotic initiation factor 5B switch II mutant.

Shin BS, Acker MG, Maag D, Kim JR, Lorsch JR, Dever TE.

Mol Cell Biol. 2007 Mar;27(5):1677-85. Epub 2006 Dec 22.

36.
38.
39.
40.

Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity.

Shin BS, Maag D, Roll-Mecak A, Arefin MS, Burley SK, Lorsch JR, Dever TE.

Cell. 2002 Dec 27;111(7):1015-25.

41.

Development and characterization of a reconstituted yeast translation initiation system.

Algire MA, Maag D, Savio P, Acker MG, Tarun SZ Jr, Sachs AB, Asano K, Nielsen KH, Olsen DS, Phan L, Hinnebusch AG, Lorsch JR.

RNA. 2002 Mar;8(3):382-97.

42.

Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin.

Maag D, Castro C, Hong Z, Cameron CE.

J Biol Chem. 2001 Dec 7;276(49):46094-8. Epub 2001 Oct 15.

43.

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen.

Crotty S, Maag D, Arnold JJ, Zhong W, Lau JY, Hong Z, Andino R, Cameron CE.

Nat Med. 2000 Dec;6(12):1375-9. Erratum in: Nat Med 2001 Feb;7(2):255.

PMID:
11100123
44.

Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase.

Zhong W, Ferrari E, Lesburg CA, Maag D, Ghosh SK, Cameron CE, Lau JY, Hong Z.

J Virol. 2000 Oct;74(19):9134-43.

45.

Commissioning and periodic quality assurance of a clinical electronic portal imaging device.

Low DA, Klein EE, Maag DK, Umfleet WE, Purdy JA.

Int J Radiat Oncol Biol Phys. 1996 Jan 1;34(1):117-23.

PMID:
12118539
46.

A quality assurance program for ancillary high technology devices on a dual-energy accelerator.

Klein EE, Low DA, Maag D, Purdy JA.

Radiother Oncol. 1996 Jan;38(1):51-60.

PMID:
8850426
47.

AN IMPROVED METHOD FOR DETERMINATION OF SELENIUM IN BIOLOGICAL MATERIAL.

CUMMINS LM, MARTIN JL, MAAG DD.

Anal Chem. 1965 Mar;37:430-1. No abstract available.

PMID:
14274124
48.

The effect of sodium selenite on cattle.

MAAG DD, ORSBORN JS, CLOPTON JR.

Am J Vet Res. 1960 Nov;21:1049-53. No abstract available.

PMID:
13764645
49.

Studies on urolithiasis. I. Experimental production associated with feeding in steers.

UDALL RH, DEEM AW, MAAG DD.

Am J Vet Res. 1958 Oct;19(73):825-9. No abstract available.

PMID:
13583364
50.

Enzootic ataxia from copper deficiency in sheep in Colorado.

JENSEN R, MAAG DD, FLINT JC.

J Am Vet Med Assoc. 1958 Sep 15;133(6):336-40. No abstract available.

PMID:
13575309

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