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Items: 1 to 50 of 103

1.

Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.

Ho KL, Zhang L, Wagg C, Al Batran R, Gopal K, Levasseur J, Leone T, Dyck JRB, Ussher JR, Muoio DM, Kelly DP, Lopaschuk GD.

Cardiovasc Res. 2019 Sep 1;115(11):1606-1616. doi: 10.1093/cvr/cvz045.

PMID:
30778524
2.

Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.

Lin KH, Xie A, Rutter JC, Ahn YR, Lloyd-Cowden JM, Nichols AG, Soderquist RS, Koves TR, Muoio DM, MacIver NJ, Lamba JK, Pardee TS, McCall CM, Rizzieri DA, Wood KC.

Cell Metab. 2019 May 7;29(5):1217-1231.e7. doi: 10.1016/j.cmet.2019.01.011. Epub 2019 Feb 14.

PMID:
30773463
3.

Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.

Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM.

Cell Rep. 2019 Feb 5;26(6):1557-1572.e8. doi: 10.1016/j.celrep.2019.01.057.

4.

The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.

Horton JL, Davidson MT, Kurishima C, Vega RB, Powers JC, Matsuura TR, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP.

JCI Insight. 2019 Feb 21;4(4). pii: 124079. doi: 10.1172/jci.insight.124079. eCollection 2019 Feb 21.

5.

Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.

Haldeman JM, Conway AE, Arlotto ME, Slentz DH, Muoio DM, Becker TC, Newgard CB.

Nucleic Acids Res. 2019 Feb 28;47(4):e23. doi: 10.1093/nar/gky1286.

6.

Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes.

Fisher-Wellman KH, Davidson MT, Narowski TM, Lin CT, Koves TR, Muoio DM.

Cell Rep. 2018 Sep 25;24(13):3593-3606.e10. doi: 10.1016/j.celrep.2018.08.091.

7.

Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle.

Khodabukus A, Madden L, Prabhu NK, Koves TR, Jackman CP, Muoio DM, Bursac N.

Biomaterials. 2019 Apr;198:259-269. doi: 10.1016/j.biomaterials.2018.08.058. Epub 2018 Aug 31.

PMID:
30180985
8.

Metabolomic analysis of insulin resistance across different mouse strains and diets.

Stöckli J, Fisher-Wellman KH, Chaudhuri R, Zeng XY, Fazakerley DJ, Meoli CC, Thomas KC, Hoffman NJ, Mangiafico SP, Xirouchaki CE, Yang CH, Ilkayeva O, Wong K, Cooney GJ, Andrikopoulos S, Muoio DM, James DE.

J Biol Chem. 2017 Nov 24;292(47):19135-19145. doi: 10.1074/jbc.M117.818351. Epub 2017 Oct 5.

9.

Bicarbonate alters cellular responses in respiration assays.

Krycer JR, Fisher-Wellman KH, Fazakerley DJ, Muoio DM, James DE.

Biochem Biophys Res Commun. 2017 Aug 5;489(4):399-403. doi: 10.1016/j.bbrc.2017.05.151. Epub 2017 May 27.

10.

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.

Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, Hirschey MD.

Cell Metab. 2017 Apr 4;25(4):838-855.e15. doi: 10.1016/j.cmet.2017.03.003.

11.

HDAC3 sets the timer on muscle fuel switching.

Muoio DM.

Nat Med. 2017 Feb 7;23(2):148-150. doi: 10.1038/nm.4282. No abstract available.

PMID:
28170378
12.

Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability.

Huffman KM, Jessee R, Andonian B, Davis BN, Narowski R, Huebner JL, Kraus VB, McCracken J, Gilmore BF, Tune KN, Campbell M, Koves TR, Muoio DM, Hubal MJ, Kraus WE.

Arthritis Res Ther. 2017 Jan 23;19(1):12. doi: 10.1186/s13075-016-1215-7.

13.

Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction.

Consitt LA, Koves TR, Muoio DM, Nakazawa M, Newton CA, Houmard JA.

Biochem Biophys Res Commun. 2016 Oct 28;479(4):868-874. doi: 10.1016/j.bbrc.2016.09.116. Epub 2016 Sep 28.

14.

Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts.

Crown SB, Kelleher JK, Rouf R, Muoio DM, Antoniewicz MR.

Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H881-H891. doi: 10.1152/ajpheart.00428.2016. Epub 2016 Aug 5.

15.

Mitochondrial protein hyperacetylation in the failing heart.

Horton JL, Martin OJ, Lai L, Riley NM, Richards AL, Vega RB, Leone TC, Pagliarini DJ, Muoio DM, Bedi KC Jr, Margulies KB, Coon JJ, Kelly DP.

JCI Insight. 2016 Feb;2(1). pii: e84897. Epub 2016 Feb 25.

16.

Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle.

Barrientos T, Laothamatas I, Koves TR, Soderblom EJ, Bryan M, Moseley MA, Muoio DM, Andrews NC.

EBioMedicine. 2015 Oct 4;2(11):1705-17. doi: 10.1016/j.ebiom.2015.09.041. eCollection 2015 Nov.

17.

The Failing Heart Relies on Ketone Bodies as a Fuel.

Aubert G, Martin OJ, Horton JL, Lai L, Vega RB, Leone TC, Koves T, Gardell SJ, Krüger M, Hoppel CL, Lewandowski ED, Crawford PA, Muoio DM, Kelly DP.

Circulation. 2016 Feb 23;133(8):698-705. doi: 10.1161/CIRCULATIONAHA.115.017355. Epub 2016 Jan 27. Erratum in: Circulation. 2018 Oct 9;138(15):e422.

18.

The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.

Davies MN, Kjalarsdottir L, Thompson JW, Dubois LG, Stevens RD, Ilkayeva OR, Brosnan MJ, Rolph TP, Grimsrud PA, Muoio DM.

Cell Rep. 2016 Jan 12;14(2):243-54. doi: 10.1016/j.celrep.2015.12.030. Epub 2015 Dec 31.

19.

Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.

Kraus WE, Muoio DM, Stevens R, Craig D, Bain JR, Grass E, Haynes C, Kwee L, Qin X, Slentz DH, Krupp D, Muehlbauer M, Hauser ER, Gregory SG, Newgard CB, Shah SH.

PLoS Genet. 2015 Nov 5;11(11):e1005553. doi: 10.1371/journal.pgen.1005553. eCollection 2015 Nov.

20.

ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.

Keenan MM, Liu B, Tang X, Wu J, Cyr D, Stevens RD, Ilkayeva O, Huang Z, Tollini LA, Murphy SK, Lucas J, Muoio DM, Kim SY, Chi JT.

PLoS Genet. 2015 Oct 9;11(10):e1005599. doi: 10.1371/journal.pgen.1005599. eCollection 2015 Oct.

21.

SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control.

Huynh FK, Muoio DM, Hirschey MD.

Diabetes. 2015 Sep;64(9):3058-60. doi: 10.2337/db15-0709. No abstract available.

22.

Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.

Kien CL, Matthews DE, Poynter ME, Bunn JY, Fukagawa NK, Crain KI, Ebenstein DB, Tarleton EK, Stevens RD, Koves TR, Muoio DM.

J Lipid Res. 2015 Sep;56(9):1795-807. doi: 10.1194/jlr.M060137. Epub 2015 Jul 8.

23.

Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise.

Seiler SE, Koves TR, Gooding JR, Wong KE, Stevens RD, Ilkayeva OR, Wittmann AH, DeBalsi KL, Davies MN, Lindeboom L, Schrauwen P, Schrauwen-Hinderling VB, Muoio DM.

Cell Metab. 2015 Jul 7;22(1):65-76. doi: 10.1016/j.cmet.2015.06.003.

24.

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits.

Neufer PD, Bamman MM, Muoio DM, Bouchard C, Cooper DM, Goodpaster BH, Booth FW, Kohrt WM, Gerszten RE, Mattson MP, Hepple RT, Kraus WE, Reid MB, Bodine SC, Jakicic JM, Fleg JL, Williams JP, Joseph L, Evans M, Maruvada P, Rodgers M, Roary M, Boyce AT, Drugan JK, Koenig JI, Ingraham RH, Krotoski D, Garcia-Cazarin M, McGowan JA, Laughlin MR.

Cell Metab. 2015 Jul 7;22(1):4-11. doi: 10.1016/j.cmet.2015.05.011. Epub 2015 Jun 11. Review.

25.

Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans.

Baker PR 2nd, Boyle KE, Koves TR, Ilkayeva OR, Muoio DM, Houmard JA, Friedman JE.

Obesity (Silver Spring). 2015 May;23(5):981-988. doi: 10.1002/oby.21046. Epub 2015 Apr 10.

26.

Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.

Fisher-Wellman KH, Lin CT, Ryan TE, Reese LR, Gilliam LA, Cathey BL, Lark DS, Smith CD, Muoio DM, Neufer PD.

Biochem J. 2015 Apr 15;467(2):271-80. doi: 10.1042/BJ20141447.

27.

Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock.

Muoio DM.

Cell. 2014 Dec 4;159(6):1253-62. doi: 10.1016/j.cell.2014.11.034.

28.

Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction.

Wong KE, Mikus CR, Slentz DH, Seiler SE, DeBalsi KL, Ilkayeva OR, Crain KI, Kinter MT, Kien CL, Stevens RD, Muoio DM.

Diabetes. 2015 May;64(5):1532-43. doi: 10.2337/db14-0827. Epub 2014 Nov 24.

29.

Diabetes: The good in fat.

Muoio DM, Newgard CB.

Nature. 2014 Dec 4;516(7529):49-50. doi: 10.1038/nature14070. Epub 2014 Nov 19. No abstract available.

30.

Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection.

Lindeboom L, Nabuurs CI, Hoeks J, Brouwers B, Phielix E, Kooi ME, Hesselink MK, Wildberger JE, Stevens RD, Koves T, Muoio DM, Schrauwen P, Schrauwen-Hinderling VB.

J Clin Invest. 2014 Nov;124(11):4915-25. doi: 10.1172/JCI74830. Epub 2014 Oct 1.

31.

Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach.

Lai L, Leone TC, Keller MP, Martin OJ, Broman AT, Nigro J, Kapoor K, Koves TR, Stevens R, Ilkayeva OR, Vega RB, Attie AD, Muoio DM, Kelly DP.

Circ Heart Fail. 2014 Nov;7(6):1022-31. doi: 10.1161/CIRCHEARTFAILURE.114.001469. Epub 2014 Sep 18.

32.

Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness.

Huffman KM, Koves TR, Hubal MJ, Abouassi H, Beri N, Bateman LA, Stevens RD, Ilkayeva OR, Hoffman EP, Muoio DM, Kraus WE.

Diabetologia. 2014 Nov;57(11):2282-95. doi: 10.1007/s00125-014-3343-4. Epub 2014 Aug 5.

33.

Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis.

Li LO, Grevengoed TJ, Paul DS, Ilkayeva O, Koves TR, Pascual F, Newgard CB, Muoio DM, Coleman RA.

Diabetes. 2015 Jan;64(1):23-35. doi: 10.2337/db13-1070. Epub 2014 Jul 28.

34.

Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion.

Soni MS, Rabaglia ME, Bhatnagar S, Shang J, Ilkayeva O, Mynatt R, Zhou YP, Schadt EE, Thornberry NA, Muoio DM, Keller MP, Attie AD.

Diabetes. 2014 Nov;63(11):3805-14. doi: 10.2337/db13-1677. Epub 2014 Jun 26.

35.

Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice.

Ussher JR, Keung W, Fillmore N, Koves TR, Mori J, Zhang L, Lopaschuk DG, Ilkayeva OR, Wagg CS, Jaswal JS, Muoio DM, Lopaschuk GD.

J Pharmacol Exp Ther. 2014 Jun;349(3):487-96. doi: 10.1124/jpet.114.214197. Epub 2014 Apr 3.

36.

Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle.

DeBalsi KL, Wong KE, Koves TR, Slentz DH, Seiler SE, Wittmann AH, Ilkayeva OR, Stevens RD, Perry CG, Lark DS, Hui ST, Szweda L, Neufer PD, Muoio DM.

J Biol Chem. 2014 Mar 21;289(12):8106-20. doi: 10.1074/jbc.M113.511535. Epub 2014 Jan 30.

37.

Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.

Kien CL, Bunn JY, Stevens R, Bain J, Ikayeva O, Crain K, Koves TR, Muoio DM.

Am J Clin Nutr. 2014 Mar;99(3):436-45. doi: 10.3945/ajcn.113.070557. Epub 2014 Jan 15.

38.

Obesity and lipid stress inhibit carnitine acetyltransferase activity.

Seiler SE, Martin OJ, Noland RC, Slentz DH, DeBalsi KL, Ilkayeva OR, An J, Newgard CB, Koves TR, Muoio DM.

J Lipid Res. 2014 Apr;55(4):635-44. doi: 10.1194/jlr.M043448. Epub 2014 Jan 6.

39.

A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth.

Martin OJ, Lai L, Soundarapandian MM, Leone TC, Zorzano A, Keller MP, Attie AD, Muoio DM, Kelly DP.

Circ Res. 2014 Feb 14;114(4):626-36. doi: 10.1161/CIRCRESAHA.114.302562. Epub 2013 Dec 23.

40.

Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation.

Wendel AA, Cooper DE, Ilkayeva OR, Muoio DM, Coleman RA.

J Biol Chem. 2013 Sep 20;288(38):27299-306. doi: 10.1074/jbc.M113.485219. Epub 2013 Aug 1.

41.

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.

Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC.

Mol Cell. 2013 Jun 6;50(5):686-98. doi: 10.1016/j.molcel.2013.05.012.

42.

Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood.

Kien CL, Bunn JY, Tompkins CL, Dumas JA, Crain KI, Ebenstein DB, Koves TR, Muoio DM.

Am J Clin Nutr. 2013 Apr;97(4):689-97. doi: 10.3945/ajcn.112.051730. Epub 2013 Feb 27. Erratum in: Am J Clin Nutr. 2013 Aug;98(2):511.

43.

Genome-wide chromatin state transitions associated with developmental and environmental cues.

Zhu J, Adli M, Zou JY, Verstappen G, Coyne M, Zhang X, Durham T, Miri M, Deshpande V, De Jager PL, Bennett DA, Houmard JA, Muoio DM, Onder TT, Camahort R, Cowan CA, Meissner A, Epstein CB, Shoresh N, Bernstein BE.

Cell. 2013 Jan 31;152(3):642-54. doi: 10.1016/j.cell.2012.12.033. Epub 2013 Jan 17.

44.

A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.

Kien CL, Bunn JY, Poynter ME, Stevens R, Bain J, Ikayeva O, Fukagawa NK, Champagne CM, Crain KI, Koves TR, Muoio DM.

Diabetes. 2013 Apr;62(4):1054-63. doi: 10.2337/db12-0363. Epub 2012 Dec 13.

45.

Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice.

Jackson KC, Wohlers LM, Lovering RM, Schuh RA, Maher AC, Bonen A, Koves TR, Ilkayeva O, Thomson DM, Muoio DM, Spangenburg EE.

Am J Physiol Regul Integr Comp Physiol. 2013 Feb;304(3):R206-17. doi: 10.1152/ajpregu.00428.2012. Epub 2012 Nov 28.

46.

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans.

Koves TR, Sparks LM, Kovalik JP, Mosedale M, Arumugam R, DeBalsi KL, Everingham K, Thorne L, Phielix E, Meex RC, Kien CL, Hesselink MK, Schrauwen P, Muoio DM.

J Lipid Res. 2013 Feb;54(2):522-34. doi: 10.1194/jlr.P028910. Epub 2012 Nov 21.

47.

Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research.

Zeisel SH, Waterland RA, Ordovás JM, Muoio DM, Jia W, Fodor A.

JPEN J Parenter Enteral Nutr. 2013 Mar;37(2):190-200. doi: 10.1177/0148607112462401. Epub 2012 Oct 5.

48.

Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates.

Smith BK, Perry CG, Koves TR, Wright DC, Smith JC, Neufer PD, Muoio DM, Holloway GP.

Biochem J. 2012 Nov 15;448(1):13-20. doi: 10.1042/BJ20121110.

49.

Revisiting the connection between intramyocellular lipids and insulin resistance: a long and winding road.

Muoio DM.

Diabetologia. 2012 Oct;55(10):2551-2554. doi: 10.1007/s00125-012-2597-y. Epub 2012 Jun 3.

PMID:
22660796
50.

Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.

Muoio DM, Noland RC, Kovalik JP, Seiler SE, Davies MN, DeBalsi KL, Ilkayeva OR, Stevens RD, Kheterpal I, Zhang J, Covington JD, Bajpeyi S, Ravussin E, Kraus W, Koves TR, Mynatt RL.

Cell Metab. 2012 May 2;15(5):764-77. doi: 10.1016/j.cmet.2012.04.005.

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