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Items: 1 to 50 of 156

1.

Inhibition of Endocytosis of Clathrin-Mediated Angiotensin II Receptor Type 1 in Podocytes Augments Glomerular Injury.

Inoue K, Tian X, Velazquez H, Soda K, Wang Z, Pedigo CE, Wang Y, Cross E, Groener M, Shin JW, Li W, Hassan H, Yamamoto K, Mundel P, Ishibe S.

J Am Soc Nephrol. 2019 Sep 11. pii: ASN.2019010053. doi: 10.1681/ASN.2019010053. [Epub ahead of print]

PMID:
31511362
2.

Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities.

Christov M, Clark AR, Corbin B, Hakroush S, Rhee EP, Saito H, Brooks D, Hesse E, Bouxsein M, Galjart N, Jung JY, Mundel P, Jüppner H, Weins A, Greka A.

JCI Insight. 2018 Feb 22;3(4). pii: 95091. doi: 10.1172/jci.insight.95091. eCollection 2018 Feb 22.

3.

GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death.

Sieber J, Wieder N, Clark A, Reitberger M, Matan S, Schoenfelder J, Zhang J, Mandinova A, Bittker JA, Gutierrez J, Aygün O, Udeshi N, Carr S, Mundel P, Jehle AW, Greka A.

Cell Chem Biol. 2018 Feb 15;25(2):175-184.e4. doi: 10.1016/j.chembiol.2017.11.006. Epub 2017 Dec 14.

4.

Podocytes and the quest for precision medicines for kidney diseases.

Mundel P.

Pflugers Arch. 2017 Aug;469(7-8):1029-1037. doi: 10.1007/s00424-017-2015-x. Epub 2017 Jun 23. Review.

PMID:
28646406
5.

Glomerulosclerosis Induced by Deficiency of Membrane-Associated Guanylate Kinase Inverted 2 in Kidney Podocytes.

Shirata N, Ihara KI, Yamamoto-Nonaka K, Seki T, Makino SI, Oliva Trejo JA, Miyake T, Yamada H, Campbell KN, Nakagawa T, Mori K, Yanagita M, Mundel P, Nishimori K, Asanuma K.

J Am Soc Nephrol. 2017 Sep;28(9):2654-2669. doi: 10.1681/ASN.2016121356. Epub 2017 May 24.

6.

Podocyte-Targeted Treatment for Proteinuric Kidney Disease.

Mundel P.

Semin Nephrol. 2016 Nov;36(6):459-462. doi: 10.1016/j.semnephrol.2016.09.008. No abstract available.

PMID:
27987545
7.

Personalized Comments on Challenges and Opportunities in Kidney Disease Therapeutics: The Glom-NExT Symposium.

Greka A, Gibson D, Mundel P, Demetri G, Hildebrandt F, Pollak M, Florez J.

Semin Nephrol. 2016 Nov;36(6):448. doi: 10.1016/j.semnephrol.2016.09.005.

PMID:
27987543
8.

Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes.

Buvall L, Wallentin H, Sieber J, Andreeva S, Choi HY, Mundel P, Greka A.

J Am Soc Nephrol. 2017 Mar;28(3):837-851. doi: 10.1681/ASN.2016040414. Epub 2016 Sep 14.

9.

Rewiring neuronal microcircuits of the brain via spine head protrusions--a role for synaptopodin and intracellular calcium stores.

Verbich D, Becker D, Vlachos A, Mundel P, Deller T, McKinney RA.

Acta Neuropathol Commun. 2016 Apr 22;4:38. doi: 10.1186/s40478-016-0311-x.

10.

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.

Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW.

Science. 2015 Jul 31;349(6247):1261669. doi: 10.1126/science.1261669.

11.

Dendrin ablation prolongs life span by delaying kidney failure.

Weins A, Wong JS, Basgen JM, Gupta R, Daehn I, Casagrande L, Lessman D, Schwartzman M, Meliambro K, Patrakka J, Shaw A, Tryggvason K, He JC, Nicholas SB, Mundel P, Campbell KN.

Am J Pathol. 2015 Aug;185(8):2143-57. doi: 10.1016/j.ajpath.2015.04.011. Epub 2015 Jun 12.

12.

Developing therapeutic 'arrows' with the precision of William Tell: the time has come for targeted therapies in kidney disease.

Mundel P, Greka A.

Curr Opin Nephrol Hypertens. 2015 Jul;24(4):388-92. doi: 10.1097/MNH.0000000000000137. Review.

13.

MAGI-2 scaffold protein is critical for kidney barrier function.

Balbas MD, Burgess MR, Murali R, Wongvipat J, Skaggs BJ, Mundel P, Weins A, Sawyers CL.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14876-81. doi: 10.1073/pnas.1417297111. Epub 2014 Sep 30.

14.

Role of podocyte B7-1 in diabetic nephropathy.

Fiorina P, Vergani A, Bassi R, Niewczas MA, Altintas MM, Pezzolesi MG, D'Addio F, Chin M, Tezza S, Ben Nasr M, Mattinzoli D, Ikehata M, Corradi D, Schumacher V, Buvall L, Yu CC, Chang JM, La Rosa S, Finzi G, Solini A, Vincenti F, Rastaldi MP, Reiser J, Krolewski AS, Mundel PH, Sayegh MH.

J Am Soc Nephrol. 2014 Jul;25(7):1415-29. doi: 10.1681/ASN.2013050518. Epub 2014 Mar 27.

15.

Abatacept in B7-1-positive proteinuric kidney disease.

Greka A, Weins A, Mundel P.

N Engl J Med. 2014 Mar 27;370(13):1263-6. doi: 10.1056/NEJMc1400502. No abstract available.

16.

Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.

Kampe K, Sieber J, Orellana JM, Mundel P, Jehle AW.

Am J Physiol Renal Physiol. 2014 Feb 15;306(4):F401-9. doi: 10.1152/ajprenal.00454.2013. Epub 2013 Dec 11.

17.

Extensive podocyte loss triggers a rapid parietal epithelial cell response.

Hakroush S, Cebulla A, Schaldecker T, Behr D, Mundel P, Weins A.

J Am Soc Nephrol. 2014 May;25(5):927-38. doi: 10.1681/ASN.2013070687. Epub 2013 Dec 12.

18.

Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.

Buvall L, Rashmi P, Lopez-Rivera E, Andreeva S, Weins A, Wallentin H, Greka A, Mundel P.

Nat Commun. 2013;4:2863. doi: 10.1038/ncomms3863.

19.

Abatacept in B7-1-positive proteinuric kidney disease.

Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW 3rd, Mundel P.

N Engl J Med. 2013 Dec 19;369(25):2416-23. doi: 10.1056/NEJMoa1304572. Epub 2013 Nov 8.

20.

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes.

Brouwers O, Niessen PM, Miyata T, Østergaard JA, Flyvbjerg A, Peutz-Kootstra CJ, Sieber J, Mundel PH, Brownlee M, Janssen BJ, De Mey JG, Stehouwer CD, Schalkwijk CG.

Diabetologia. 2014 Jan;57(1):224-35. doi: 10.1007/s00125-013-3088-5. Epub 2013 Oct 26.

PMID:
24162587
21.

Inhibition of type I interferon signalling prevents TLR ligand-mediated proteinuria.

Gurkan S, Cabinian A, Lopez V, Bhaumik M, Chang JM, Rabson AB, Mundel P.

J Pathol. 2013 Oct;231(2):248-56.

PMID:
24151637
22.

Essential role for synaptopodin in dendritic spine plasticity of the developing hippocampus.

Zhang XL, Pöschel B, Faul C, Upreti C, Stanton PK, Mundel P.

J Neurosci. 2013 Jul 24;33(30):12510-8. doi: 10.1523/JNEUROSCI.2983-12.2013.

23.

Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.

Sieber J, Weins A, Kampe K, Gruber S, Lindenmeyer MT, Cohen CD, Orellana JM, Mundel P, Jehle AW.

Am J Pathol. 2013 Sep;183(3):735-44. doi: 10.1016/j.ajpath.2013.05.023. Epub 2013 Jul 16.

24.

Yes-associated protein (YAP) promotes cell survival by inhibiting proapoptotic dendrin signaling.

Campbell KN, Wong JS, Gupta R, Asanuma K, Sudol M, He JC, Mundel P.

J Biol Chem. 2013 Jun 14;288(24):17057-62. doi: 10.1074/jbc.C113.457390. Epub 2013 May 10.

25.

Calcium regulates podocyte actin dynamics.

Greka A, Mundel P.

Semin Nephrol. 2012 Jul;32(4):319-26. doi: 10.1016/j.semnephrol.2012.06.003. Review.

26.

Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells.

Jeon J, Leibiger I, Moede T, Walter B, Faul C, Maiguel D, Villarreal R, Guzman J, Berggren PO, Mundel P, Ricordi C, Merscher-Gomez S, Fornoni A.

J Biol Chem. 2012 Aug 17;287(34):28932-42. doi: 10.1074/jbc.M112.389452. Epub 2012 Jun 20. Erratum in: J Biol Chem. 2013 Jan 11;288(2):1277.

27.

Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization.

Wong JS, Iorns E, Rheault MN, Ward TM, Rashmi P, Weber U, Lippman ME, Faul C, Mlodzik M, Mundel P.

EMBO J. 2012 Feb 15;31(4):1028-40. doi: 10.1038/emboj.2011.464. Epub 2011 Dec 13.

28.

Cell biology and pathology of podocytes.

Greka A, Mundel P.

Annu Rev Physiol. 2012;74:299-323. doi: 10.1146/annurev-physiol-020911-153238. Epub 2011 Nov 4. Review.

29.

FGF23 induces left ventricular hypertrophy.

Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-O M, Kusek JW, Keane MG, Wolf M.

J Clin Invest. 2011 Nov;121(11):4393-408. doi: 10.1172/JCI46122. Epub 2011 Oct 10.

30.

Balancing calcium signals through TRPC5 and TRPC6 in podocytes.

Greka A, Mundel P.

J Am Soc Nephrol. 2011 Nov;22(11):1969-80. doi: 10.1681/ASN.2011040370. Epub 2011 Oct 6. Review.

31.

COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness.

Heeringa SF, Chernin G, Chaki M, Zhou W, Sloan AJ, Ji Z, Xie LX, Salviati L, Hurd TW, Vega-Warner V, Killen PD, Raphael Y, Ashraf S, Ovunc B, Schoeb DS, McLaughlin HM, Airik R, Vlangos CN, Gbadegesin R, Hinkes B, Saisawat P, Trevisson E, Doimo M, Casarin A, Pertegato V, Giorgi G, Prokisch H, Rötig A, Nürnberg G, Becker C, Wang S, Ozaltin F, Topaloglu R, Bakkaloglu A, Bakkaloglu SA, Müller D, Beissert A, Mir S, Berdeli A, Varpizen S, Zenker M, Matejas V, Santos-Ocaña C, Navas P, Kusakabe T, Kispert A, Akman S, Soliman NA, Krick S, Mundel P, Reiser J, Nürnberg P, Clarke CF, Wiggins RC, Faul C, Hildebrandt F.

J Clin Invest. 2011 May;121(5):2013-24. doi: 10.1172/JCI45693. Epub 2011 Apr 11.

32.

Stimulation of the calcium-sensing receptor stabilizes the podocyte cytoskeleton, improves cell survival, and reduces toxin-induced glomerulosclerosis.

Oh J, Beckmann J, Bloch J, Hettgen V, Mueller J, Li L, Hoemme M, Gross ML, Penzel R, Mundel P, Schaefer F, Schmitt CP.

Kidney Int. 2011 Sep;80(5):483-92. doi: 10.1038/ki.2011.105. Epub 2011 Apr 20.

33.

Role of angiotensin II in the development of nephropathy and podocytopathy of diabetes.

Campbell KN, Raij L, Mundel P.

Curr Diabetes Rev. 2011 Jan;7(1):3-7. Review.

34.

Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids.

Sieber J, Lindenmeyer MT, Kampe K, Campbell KN, Cohen CD, Hopfer H, Mundel P, Jehle AW.

Am J Physiol Renal Physiol. 2010 Oct;299(4):F821-9. doi: 10.1152/ajprenal.00196.2010. Epub 2010 Jul 28.

35.

Proteinuria: an enzymatic disease of the podocyte?

Mundel P, Reiser J.

Kidney Int. 2010 Apr;77(7):571-80. doi: 10.1038/ki.2009.424. Epub 2009 Nov 18. Review.

36.

Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release.

Fornoni A, Jeon J, Varona Santos J, Cobianchi L, Jauregui A, Inverardi L, Mandic SA, Bark C, Johnson K, McNamara G, Pileggi A, Molano RD, Reiser J, Tryggvason K, Kerjaschki D, Berggren PO, Mundel P, Ricordi C.

Diabetes. 2010 Jan;59(1):190-9. doi: 10.2337/db09-0655. Epub 2009 Oct 15.

37.

Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria.

Jauregui A, Mintz DH, Mundel P, Fornoni A.

Curr Opin Nephrol Hypertens. 2009 Nov;18(6):539-45. doi: 10.1097/MNH.0b013e32832f7002. Review.

38.

Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis.

Shi S, Yu L, Chiu C, Sun Y, Chen J, Khitrov G, Merkenschlager M, Holzman LB, Zhang W, Mundel P, Bottinger EP.

J Am Soc Nephrol. 2008 Nov;19(11):2159-69. doi: 10.1681/ASN.2008030312. Epub 2008 Sep 5.

39.

Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease.

Krick S, Shi S, Ju W, Faul C, Tsai SY, Mundel P, Böttinger EP.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14106-11. doi: 10.1073/pnas.0801146105. Epub 2008 Sep 4.

40.

The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A.

Faul C, Donnelly M, Merscher-Gomez S, Chang YH, Franz S, Delfgaauw J, Chang JM, Choi HY, Campbell KN, Kim K, Reiser J, Mundel P.

Nat Med. 2008 Sep;14(9):931-8. doi: 10.1038/nm.1857.

41.

The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells.

Saleem MA, Zavadil J, Bailly M, McGee K, Witherden IR, Pavenstadt H, Hsu H, Sanday J, Satchell SC, Lennon R, Ni L, Bottinger EP, Mundel P, Mathieson PW.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F959-70. doi: 10.1152/ajprenal.00559.2007. Epub 2008 Aug 6.

42.

Dual effects of RAS blockade on blood pressure and podocyte function.

Reiser J, Mundel P.

Curr Hypertens Rep. 2007 Nov;9(5):403-8. Review.

PMID:
18177588
43.

Modification of kidney barrier function by the urokinase receptor.

Wei C, Möller CC, Altintas MM, Li J, Schwarz K, Zacchigna S, Xie L, Henger A, Schmid H, Rastaldi MP, Cowan P, Kretzler M, Parrilla R, Bendayan M, Gupta V, Nikolic B, Kalluri R, Carmeliet P, Mundel P, Reiser J.

Nat Med. 2008 Jan;14(1):55-63. Epub 2007 Dec 16.

PMID:
18084301
45.

Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton.

Faul C, Asanuma K, Yanagida-Asanuma E, Kim K, Mundel P.

Trends Cell Biol. 2007 Sep;17(9):428-37. Epub 2007 Sep 4. Review.

PMID:
17804239
46.

Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.

Pandit B, Sarkozy A, Pennacchio LA, Carta C, Oishi K, Martinelli S, Pogna EA, Schackwitz W, Ustaszewska A, Landstrom A, Bos JM, Ommen SR, Esposito G, Lepri F, Faul C, Mundel P, López Siguero JP, Tenconi R, Selicorni A, Rossi C, Mazzanti L, Torrente I, Marino B, Digilio MC, Zampino G, Ackerman MJ, Dallapiccola B, Tartaglia M, Gelb BD.

Nat Genet. 2007 Aug;39(8):1007-12. Epub 2007 Jul 1.

PMID:
17603483
47.

Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes.

Yanagida-Asanuma E, Asanuma K, Kim K, Donnelly M, Young Choi H, Hyung Chang J, Suetsugu S, Tomino Y, Takenawa T, Faul C, Mundel P.

Am J Pathol. 2007 Aug;171(2):415-27. Epub 2007 Jun 14.

48.

Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes.

Asanuma K, Campbell KN, Kim K, Faul C, Mundel P.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10134-9. Epub 2007 May 30.

49.

PPAR-gamma agonist protects podocytes from injury.

Kanjanabuch T, Ma LJ, Chen J, Pozzi A, Guan Y, Mundel P, Fogo AB.

Kidney Int. 2007 Jun;71(12):1232-9. Epub 2007 Apr 25.

50.

Podocytes in culture: past, present, and future.

Shankland SJ, Pippin JW, Reiser J, Mundel P.

Kidney Int. 2007 Jul;72(1):26-36. Epub 2007 Apr 25. Review.

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