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Items: 1 to 50 of 78

1.

GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation.

Witkos TM, Chan WL, Joensuu M, Rhiel M, Pallister E, Thomas-Oates J, Mould AP, Mironov AA, Biot C, Guerardel Y, Morelle W, Ungar D, Wieland FT, Jokitalo E, Tassabehji M, Kornak U, Lowe M.

Nat Commun. 2019 Jan 10;10(1):127. doi: 10.1038/s41467-018-08044-6.

2.

Analyzing Integrin-Dependent Adhesion.

Mould AP.

Curr Protoc Cell Biol. 2019 Mar;82(1):e69. doi: 10.1002/cpcb.69. Epub 2018 Oct 1.

PMID:
30277020
3.

Enteric Species F Human Adenoviruses use Laminin-Binding Integrins as Co-Receptors for Infection of Ht-29 Cells.

Rajan A, Persson BD, Frängsmyr L, Olofsson A, Sandblad L, Heino J, Takada Y, Mould AP, Schnapp LM, Gall J, Arnberg N.

Sci Rep. 2018 Jul 3;8(1):10019. doi: 10.1038/s41598-018-28255-7.

4.

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function.

Gahloth D, Heaven G, Jowitt TA, Mould AP, Bella J, Baldock C, Woodman P, Tabernero L.

Sci Rep. 2017 Aug 22;7(1):9151. doi: 10.1038/s41598-017-09467-9.

5.

Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP.

Gahloth D, Levy C, Walker L, Wunderley L, Mould AP, Taylor S, Woodman P, Tabernero L.

Structure. 2017 Jul 5;25(7):1011-1024.e4. doi: 10.1016/j.str.2017.05.005. Epub 2017 Jun 8.

6.

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex.

Tunnicliffe RB, Lockhart-Cairns MP, Levy C, Mould AP, Jowitt TA, Sito H, Baldock C, Sandri-Goldin RM, Golovanov AP.

Nucleic Acids Res. 2017 Jul 27;45(13):8064-8078. doi: 10.1093/nar/gkx419.

7.

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION.

Mould AP, Askari JA, Byron A, Takada Y, Jowitt TA, Humphries MJ.

J Biol Chem. 2016 Sep 30;291(40):20993-21007. Epub 2016 Aug 2.

8.

Screen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin.

Aguilar-Martinez E, Chen X, Webber A, Mould AP, Seifert A, Hay RT, Sharrocks AD.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4854-63. doi: 10.1073/pnas.1509716112. Epub 2015 Aug 17.

9.

Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors.

Mould AP, Craig SE, Byron SK, Humphries MJ, Jowitt TA.

Biochem J. 2014 Dec 15;464(3):301-13. doi: 10.1042/BJ20141047.

PMID:
25333419
10.

Cyclic mechanical reinforcement of integrin-ligand interactions.

Kong F, Li Z, Parks WM, Dumbauld DW, García AJ, Mould AP, Humphries MJ, Zhu C.

Mol Cell. 2013 Mar 28;49(6):1060-8. doi: 10.1016/j.molcel.2013.01.015. Epub 2013 Feb 14.

11.

Analyzing integrin-dependent adhesion.

Mould AP.

Curr Protoc Cell Biol. 2011 Dec;Chapter 9:Unit 9.4.. doi: 10.1002/0471143030.cb0904s53.

PMID:
22161548
12.

Anti-integrin monoclonal antibodies.

Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ.

J Cell Sci. 2009 Nov 15;122(Pt 22):4009-11. doi: 10.1242/jcs.056770. Review. No abstract available.

13.

Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach.

Mould AP, Koper EJ, Byron A, Zahn G, Humphries MJ.

Biochem J. 2009 Nov 11;424(2):179-89. doi: 10.1042/BJ20090992.

14.

Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling.

Jülich D, Mould AP, Koper E, Holley SA.

Development. 2009 Sep;136(17):2913-21. doi: 10.1242/dev.038935. Epub 2009 Jul 29.

15.

Demonstration of catch bonds between an integrin and its ligand.

Kong F, García AJ, Mould AP, Humphries MJ, Zhu C.

J Cell Biol. 2009 Jun 29;185(7):1275-84. doi: 10.1083/jcb.200810002.

16.

Linking integrin conformation to function.

Askari JA, Buckley PA, Mould AP, Humphries MJ.

J Cell Sci. 2009 Jan 15;122(Pt 2):165-70. doi: 10.1242/jcs.018556. Review.

17.
18.

Analyzing integrin-dependent adhesion.

Mould AP.

Curr Protoc Cell Biol. 2002 Aug;Chapter 9:Unit 9.4. doi: 10.1002/0471143030.cb0904s15. Review.

PMID:
18228412
19.

The collagens of hydra provide insight into the evolution of metazoan extracellular matrices.

Zhang X, Boot-Handford RP, Huxley-Jones J, Forse LN, Mould AP, Robertson DL, Lili, Athiyal M, Sarras MP Jr.

J Biol Chem. 2007 Mar 2;282(9):6792-802. Epub 2007 Jan 3.

20.
21.

Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio).

Mould AP, McLeish JA, Huxley-Jones J, Goonesinghe AC, Hurlstone AF, Boot-Handford RP, Humphries MJ.

BMC Cell Biol. 2006 Jun 20;7:24.

22.

A small molecule alpha 4 beta 1 antagonist prevents development of murine Lyme arthritis without affecting protective immunity.

Gläsner J, Blum H, Wehner V, Stilz HU, Humphries JD, Curley GP, Mould AP, Humphries MJ, Hallmann R, Röllinghoff M, Gessner A.

J Immunol. 2005 Oct 1;175(7):4724-34.

23.

Evidence for the presence of a low-mass beta1 integrin on the cell surface.

Meng X, Cheng K, Krohkin O, Mould AP, Humphries MJ, Ens W, Standing K, Wilkins JA.

J Cell Sci. 2005 Sep 1;118(Pt 17):4009-16. Epub 2005 Aug 16.

24.

The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family.

Ewan R, Huxley-Jones J, Mould AP, Humphries MJ, Robertson DL, Boot-Handford RP.

BMC Evol Biol. 2005 May 13;5:31.

25.

Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.

Humphries JD, Schofield NR, Mostafavi-Pour Z, Green LJ, Garratt AN, Mould AP, Humphries MJ.

J Biol Chem. 2005 Mar 18;280(11):10234-43. Epub 2005 Jan 4.

26.

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

Clark K, Pankov R, Travis MA, Askari JA, Mould AP, Craig SE, Newham P, Yamada KM, Humphries MJ.

J Cell Sci. 2005 Jan 15;118(Pt 2):291-300. Epub 2004 Dec 22.

27.

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

Mould AP, Travis MA, Barton SJ, Hamilton JA, Askari JA, Craig SE, Macdonald PR, Kammerer RA, Buckley PA, Humphries MJ.

J Biol Chem. 2005 Feb 11;280(6):4238-46. Epub 2004 Nov 22.

28.

Cell biology: adhesion articulated.

Mould AP, Humphries MJ.

Nature. 2004 Nov 4;432(7013):27-8. No abstract available.

PMID:
15525967
29.

Mechanisms of integration of cells and extracellular matrices by integrins.

Humphries MJ, Travis MA, Clark K, Mould AP.

Biochem Soc Trans. 2004 Nov;32(Pt 5):822-5. Review.

PMID:
15494024
30.

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

Mould AP, Humphries MJ.

Curr Opin Cell Biol. 2004 Oct;16(5):544-51. Review.

PMID:
15363805
31.

Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation.

Travis MA, van der Flier A, Kammerer RA, Mould AP, Sonnenberg A, Humphries MJ.

FEBS Lett. 2004 Jul 2;569(1-3):185-90.

32.

Novel activating and inactivating mutations in the integrin beta1 subunit A domain.

Barton SJ, Travis MA, Askari JA, Buckley PA, Craig SE, Humphries MJ, Mould AP.

Biochem J. 2004 Jun 1;380(Pt 2):401-7.

33.

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

Mould AP, Barton SJ, Askari JA, Craig SE, Humphries MJ.

J Biol Chem. 2003 Dec 19;278(51):51622-9. Epub 2003 Oct 7.

34.

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

Mould AP, Symonds EJ, Buckley PA, Grossmann JG, McEwan PA, Barton SJ, Askari JA, Craig SE, Bella J, Humphries MJ.

J Biol Chem. 2003 Oct 10;278(41):39993-9. Epub 2003 Jul 19.

35.

Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble.

Humphries MJ, McEwan PA, Barton SJ, Buckley PA, Bella J, Mould AP.

Trends Biochem Sci. 2003 Jun;28(6):313-20. Review.

PMID:
12826403
36.

Mapping functional residues onto integrin crystal structures.

Humphries MJ, Symonds EJ, Mould AP.

Curr Opin Struct Biol. 2003 Apr;13(2):236-43. Review.

PMID:
12727518
37.

Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement.

Mould AP, Barton SJ, Askari JA, McEwan PA, Buckley PA, Craig SE, Humphries MJ.

J Biol Chem. 2003 May 9;278(19):17028-35. Epub 2003 Mar 3.

38.

E-cadherin is a ligand for integrin alpha2beta1.

Whittard JD, Craig SE, Mould AP, Koch A, Pertz O, Engel J, Humphries MJ.

Matrix Biol. 2002 Oct;21(6):525-32.

PMID:
12392763
39.

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain.

Mould AP, Askari JA, Barton S, Kline AD, McEwan PA, Craig SE, Humphries MJ.

J Biol Chem. 2002 May 31;277(22):19800-5. Epub 2002 Mar 13.

40.

Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus.

Jackson T, Mould AP, Sheppard D, King AM.

J Virol. 2002 Feb;76(3):935-41.

41.

Structure. An anthropomorphic integrin.

Humphries MJ, Mould AP.

Science. 2001 Oct 12;294(5541):316-7. No abstract available.

PMID:
11598288
42.

Solid phase assays for studying ECM protein-protein interactions.

Mould AP.

Methods Mol Biol. 2000;139:295-9. Review. No abstract available.

PMID:
10840797
43.
45.

Molecular basis of ligand recognition by integrin alpha5beta 1. II. Specificity of arg-gly-Asp binding is determined by Trp157 OF THE alpha subunit.

Humphries JD, Askari JA, Zhang XP, Takada Y, Humphries MJ, Mould AP.

J Biol Chem. 2000 Jul 7;275(27):20337-45.

46.
47.

Identification of amino acid residues that form part of the ligand-binding pocket of integrin alpha5 beta1.

Mould AP, Burrows L, Humphries MJ.

J Biol Chem. 1998 Oct 2;273(40):25664-72.

48.

The integrin beta subunit.

Green LJ, Mould AP, Humphries MJ.

Int J Biochem Cell Biol. 1998 Feb;30(2):179-84. Review.

PMID:
9608671
50.

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