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The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells.

Camacho-Moll ME, Macdonald J, Looijenga LHJ, Rimmer MP, Donat R, Marwick JA, Shukla CJ, Carragher N, Jørgensen A, Mitchell RT.

BMC Cancer. 2019 Nov 19;19(1):1124. doi: 10.1186/s12885-019-6340-7.


Dysregulation of FGFR signalling by a selective inhibitor reduces germ cell survival in human fetal gonads of both sexes and alters the somatic niche in fetal testes.

Harpelunde Poulsen K, Nielsen JE, Frederiksen H, Melau C, Juul Hare K, Langhoff Thuesen L, Perlman S, Lundvall L, Mitchell RT, Juul A, Rajpert-De Meyts E, Jørgensen A.

Hum Reprod. 2019 Nov 1;34(11):2228-2243. doi: 10.1093/humrep/dez191.


Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing.

Gannon AL, O'Hara L, Mason JI, Jørgensen A, Frederiksen H, Milne L, Smith S, Mitchell RT, Smith LB.

Sci Rep. 2019 Jul 18;9(1):10457. doi: 10.1038/s41598-019-46049-3.


Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis.

O'Shaughnessy PJ, Mitchell RT, Monteiro A, O'Hara L, Cruickshanks L, der Grinten HC, Brown P, Abel M, Smith LB.

BMC Dev Biol. 2019 Apr 17;19(1):8. doi: 10.1186/s12861-019-0189-5.


Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders.

Gannon AL, O'Hara L, Mason JI, Rebourcet D, Smith S, Traveres A, Alcaide-Corral CJ, Frederiksen H, Jørgensen A, Milne L, Mitchell RT, Smith LB.

Sci Rep. 2019 Mar 1;9(1):3250. doi: 10.1038/s41598-019-39867-y.


Complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primate.

Ntemou E, Kadam P, Van Saen D, Wistuba J, Mitchell RT, Schlatt S, Goossens E.

Hum Reprod. 2019 Mar 1;34(3):403-413. doi: 10.1093/humrep/dey373.


Characterization of Human Adrenal Steroidogenesis During Fetal Development.

Melau C, Nielsen JE, Frederiksen H, Kilcoyne K, Perlman S, Lundvall L, Langhoff Thuesen L, Juul Hare K, Andersson AM, Mitchell RT, Juul A, Jørgensen A.

J Clin Endocrinol Metab. 2019 May 1;104(5):1802-1812. doi: 10.1210/jc.2018-01759.


Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis.

Jørgensen A, Macdonald J, Nielsen JE, Kilcoyne KR, Perlman S, Lundvall L, Langhoff Thuesen L, Juul Hare K, Frederiksen H, Andersson AM, Skakkebæk NE, Juul A, Sharpe RM, Rajpert-De Meyts E, Mitchell RT.

Cell Rep. 2018 Nov 13;25(7):1924-1937.e4. doi: 10.1016/j.celrep.2018.10.064.


DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads.

Macdonald J, Kilcoyne KR, Sharpe RM, Kavanagh Á, Anderson RA, Brown P, Smith LB, Jørgensen A, Mitchell RT.

Hum Reprod. 2018 Nov 1;33(11):2107-2121. doi: 10.1093/humrep/dey289.


Spermatogonial quantity in human prepubertal testicular tissue collected for fertility preservation prior to potentially sterilizing therapy.

Stukenborg JB, Alves-Lopes JP, Kurek M, Albalushi H, Reda A, Keros V, Töhönen V, Bjarnason R, Romerius P, Sundin M, Norén Nyström U, Langenskiöld C, Vogt H, Henningsohn L, Mitchell RT, Söder O, Petersen C, Jahnukainen K.

Hum Reprod. 2018 Sep 1;33(9):1677-1683. doi: 10.1093/humrep/dey240.


Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems.

Hurtado-Gonzalez P, Anderson RA, Macdonald J, van den Driesche S, Kilcoyne K, Jørgensen A, McKinnell C, Macpherson S, Sharpe RM, Mitchell RT.

Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.


Ibuprofen is deleterious for the development of first trimester human fetal ovary ex vivo.

Leverrier-Penna S, Mitchell RT, Becker E, Lecante L, Ben Maamar M, Homer N, Lavoué V, Kristensen DM, Dejucq-Rainsford N, Jégou B, Mazaud-Guittot S.

Hum Reprod. 2018 Mar 1;33(3):482-493. doi: 10.1093/humrep/dex383.


Chemotherapy drugs cyclophosphamide, cisplatin and doxorubicin induce germ cell loss in an in vitro model of the prepubertal testis.

Smart E, Lopes F, Rice S, Nagy B, Anderson RA, Mitchell RT, Spears N.

Sci Rep. 2018 Jan 29;8(1):1773. doi: 10.1038/s41598-018-19761-9.


Cancer treatment in childhood and testicular function: the importance of the somatic environment.

Stukenborg JB, Jahnukainen K, Hutka M, Mitchell RT.

Endocr Connect. 2018 Feb;7(2):R69-R87. doi: 10.1530/EC-17-0382. Epub 2018 Jan 19. Review.


Experimental models of testicular development and function using human tissue and cells.

Tharmalingam MD, Jorgensen A, Mitchell RT.

Mol Cell Endocrinol. 2018 Jun 15;468:95-110. doi: 10.1016/j.mce.2017.12.011. Epub 2018 Jan 6. Review.


GATA transcription factors in testicular adrenal rest tumours.

Engels M, Span PN, Mitchell RT, Heuvel JJTM, Marijnissen-van Zanten MA, van Herwaarden AE, Hulsbergen-van de Kaa CA, Oosterwijk E, Stikkelbroeck NM, Smith LB, Sweep FCGJ, Claahsen-van der Grinten HL.

Endocr Connect. 2017 Nov;6(8):866-875. doi: 10.1530/EC-17-0215. Epub 2017 Oct 16.


Xenotransplantation as a model for human testicular development.

Hutka M, Smith LB, Mitchell RT.

Differentiation. 2017 Sep - Oct;97:44-53. doi: 10.1016/j.diff.2017.09.001. Epub 2017 Sep 13. Review.


Follicle Stimulating Hormone is an accurate predictor of azoospermia in childhood cancer survivors.

Kelsey TW, McConville L, Edgar AB, Ungurianu AI, Mitchell RT, Anderson RA, Wallace WHB.

PLoS One. 2017 Jul 20;12(7):e0181377. doi: 10.1371/journal.pone.0181377. eCollection 2017. Review.


Assessing the impact of in-utero exposures: potential effects of paracetamol on male reproductive development.

Kilcoyne KR, Mitchell RT.

Arch Dis Child. 2017 Dec;102(12):1169-1175. doi: 10.1136/archdischild-2016-311374. Epub 2017 Jun 6. Review.


Ibuprofen results in alterations of human fetal testis development.

Ben Maamar M, Lesné L, Hennig K, Desdoits-Lethimonier C, Kilcoyne KR, Coiffec I, Rolland AD, Chevrier C, Kristensen DM, Lavoué V, Antignac JP, Le Bizec B, Dejucq-Rainsford N, Mitchell RT, Mazaud-Guittot S, Jégou B.

Sci Rep. 2017 Mar 10;7:44184. doi: 10.1038/srep44184.


Analgesic use in pregnancy and male reproductive development.

Hurtado-Gonzalez P, Mitchell RT.

Curr Opin Endocrinol Diabetes Obes. 2017 Jun;24(3):225-232. doi: 10.1097/MED.0000000000000338. Review.


Fertility preservation: don't forget the boys.

Mitchell RT, Nahata L, Quinn GP.

BMJ. 2017 Feb 2;356:j495. doi: 10.1136/bmj.j495. No abstract available.


Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice.

Lopes F, Smith R, Nash S, Mitchell RT, Spears N.

Mol Hum Reprod. 2016 Nov;22(11):745-755. Epub 2016 Jul 28.


Autologous Fat Grafting for Pedal Fat Pad Atrophy: A Prospective Randomized Clinical Trial.

Gusenoff JA, Mitchell RT, Jeong K, Wukich DK, Gusenoff BR.

Plast Reconstr Surg. 2016 Nov;138(5):1099-1108.


Salinity-induced changes in gene expression from anterior and posterior gills of Callinectes sapidus (Crustacea: Portunidae) with implications for crustacean ecological genomics.

Havird JC, Mitchell RT, Henry RP, Santos SR.

Comp Biochem Physiol Part D Genomics Proteomics. 2016 Sep;19:34-44. doi: 10.1016/j.cbd.2016.06.002. Epub 2016 Jun 11.


Creating a Global Community of Practice for Oncofertility.

Ataman LM, Rodrigues JK, Marinho RM, Caetano JP, Chehin MB, Alves da Motta EL, Serafini P, Suzuki N, Furui T, Takae S, Sugishita Y, Morishige KI, Almeida-Santos T, Melo C, Buzaglo K, Irwin K, Wallace WH, Anderson RA, Mitchell RT, Telfer EE, Adiga SK, Anazodo A, Stern C, Sullivan E, Jayasinghe Y, Orme L, Cohn R, McLachlan R, Deans R, Agresta F, Gerstl B, Ledger WL, Robker RL, de Meneses E Silva JM, Silva LH, Lunardi FO, Lee JR, Suh CS, De Vos M, Van Moer E, Stoop D, Vloeberghs V, Smitz J, Tournaye H, Wildt L, Winkler-Crepaz K, Andersen CY, Smith BM, Smith K, Woodruff TK.

J Glob Oncol. 2016 Apr;2(2):83-96. Epub 2015 Dec 23.


Sertoli Cells Modulate Testicular Vascular Network Development, Structure, and Function to Influence Circulating Testosterone Concentrations in Adult Male Mice.

Rebourcet D, Wu J, Cruickshanks L, Smith SE, Milne L, Fernando A, Wallace RJ, Gray CD, Hadoke PW, Mitchell RT, O'Shaughnessy PJ, Smith LB.

Endocrinology. 2016 Jun;157(6):2479-88. doi: 10.1210/en.2016-1156. Epub 2016 May 4.


A Normative Model of Serum Inhibin B in Young Males.

Kelsey TW, Miles A, Mitchell RT, Anderson RA, Wallace WH.

PLoS One. 2016 Apr 14;11(4):e0153843. doi: 10.1371/journal.pone.0153843. eCollection 2016.


Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences.

Dean A, van den Driesche S, Wang Y, McKinnell C, Macpherson S, Eddie SL, Kinnell H, Hurtado-Gonzalez P, Chambers TJ, Stevenson K, Wolfinger E, Hrabalkova L, Calarrao A, Bayne RA, Hagen CP, Mitchell RT, Anderson RA, Sharpe RM.

Sci Rep. 2016 Jan 27;6:19789. doi: 10.1038/srep19789.


Coeliac screening in a Scottish cohort of children with type 1 diabetes mellitus: is DQ typing the way forward?

Mitchell RT, Sun A, Mayo A, Forgan M, Comrie A, Gillett PM.

Arch Dis Child. 2016 Mar;101(3):230-3. doi: 10.1136/archdischild-2015-309754. Epub 2015 Dec 30.


Clinical Applications of Barbed Suture in Aesthetic Breast Surgery.

Mitchell RT, Bengtson BP.

Clin Plast Surg. 2015 Oct;42(4):595-604. doi: 10.1016/j.cps.2015.06.003. Review.


A European perspective on testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boys.

Picton HM, Wyns C, Anderson RA, Goossens E, Jahnukainen K, Kliesch S, Mitchell RT, Pennings G, Rives N, Tournaye H, van Pelt AM, Eichenlaub-Ritter U, Schlatt S; ESHRE Task Force On Fertility Preservation In Severe Diseases.

Hum Reprod. 2015 Nov;30(11):2463-75. doi: 10.1093/humrep/dev190. Epub 2015 Sep 10. Review.


Ex vivo culture of human fetal gonads: manipulation of meiosis signalling by retinoic acid treatment disrupts testis development.

Jørgensen A, Nielsen JE, Perlman S, Lundvall L, Mitchell RT, Juul A, Rajpert-De Meyts E.

Hum Reprod. 2015 Oct;30(10):2351-63. doi: 10.1093/humrep/dev194. Epub 2015 Aug 6.


Sertoli cell androgen receptor signalling in adulthood is essential for post-meiotic germ cell development.

Willems A, Roesl C, Mitchell RT, Milne L, Jeffery N, Smith S, Verhoeven G, Brown P, Smith LB.

Mol Reprod Dev. 2015 Sep;82(9):626-7. doi: 10.1002/mrd.22506. Epub 2015 Jun 9. No abstract available.


Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model.

van den Driesche S, Macdonald J, Anderson RA, Johnston ZC, Chetty T, Smith LB, Mckinnell C, Dean A, Homer NZ, Jorgensen A, Camacho-Moll ME, Sharpe RM, Mitchell RT.

Sci Transl Med. 2015 May 20;7(288):288ra80. doi: 10.1126/scitranslmed.aaa4097.


Cancer treatment and gonadal function: experimental and established strategies for fertility preservation in children and young adults.

Anderson RA, Mitchell RT, Kelsey TW, Spears N, Telfer EE, Wallace WH.

Lancet Diabetes Endocrinol. 2015 Jul;3(7):556-67. doi: 10.1016/S2213-8587(15)00039-X. Epub 2015 Apr 12. Review.


Testicular function and fertility preservation after treatment for haematological cancer.

Jahnukainen K, Mitchell RT, Stukenborg JB.

Curr Opin Endocrinol Diabetes Obes. 2015 Jun;22(3):217-23. doi: 10.1097/MED.0000000000000156. Review.


Comparative effects of di(n-butyl) phthalate exposure on fetal germ cell development in the rat and in human fetal testis xenografts.

van den Driesche S, McKinnell C, Calarrão A, Kennedy L, Hutchison GR, Hrabalkova L, Jobling MS, Macpherson S, Anderson RA, Sharpe RM, Mitchell RT.

Environ Health Perspect. 2015 Mar;123(3):223-30. doi: 10.1289/ehp.1408248. Epub 2014 Dec 16.


Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and men.

O'Hara L, McInnes K, Simitsidellis I, Morgan S, Atanassova N, Slowikowska-Hilczer J, Kula K, Szarras-Czapnik M, Milne L, Mitchell RT, Smith LB.

FASEB J. 2015 Mar;29(3):894-910. doi: 10.1096/fj.14-255729. Epub 2014 Nov 17.


Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action.

Mitchell RT, Mungall W, McKinnell C, Sharpe RM, Cruickshanks L, Milne L, Smith LB.

Endocrinology. 2015 Jan;156(1):24-31. doi: 10.1210/en.2014-1534.


A validated age-related normative model for male total testosterone shows increasing variance but no decline after age 40 years.

Kelsey TW, Li LQ, Mitchell RT, Whelan A, Anderson RA, Wallace WH.

PLoS One. 2014 Oct 8;9(10):e109346. doi: 10.1371/journal.pone.0109346. eCollection 2014. Erratum in: PLoS One. 2015;10(2):e0117674.


The Fleur-De-Lis abdominoplasty.

Mitchell RT, Rubin JP.

Clin Plast Surg. 2014 Oct;41(4):673-80. doi: 10.1016/j.cps.2014.07.007. Review.


Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis.

Rebourcet D, O'Shaughnessy PJ, Monteiro A, Milne L, Cruickshanks L, Jeffrey N, Guillou F, Freeman TC, Mitchell RT, Smith LB.

PLoS One. 2014 Aug 21;9(8):e105687. doi: 10.1371/journal.pone.0105687. eCollection 2014.


Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis.

Rebourcet D, O'Shaughnessy PJ, Pitetti JL, Monteiro A, O'Hara L, Milne L, Tsai YT, Cruickshanks L, Riethmacher D, Guillou F, Mitchell RT, van't Hof R, Freeman TC, Nef S, Smith LB.

Development. 2014 May;141(10):2139-49. doi: 10.1242/dev.107029.


Regulation of the germ stem cell niche as the foundation for adult spermatogenesis: a role for miRNAs?

van den Driesche S, Sharpe RM, Saunders PT, Mitchell RT.

Semin Cell Dev Biol. 2014 May;29:76-83. doi: 10.1016/j.semcdb.2014.04.006. Epub 2014 Apr 6. Review.


Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential.

Mitchell RT, Camacho-Moll M, Macdonald J, Anderson RA, Kelnar CJ, O'Donnell M, Sharpe RM, Smith LB, Grigor KM, Wallace WHB, Stoop H, Wolffenbuttel KP, Donat R, Saunders PT, Looijenga LH.

Mod Pathol. 2014 Sep;27(9):1255-1266. doi: 10.1038/modpathol.2013.246. Epub 2014 Jan 24.


Carbonic anhydrase induction in euryhaline crustaceans is rate-limited at the post-transcriptional level.

Mitchell RT, Henry RP.

Comp Biochem Physiol A Mol Integr Physiol. 2014 Mar;169:15-23. doi: 10.1016/j.cbpa.2013.12.004. Epub 2013 Dec 12.


Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts.

Mitchell RT, Sharpe RM, Anderson RA, McKinnell C, Macpherson S, Smith LB, Wallace WH, Kelnar CJ, van den Driesche S.

PLoS One. 2013 Apr 19;8(4):e61726. doi: 10.1371/journal.pone.0061726. Print 2013.

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