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Items: 1 to 50 of 107

1.

Characterization of the polarized endothelial secretome.

Wei H, Sundararaman A, Dickson E, Rennie-Campbell L, Cross E, Heesom KJ, Mellor H.

FASEB J. 2019 Aug 20:fj201900262R. doi: 10.1096/fj.201900262R. [Epub ahead of print]

PMID:
31431053
2.

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression.

Gurevich DB, Severn CE, Twomey C, Greenhough A, Cash J, Toye AM, Mellor H, Martin P.

EMBO J. 2018 Jul 2;37(13). pii: e97786. doi: 10.15252/embj.201797786. Epub 2018 Jun 4.

3.

Direct Activation of NADPH Oxidase 2 by 2-Deoxyribose-1-Phosphate Triggers Nuclear Factor Kappa B-Dependent Angiogenesis.

Vara D, Watt JM, Fortunato TM, Mellor H, Burgess M, Wicks K, Mace K, Reeksting S, Lubben A, Wheeler-Jones CPD, Pula G.

Antioxid Redox Signal. 2018 Jan 10;28(2):110-130. doi: 10.1089/ars.2016.6869. Epub 2017 Sep 18.

4.

The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B.

McKinnon CM, Mellor H.

BMC Cancer. 2017 Feb 20;17(1):145. doi: 10.1186/s12885-017-3138-3.

5.

Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury.

Carr DF, Ayehunie S, Davies A, Duckworth CA, French S, Hall N, Hussain S, Mellor HR, Norris A, Park BK, Penrose A, Pritchard DM, Probert CS, Ramaiah S, Sadler C, Schmitt M, Shaw A, Sidaway JE, Vries RG, Wagoner M, Pirmohamed M.

Pharmacol Ther. 2017 Apr;172:181-194. doi: 10.1016/j.pharmthera.2017.01.002. Epub 2017 Jan 27. Review.

PMID:
28132905
6.

In Vitro Coculture Assays of Angiogenesis.

Richards M, Mellor H.

Methods Mol Biol. 2016;1430:159-66. doi: 10.1007/978-1-4939-3628-1_10.

PMID:
27172952
7.

The Formin FMNL3 Controls Early Apical Specification in Endothelial Cells by Regulating the Polarized Trafficking of Podocalyxin.

Richards M, Hetheridge C, Mellor H.

Curr Biol. 2015 Aug 31;25(17):2325-31. doi: 10.1016/j.cub.2015.07.045. Epub 2015 Aug 20.

8.

Platelet Rho GTPases-a focus on novel players, roles and relationships.

Goggs R, Williams CM, Mellor H, Poole AW.

Biochem J. 2015 Mar 15;466(3):431-42. doi: 10.1042/BJ20141404. Review.

9.

The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction.

Fan L, Yan H, Pellegrin S, Morigen, Mellor H.

Neurosci Lett. 2015 Mar 17;590:178-83. doi: 10.1016/j.neulet.2015.02.010. Epub 2015 Feb 7.

PMID:
25668492
10.

The coculture organotypic assay of angiogenesis.

Allen JL, Mellor H.

Methods Mol Biol. 2015;1214:265-70. doi: 10.1007/978-1-4939-1462-3_17.

PMID:
25468611
11.

Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury.

Cross MJ, Berridge BR, Clements PJ, Cove-Smith L, Force TL, Hoffmann P, Holbrook M, Lyon AR, Mellor HR, Norris AA, Pirmohamed M, Tugwood JD, Sidaway JE, Park BK.

Br J Pharmacol. 2015 Feb;172(4):957-74. doi: 10.1111/bph.12979. Epub 2015 Jan 12. Review.

12.

An integrated characterization of serological, pathological, and functional events in doxorubicin-induced cardiotoxicity.

Cove-Smith L, Woodhouse N, Hargreaves A, Kirk J, Smith S, Price SA, Galvin M, Betts CJ, Brocklehurst S, Backen A, Radford J, Linton K, Roberts RA, Schmitt M, Dive C, Tugwood JD, Hockings PD, Mellor HR.

Toxicol Sci. 2014 Jul;140(1):3-15. doi: 10.1093/toxsci/kfu057. Epub 2014 Mar 27.

PMID:
24675088
13.

Targeted inhibition of the FGF19-FGFR4 pathway in hepatocellular carcinoma; translational safety considerations.

Mellor HR.

Liver Int. 2014 Jul;34(6):e1-9. doi: 10.1111/liv.12462. Epub 2014 Jan 24. Review.

PMID:
24393342
14.

RNA interference approaches to examine Golgi function in animal cell culture.

Miller VJ, McKinnon CM, Mellor H, Stephens DJ.

Methods Cell Biol. 2013;118:15-34. doi: 10.1016/B978-0-12-417164-0.00002-1.

PMID:
24295298
15.

Reducing attrition in drug development: smart loading preclinical safety assessment.

Roberts RA, Kavanagh SL, Mellor HR, Pollard CE, Robinson S, Platz SJ.

Drug Discov Today. 2014 Mar;19(3):341-7. doi: 10.1016/j.drudis.2013.11.014. Epub 2013 Nov 21. Review.

PMID:
24269835
16.

RhoG protein regulates platelet granule secretion and thrombus formation in mice.

Goggs R, Harper MT, Pope RJ, Savage JS, Williams CM, Mundell SJ, Heesom KJ, Bass M, Mellor H, Poole AW.

J Biol Chem. 2013 Nov 22;288(47):34217-29. doi: 10.1074/jbc.M113.504100. Epub 2013 Oct 8.

17.

The small GTPase Rif is dispensable for platelet filopodia generation in mice.

Goggs R, Savage JS, Mellor H, Poole AW.

PLoS One. 2013;8(1):e54663. doi: 10.1371/journal.pone.0054663. Epub 2013 Jan 24.

18.

The formin FMNL3 is a cytoskeletal regulator of angiogenesis.

Hetheridge C, Scott AN, Swain RK, Copeland JW, Higgs HN, Bicknell R, Mellor H.

J Cell Sci. 2012 Mar 15;125(Pt 6):1420-8. doi: 10.1242/jcs.091066. Epub 2012 Jan 24.

19.

The small Rho GTPase Rif and actin cytoskeletal remodelling.

Fan L, Mellor H.

Biochem Soc Trans. 2012 Feb;40(1):268-72. doi: 10.1042/BST20110625. Review.

PMID:
22260703
20.

Uses of the in vitro endothelial-fibroblast organotypic co-culture assay in angiogenesis research.

Hetheridge C, Mavria G, Mellor H.

Biochem Soc Trans. 2011 Dec;39(6):1597-600. doi: 10.1042/BST20110738. Review.

PMID:
22103493
21.

Induction of heart valve lesions by small-molecule ALK5 inhibitors.

Anderton MJ, Mellor HR, Bell A, Sadler C, Pass M, Powell S, Steele SJ, Roberts RR, Heier A.

Toxicol Pathol. 2011 Oct;39(6):916-24. doi: 10.1177/0192623311416259. Epub 2011 Aug 22.

PMID:
21859884
22.

Site recognition and substrate screens for PKN family proteins.

Collazos A, Michael N, Whelan RD, Kelly G, Mellor H, Pang LC, Totty N, Parker PJ.

Biochem J. 2011 Sep 15;438(3):535-43. doi: 10.1042/BJ20110521.

PMID:
21749319
23.

Using mode of action information to improve regulatory decision-making: an ECETOC/ILSI RF/HESI workshop overview.

Carmichael N, Bausen M, Boobis AR, Cohen SM, Embry M, Fruijtier-Pölloth C, Greim H, Lewis R, Bette Meek ME, Mellor H, Vickers C, Doe J.

Crit Rev Toxicol. 2011 Mar;41(3):175-86. doi: 10.3109/10408444.2010.541225. Review.

PMID:
21401325
24.

Accumulation and distribution of doxorubicin in tumour spheroids: the influence of acidity and expression of P-glycoprotein.

Mellor HR, Callaghan R.

Cancer Chemother Pharmacol. 2011 Nov;68(5):1179-90. doi: 10.1007/s00280-011-1598-8. Epub 2011 Mar 15.

PMID:
21400240
25.

Cardiotoxicity associated with targeting kinase pathways in cancer.

Mellor HR, Bell AR, Valentin JP, Roberts RR.

Toxicol Sci. 2011 Mar;120(1):14-32. doi: 10.1093/toxsci/kfq378. Epub 2010 Dec 22. Review.

PMID:
21177772
26.

Regulation of autophagy by ATF4 in response to severe hypoxia.

Rzymski T, Milani M, Pike L, Buffa F, Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I, Harris AL.

Oncogene. 2010 Aug 5;29(31):4424-35. doi: 10.1038/onc.2010.191. Epub 2010 May 31.

PMID:
20514020
27.

The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells.

Fan L, Pellegrin S, Scott A, Mellor H.

J Cell Sci. 2010 Apr 15;123(Pt 8):1247-52. doi: 10.1242/jcs.061754. Epub 2010 Mar 16.

28.

Gender differences in drug toxicity.

Nicolson TJ, Mellor HR, Roberts RR.

Trends Pharmacol Sci. 2010 Mar;31(3):108-14. doi: 10.1016/j.tips.2009.12.001. Epub 2010 Feb 1. Review.

PMID:
20117848
29.

Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase.

Mellor HR, Rouschop KM, Wigfield SM, Wouters BG, Harris AL.

Biochem Pharmacol. 2010 Jun 1;79(11):1562-72. doi: 10.1016/j.bcp.2010.01.019. Epub 2010 Jan 25.

PMID:
20100468
30.

VEGF receptor trafficking in angiogenesis.

Scott A, Mellor H.

Biochem Soc Trans. 2009 Dec;37(Pt 6):1184-8. doi: 10.1042/BST0371184.

PMID:
19909243
31.

The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib.

Milani M, Rzymski T, Mellor HR, Pike L, Bottini A, Generali D, Harris AL.

Cancer Res. 2009 May 15;69(10):4415-23. doi: 10.1158/0008-5472.CAN-08-2839. Epub 2009 May 5.

32.

VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching.

Jones MC, Caswell PT, Moran-Jones K, Roberts M, Barry ST, Gampel A, Mellor H, Norman JC.

Traffic. 2009 Jun;10(6):754-66. doi: 10.1111/j.1600-0854.2009.00898.x.

33.

The role of formins in filopodia formation.

Mellor H.

Biochim Biophys Acta. 2010 Feb;1803(2):191-200. doi: 10.1016/j.bbamcr.2008.12.018. Epub 2009 Jan 3. Review.

34.

The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells.

McKinnon CM, Lygoe KA, Skelton L, Mitter R, Mellor H.

Oncogene. 2008 Nov 20;27(54):6856-65. doi: 10.1038/onc.2008.317. Epub 2008 Sep 1.

PMID:
18762809
35.

Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis.

Scott AN, Hetheridge C, Reynolds AR, Nayak V, Hodivala-Dilke K, Mellor H.

Angiogenesis. 2008;11(4):337-46. doi: 10.1007/s10456-008-9115-3. Epub 2008 Aug 30.

PMID:
18758974
36.

Rho GTPase activation assays.

Pellegrin S, Mellor H.

Curr Protoc Cell Biol. 2008 Mar;Chapter 14:Unit 14.8. doi: 10.1002/0471143030.cb1408s38.

PMID:
18360815
37.

Escherichia coli isolated from bovine mastitis invade mammary cells by a modified endocytic pathway.

Passey S, Bradley A, Mellor H.

Vet Microbiol. 2008 Jul 27;130(1-2):151-64. doi: 10.1016/j.vetmic.2008.01.003. Epub 2008 Jan 20.

PMID:
18299177
38.

Resistance to chemotherapy in cancer: a complex and integrated cellular response.

Mellor HR, Callaghan R.

Pharmacology. 2008;81(4):275-300. doi: 10.1159/000115967. Epub 2008 Feb 7. Review.

39.

Scanning electron microscopy of cell surface morphology.

Passey S, Pellegrin S, Mellor H.

Curr Protoc Cell Biol. 2007 Dec;Chapter 4:Unit4.17. doi: 10.1002/0471143030.cb0417s37.

PMID:
18228517
40.

Elemental tomography of cancer-cell spheroids reveals incomplete uptake of both platinum(II) and platinum(IV) complexes.

Alderden RA, Mellor HR, Modok S, Hall MD, Sutton SR, Newville MG, Callaghan R, Hambley TW.

J Am Chem Soc. 2007 Nov 7;129(44):13400-1. Epub 2007 Oct 12. No abstract available.

PMID:
17929931
41.

Actin stress fibres.

Pellegrin S, Mellor H.

J Cell Sci. 2007 Oct 15;120(Pt 20):3491-9. Review.

42.

The role of the hypoxia-inducible BH3-only proteins BNIP3 and BNIP3L in cancer.

Mellor HR, Harris AL.

Cancer Metastasis Rev. 2007 Dec;26(3-4):553-66. Review.

PMID:
17805942
43.

Basis for design and development of platinum(IV) anticancer complexes.

Hall MD, Mellor HR, Callaghan R, Hambley TW.

J Med Chem. 2007 Jul 26;50(15):3403-11. Epub 2007 Jun 28. Review. No abstract available.

PMID:
17602547
44.

Transport kinetics of four- and six-coordinate platinum compounds in the multicell layer tumour model.

Modok S, Scott R, Alderden RA, Hall MD, Mellor HR, Bohic S, Roose T, Hambley TW, Callaghan R.

Br J Cancer. 2007 Jul 16;97(2):194-200. Epub 2007 Jun 19.

45.
46.

Diffusivity and distribution of vinblastine in three-dimensional tumour tissue: experimental and mathematical modelling.

Modok S, Hyde P, Mellor HR, Roose T, Callaghan R.

Eur J Cancer. 2006 Sep;42(14):2404-13. Epub 2006 Aug 9.

PMID:
16901688
47.

Optimising non-viral gene delivery in a tumour spheroid model.

Mellor HR, Davies LA, Caspar H, Pringle CR, Hyde SC, Gill DR, Callaghan R.

J Gene Med. 2006 Sep;8(9):1160-70.

PMID:
16807955
48.

Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer.

Modok S, Mellor HR, Callaghan R.

Curr Opin Pharmacol. 2006 Aug;6(4):350-4. Epub 2006 May 11. Review.

PMID:
16690355
49.

VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment.

Gampel A, Moss L, Jones MC, Brunton V, Norman JC, Mellor H.

Blood. 2006 Oct 15;108(8):2624-31. Epub 2006 Apr 25.

50.

Expression of RND proteins in human myometrium.

Lartey J, Gampel A, Pawade J, Mellor H, Bernal AL.

Biol Reprod. 2006 Sep;75(3):452-61. Epub 2006 Mar 22.

PMID:
16554414

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