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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
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2001 8
2002 8
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2004 13
2005 11
2006 14
2007 17
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493 results

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Page 1
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.
Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey RC, McCastlain K, Reshmi SC, Payne-Turner D, Iacobucci I, Shao Y, Chen IM, Valentine M, Pei D, Mungall KL, Mungall AJ, Ma Y, Moore R, Marra M, Stonerock E, Gastier-Foster JM, Devidas M, Dai Y, Wood B, Borowitz M, Larsen EE, Maloney K, Mattano LA Jr, Angiolillo A, Salzer WL, Burke MJ, Gianni F, Spinelli O, Radich JP, Minden MD, Moorman AV, Patel B, Fielding AK, Rowe JM, Luger SM, Bhatia R, Aldoss I, Forman SJ, Kohlschmidt J, Mrózek K, Marcucci G, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Paietta E, Willman CL, Loh ML, Hunger SP, Mullighan CG. Gu Z, et al. Nat Commun. 2016 Nov 8;7:13331. doi: 10.1038/ncomms13331. Nat Commun. 2016. PMID: 27824051 Free PMC article.
Here using RNA sequencing of 560 ALL cases, we identify rearrangements between MEF2D (myocyte enhancer factor 2D) and five genes (BCL9, CSF1R, DAZAP1, HNRNPUL1 and SS18) in 22 B progenitor ALL (B-ALL) cases with a distinct gene expression profile, the most common of which …
Here using RNA sequencing of 560 ALL cases, we identify rearrangements between MEF2D (myocyte enhancer factor 2D) and five genes (BCL …
The transcription factor Mef2d regulates B:T synapse-dependent GC-T(FH) differentiation and IL-21-mediated humoral immunity.
Kim YJ, Oh J, Jung S, Kim CJ, Choi J, Jeon YK, Kim HJ, Kim JW, Suh CH, Lee Y, Im SH, Crotty S, Choi YS. Kim YJ, et al. Sci Immunol. 2023 Mar 31;8(81):eadf2248. doi: 10.1126/sciimmunol.adf2248. Epub 2023 Mar 24. Sci Immunol. 2023. PMID: 36961907 Free PMC article.
Mef2d also impeded IL-21 production by CD4 T cells, an important B cell help signaling molecule, via direct repression of the Il21 gene. ...These findings highlight Mef2d as a pivotal rheostat in CD4 T cells for controlling GC formation and antibody production by B …
Mef2d also impeded IL-21 production by CD4 T cells, an important B cell help signaling molecule, via direct repression of the Il21 ge …
Disruption of SIRT7 Increases the Efficacy of Checkpoint Inhibitor via MEF2D Regulation of Programmed Cell Death 1 Ligand 1 in Hepatocellular Carcinoma Cells.
Xiang J, Zhang N, Sun H, Su L, Zhang C, Xu H, Feng J, Wang M, Chen J, Liu L, Shan J, Shen J, Yang Z, Wang G, Zhou H, Prieto J, Ávila MA, Liu C, Qian C. Xiang J, et al. Gastroenterology. 2020 Feb;158(3):664-678.e24. doi: 10.1053/j.gastro.2019.10.025. Epub 2019 Oct 31. Gastroenterology. 2020. PMID: 31678303
In human and mouse HCC cells, MEF2D knockdown or knockout reduced expression of PD-L1. MEF2D bound the promoter region of the CD274 gene (encodes PD-L1) and activated its transcription. ...Exposure of HCC cells to IFNG induced expression of p300 and its binding M …
In human and mouse HCC cells, MEF2D knockdown or knockout reduced expression of PD-L1. MEF2D bound the promoter region of the …
A Ubiquitin-Dependent Switch on MEF2D Senses Pro-Metastatic Niche Signals to Facilitate Intrahepatic Metastasis of Liver Cancer.
Xiang J, Zhang N, Du A, Li J, Luo M, Wang Y, Liu M, Yang L, Li X, Wang L, Liu Q, Chen D, Wang T, Bian XW, Qin ZY, Su L, Wen L, Wang B. Xiang J, et al. Adv Sci (Weinh). 2023 Dec;10(35):e2305550. doi: 10.1002/advs.202305550. Epub 2023 Oct 12. Adv Sci (Weinh). 2023. PMID: 37828611 Free PMC article.
In turn, an integrin-FAK circuit promotes a phosphorylation-dependent USP14-orchastrated deubiquitination switch to stabilize MEF2D via circumventing degradation by the E3-ubiquitin-ligase MDM2. ...Together, DCCs exploit a deubiquitination-dependent switch on MEF2D …
In turn, an integrin-FAK circuit promotes a phosphorylation-dependent USP14-orchastrated deubiquitination switch to stabilize MEF2D v …
DYRK1A phosphorylates MEF2D and decreases its transcriptional activity.
Wang P, Zhao J, Sun X. Wang P, et al. J Cell Mol Med. 2021 Jul;25(13):6082-6093. doi: 10.1111/jcmm.16505. Epub 2021 Jun 9. J Cell Mol Med. 2021. PMID: 34109727 Free PMC article.
Phosphorylation of MEF2D by DYRK1A significantly increased MEF2D protein level but attenuated its transcriptional activity, which resulted in decreased transcriptions of MEF2D target genes. Phosphorylation mutated Ser251A MEF2D exhibited enhanced trans …
Phosphorylation of MEF2D by DYRK1A significantly increased MEF2D protein level but attenuated its transcriptional activity, wh …
MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis.
Shiozaki Y, Miyazaki-Anzai S, Keenan AL, Miyazaki M. Shiozaki Y, et al. Autophagy. 2022 May;18(5):1049-1061. doi: 10.1080/15548627.2021.1968228. Epub 2021 Sep 14. Autophagy. 2022. PMID: 34517786 Free PMC article.
AAD: amino acid deficiency; APOC3: apolipoprotein C3; BACH1: BTB domain and CNC homolog 1; CEBP: CCAAT enhancer binding protein; DDIT3/CHOP: DNA damage inducible transcript 3; EBSS: Earle's Balanced Salt Solution; EIF2AK4/GCN2: eukaryotic translation initiation factor 2 alpha kin …
AAD: amino acid deficiency; APOC3: apolipoprotein C3; BACH1: BTB domain and CNC homolog 1; CEBP: CCAAT enhancer binding protein; DDIT3/CHOP: …
Molecular markers in ALL: Clinical implications.
Kimura S, Mullighan CG. Kimura S, et al. Best Pract Res Clin Haematol. 2020 Sep;33(3):101193. doi: 10.1016/j.beha.2020.101193. Epub 2020 Jun 7. Best Pract Res Clin Haematol. 2020. PMID: 33038982 Free PMC article. Review.
MEF2D Participates in Microglia-Mediated Neuroprotection in Cerebral Ischemia-Reperfusion Rats.
Shi L, Li B, Chen G, Huang Y, Tian Z, Zhang L, Tian L, Fu Q. Shi L, et al. Shock. 2022 Jan 1;57(1):118-130. doi: 10.1097/SHK.0000000000001844. Shock. 2022. PMID: 34905532
RESULTS: We found that oxygen-glucose deprivation increased MEF2D expression in a time-dependent manner in BV2 cells and primary microglia. ...In the middle cerebral artery occlusion model, microglial activation, the neuroinflammatory response, mitochondrial dysfunction, b …
RESULTS: We found that oxygen-glucose deprivation increased MEF2D expression in a time-dependent manner in BV2 cells and primary micr …
Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis.
Gönczi M, Teixeira JMC, Barrera-Vilarmau S, Mediani L, Antoniani F, Nagy TM, Fehér K, Ráduly Z, Ambrus V, Tőzsér J, Barta E, Kövér KE, Csernoch L, Carra S, Fuxreiter M. Gönczi M, et al. Nat Commun. 2023 Mar 10;14(1):1329. doi: 10.1038/s41467-023-37017-7. Nat Commun. 2023. PMID: 36898987 Free PMC article.
During muscle cell differentiation, the alternatively spliced, acidic beta-domain potentiates transcription of Myocyte-specific Enhancer Factor 2 (Mef2D). Sequence analysis by the FuzDrop method indicates that the beta-domain can serve as an interaction element for Mef2 …
During muscle cell differentiation, the alternatively spliced, acidic beta-domain potentiates transcription of Myocyte-specific Enhancer Fac …
Dexmedetomidine abates myocardial ischemia reperfusion injury through inhibition of pyroptosis via regulation of miR-665/MEF2D/Nrf2 axis.
Wang L, Liu J, Wang Z, Qian X, Zhao Y, Wang Q, Dai N, Xie Y, Zeng W, Yang W, Bai X, Yang Y, Qian J. Wang L, et al. Biomed Pharmacother. 2023 Sep;165:115255. doi: 10.1016/j.biopha.2023.115255. Epub 2023 Aug 5. Biomed Pharmacother. 2023. PMID: 37549462 Free article.
MEF2D was validated to be a target gene of miR-665. Overexpression of miR-665 decreased the expression of MEF2D and blunted the protective effects of Dex in H9c2 cells. Moreover, the functional rescue experiment further verified that Dex regulated MEF2D/Nrf2 …
MEF2D was validated to be a target gene of miR-665. Overexpression of miR-665 decreased the expression of MEF2D and blunted th …
493 results