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Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity.

Gittings LM, Boeynaems S, Lightwood D, Clargo A, Topia S, Nakayama L, Troakes C, Mann DMA, Gitler AD, Lashley T, Isaacs AM.

Acta Neuropathol. 2020 Feb;139(2):407-410. doi: 10.1007/s00401-019-02104-x. Epub 2019 Dec 12. No abstract available.


A Comparative Study of Pathological Outcomes in The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age and Brains for Dementia Research Cohorts.

Robinson AC, Chew-Graham S, Davidson YS, Horan MA, Roncaroli F, Minshull J, du Plessis D, Pal P, Payton A, Pendleton N, Mann DMA.

J Alzheimers Dis. 2020;73(2):619-632. doi: 10.3233/JAD-190580.


Using normalisation process theory to understand workflow implications of decision support implementation across diverse primary care settings.

Mishuris RG, Palmisano J, McCullagh L, Hess R, Feldstein DA, Smith PD, McGinn T, Mann DM.

BMJ Health Care Inform. 2019 Oct;26(1). pii: e100088. doi: 10.1136/bmjhci-2019-100088.


Building digital innovation capacity at a large academic medical center.

Mann DM, Chokshi SK, Lebwohl R, Mainiero M, Dinh-Le C, Driscoll K, Robinson S, Egger H.

NPJ Digit Med. 2019 Mar 7;2:13. doi: 10.1038/s41746-019-0088-y. eCollection 2019.


No association between head injury with loss of consciousness and Alzheimer disease pathology-Findings from the University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age.

Robinson AC, Davidson YS, Horan MA, Cairns M, Pendleton N, Mann DMA.

Int J Geriatr Psychiatry. 2019 Aug;34(8):1262-1266. doi: 10.1002/gps.5129. Epub 2019 May 10.


Dysfunctional endogenous FIX impairs prophylaxis in a mouse hemophilia B model.

Cooley B, Broze GJ Jr, Mann DM, Lin FC, Pedersen LG, Stafford DW.

Blood. 2019 May 30;133(22):2445-2451. doi: 10.1182/blood.2018884015. Epub 2019 Apr 16.


Methamphetamine psychosis: Lack of association with stimulant prescription ADHD medications.

Mann DM, Marco CA, Detherage JP 3rd, Greene PJ, Ross DE.

Am J Emerg Med. 2019 Sep;37(9):1802-1803. doi: 10.1016/j.ajem.2019.03.018. Epub 2019 Mar 12. No abstract available.


Frontotemporal lobar degenerations: from basic science to clinical manifestations.

Revesz T, Mann DM, Lashley T.

Neuropathol Appl Neurobiol. 2019 Feb;45(1):3-5. doi: 10.1111/nan.12537. No abstract available.


Innovating From Within: A Process Model for User-Centered Digital Development in Academic Medical Centers.

Chokshi SK, Mann DM.

JMIR Hum Factors. 2018 Dec 19;5(4):e11048. doi: 10.2196/11048.


Implementation and early adaptation of patient-reported outcome measures into an electronic health record: A technical report.

Gold HT, Karia RJ, Link A, Lebwohl R, Zuckerman JD, Errico TJ, Slover JD, Buckland AJ, Mann DM, Cantor MN.

Health Informatics J. 2018 Dec 5:1460458218813710. doi: 10.1177/1460458218813710. [Epub ahead of print]


Blood-based near-infrared spectroscopy for the rapid low-cost detection of Alzheimer's disease.

Paraskevaidi M, Morais CLM, Freitas DLD, Lima KMG, Mann DMA, Allsop D, Martin-Hirsch PL, Martin FL.

Analyst. 2018 Dec 3;143(24):5959-5964. doi: 10.1039/c8an01205a.


The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome.

Davidson YS, Robinson A, Prasher VP, Mann DMA.

Acta Neuropathol Commun. 2018 Jul 4;6(1):56. doi: 10.1186/s40478-018-0559-4.


Raman Spectroscopy to Diagnose Alzheimer's Disease and Dementia with Lewy Bodies in Blood.

Paraskevaidi M, Morais CLM, Halliwell DE, Mann DMA, Allsop D, Martin-Hirsch PL, Martin FL.

ACS Chem Neurosci. 2018 Nov 21;9(11):2786-2794. doi: 10.1021/acschemneuro.8b00198. Epub 2018 Jun 14.


Pathological Correlates of Cognitive Impairment in The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age.

Robinson AC, Davidson YS, Horan MA, Pendleton N, Mann DMA.

J Alzheimers Dis. 2018;64(2):483-496. doi: 10.3233/JAD-180171.


The role of lysosomes and autophagosomes in frontotemporal lobar degeneration.

Bain HDC, Davidson YS, Robinson AC, Ryan S, Rollinson S, Richardson A, Jones M, Snowden JS, Pickering-Brown S, Mann DMA.

Neuropathol Appl Neurobiol. 2019 Apr;45(3):244-261. doi: 10.1111/nan.12500. Epub 2018 Jun 19.


Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease.

Mann DMA, Davidson YS, Robinson AC, Allen N, Hashimoto T, Richardson A, Jones M, Snowden JS, Pendleton N, Potier MC, Laquerrière A, Prasher V, Iwatsubo T, Strydom A.

Acta Neuropathol. 2018 Oct;136(4):569-587. doi: 10.1007/s00401-018-1866-3. Epub 2018 May 16.


Lysosomes, autophagosomes and Alzheimer pathology in dementia with Lewy body disease.

Gurney R, Davidson YS, Robinson AC, Richardson A, Jones M, Snowden JS, Mann DMA.

Neuropathology. 2018 May 10. doi: 10.1111/neup.12472. [Epub ahead of print]


Scores Obtained from a Simple Cognitive Test of Visuospatial Episodic Memory Performed Decades before Death Are Associated with the Ultimate Presence of Alzheimer Disease Pathology.

Robinson AC, McNamee R, Davidson YS, Horan MA, Snowden JS, McInnes L, Pendleton N, Mann DMA.

Dement Geriatr Cogn Disord. 2018;45(1-2):79-90. doi: 10.1159/000486827. Epub 2018 Apr 25.


Association between semantic dementia and progressive supranuclear palsy.

Snowden JS, Kobylecki C, Jones M, Thompson JC, Richardson AM, Mann DMA.

J Neurol Neurosurg Psychiatry. 2019 Jan;90(1):115-117. doi: 10.1136/jnnp-2017-317839. Epub 2018 Apr 16. No abstract available.


Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study.

Taipa R, Ferreira V, Brochado P, Robinson A, Reis I, Marques F, Mann DM, Melo-Pires M, Sousa N.

Neuropathol Appl Neurobiol. 2018 Apr;44(3):298-313. doi: 10.1111/nan.12445. Epub 2017 Nov 27.


Differential diagnosis of Alzheimer's disease using spectrochemical analysis of blood.

Paraskevaidi M, Morais CLM, Lima KMG, Snowden JS, Saxon JA, Richardson AMT, Jones M, Mann DMA, Allsop D, Martin-Hirsch PL, Martin FL.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7929-E7938. doi: 10.1073/pnas.1701517114. Epub 2017 Sep 5.


Immunohistochemical detection of C9orf72 protein in frontotemporal lobar degeneration and motor neurone disease: patterns of immunostaining and an evaluation of commercial antibodies.

Davidson YS, Robinson AC, Rollinson S, Pickering-Brown S, Xiao S, Robertson J, Mann DMA.

Amyotroph Lateral Scler Frontotemporal Degener. 2018 Feb;19(1-2):102-111. doi: 10.1080/21678421.2017.1359304. Epub 2017 Aug 2.


Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration.

Davidson YS, Robinson AC, Flood L, Rollinson S, Benson BC, Asi YT, Richardson A, Jones M, Snowden JS, Pickering-Brown S, Lashley T, Mann DMA.

Acta Neuropathol Commun. 2017 Jun 30;5(1):54. doi: 10.1186/s40478-017-0454-4.


Examining the language and behavioural profile in FTD and ALS-FTD.

Saxon JA, Thompson JC, Jones M, Harris JM, Richardson AM, Langheinrich T, Neary D, Mann DM, Snowden JS.

J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):675-680. doi: 10.1136/jnnp-2017-315667. Epub 2017 Jun 8.


Semantic dementia, progressive non-fluent aphasia and their association with amyotrophic lateral sclerosis.

Saxon JA, Harris JM, Thompson JC, Jones M, Richardson AMT, Langheinrich T, Neary D, Mann DMA, Snowden JS.

J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):711-712. doi: 10.1136/jnnp-2016-314912. Epub 2017 May 29. No abstract available.


Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation.

Hosokawa M, Kondo H, Serrano GE, Beach TG, Robinson AC, Mann DM, Akiyama H, Hasegawa M, Arai T.

Sci Rep. 2017 May 4;7(1):1513. doi: 10.1038/s41598-017-01587-6.


Patterns of Microglial Cell Activation in Alzheimer Disease and Frontotemporal Lobar Degeneration.

Taipa R, Brochado P, Robinson A, Reis I, Costa P, Mann DM, Melo Pires M, Sousa N.

Neurodegener Dis. 2017;17(4-5):145-154. doi: 10.1159/000457127. Epub 2017 Apr 27.


Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene.

Davidson YS, Flood L, Robinson AC, Nihei Y, Mori K, Rollinson S, Richardson A, Benson BC, Jones M, Snowden JS, Pickering-Brown S, Haass C, Lashley T, Mann DMA.

Acta Neuropathol Commun. 2017 Apr 21;5(1):31. doi: 10.1186/s40478-017-0437-5.


Pilot and Feasibility Test of a Mobile Health-Supported Behavioral Counseling Intervention for Weight Management Among Breast Cancer Survivors.

M Quintiliani L, Mann DM, Puputti M, Quinn E, Bowen DJ.

JMIR Cancer. 2016 May 9;2(1):e4. doi: 10.2196/cancer.5305.


Frontotemporal lobar degeneration: Pathogenesis, pathology and pathways to phenotype.

Mann DMA, Snowden JS.

Brain Pathol. 2017 Nov;27(6):723-736. doi: 10.1111/bpa.12486. Epub 2017 Mar 2. Review.


Presymptomatic anterior frontal involvement in corticobasal degeneration.

Kobylecki C, Mann DM.

Brain. 2016 Dec;139(Pt 12):3059-3062. No abstract available.


Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array.

Barber IS, Braae A, Clement N, Patel T, Guetta-Baranes T, Brookes K, Medway C, Chappell S, Guerreiro R, Bras J, Hernandez D, Singleton A, Hardy J, Mann DM; ARUK Consortium, Morgan K.

Neurobiol Aging. 2017 Jan;49:215.e1-215.e8. doi: 10.1016/j.neurobiolaging.2016.09.008. Epub 2016 Sep 23.


Extended post-mortem delay times should not be viewed as a deterrent to the scientific investigation of human brain tissue: a study from the Brains for Dementia Research Network Neuropathology Study Group, UK.

Robinson AC, Palmer L, Love S, Hamard M, Esiri M, Ansorge O, Lett D, Attems J, Morris C, Troakes C, Selvackadunco S, King A, Al-Sarraj S, Mann DM.

Acta Neuropathol. 2016 Nov;132(5):753-755. Epub 2016 Sep 15. No abstract available.


Magnetite pollution nanoparticles in the human brain.

Maher BA, Ahmed IA, Karloukovski V, MacLaren DA, Foulds PG, Allsop D, Mann DM, Torres-Jardón R, Calderon-Garciduenas L.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10797-801. doi: 10.1073/pnas.1605941113. Epub 2016 Sep 6.


A pilot randomized trial of technology-assisted goal setting to improve physical activity among primary care patients with prediabetes.

Mann DM, Palmisano J, Lin JJ.

Prev Med Rep. 2016 May 21;4:107-12. doi: 10.1016/j.pmedr.2016.05.012. eCollection 2016 Dec.


Role of Coronary Angiography in the Assessment of Cardiovascular Risk in Kidney Transplant Candidates.

Mann DM, Fernandez S, Mondal Z, Laskow D, Osband A, Debroy M, Lebowitz J, Coromilas J, Vagaonescu T, Moreyra A, Melita EA, Mann RA.

Am J Cardiol. 2016 Sep 1;118(5):679-83. doi: 10.1016/j.amjcard.2016.06.017. Epub 2016 Jun 15.


Co-Occurrence of Language and Behavioural Change in Frontotemporal Lobar Degeneration.

Harris JM, Jones M, Gall C, Richardson AM, Neary D, du Plessis D, Pal P, Mann DM, Snowden JS, Thompson JC.

Dement Geriatr Cogn Dis Extra. 2016 Jun 1;6(2):205-13. doi: 10.1159/000444848. eCollection 2016 May-Aug.


Prophylactic efficacy of BeneFIX vs Alprolix in hemophilia B mice.

Cooley B, Funkhouser W, Monroe D, Ezzell A, Mann DM, Lin FC, Monahan PE, Stafford DW.

Blood. 2016 Jul 14;128(2):286-92. doi: 10.1182/blood-2016-01-696104. Epub 2016 Apr 22.


Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy.

Behrouzi R, Liu X, Wu D, Robinson AC, Tanaguchi-Watanabe S, Rollinson S, Shi J, Tian J, Hamdalla HH, Ealing J, Richardson A, Jones M, Pickering-Brown S, Davidson YS, Strong MJ, Hasegawa M, Snowden JS, Mann DM.

Acta Neuropathol Commun. 2016 Mar 31;4:33. doi: 10.1186/s40478-016-0301-z.


Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer's disease.

Barber IS, García-Cárdenas JM, Sakdapanichkul C, Deacon C, Zapata Erazo G, Guerreiro R, Bras J, Hernandez D, Singleton A, Guetta-Baranes T, Braae A, Clement N, Patel T, Brookes K, Medway C, Chappell S, Mann DM; ARUK Consortium, Morgan K.

Neurobiol Aging. 2016 Mar;39:220.e1-7. doi: 10.1016/j.neurobiolaging.2015.12.011. Epub 2015 Dec 29.


Academic Medical Center R&D: A Call for Creating an Operational Research Infrastructure within the Academic Medical Center.

Mann DM, Hess R.

Clin Transl Sci. 2015 Dec;8(6):871-2. doi: 10.1111/cts.12329. Epub 2015 Sep 10. No abstract available.


Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, Murray ME, Nelson PT, Takahashi H, Trojanowski JQ, Ansorge O, Arzberger T, Baborie A, Beach TG, Bieniek KF, Bigio EH, Bodi I, Dugger BN, Feany M, Gelpi E, Gentleman SM, Giaccone G, Hatanpaa KJ, Heale R, Hof PR, Hofer M, Hortobágyi T, Jellinger K, Jicha GA, Ince P, Kofler J, Kövari E, Kril JJ, Mann DM, Matej R, McKee AC, McLean C, Milenkovic I, Montine TJ, Murayama S, Lee EB, Rahimi J, Rodriguez RD, Rozemüller A, Schneider JA, Schultz C, Seeley W, Seilhean D, Smith C, Tagliavini F, Takao M, Thal DR, Toledo JB, Tolnay M, Troncoso JC, Vinters HV, Weis S, Wharton SB, White CL 3rd, Wisniewski T, Woulfe JM, Yamada M, Dickson DW.

Acta Neuropathol. 2016 Jan;131(1):87-102. doi: 10.1007/s00401-015-1509-x. Epub 2015 Dec 10. Review.


Early changes in extracellular matrix in Alzheimer's disease.

Lepelletier FX, Mann DM, Robinson AC, Pinteaux E, Boutin H.

Neuropathol Appl Neurobiol. 2017 Feb;43(2):167-182. doi: 10.1111/nan.12295. Epub 2015 Nov 30.


Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins.

Davidson Y, Robinson AC, Liu X, Wu D, Troakes C, Rollinson S, Masuda-Suzukake M, Suzuki G, Nonaka T, Shi J, Tian J, Hamdalla H, Ealing J, Richardson A, Jones M, Pickering-Brown S, Snowden JS, Hasegawa M, Mann DM.

Neuropathol Appl Neurobiol. 2016 Apr;42(3):242-54. doi: 10.1111/nan.12292. Epub 2015 Dec 7.


Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau.

Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M, Akiyama H, Robinson A, Mann DMA, Iwatsubo T, Hasegawa M.

Acta Neuropathol. 2016 Feb;131(2):267-280. doi: 10.1007/s00401-015-1503-3. Epub 2015 Nov 4.


Risk Factors for the Development of BK Virus Nephropathy in Renal Transplant Recipients.

Pai D, Mann DM, Malik A, Hoover DR, Fyfe B, Mann RA.

Transplant Proc. 2015 Oct;47(8):2465-9. doi: 10.1016/j.transproceed.2015.08.006.


Distinct clinical and pathological phenotypes in frontotemporal dementia associated with MAPT, PGRN and C9orf72 mutations.

Snowden JS, Adams J, Harris J, Thompson JC, Rollinson S, Richardson A, Jones M, Neary D, Mann DM, Pickering-Brown S.

Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(7-8):497-505. doi: 10.3109/21678421.2015.1074700. Epub 2015 Oct 16.


Effect of gamma irradiation on the structural stability and functional activity of plasma-derived IgG.

Smeltzer CC, Lukinova NI, Towcimak ND, Yan X, Mann DM, Drohan WN, Griko YV.

Biologicals. 2015 Jul;43(4):242-9. doi: 10.1016/j.biologicals.2015.04.003. Epub 2015 May 8.


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