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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 3
1991 1
1992 2
1993 2
1994 1
1995 1
1996 2
1997 7
1998 1
1999 7
2000 3
2001 6
2002 5
2003 6
2004 5
2005 4
2006 5
2007 8
2008 8
2009 7
2010 5
2011 9
2012 8
2013 4
2014 8
2015 10
2016 8
2017 10
2018 14
2019 17
2020 14
2021 22
2022 12
2023 23
2024 8

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225 results

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Page 1
Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation.
Calcagni' A, Staiano L, Zampelli N, Minopoli N, Herz NJ, Di Tullio G, Huynh T, Monfregola J, Esposito A, Cirillo C, Bajic A, Zahabiyon M, Curnock R, Polishchuk E, Parkitny L, Medina DL, Pastore N, Cullen PJ, Parenti G, De Matteis MA, Grumati P, Ballabio A. Calcagni' A, et al. Nat Commun. 2023 Jul 3;14(1):3911. doi: 10.1038/s41467-023-39643-7. Nat Commun. 2023. PMID: 37400440 Free PMC article.
Proteomic analysis reveals that CLN3 interacts with several endo-lysosomal trafficking proteins, including the cation-independent mannose 6 phosphate receptor (CI-M6PR), which coordinates the targeting of lysosomal enzymes to lysosomes. CLN3 depletion results in mis-traffi …
Proteomic analysis reveals that CLN3 interacts with several endo-lysosomal trafficking proteins, including the cation-independent mannose 6 …
M6PR- and EphB4-Rich Exosomes Secreted by Serglycin-Overexpressing Esophageal Cancer Cells Promote Cancer Progression.
Yan D, Cui D, Zhu Y, Chan CKW, Choi CHJ, Liu T, Lee NPY, Law S, Tsao SW, Ma S, Cheung ALM. Yan D, et al. Int J Biol Sci. 2023 Jan 1;19(2):625-640. doi: 10.7150/ijbs.79875. eCollection 2023. Int J Biol Sci. 2023. PMID: 36632458 Free PMC article.
Both M6PR and EphB4 expression levels were positively correlated with that of SRGN in the serum of patients with ESCC. High level of serum M6PR was associated with poor overall survival rates. Taken together, this study presents the first proof that exosomal M6PR …
Both M6PR and EphB4 expression levels were positively correlated with that of SRGN in the serum of patients with ESCC. High level of …
Lysosome-targeting chimaeras for degradation of extracellular proteins.
Banik SM, Pedram K, Wisnovsky S, Ahn G, Riley NM, Bertozzi CR. Banik SM, et al. Nature. 2020 Aug;584(7820):291-297. doi: 10.1038/s41586-020-2545-9. Epub 2020 Jul 29. Nature. 2020. PMID: 32728216 Free PMC article.
These initial lysosome-targeting chimaeras, which we term LYTACs, consist of a small molecule or antibody fused to chemically synthesized glycopeptide ligands that are agonists of the cation-independent mannose-6-phosphate receptor (CI-M6PR). We use LYTACs to develop a CRI …
These initial lysosome-targeting chimaeras, which we term LYTACs, consist of a small molecule or antibody fused to chemically synthesized gl …
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation.
Ahn G, Banik SM, Miller CL, Riley NM, Cochran JR, Bertozzi CR. Ahn G, et al. Nat Chem Biol. 2021 Sep;17(9):937-946. doi: 10.1038/s41589-021-00770-1. Epub 2021 Mar 25. Nat Chem Biol. 2021. PMID: 33767387 Free PMC article.
The first lysosome-targeting chimeras (LYTACs) targeted extracellular and membrane proteins for degradation by bridging a target protein to the cation-independent mannose-6-phosphate receptor (CI-M6PR). Here, we developed LYTACs that engage the asialoglycoprotein receptor …
The first lysosome-targeting chimeras (LYTACs) targeted extracellular and membrane proteins for degradation by bridging a target protein to …
Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras.
Ahn G, Riley NM, Kamber RA, Wisnovsky S, Moncayo von Hase S, Bassik MC, Banik SM, Bertozzi CR. Ahn G, et al. Science. 2023 Oct 20;382(6668):eadf6249. doi: 10.1126/science.adf6249. Epub 2023 Oct 20. Science. 2023. PMID: 37856615 Free PMC article.
Lysosome-targeting chimeras (LYTACs) harness receptors, such as the cation-independent mannose 6-phosphate receptor (CI-M6PR), to direct extracellular proteins to lysosomes. In this work, we used a genome-wide CRISPR knockout approach to identify modulators of LYTAC-mediat …
Lysosome-targeting chimeras (LYTACs) harness receptors, such as the cation-independent mannose 6-phosphate receptor (CI-M6PR), to dir …
Topological Requirements for CI-M6PR-Mediated Cell Uptake.
Ali LMA, Simon M, El Cheikh K, Aguesseau-Kondrotas J, Godefroy A, Nguyen C, Garcia M, Morère A, Gary-Bobo M, Maillard L. Ali LMA, et al. Bioconjug Chem. 2019 Oct 16;30(10):2533-2538. doi: 10.1021/acs.bioconjchem.9b00590. Epub 2019 Sep 26. Bioconjug Chem. 2019. PMID: 31538768
M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes.
Hu Y, Jiang L, Wang G, Song Y, Shan Z, Wang X, Deng G, Shi J, Tian G, Zeng X, Liu L, Chen H, Li C. Hu Y, et al. Sci China Life Sci. 2024 Mar;67(3):579-595. doi: 10.1007/s11427-023-2471-4. Epub 2023 Nov 22. Sci China Life Sci. 2024. PMID: 38038885
In this study, we identified cation-dependent mannose-6-phosphate receptor (M6PR) as a crucial host factor for the replication of IAV. We found that siRNA knockdown of M6PR expression significantly reduced the growth titers of different subtypes of IAV, and that the …
In this study, we identified cation-dependent mannose-6-phosphate receptor (M6PR) as a crucial host factor for the replication of IAV …
Gimap5 promoted RSV degradation through interaction with M6PR.
Dai P, Ruan P, Mao Y, Tang Z, Qiu X, Bajinka O, Tan Y. Dai P, et al. J Med Virol. 2023 Jan;95(1):e28390. doi: 10.1002/jmv.28390. J Med Virol. 2023. PMID: 36484389
Computer virtual screening was used to screen small molecule compounds targeting Gimap5 and the anti-RSV effects were explored through in vivo and in vitro experiments. GIMAP5 and M6PR were significantly downregulated after RSV infection. Gimap5 accelerated RSV degradation …
Computer virtual screening was used to screen small molecule compounds targeting Gimap5 and the anti-RSV effects were explored through in vi …
RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.
Rawat S, Chatterjee D, Marwaha R, Charak G, Kumar G, Shaw S, Khatter D, Sharma S, de Heus C, Liv N, Klumperman J, Tuli A, Sharma M. Rawat S, et al. J Cell Biol. 2023 Jan 2;222(1):e202108001. doi: 10.1083/jcb.202108001. Epub 2022 Oct 25. J Cell Biol. 2023. PMID: 36282215 Free PMC article.
Arl8b determines RUFY1 endosomal localization through regulating its interaction with Rab14. RUFY1 depletion led to a delay in CI-M6PR retrieval from endosomes to the TGN, resulting in impaired delivery of newly synthesized hydrolases to lysosomes. ...Our findings suggest …
Arl8b determines RUFY1 endosomal localization through regulating its interaction with Rab14. RUFY1 depletion led to a delay in CI-M6PR …
Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.
Liang XH, Sun H, Hsu CW, Nichols JG, Vickers TA, De Hoyos CL, Crooke ST. Liang XH, et al. Nucleic Acids Res. 2020 Feb 20;48(3):1372-1391. doi: 10.1093/nar/gkz1171. Nucleic Acids Res. 2020. PMID: 31840180 Free PMC article.
Here, we examined the role of Golgi-endosome transport, specifically M6PR shuttling mediated by GCC2, in PS-ASO trafficking and activity. ...GCC2 relocated to LEs upon PS-ASO treatment, and M6PR also co-localized with PS-ASOs in LEs or on LE membranes. These protein …
Here, we examined the role of Golgi-endosome transport, specifically M6PR shuttling mediated by GCC2, in PS-ASO trafficking and activ …
225 results