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Items: 11

1.

Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties.

Weidner C, Wowro SJ, Freiwald A, Kawamoto K, Witzke A, Kliem M, Siems K, Müller-Kuhrt L, Schroeder FC, Sauer S.

Diabetologia. 2013 Aug;56(8):1802-12. doi: 10.1007/s00125-013-2920-2. Epub 2013 May 18.

PMID:
23680913
2.

Amorfrutins are potent antidiabetic dietary natural products.

Weidner C, de Groot JC, Prasad A, Freiwald A, Quedenau C, Kliem M, Witzke A, Kodelja V, Han CT, Giegold S, Baumann M, Klebl B, Siems K, Müller-Kuhrt L, Schürmann A, Schüler R, Pfeiffer AF, Schroeder FC, Büssow K, Sauer S.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7257-62. doi: 10.1073/pnas.1116971109. Epub 2012 Apr 16.

3.

The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans.

Zarse K, Bossecker A, Müller-Kuhrt L, Siems K, Hernandez MA, Berendsohn WG, Birringer M, Ristow M.

Horm Metab Res. 2011 Apr;43(4):241-3. doi: 10.1055/s-0030-1270524. Epub 2011 Jan 24.

PMID:
21264793
4.

Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators.

Steri R, Rupp M, Proschak E, Schroeter T, Zettl H, Hansen K, Schwarz O, Müller-Kuhrt L, Müller KR, Schneider G, Schubert-Zsilavecz M.

Bioorg Med Chem Lett. 2010 May 1;20(9):2920-3. doi: 10.1016/j.bmcl.2010.03.026. Epub 2010 Mar 7.

PMID:
20347594
5.

From machine learning to natural product derivatives that selectively activate transcription factor PPARgamma.

Rupp M, Schroeter T, Steri R, Zettl H, Proschak E, Hansen K, Rau O, Schwarz O, Müller-Kuhrt L, Schubert-Zsilavecz M, Müller KR, Schneider G.

ChemMedChem. 2010 Feb 1;5(2):191-4. doi: 10.1002/cmdc.200900469. No abstract available.

PMID:
20043315
6.

Revisiting old drugs as novel agents for retinoblastoma: in vitro and in vivo antitumor activity of cardenolides.

Antczak C, Kloepping C, Radu C, Genski T, Müller-Kuhrt L, Siems K, de Stanchina E, Abramson DH, Djaballah H.

Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3065-73. doi: 10.1167/iovs.08-3158. Epub 2009 Jan 17.

7.

Structure-based pharmacophore screening for natural-product-derived PPARgamma agonists.

Tanrikulu Y, Rau O, Schwarz O, Proschak E, Siems K, Müller-Kuhrt L, Schubert-Zsilavecz M, Schneider G.

Chembiochem. 2009 Jan 5;10(1):75-8. doi: 10.1002/cbic.200800520. No abstract available.

PMID:
19067454
8.

A cell-based high-throughput assay system reveals modulation of oxidative and nonoxidative glucose metabolism due to commonly used organic solvents.

Zimmermann S, Zarse K, Schulz TJ, Siems K, Müller-Kuhrt L, Birringer M, Ristow M.

Horm Metab Res. 2008 Jan;40(1):29-37. doi: 10.1055/s-2007-1004542.

PMID:
18197582
9.

Natural products in parallel chemistry--novel 5-lipoxygenase inhibitors from BIOS-based libraries starting from alpha-santonin.

Schwarz O, Jakupovic S, Ambrosi HD, Haustedt LO, Mang C, Müller-Kuhrt L.

J Comb Chem. 2007 Nov-Dec;9(6):1104-13. Epub 2007 Sep 13.

PMID:
17850107
10.

Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening.

Franke L, Schwarz O, Müller-Kuhrt L, Hoernig C, Fischer L, George S, Tanrikulu Y, Schneider P, Werz O, Steinhilber D, Schneider G.

J Med Chem. 2007 May 31;50(11):2640-6. Epub 2007 Apr 27.

PMID:
17461565
11.

Putting nature back into drug discovery.

Müller-Kuhrt L.

Nat Biotechnol. 2003 Jun;21(6):602. No abstract available.

PMID:
12776140

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