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Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome.

Herber J, Njavro J, Feederle R, Schepers U, Müller UC, Bräse S, Müller SA, Lichtenthaler SF.

Mol Cell Proteomics. 2018 Aug;17(8):1487-1501. doi: 10.1074/mcp.RA118.000608. Epub 2018 May 1.


Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.

Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Salzburger LR, Klein S, Han K, Weyer SW, Fritz AK, Laube B, Wolfer DP, Buchholz CJ, Korte M, Müller UC.

EMBO J. 2018 Jun 1;37(11). pii: e98335. doi: 10.15252/embj.201798335. Epub 2018 Apr 16.


Editorial: The Physiological Functions of the APP Gene Family.

Müller UC, Deller T.

Front Mol Neurosci. 2017 Oct 23;10:334. doi: 10.3389/fnmol.2017.00334. eCollection 2017. No abstract available.


Amyloid-precursor Like Proteins APLP1 and APLP2 Are Dispensable for Normal Development of the Neonatal Respiratory Network.

Han K, Müller UC, Hülsmann S.

Front Mol Neurosci. 2017 Jun 22;10:189. doi: 10.3389/fnmol.2017.00189. eCollection 2017.


APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.

Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S, Eggert S.

J Neurosci. 2017 May 24;37(21):5345-5365. doi: 10.1523/JNEUROSCI.1875-16.2017. Epub 2017 Apr 27.


Not just amyloid: physiological functions of the amyloid precursor protein family.

Müller UC, Deller T, Korte M.

Nat Rev Neurosci. 2017 May;18(5):281-298. doi: 10.1038/nrn.2017.29. Epub 2017 Mar 31. Review.


Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα.

Mockett BG, Richter M, Abraham WC, Müller UC.

Front Mol Neurosci. 2017 Feb 7;10:30. doi: 10.3389/fnmol.2017.00030. eCollection 2017. Review.


APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones.

Laßek M, Weingarten J, Wegner M, Neupärtl M, Array TN, Harde E, Beckert B, Golghalyani V, Ackermann J, Koch I, Müller UC, Karas M, Acker-Palmer A, Volknandt W.

Front Synaptic Neurosci. 2017 Jan 20;9:1. doi: 10.3389/fnsyn.2017.00001. eCollection 2017.


Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus.

Del Turco D, Paul MH, Schlaudraff J, Hick M, Endres K, Müller UC, Deller T.

Front Mol Neurosci. 2016 Nov 29;9:134. eCollection 2016.


Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis.

Zou C, Crux S, Marinesco S, Montagna E, Sgobio C, Shi Y, Shi S, Zhu K, Dorostkar MM, Müller UC, Herms J.

EMBO J. 2016 Oct 17;35(20):2213-2222. Epub 2016 Aug 29.


Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP.

Kundu A, Milosch N, Antonietti P, Baumkötter F, Zymny A, Müller UC, Kins S, Hajieva P, Behl C, Kögel D.

Mol Neurobiol. 2016 Nov;53(9):5985-5994. doi: 10.1007/s12035-015-9501-y. Epub 2015 Nov 2.


Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels.

Hefter D, Kaiser M, Weyer SW, Papageorgiou IE, Both M, Kann O, Müller UC, Draguhn A.

J Neurosci. 2016 Aug 10;36(32):8356-71. doi: 10.1523/JNEUROSCI.4130-15.2016.


Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.

Strilic B, Yang L, Albarrán-Juárez J, Wachsmuth L, Han K, Müller UC, Pasparakis M, Offermanns S.

Nature. 2016 Aug 11;536(7615):215-8. Epub 2016 Aug 3.


Impaired theta-gamma coupling in APP-deficient mice.

Zhang X, Zhong W, Brankačk J, Weyer SW, Müller UC, Tort AB, Draguhn A.

Sci Rep. 2016 Feb 24;6:21948. doi: 10.1038/srep21948.


The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior.

Klevanski M, Herrmann U, Weyer SW, Fol R, Cartier N, Wolfer DP, Caldwell JH, Korte M, Müller UC.

J Neurosci. 2015 Dec 9;35(49):16018-33. doi: 10.1523/JNEUROSCI.2009-15.2015.


Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model.

Fol R, Braudeau J, Ludewig S, Abel T, Weyer SW, Roederer JP, Brod F, Audrain M, Bemelmans AP, Buchholz CJ, Korte M, Cartier N, Müller UC.

Acta Neuropathol. 2016 Feb;131(2):247-266. doi: 10.1007/s00401-015-1498-9. Epub 2015 Nov 4.


Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.

Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Müller UC, Di Luca M, De Strooper B, Bagni C.

Neuron. 2015 Jul 15;87(2):382-98. doi: 10.1016/j.neuron.2015.06.032. Erratum in: Neuron. 2015 Aug 19;87(4):908.


Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.

Vnencak M, Paul MH, Hick M, Schwarzacher SW, Del Turco D, Müller UC, Deller T, Jedlicka P.

J Comp Neurol. 2015 Aug 1;523(11):1717-29. doi: 10.1002/cne.23766. Epub 2015 Apr 7.


Erratum to: Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity.

Hick M, Herrmann U, Weyer SW, Mallm JP, Tschäpe JA, Borgers M, Mercken M, Roth FC, Draguhn A, Slomianka L, Wolfer DP, Korte M, Müller UC.

Acta Neuropathol. 2015 Jan;129(1):161-2. doi: 10.1007/s00401-014-1374-z. No abstract available.


Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity.

Hick M, Herrmann U, Weyer SW, Mallm JP, Tschäpe JA, Borgers M, Mercken M, Roth FC, Draguhn A, Slomianka L, Wolfer DP, Korte M, Müller UC.

Acta Neuropathol. 2015 Jan;129(1):21-37. doi: 10.1007/s00401-014-1368-x. Epub 2014 Nov 29. Erratum in: Acta Neuropathol. 2015 Jan;129(1):161-2.


Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway.

Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW, Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D.

Cell Death Dis. 2014 Aug 28;5:e1391. doi: 10.1038/cddis.2014.352.


Differential role of APP and APLPs for neuromuscular synaptic morphology and function.

Klevanski M, Saar M, Baumkötter F, Weyer SW, Kins S, Müller UC.

Mol Cell Neurosci. 2014 Jul;61:201-10. doi: 10.1016/j.mcn.2014.06.004. Epub 2014 Jul 4.


Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression.

Weyer SW, Zagrebelsky M, Herrmann U, Hick M, Ganss L, Gobbert J, Gruber M, Altmann C, Korte M, Deller T, Müller UC.

Acta Neuropathol Commun. 2014 Mar 31;2:36. doi: 10.1186/2051-5960-2-36.


Genetics of preparation and response control in ADHD: the role of DRD4 and DAT1.

Albrecht B, Brandeis D, Uebel-von Sandersleben H, Valko L, Heinrich H, Xu X, Drechsler R, Heise A, Kuntsi J, Müller UC, Asherson P, Steinhausen HC, Rothenberger A, Banaschewski T.

J Child Psychol Psychiatry. 2014 Aug;55(8):914-23. doi: 10.1111/jcpp.12212. Epub 2014 Feb 13.


Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP.

Robinson A, Grösgen S, Mett J, Zimmer VC, Haupenthal VJ, Hundsdörfer B, Stahlmann CP, Slobodskoy Y, Müller UC, Hartmann T, Stein R, Grimm MO.

Aging Cell. 2014 Apr;13(2):263-72. doi: 10.1111/acel.12183. Epub 2013 Dec 17.


Specific gene delivery to liver sinusoidal and artery endothelial cells.

Abel T, El Filali E, Waern J, Schneider IC, Yuan Q, Münch RC, Hick M, Warnecke G, Madrahimov N, Kontermann RE, Schüttrumpf J, Müller UC, Seppen J, Ott M, Buchholz CJ.

Blood. 2013 Sep 19;122(12):2030-8. doi: 10.1182/blood-2012-11-468579. Epub 2013 Jul 24.


Hippocampal network oscillations in APP/APLP2-deficient mice.

Zhang X, Herrmann U, Weyer SW, Both M, Müller UC, Korte M, Draguhn A.

PLoS One. 2013 Apr 9;8(4):e61198. doi: 10.1371/journal.pone.0061198. Print 2013.


Roles of the amyloid precursor protein family in the peripheral nervous system.

Caldwell JH, Klevanski M, Saar M, Müller UC.

Mech Dev. 2013 Jun-Aug;130(6-8):433-46. doi: 10.1016/j.mod.2012.11.001. Epub 2012 Nov 29. Review.


Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder.

Albrecht B, Brandeis D, Uebel H, Valko L, Heinrich H, Drechsler R, Heise A, Müller UC, Steinhausen HC, Rothenberger A, Banaschewski T.

Psychol Med. 2013 Sep;43(9):1997-2011. doi: 10.1017/S003329171200270X. Epub 2012 Dec 3.


Diagnostic value of resting electroencephalogram in attention-deficit/hyperactivity disorder across the lifespan.

Liechti MD, Valko L, Müller UC, Döhnert M, Drechsler R, Steinhausen HC, Brandeis D.

Brain Topogr. 2013 Jan;26(1):135-51. doi: 10.1007/s10548-012-0258-6. Epub 2012 Oct 9.


Volcanic ash layers illuminate the resilience of Neanderthals and early modern humans to natural hazards.

Lowe J, Barton N, Blockley S, Ramsey CB, Cullen VL, Davies W, Gamble C, Grant K, Hardiman M, Housley R, Lane CS, Lee S, Lewis M, MacLeod A, Menzies M, Müller W, Pollard M, Price C, Roberts AP, Rohling EJ, Satow C, Smith VC, Stringer CB, Tomlinson EL, White D, Albert P, Arienzo I, Barker G, Boric D, Carandente A, Civetta L, Ferrier C, Guadelli JL, Karkanas P, Koumouzelis M, Müller UC, Orsi G, Pross J, Rosi M, Shalamanov-Korobar L, Sirakov N, Tzedakis PC.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13532-7. doi: 10.1073/pnas.1204579109. Epub 2012 Jul 23.


Psychopathology and personality in parents of children with ADHD.

Steinhausen HC, Göllner J, Brandeis D, Müller UC, Valko L, Drechsler R.

J Atten Disord. 2013 Jan;17(1):38-46. doi: 10.1177/1087054711427562. Epub 2012 Mar 5.


Physiological functions of APP family proteins.

Müller UC, Zheng H.

Cold Spring Harb Perspect Med. 2012 Feb;2(2):a006288. doi: 10.1101/cshperspect.a006288. Review.


The physiological functions of the β-amyloid precursor protein APP.

Müller UC, Pietrzik CU, Deller T.

Exp Brain Res. 2012 Apr;217(3-4):325-9. doi: 10.1007/s00221-012-3039-2. No abstract available.


The behavioural profile of children with attention-deficit/ hyperactivity disorder and of their siblings.

Steinhausen HC, Zülli-Weilenmann N, Brandeis D, Müller UC, Valko L, Drechsler R.

Eur Child Adolesc Psychiatry. 2012 Mar;21(3):157-64. doi: 10.1007/s00787-012-0249-x. Epub 2012 Feb 2.


Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo.

Jedlicka P, Owen M, Vnencak M, Tschäpe JA, Hick M, Müller UC, Deller T.

Exp Brain Res. 2012 Apr;217(3-4):441-7. doi: 10.1007/s00221-011-2911-9. Epub 2011 Nov 11.


Functions of the APP gene family in the nervous system: insights from mouse models.

Aydin D, Weyer SW, Müller UC.

Exp Brain Res. 2012 Apr;217(3-4):423-34. doi: 10.1007/s00221-011-2861-2. Epub 2011 Sep 20. Review.


APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.

Weyer SW, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov M, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jäschke A, Korte M, Wolfer DP, Caldwell JH, Müller UC.

EMBO J. 2011 Jun 1;30(11):2266-80. doi: 10.1038/emboj.2011.119. Epub 2011 Apr 26. Erratum in: EMBO J. 2011 Jun 1;30(11):2306.


The impact of study design and diagnostic approach in a large multi-centre ADHD study: Part 2: Dimensional measures of psychopathology and intelligence.

Müller UC, Asherson P, Banaschewski T, Buitelaar JK, Ebstein RP, Eisenberg J, Gill M, Manor I, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant JA, Sonuga-Barke EJ, Thompson M, Faraone SV, Steinhausen HC.

BMC Psychiatry. 2011 Apr 7;11:55. doi: 10.1186/1471-244X-11-55.


The impact of study design and diagnostic approach in a large multi-centre ADHD study. Part 1: ADHD symptom patterns.

Müller UC, Asherson P, Banaschewski T, Buitelaar JK, Ebstein RP, Eisenberg J, Gill M, Manor I, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant JA, Sonuga-Barke EJ, Thompson M, Faraone SV, Steinhausen HC.

BMC Psychiatry. 2011 Apr 7;11:54. doi: 10.1186/1471-244X-11-54.


Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex.

Aydin D, Filippov MA, Tschäpe JA, Gretz N, Prinz M, Eils R, Brors B, Müller UC.

BMC Genomics. 2011 Mar 24;12:160. doi: 10.1186/1471-2164-12-160.


Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors.

Anliker B, Abel T, Kneissl S, Hlavaty J, Caputi A, Brynza J, Schneider IC, Münch RC, Petznek H, Kontermann RE, Koehl U, Johnston IC, Keinänen K, Müller UC, Hohenadl C, Monyer H, Cichutek K, Buchholz CJ.

Nat Methods. 2010 Nov;7(11):929-35. doi: 10.1038/nmeth.1514. Epub 2010 Oct 10.


sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress.

Copanaki E, Chang S, Vlachos A, Tschäpe JA, Müller UC, Kögel D, Deller T.

Mol Cell Neurosci. 2010 Aug;44(4):386-93. doi: 10.1016/j.mcn.2010.04.007. Epub 2010 May 21.


Predictability of oppositional defiant disorder and symptom dimensions in children and adolescents with ADHD combined type.

Aebi M, Müller UC, Asherson P, Banaschewski T, Buitelaar J, Ebstein R, Eisenberg J, Gill M, Manor I, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Thompson M, Taylor E, Faraone SV, Steinhausen HC.

Psychol Med. 2010 Dec;40(12):2089-100. doi: 10.1017/S0033291710000590. Epub 2010 Apr 12.


Generation of conditional null alleles for APP and APLP2.

Mallm JP, Tschäpe JA, Hick M, Filippov MA, Müller UC.

Genesis. 2010 Mar;48(3):200-6. doi: 10.1002/dvg.20601.


Plasticity of synaptic inhibition in mouse spinal cord lamina II neurons during early postnatal development and after inactivation of the glycine receptor alpha3 subunit gene.

Rajalu M, Müller UC, Caley A, Harvey RJ, Poisbeau P.

Eur J Neurosci. 2009 Dec;30(12):2284-92. doi: 10.1111/j.1460-9568.2009.07018.x. Epub 2009 Dec 10.


A Selective Role for alpha3 Subunit Glycine Receptors in Inflammatory Pain.

Harvey VL, Caley A, Müller UC, Harvey RJ, Dickenson AH.

Front Mol Neurosci. 2009 Nov 4;2:14. doi: 10.3389/neuro.02.014.2009. eCollection 2009.


Vaccination with Abeta-displaying virus-like particles reduces soluble and insoluble cerebral Abeta and lowers plaque burden in APP transgenic mice.

Bach P, Tschäpe JA, Kopietz F, Braun G, Baade JK, Wiederhold KH, Staufenbiel M, Prinz M, Deller T, Kalinke U, Buchholz CJ, Müller UC.

J Immunol. 2009 Jun 15;182(12):7613-24. doi: 10.4049/jimmunol.0803366.


Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice.

Frank S, Copanaki E, Burbach GJ, Müller UC, Deller T.

Neurosci Lett. 2009 Mar 27;453(1):41-4. doi: 10.1016/j.neulet.2009.01.075. Epub 2009 Feb 4.


No association between two polymorphisms of the serotonin transporter gene and combined type attention deficit hyperactivity disorder.

Xu X, Duman EA, Anney R, Brookes K, Franke B, Zhou K, Buschgens C, Chen W, Christiansen H, Eisenberg J, Gabriëls I, Manor I, Marco R, Müller UC, Mulligan A, Rommelse N, Thompson M, Uebel H, Banaschewski T, Buitelaar J, Ebstein R, Gill M, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen HC, Taylor E, Faraone SV, Asherson P.

Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1306-9. doi: 10.1002/ajmg.b.30737. Erratum in: Am J Med Genet B Neuropsychiatr Genet. 2009 Mar 5;150B(2):307. Duman, Elif Aysimi [corrected to Duman, EA]. Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):154.. Aysimi, E [corrected to Duman, Elif Aysimi].


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