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Magnetically guided virus stamping for the targeted infection of single cells or groups of cells.

Schubert R, Herzog S, Trenholm S, Roska B, Müller DJ.

Nat Protoc. 2019 Nov;14(11):3205-3219. doi: 10.1038/s41596-019-0221-z. Epub 2019 Oct 18.


Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants.

Ju C, Fiori LM, Belzeaux R, Theroux JF, Chen GG, Aouabed Z, Blier P, Farzan F, Frey BN, Giacobbe P, Lam RW, Leri F, MacQueen GM, Milev R, Müller DJ, Parikh SV, Rotzinger S, Soares CN, Uher R, Li Q, Foster JA, Kennedy SH, Turecki G.

Transl Psychiatry. 2019 Oct 8;9(1):254. doi: 10.1038/s41398-019-0589-0.


Childhood maltreatment and cognitive functioning in patients with major depressive disorder: a CAN-BIND-1 report.

Chakrabarty T, Harkness KL, McInerney SJ, Quilty LC, Milev RV, Kennedy SH, Frey BN, MacQueen GM, Müller DJ, Rotzinger S, Uher R, Lam RW.

Psychol Med. 2019 Oct 4:1-12. doi: 10.1017/S003329171900268X. [Epub ahead of print]


Towards precision medicine in generalized anxiety disorder: Review of genetics and pharmaco(epi)genetics.

Tomasi J, Lisoway AJ, Zai CC, Harripaul R, Müller DJ, Zai GCM, McCabe RE, Richter MA, Kennedy JL, Tiwari AK.

J Psychiatr Res. 2019 Dec;119:33-47. doi: 10.1016/j.jpsychires.2019.09.002. Epub 2019 Sep 6. Review.


From the Origins of Pharmacogenetics to First Applications in Psychiatry.

Müller DJ, Rizhanovsky Z.

Pharmacopsychiatry. 2019 Sep 23. doi: 10.1055/a-0979-2322. [Epub ahead of print]


Genome-wide association study on antipsychotic-induced weight gain in Europeans and African-Americans.

Maciukiewicz M, Tiwari AK, Zai CC, Gorbovskaya I, Laughlin CP, Nurmi EL, Liebermann JA, Meltzer HY, Kennedy JL, Müller DJ.

Schizophr Res. 2019 Oct;212:204-212. doi: 10.1016/j.schres.2019.07.022. Epub 2019 Aug 22.


Conformational Plasticity of Human Protease-Activated Receptor 1 upon Antagonist- and Agonist-Binding.

Spoerri PM, Sapra KT, Zhang C, Mari SA, Kato HE, Kobilka BK, Müller DJ.

Structure. 2019 Oct 1;27(10):1517-1526.e3. doi: 10.1016/j.str.2019.07.014. Epub 2019 Aug 15.


Reduced accuracy accompanied by reduced neural activity during the performance of an emotional conflict task by unmedicated patients with major depression: A CAN-BIND fMRI study.

Alders GL, Davis AD, MacQueen G, Strother SC, Hassel S, Zamyadi M, Sharma GB, Arnott SR, Downar J, Harris JK, Lam RW, Milev R, Müller DJ, Ravindran A, Kennedy SH, Frey BN, Minuzzi L, Hall GB; CAN-BIND Investigator Team.

J Affect Disord. 2019 Oct 1;257:765-773. doi: 10.1016/j.jad.2019.07.037. Epub 2019 Jul 6.


High-Resolution Imaging of Maltoporin LamB while Quantifying the Free-Energy Landscape and Asymmetry of Sugar Binding.

Mulvihill E, Pfreundschuh M, Thoma J, Ritzmann N, Müller DJ.

Nano Lett. 2019 Sep 11;19(9):6442-6453. doi: 10.1021/acs.nanolett.9b02674. Epub 2019 Aug 12.


Publisher Correction: Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding.

Stewart MP, Helenius J, Toyoda Y, Ramanathan SP, Muller DJ, Hyman AA.

Nature. 2019 Jul;571(7764):E5. doi: 10.1038/s41586-019-1327-8.


Membrane perforation by the pore-forming toxin pneumolysin.

Vögele M, Bhaskara RM, Mulvihill E, van Pee K, Yildiz Ö, Kühlbrandt W, Müller DJ, Hummer G.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13352-13357. doi: 10.1073/pnas.1904304116. Epub 2019 Jun 17.


New insights into tardive dyskinesia genetics: Implementation of whole-exome sequencing approach.

Alkelai A, Greenbaum L, Heinzen EL, Baugh EH, Teitelbaum A, Zhu X, Strous RD, Tatarskyy P, Zai CC, Tiwari AK, Tampakeras M, Freeman N, Müller DJ, Voineskos AN, Lieberman JA, Delaney SL, Meltzer HY, Remington G, Kennedy JL, Pulver AE, Peabody EP, Levy DL, Lerer B.

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 30;94:109659. doi: 10.1016/j.pnpbp.2019.109659. Epub 2019 May 30.


Predicting Worsening Suicidal Ideation With Clinical Features and Peripheral Expression of Messenger RNA and MicroRNA During Antidepressant Treatment.

Belzeaux R, Fiori LM, Lopez JP, Boucekine M, Boyer L, Blier P, Farzan F, Frey BN, Giacobbe P, Lam RW, Leri F, MacQueen GM, Milev R, Müller DJ, Parikh SV, Rotzinger S, Soares CN, Uher R, Foster JA, Kennedy SH, Turecki G.

J Clin Psychiatry. 2019 May 7;80(3). pii: 18m12556. doi: 10.4088/JCP.18m12556.


The coming-of-age of pharmacogenetic testing in clinical psychiatry.

Yoshida K, Müller DJ, Kennedy JL.

Psychiatry Clin Neurosci. 2019 May;73(5):203. doi: 10.1111/pcn.12832. No abstract available.


Getting to precision psychopharmacology: Combining clinical and genetic information to predict fat gain from aripiprazole.

Oughli H, Lenze EJ, Locke AE, Yingling MD, Zhong Y, Miller JP, Reynolds CF 3rd, Mulsant BH, Newcomer JW, Peterson TR, Müller DJ, Nicol GE.

J Psychiatr Res. 2019 Jul;114:67-74. doi: 10.1016/j.jpsychires.2019.04.017. Epub 2019 Apr 23.


Navigating the Labyrinth of Pharmacogenetic Testing: A Guide to Test Selection.

Bousman CA, Zierhut H, Müller DJ.

Clin Pharmacol Ther. 2019 Aug;106(2):309-312. doi: 10.1002/cpt.1432. Epub 2019 Apr 20. No abstract available.


Investigation of the Gut Microbiome in Patients with Schizophrenia and Clozapine-Induced Weight Gain: Protocol and Clinical Characteristics of First Patient Cohorts.

Gorbovskaya I, Kanji S, Liu JCW, MacKenzie NE, Agarwal SM, Marshe VS, Sriretnakumar V, Verdu EF, Bercik P, De Palma G, Hahn MK, Müller DJ.

Neuropsychobiology. 2019 Mar 29:1-8. doi: 10.1159/000494696. [Epub ahead of print]


Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report.

Kennedy SH, Lam RW, Rotzinger S, Milev RV, Blier P, Downar J, Evans KR, Farzan F, Foster JA, Frey BN, Giacobbe P, Hall GB, Harkness KL, Hassel S, Ismail Z, Leri F, McInerney S, MacQueen GM, Minuzzi L, Müller DJ, Parikh SV, Placenza FM, Quilty LC, Ravindran AV, Sassi RB, Soares CN, Strother SC, Turecki G, Vaccarino AL, Vila-Rodriguez F, Yu J, Uher R; CAN-BIND Investigator Team.

J Clin Psychiatry. 2019 Feb 5;80(2). pii: 18m12202. doi: 10.4088/JCP.18m12202.


The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols

MacQueen GM, Hassel S, Arnott SR, Jean A, Bowie CR, Bray SL, Davis AD, Downar J, Foster JA, Frey BN, Goldstein BI, Hall GB, Harkness KL, Harris J, Lam RW, Lebel C, Milev R, Müller DJ, Parikh SV, Rizvi S, Rotzinger S, Sharma GB, Soares CN, Turecki G, Vila-Rodriguez F, Yu J, Zamyadi M, Strother SC, Kennedy SH; CAN-BIND Investigator Team.

J Psychiatry Neurosci. 2019 Jul 1;44(4):223-236.


Insertion and folding pathways of single membrane proteins guided by translocases and insertases.

Serdiuk T, Steudle A, Mari SA, Manioglu S, Kaback HR, Kuhn A, Müller DJ.

Sci Adv. 2019 Jan 30;5(1):eaau6824. doi: 10.1126/sciadv.aau6824. eCollection 2019 Jan.


Spatiotemporally Controlled Myosin Relocalization and Internal Pressure Generate Sibling Cell Size Asymmetry.

Pham TT, Monnard A, Helenius J, Lund E, Lee N, Müller DJ, Cabernard C.

iScience. 2019 Mar 29;13:9-19. doi: 10.1016/j.isci.2019.02.002. Epub 2019 Feb 6.


Design and assembly of a chemically switchable and fluorescently traceable light-driven proton pump system for bionanotechnological applications.

Hirschi S, Fischer N, Kalbermatter D, Laskowski PR, Ucurum Z, Müller DJ, Fotiadis D.

Sci Rep. 2019 Jan 31;9(1):1046. doi: 10.1038/s41598-018-37260-9.


Towards pharmacogenetic-based treatment in psychiatry.

Bousman CA, Menke A, Müller DJ.

J Neural Transm (Vienna). 2019 Jan;126(1):1-3. doi: 10.1007/s00702-018-01968-9. No abstract available.


Loss of NFAT2 expression results in the acceleration of clonal evolution in chronic lymphocytic leukemia.

Müller DJ, Wirths S, Fuchs AR, Märklin M, Heitmann JS, Sturm M, Haap M, Kirschniak A, Sasaki Y, Kanz L, Kopp HG, Müller MR.

J Leukoc Biol. 2019 Mar;105(3):531-538. doi: 10.1002/JLB.2AB0218-076RR. Epub 2018 Dec 17.


Pharmacogenetic guidelines and decision support tools for depression treatment: application to late-life.

Chang DD, Eyreeuro HA, Abbott R, Coudreaut M, Baune BT, Shaman JA, Lavretsky H, Lenze EJ, Merrill DA, Singh AB, Mulsant BH, Reynolds CF 3rd, Müller DJ, Bousman C.

Pharmacogenomics. 2018 Nov;19(16):1269-1284. doi: 10.2217/pgs-2018-0099. Review.


Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility.

Beerli C, Yakimovich A, Kilcher S, Reynoso GV, Fläschner G, Müller DJ, Hickman HD, Mercer J.

Nat Microbiol. 2019 Feb;4(2):216-225. doi: 10.1038/s41564-018-0288-2. Epub 2018 Nov 12.


Seeing and sensing single G protein-coupled receptors by atomic force microscopy.

Sapra KT, Spoerri PM, Engel A, Alsteens D, Müller DJ.

Curr Opin Cell Biol. 2019 Apr;57:25-32. doi: 10.1016/ Epub 2018 Nov 6. Review.


Clinical implications of APOE genotyping for late-onset Alzheimer's disease (LOAD) risk estimation: a review of the literature.

Marshe VS, Gorbovskaya I, Kanji S, Kish M, Müller DJ.

J Neural Transm (Vienna). 2019 Jan;126(1):65-85. doi: 10.1007/s00702-018-1934-9. Epub 2018 Oct 31. Review.


Towards the integration of pharmacogenetics in psychiatry: a minimum, evidence-based genetic testing panel.

Bousman C, Maruf AA, Müller DJ.

Curr Opin Psychiatry. 2019 Jan;32(1):7-15. doi: 10.1097/YCO.0000000000000465.


Investigation of the HSPG2 Gene in Tardive Dyskinesia - New Data and Meta-Analysis.

Zai CC, Lee FH, Tiwari AK, Lu JY, de Luca V, Maes MS, Herbert D, Shahmirian A, Cheema SY, Zai GC, Atukuri A, Sherman M, Shaikh SA, Tampakeras M, Freeman N, King N, Müller DJ, Greenbaum L, Lerer B, Voineskos AN, Potkin SG, Lieberman JA, Meltzer HY, Remington G, Kennedy JL.

Front Pharmacol. 2018 Sep 18;9:974. doi: 10.3389/fphar.2018.00974. eCollection 2018.


Protein-enriched outer membrane vesicles as a native platform for outer membrane protein studies.

Thoma J, Manioglu S, Kalbermatter D, Bosshart PD, Fotiadis D, Müller DJ.

Commun Biol. 2018 Apr 5;1:23. doi: 10.1038/s42003-018-0027-5. eCollection 2018.


Genetic validation study of protein tyrosine phosphatase receptor type D (PTPRD) gene variants and risk for antipsychotic-induced weight gain.

Maciukiewicz M, Gorbovskaya I, Tiwari AK, Zai CC, Freeman N, Meltzer HY, Kennedy JL, Müller DJ.

J Neural Transm (Vienna). 2019 Jan;126(1):27-33. doi: 10.1007/s00702-018-1921-1. Epub 2018 Sep 18.


Early change in reward and punishment sensitivity as a predictor of response to antidepressant treatment for major depressive disorder: a CAN-BIND-1 report.

Allen TA, Lam RW, Milev R, Rizvi SJ, Frey BN, MacQueen GM, Müller DJ, Uher R, Kennedy SH, Quilty LC.

Psychol Med. 2019 Jul;49(10):1629-1638. doi: 10.1017/S0033291718002441. Epub 2018 Sep 17.


Pharmacogenetics in Psychiatry: A Companion, Rather Than Competitor, to Protocol-Based Care.

Bousman CA, Müller DJ.

JAMA Psychiatry. 2018 Oct 1;75(10):1090. doi: 10.1001/jamapsychiatry.2018.2344. No abstract available.


PharmGKB summary: clozapine pathway, pharmacokinetics.

Thorn CF, Müller DJ, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 Sep;28(9):214-222. doi: 10.1097/FPC.0000000000000347. No abstract available.


Association study of Disrupted-In-Schizophrenia-1 gene variants and tardive dyskinesia.

Lu JY, Tiwari AK, Zai GC, Rastogi A, Shaikh SA, Müller DJ, Voineskos AN, Potkin SG, Lieberman JA, Meltzer HY, Remington G, Wong AHC, Kennedy JL, Zai CC.

Neurosci Lett. 2018 Nov 1;686:17-22. doi: 10.1016/j.neulet.2018.08.007. Epub 2018 Aug 15.


Oscillatory Switches of Dorso-Ventral Polarity in Cells Confined between Two Surfaces.

Helenius J, Ecke M, Müller DJ, Gerisch G.

Biophys J. 2018 Jul 3;115(1):150-162. doi: 10.1016/j.bpj.2018.05.025.


Pharmacogenetic evaluation of a DISP1 gene variant in antidepressant treatment of obsessive-compulsive disorder.

Lisoway AJ, Zai G, Tiwari AK, Zai CC, Wigg K, Goncalves V, Zhang D, Freeman N, Müller DJ, Kennedy JL, Richter MA.

Hum Psychopharmacol. 2018 Jul;33(4):e2659. doi: 10.1002/hup.2659. Epub 2018 Jun 28.


Imaging in Biologically-Relevant Environments with AFM Using Stiff qPlus Sensors.

Pürckhauer K, Weymouth AJ, Pfeffer K, Kullmann L, Mulvihill E, Krahn MP, Müller DJ, Giessibl FJ.

Sci Rep. 2018 Jun 19;8(1):9330. doi: 10.1038/s41598-018-27608-6.


Mechanism of membrane pore formation by human gasdermin-D.

Mulvihill E, Sborgi L, Mari SA, Pfreundschuh M, Hiller S, Müller DJ.

EMBO J. 2018 Jul 13;37(14). pii: e98321. doi: 10.15252/embj.201798321. Epub 2018 Jun 13.


Single-Molecule Force Spectroscopy of Transmembrane β-Barrel Proteins.

Thoma J, Sapra KT, Müller DJ.

Annu Rev Anal Chem (Palo Alto Calif). 2018 Jun 12;11(1):375-395. doi: 10.1146/annurev-anchem-061417-010055. Review.


POTRA Domains, Extracellular Lid, and Membrane Composition Modulate the Conformational Stability of the β Barrel Assembly Factor BamA.

Thoma J, Sun Y, Ritzmann N, Müller DJ.

Structure. 2018 Jul 3;26(7):987-996.e3. doi: 10.1016/j.str.2018.04.017. Epub 2018 May 31.


Cells Stiffen for Cytokines.

Newton R, Müller DJ.

Cell Chem Biol. 2018 May 17;25(5):495-496. doi: 10.1016/j.chembiol.2018.05.006.


Structural Properties of the Human Protease-Activated Receptor 1 Changing by a Strong Antagonist.

Spoerri PM, Kato HE, Pfreundschuh M, Mari SA, Serdiuk T, Thoma J, Sapra KT, Zhang C, Kobilka BK, Müller DJ.

Structure. 2018 Jun 5;26(6):829-838.e4. doi: 10.1016/j.str.2018.03.020. Epub 2018 May 3.


Genetic testing for CYP2D6 and CYP2C19 suggests improved outcome for antidepressant and antipsychotic medication.

Walden LM, Brandl EJ, Tiwari AK, Cheema S, Freeman N, Braganza N, Kennedy JL, Müller DJ.

Psychiatry Res. 2019 Sep;279:111-115. doi: 10.1016/j.psychres.2018.02.055. Epub 2018 Mar 9.


Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes.

Mari SA, Wegmann S, Tepper K, Hyman BT, Mandelkow EM, Mandelkow E, Müller DJ.

Nano Lett. 2018 May 9;18(5):3271-3281. doi: 10.1021/acs.nanolett.8b01085. Epub 2018 Apr 17.


GWAS-based machine learning approach to predict duloxetine response in major depressive disorder.

Maciukiewicz M, Marshe VS, Hauschild AC, Foster JA, Rotzinger S, Kennedy JL, Kennedy SH, Müller DJ, Geraci J.

J Psychiatr Res. 2018 Apr;99:62-68. doi: 10.1016/j.jpsychires.2017.12.009. Epub 2018 Feb 2.


The Complex Relationship between Antipsychotic-Induced Weight Gain and Therapeutic Benefits: A Systematic Review and Implications for Treatment.

Raben AT, Marshe VS, Chintoh A, Gorbovskaya I, Müller DJ, Hahn MK.

Front Neurosci. 2018 Jan 22;11:741. doi: 10.3389/fnins.2017.00741. eCollection 2017. Review.


Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update.

Phillips EJ, Sukasem C, Whirl-Carrillo M, Müller DJ, Dunnenberger HM, Chantratita W, Goldspiel B, Chen YT, Carleton BC, George AL Jr, Mushiroda T, Klein T, Gammal RS, Pirmohamed M.

Clin Pharmacol Ther. 2018 Apr;103(4):574-581. doi: 10.1002/cpt.1004. Epub 2018 Feb 2.


[Pharmacogenetics in psychiatry: state of the art].

Müller DJ, Brandl EJ, Degenhardt F, Domschke K, Grabe H, Gruber O, Hebebrand J, Maier W, Menke A, Riemenschneider M, Rietschel M, Rujescu D, Schulze TG, Tebartz van Elst L, Tüscher O, Deckert J; das DGPPN Referat Neurobiologie und Genetik.

Nervenarzt. 2018 Mar;89(3):290-299. doi: 10.1007/s00115-017-0479-8. Review. German.


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