Sort by
Items per page

Send to

Choose Destination

Best matches for Müller CE[au]:

Medicinal chemistry of adenosine, P2Y and P2X receptors. Jacobson KA et al. Neuropharmacology. (2016)

Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms. Jespers W et al. Trends Pharmacol Sci. (2018)

Anthraquinones As Pharmacological Tools and Drugs. Malik EM et al. Med Res Rev. (2016)

Search results

Items: 1 to 50 of 392


Structural and Conformational Studies on Carboxamides of 5,6-Diaminouracils-Precursors of Biologically Active Xanthine Derivatives.

Marx D, Schnakenburg G, Grimme S, Müller CE.

Molecules. 2019 Jun 9;24(11). pii: E2168. doi: 10.3390/molecules24112168.


[Progress in cannabis research from a pharmaceutical chemist's point of view].

Müller CE.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Jul;62(7):818-824. doi: 10.1007/s00103-019-02964-4. Review. German.


Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism.

Mouro FM, Köfalvi A, André LA, Baqi Y, Müller CE, Ribeiro JA, Sebastião AM.

Neuropharmacology. 2019 Sep 1;155:10-21. doi: 10.1016/j.neuropharm.2019.05.003. Epub 2019 May 16.


Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuating undesired NPPase activity in human osteoarthritic chondrocytes.

Nassir M, Arad U, Lee SY, Journo S, Mirza S, Renn C, Müller CE, Fischer B.

Purinergic Signal. 2019 Apr 25. doi: 10.1007/s11302-019-09649-2. [Epub ahead of print]


Investigation on 2',3'-O-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists.

Dal Ben D, Buccioni M, Lambertucci C, Marucci G, Spinaci A, Marchenkova A, Abdelrahman A, Nistri A, Müller CE, Volpini R.

ACS Med Chem Lett. 2018 Dec 26;10(4):493-498. doi: 10.1021/acsmedchemlett.8b00524. eCollection 2019 Apr 11.


Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus.

Rausch M, Deisinger JP, Ulm H, Müller A, Li W, Hardt P, Wang X, Li X, Sylvester M, Engeser M, Vollmer W, Müller CE, Sahl HG, Lee JC, Schneider T.

Nat Commun. 2019 Mar 29;10(1):1404. doi: 10.1038/s41467-019-09356-x.


Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors.

Junker A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, Irjala H, Duca S, Balasubramanian R, Chakraborty S, Börgel F, Zimmermann H, Yegutkin GG, Müller CE, Jacobson KA.

J Med Chem. 2019 Apr 11;62(7):3677-3695. doi: 10.1021/acs.jmedchem.9b00164. Epub 2019 Mar 21.


A2B Adenosine Receptor Antagonists with Picomolar Potency.

Jiang J, Seel CJ, Temirak A, Namasivayam V, Arridu A, Schabikowski J, Baqi Y, Hinz S, Hockemeyer J, Müller CE.

J Med Chem. 2019 Apr 25;62(8):4032-4055. doi: 10.1021/acs.jmedchem.9b00071. Epub 2019 Apr 15.


Fast, Efficient, and Versatile Synthesis of 6-amino-5-carboxamidouracils as Precursors for 8-Substituted Xanthines.

Marx D, Wingen LM, Schnakenburg G, Müller CE, Scholz MS.

Front Chem. 2019 Feb 18;7:56. doi: 10.3389/fchem.2019.00056. eCollection 2019.


Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.

Załuski M, Schabikowski J, Schlenk M, Olejarz-Maciej A, Kubas B, Karcz T, Kuder K, Latacz G, Zygmunt M, Synak D, Hinz S, Müller CE, Kieć-Kononowicz K.

Bioorg Med Chem. 2019 Apr 1;27(7):1195-1210. doi: 10.1016/j.bmc.2019.02.004. Epub 2019 Feb 2.


Modulating P1 Adenosine Receptors in Disease Progression of SOD1G93A Mutant Mice.

Armida M, Matteucci A, Pèzzola A, Baqi Y, Müller CE, Popoli P, Potenza RL.

Neurochem Res. 2019 May;44(5):1037-1042. doi: 10.1007/s11064-019-02745-0. Epub 2019 Feb 12.


Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.

Zeiner J, Loukovaara S, Losenkova K, Zuccarini M, Korhonen AM, Lehti K, Kauppinen A, Kaarniranta K, Müller CE, Jalkanen S, Yegutkin GG.

J Mol Med (Berl). 2019 Mar;97(3):341-354. doi: 10.1007/s00109-018-01734-0. Epub 2019 Jan 7.


Koala and Wombat Gammaherpesviruses Encode the First Known Viral NTPDase Homologs and Are Phylogenetically Divergent from All Known Gammaherpesviruses.

Vaz PK, Hartley CA, Lee SY, Sansom FM, Adams TE, Stalder K, Pearce L, Lovrecz G, Browning GF, Müller CE, Devlin JM.

J Virol. 2019 Mar 5;93(6). pii: e01404-18. doi: 10.1128/JVI.01404-18. Print 2019 Mar 15.


Diabetes-induced Neuropathic Mechanical Hyperalgesia Depends on P2X4 Receptor Activation in Dorsal Root Ganglia.

Teixeira JM, Dos Santos GG, Neves AF, Athie MCP, Bonet IJM, Nishijima CM, Farias FH, Figueiredo JG, Hernandez-Olmos V, Alshaibani S, Tambeli CH, Müller CE, Parada CA.

Neuroscience. 2019 Feb 1;398:158-170. doi: 10.1016/j.neuroscience.2018.12.003. Epub 2018 Dec 8.


Development of a selective and highly sensitive fluorescence assay for nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39).

Lee SY, Luo X, Namasivayam V, Geiss J, Mirza S, Pelletier J, Stephan H, Sévigny J, Müller CE.

Analyst. 2018 Nov 5;143(22):5417-5430. doi: 10.1039/c8an01108g.


Cyclopropane-Containing Fatty Acids from the Marine Bacterium Labrenzia sp. 011 with Antimicrobial and GPR84 Activity.

Amiri Moghaddam J, Dávila-Céspedes A, Kehraus S, Crüsemann M, Köse M, Müller CE, König GM.

Mar Drugs. 2018 Oct 8;16(10). pii: E369. doi: 10.3390/md16100369.


Antithrombotic P2Y12 receptor antagonists: recent developments in drug discovery.

Baqi Y, Müller CE.

Drug Discov Today. 2019 Jan;24(1):325-333. doi: 10.1016/j.drudis.2018.09.021. Epub 2018 Oct 3. Review.


Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties.

Załuski M, Stanuch K, Karcz T, Hinz S, Latacz G, Szymańska E, Schabikowski J, Doroż-Płonka A, Handzlik J, Drabczyńska A, Müller CE, Kieć-Kononowicz K.

Medchemcomm. 2018 May 14;9(6):951-962. doi: 10.1039/c8md00070k. eCollection 2018 Jun 1.


Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A2B receptor.

Lindemann M, Hinz S, Deuther-Conrad W, Namasivayam V, Dukic-Stefanovic S, Teodoro R, Toussaint M, Kranz M, Juhl C, Steinbach J, Brust P, Müller CE, Wenzel B.

Bioorg Med Chem. 2018 Sep 1;26(16):4650-4663. doi: 10.1016/j.bmc.2018.07.045. Epub 2018 Jul 29.


Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease.

Faivre E, Coelho JE, Zornbach K, Malik E, Baqi Y, Schneider M, Cellai L, Carvalho K, Sebda S, Figeac M, Eddarkaoui S, Caillierez R, Chern Y, Heneka M, Sergeant N, Müller CE, Halle A, Buée L, Lopes LV, Blum D.

Front Mol Neurosci. 2018 Jul 12;11:235. doi: 10.3389/fnmol.2018.00235. eCollection 2018.


3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17.

Baqi Y, Pillaiyar T, Abdelrahman A, Kaufmann O, Alshaibani S, Rafehi M, Ghasimi S, Akkari R, Ritter K, Simon K, Spinrath A, Kostenis E, Zhao Q, Köse M, Namasivayam V, Müller CE.

J Med Chem. 2018 Sep 27;61(18):8136-8154. doi: 10.1021/acs.jmedchem.7b01768. Epub 2018 Sep 5.


General Synthesis of Unsymmetrical 3,3'-(Aza)diindolylmethane Derivatives.

Pillaiyar T, Gorska E, Schnakenburg G, Müller CE.

J Org Chem. 2018 Sep 7;83(17):9902-9913. doi: 10.1021/acs.joc.8b01349. Epub 2018 Jul 31.


6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84).

Pillaiyar T, Köse M, Namasivayam V, Sylvester K, Borges G, Thimm D, von Kügelgen I, Müller CE.

ACS Omega. 2018 Mar 31;3(3):3365-3383. doi: 10.1021/acsomega.7b02092. Epub 2018 Mar 20.


Extracellular adenosine reversibly inhibits the activation of human regulatory T cells and negatively influences the achievement of the operational tolerance in liver transplantation.

Baroja-Mazo A, Revilla-Nuin B, de Bejar Á, Martínez-Alarcón L, Herrero JI, El-Tayeb A, Müller CE, Aparicio P, Pelegrín P, Pons JA.

Am J Transplant. 2019 Jan;19(1):48-61. doi: 10.1111/ajt.15023. Epub 2018 Aug 31.


Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity.

Koch P, Brunschweiger A, Namasivayam V, Ullrich S, Maruca A, Lazzaretto B, Küppers P, Hinz S, Hockemeyer J, Wiese M, Heer J, Alcaro S, Kiec-Kononowicz K, Müller CE.

Front Chem. 2018 Jun 26;6:206. doi: 10.3389/fchem.2018.00206. eCollection 2018.


Pharmacological evaluation of new constituents of "Spice": synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds.

Schoeder CT, Hess C, Madea B, Meiler J, Müller CE.

Forensic Toxicol. 2018;36(2):385-403. doi: 10.1007/s11419-018-0415-z. Epub 2018 Apr 26.


Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors.

Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV.

Mol Psychiatry. 2018 Jun 27. doi: 10.1038/s41380-018-0110-9. [Epub ahead of print]


Applying Molecular Networking for the Detection of Natural Sources and Analogues of the Selective Gq Protein Inhibitor FR900359.

Reher R, Kuschak M, Heycke N, Annala S, Kehraus S, Dai HF, Müller CE, Kostenis E, König GM, Crüsemann M.

J Nat Prod. 2018 Jul 27;81(7):1628-1635. doi: 10.1021/acs.jnatprod.8b00222. Epub 2018 Jun 26.


Structure-activity relationships of imidazothiazinones and analogs as antagonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18.

Schoeder CT, Kaleta M, Mahardhika AB, Olejarz-Maciej A, Łażewska D, Kieć-Kononowicz K, Müller CE.

Eur J Med Chem. 2018 Jul 15;155:381-397. doi: 10.1016/j.ejmech.2018.05.050. Epub 2018 Jun 1.


Molecular and functional interaction between GPR18 and cannabinoid CB2 G-protein-coupled receptors. Relevance in neurodegenerative diseases.

Reyes-Resina I, Navarro G, Aguinaga D, Canela EI, Schoeder CT, Załuski M, Kieć-Kononowicz K, Saura CA, Müller CE, Franco R.

Biochem Pharmacol. 2018 Nov;157:169-179. doi: 10.1016/j.bcp.2018.06.001. Epub 2018 Jun 2.


Tritium-labeled agonists as tools for studying adenosine A2B receptors.

Hinz S, Alnouri WM, Pleiss U, Müller CE.

Purinergic Signal. 2018 Sep;14(3):223-233. doi: 10.1007/s11302-018-9608-5. Epub 2018 May 11.


Time trends in characteristics, clinical course, and outcomes of 13,791 patients with acute heart failure.

Llorens P, Javaloyes P, Martín-Sánchez FJ, Jacob J, Herrero-Puente P, Gil V, Garrido JM, Salvo E, Fuentes M, Alonso H, Richard F, Lucas FJ, Bueno H, Parissis J, Müller CE, Miró Ò; ICA-SEMES Research Group.

Clin Res Cardiol. 2018 Oct;107(10):897-913. doi: 10.1007/s00392-018-1261-z. Epub 2018 May 4.


Fluorescent-Labeled Selective Adenosine A2B Receptor Antagonist Enables Competition Binding Assay by Flow Cytometry.

Köse M, Gollos S, Karcz T, Fiene A, Heisig F, Behrenswerth A, Kieć-Kononowicz K, Namasivayam V, Müller CE.

J Med Chem. 2018 May 24;61(10):4301-4316. doi: 10.1021/acs.jmedchem.7b01627. Epub 2018 May 15.


Mechanism underlying the contractile activity of UTP in the mammalian heart.

Gergs U, Rothkirch D, Hofmann B, Treede H, Robaye B, Simm A, Müller CE, Neumann J.

Eur J Pharmacol. 2018 Jul 5;830:47-58. doi: 10.1016/j.ejphar.2018.04.013. Epub 2018 Apr 17.


Tools and drugs for uracil nucleotide-activated P2Y receptors.

Rafehi M, Müller CE.

Pharmacol Ther. 2018 Oct;190:24-80. doi: 10.1016/j.pharmthera.2018.04.002. Epub 2018 Apr 13. Review.


Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells.

Kwak SH, Shin S, Lee JH, Shim JK, Kim M, Lee SD, Lee A, Bae J, Park JH, Abdelrahman A, Müller CE, Cho SK, Kang SG, Bae MA, Yang JY, Ko H, Goddard WA 3rd, Kim YC.

Eur J Med Chem. 2018 May 10;151:462-481. doi: 10.1016/j.ejmech.2018.03.023. Epub 2018 Mar 9.


Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.

Poppe D, Doerr J, Schneider M, Wilkens R, Steinbeck JA, Ladewig J, Tam A, Paschon DE, Gregory PD, Reik A, Müller CE, Koch P, Brüstle O.

Stem Cells Transl Med. 2018 Jun;7(6):477-486. doi: 10.1002/sctm.16-0272. Epub 2018 Mar 28.


Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors.

Hinz S, Navarro G, Borroto-Escuela D, Seibt BF, Ammon YC, de Filippo E, Danish A, Lacher SK, Červinková B, Rafehi M, Fuxe K, Schiedel AC, Franco R, Müller CE.

Oncotarget. 2018 Feb 6;9(17):13593-13611. doi: 10.18632/oncotarget.24423. eCollection 2018 Mar 2.


Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation.

Borroto-Escuela DO, Hinz S, Navarro G, Franco R, Müller CE, Fuxe K.

Front Neurosci. 2018 Feb 6;12:43. doi: 10.3389/fnins.2018.00043. eCollection 2018.


Interaction of Purinergic P2X4 and P2X7 Receptor Subunits.

Schneider M, Prudic K, Pippel A, Klapperstück M, Braam U, Müller CE, Schmalzing G, Markwardt F.

Front Pharmacol. 2017 Nov 22;8:860. doi: 10.3389/fphar.2017.00860. eCollection 2017.


Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms.

Jespers W, Schiedel AC, Heitman LH, Cooke RM, Kleene L, van Westen GJP, Gloriam DE, Müller CE, Sotelo E, Gutiérrez-de-Terán H.

Trends Pharmacol Sci. 2018 Jan;39(1):75-89. doi: 10.1016/ Epub 2017 Dec 5. Review.


Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359.

Crüsemann M, Reher R, Schamari I, Brachmann AO, Ohbayashi T, Kuschak M, Malfacini D, Seidinger A, Pinto-Carbó M, Richarz R, Reuter T, Kehraus S, Hallab A, Attwood M, Schiöth HB, Mergaert P, Kikuchi Y, Schäberle TF, Kostenis E, Wenzel D, Müller CE, Piel J, Carlier A, Eberl L, König GM.

Angew Chem Int Ed Engl. 2018 Jan 15;57(3):836-840. doi: 10.1002/anie.201707996. Epub 2017 Dec 20.


Anti-inflammatory effect of a novel locally acting A2A receptor agonist in a rat model of oxazolone-induced colitis.

Antonioli L, El-Tayeb A, Pellegrini C, Fornai M, Awwad O, Giustarini G, Natale G, Ryskalin L, Németh ZH, Müller CE, Blandizzi C, Colucci R.

Purinergic Signal. 2018 Mar;14(1):27-36. doi: 10.1007/s11302-017-9591-2. Epub 2017 Nov 8.


Mechanisms of the action of adenine on anti-allergic effects in mast cells.

Hosoi T, Ino S, Ohnishi F, Todoroki K, Yoshii M, Kakimoto M, Müller CE, Ozawa K.

Immun Inflamm Dis. 2018 Mar;6(1):97-105. doi: 10.1002/iid3.200. Epub 2017 Nov 1.


Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage.

Boia R, Elvas F, Madeira MH, Aires ID, Rodrigues-Neves AC, Tralhão P, Szabó EC, Baqi Y, Müller CE, Tomé ÂR, Cunha RA, Ambrósio AF, Santiago AR.

Cell Death Dis. 2017 Oct 5;8(10):e3065. doi: 10.1038/cddis.2017.451.


Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y2 Receptor.

Rafehi M, Neumann A, Baqi Y, Malik EM, Wiese M, Namasivayam V, Müller CE.

J Med Chem. 2017 Oct 26;60(20):8425-8440. doi: 10.1021/acs.jmedchem.7b00854. Epub 2017 Oct 10.


Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma.

Matthey M, Roberts R, Seidinger A, Simon A, Schröder R, Kuschak M, Annala S, König GM, Müller CE, Hall IP, Kostenis E, Fleischmann BK, Wenzel D.

Sci Transl Med. 2017 Sep 13;9(407). pii: eaag2288. doi: 10.1126/scitranslmed.aag2288.


Dinosaur origin of egg color: oviraptors laid blue-green eggs.

Wiemann J, Yang TR, Sander PN, Schneider M, Engeser M, Kath-Schorr S, Müller CE, Sander PM.

PeerJ. 2017 Aug 29;5:e3706. doi: 10.7717/peerj.3706. eCollection 2017.


Quantification of green fluorescent protein-(GFP-) tagged membrane proteins by capillary gel electrophoresis.

Danish A, Lee SY, Müller CE.

Analyst. 2017 Oct 7;142(19):3648-3655. doi: 10.1039/c7an00981j. Epub 2017 Aug 31.


GPR55: A therapeutic target for Parkinson's disease?

Celorrio M, Rojo-Bustamante E, Fernández-Suárez D, Sáez E, Estella-Hermoso de Mendoza A, Müller CE, Ramírez MJ, Oyarzábal J, Franco R, Aymerich MS.

Neuropharmacology. 2017 Oct;125:319-332. doi: 10.1016/j.neuropharm.2017.08.017. Epub 2017 Aug 12.


Supplemental Content

Loading ...
Support Center