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Items: 1 to 50 of 195

1.

A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection.

Mangan MS, Melo-Silva CR, Luu J, Bird CH, Koskinen A, Rizzitelli A, Prakash M, Scarff KL, Müllbacher A, Regner M, Bird PI.

Immunol Cell Biol. 2017 Nov;95(10):884-894. doi: 10.1038/icb.2017.59. Epub 2017 Aug 15.

PMID:
28722018
2.

Ectromelia virus N1L is essential for virulence but not dissemination in a classical model of mousepox.

Melo-Silva CR, Tscharke DC, Lobigs M, Koskinen A, Müllbacher A, Regner M.

Virus Res. 2017 Jan 15;228:61-65. doi: 10.1016/j.virusres.2016.11.017. Epub 2016 Nov 16.

PMID:
27865865
3.

Mysteries of type I IFN response: benefits versus detriments.

Furuya Y, Ludewick HP, Müllbacher A.

Front Immunol. 2015 Jan 28;6:21. doi: 10.3389/fimmu.2015.00021. eCollection 2015. No abstract available.

4.

Type I IFN exhaustion is a host defence protecting against secondary bacterial infections.

Furuya Y, Müllbacher A.

Scand J Immunol. 2013 Nov;78(5):395-400. doi: 10.1111/sji.12107. Review.

5.

MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies.

Alsharifi M, Koskinen A, Wijesundara DK, Bettadapura J, Müllbacher A.

PLoS One. 2013 Jun 28;8(6):e68458. doi: 10.1371/journal.pone.0068458. Print 2013.

6.

Bis(methyl)gliotoxin proves to be a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis.

Domingo MP, Colmenarejo C, Martínez-Lostao L, Müllbacher A, Jarne C, Revillo MJ, Delgado P, Roc L, Meis JF, Rezusta A, Pardo J, Gálvez EM.

Diagn Microbiol Infect Dis. 2012 May;73(1):57-64. doi: 10.1016/j.diagmicrobio.2012.01.012. Epub 2012 Apr 4.

PMID:
22480566
7.

Gamma-irradiated influenza virus uniquely induces IFN-I mediated lymphocyte activation independent of the TLR7/MyD88 pathway.

Furuya Y, Chan J, Wan EC, Koskinen A, Diener KR, Hayball JD, Regner M, Müllbacher A, Alsharifi M.

PLoS One. 2011;6(10):e25765. doi: 10.1371/journal.pone.0025765. Epub 2011 Oct 5.

8.

In vivo elimination of MHC-I-deficient lymphocytes by activated natural killer cells is independent of granzymes A and B.

Regner M, Pavlinovic L, Young N, Müllbacher A.

PLoS One. 2011;6(8):e23252. doi: 10.1371/journal.pone.0023252. Epub 2011 Aug 11.

9.

The ectromelia virus SPI-2 protein causes lethal mousepox by preventing NK cell responses.

Melo-Silva CR, Tscharke DC, Lobigs M, Koskinen A, Wong YC, Buller RM, Müllbacher A, Regner M.

J Virol. 2011 Nov;85(21):11170-82. doi: 10.1128/JVI.00256-11. Epub 2011 Aug 17.

10.

TCR down-regulation boosts T-cell-mediated cytotoxicity and protection against poxvirus infections.

Hansen AK, Regner M, Bonefeld CM, Boding L, Kongsbak M, Ødum N, Müllbacher A, Geisler C, von Essen MR.

Eur J Immunol. 2011 Jul;41(7):1948-57. doi: 10.1002/eji.201141413. Epub 2011 May 27.

11.

Antigen-specific activation thresholds of CD8+ T cells are independent of IFN-I-mediated partial lymphocyte activation.

Wijesundara DK, Kumar S, Alsharifi M, Müllbacher A, Regner M.

Int Immunol. 2010 Sep;22(9):757-67. doi: 10.1093/intimm/dxq064. Epub 2010 Aug 2.

PMID:
20682547
12.

Cytotoxic T cells are the predominant players providing cross-protective immunity induced by {gamma}-irradiated influenza A viruses.

Furuya Y, Chan J, Regner M, Lobigs M, Koskinen A, Kok T, Manavis J, Li P, Müllbacher A, Alsharifi M.

J Virol. 2010 May;84(9):4212-21. doi: 10.1128/JVI.02508-09. Epub 2010 Feb 17.

13.

Effect of inactivation method on the cross-protective immunity induced by whole 'killed' influenza A viruses and commercial vaccine preparations.

Furuya Y, Regner M, Lobigs M, Koskinen A, Müllbacher A, Alsharifi M.

J Gen Virol. 2010 Jun;91(Pt 6):1450-60. doi: 10.1099/vir.0.018168-0. Epub 2010 Feb 10.

PMID:
20147516
14.

The gamma-irradiated influenza vaccine and the prospect of producing safe vaccines in general.

Alsharifi M, Müllbacher A.

Immunol Cell Biol. 2010 Feb;88(2):103-4. doi: 10.1038/icb.2009.81. Epub 2009 Oct 27. No abstract available.

PMID:
19859081
15.

Caspase-dependent inhibition of mousepox replication by gzmB.

Pardo J, Gálvez EM, Koskinen A, Simon MM, Lobigs M, Regner M, Müllbacher A.

PLoS One. 2009 Oct 19;4(10):e7512. doi: 10.1371/journal.pone.0007512.

16.

Cutting edge: rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B.

Regner M, Pavlinovic L, Koskinen A, Young N, Trapani JA, Müllbacher A.

J Immunol. 2009 Jul 1;183(1):37-40. doi: 10.4049/jimmunol.0900466. Epub 2009 Jun 12.

17.

Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infections.

Alsharifi M, Furuya Y, Bowden TR, Lobigs M, Koskinen A, Regner M, Trinidad L, Boyle DB, Müllbacher A.

PLoS One. 2009;4(4):e5336. doi: 10.1371/journal.pone.0005336. Epub 2009 Apr 29.

18.

EMBO workshop on cytotoxicity, cell death and the immune system.

Anel A, Bleackley C, Borner C, Golstein P, Krammer PH, Müllbacher A, Pardo J, Simon MM, Trapani JA.

Cell Death Differ. 2009 May;16(5):790-3. doi: 10.1038/cdd.2009.4. No abstract available.

19.

The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation.

Pardo J, Aguilo JI, Anel A, Martin P, Joeckel L, Borner C, Wallich R, Müllbacher A, Froelich CJ, Simon MM.

Microbes Infect. 2009 Apr;11(4):452-9. doi: 10.1016/j.micinf.2009.02.004. Epub 2009 Feb 26. Review.

PMID:
19249384
20.

Restricted Semliki Forest virus replication in perforin and Fas-ligand double-deficient mice.

Alsharifi M, Lobigs M, Bettadapura J, Koskinen A, Müllbacher A.

J Gen Virol. 2008 Aug;89(Pt 8):1942-4. doi: 10.1099/vir.0.83626-0.

PMID:
18632965
21.

Interferon type I responses in primary and secondary infections.

Alsharifi M, Müllbacher A, Regner M.

Immunol Cell Biol. 2008 Mar-Apr;86(3):239-45. doi: 10.1038/sj.icb.7100159. Epub 2008 Jan 8. Review.

PMID:
18180794
22.

Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs.

Pardo J, Wallich R, Martin P, Urban C, Rongvaux A, Flavell RA, Müllbacher A, Borner C, Simon MM.

Cell Death Differ. 2008 Mar;15(3):567-79. Epub 2007 Dec 7.

23.

Role of laeA in the Regulation of alb1, gliP, Conidial Morphology, and Virulence in Aspergillus fumigatus.

Sugui JA, Pardo J, Chang YC, Müllbacher A, Zarember KA, Galvez EM, Brinster L, Zerfas P, Gallin JI, Simon MM, Kwon-Chung KJ.

Eukaryot Cell. 2007 Sep;6(9):1552-61. Epub 2007 Jul 13.

24.

Gliotoxin is a virulence factor of Aspergillus fumigatus: gliP deletion attenuates virulence in mice immunosuppressed with hydrocortisone.

Sugui JA, Pardo J, Chang YC, Zarember KA, Nardone G, Galvez EM, Müllbacher A, Gallin JI, Simon MM, Kwon-Chung KJ.

Eukaryot Cell. 2007 Sep;6(9):1562-9. Epub 2007 Jun 29.

25.

Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin.

Pardo J, Wallich R, Ebnet K, Iden S, Zentgraf H, Martin P, Ekiciler A, Prins A, Müllbacher A, Huber M, Simon MM.

Cell Death Differ. 2007 Oct;14(10):1768-79. Epub 2007 Jun 29.

26.

Increased survival after gemfibrozil treatment of severe mouse influenza.

Budd A, Alleva L, Alsharifi M, Koskinen A, Smythe V, Müllbacher A, Wood J, Clark I.

Antimicrob Agents Chemother. 2007 Aug;51(8):2965-8. Epub 2007 Jun 11.

27.

Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.

Sutton VR, Waterhouse NJ, Browne KA, Sedelies K, Ciccone A, Anthony D, Koskinen A, Mullbacher A, Trapani JA.

J Cell Biol. 2007 Feb 12;176(4):425-33. Epub 2007 Feb 5.

28.

Beta cells cannot directly prime diabetogenic CD8 T cells in nonobese diabetic mice.

de Jersey J, Snelgrove SL, Palmer SE, Teteris SA, Mullbacher A, Miller JF, Slattery RM.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1295-300. Epub 2007 Jan 17.

29.

CD8(+) T cell-mediated immune responses in West Nile virus (Sarafend strain) encephalitis are independent of gamma interferon.

Wang Y, Lobigs M, Lee E, Koskinen A, Müllbacher A.

J Gen Virol. 2006 Dec;87(Pt 12):3599-609.

PMID:
17098975
30.

Exhaustion of type I interferon response following an acute viral infection.

Alsharifi M, Regner M, Blanden R, Lobigs M, Lee E, Koskinen A, Müllbacher A.

J Immunol. 2006 Sep 1;177(5):3235-41.

31.

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice.

Pardo J, Urban C, Galvez EM, Ekert PG, Müller U, Kwon-Chung J, Lobigs M, Müllbacher A, Wallich R, Borner C, Simon MM.

J Cell Biol. 2006 Aug 14;174(4):509-19. Epub 2006 Aug 7.

32.

Cytotoxic T-cell immunity as a target for influenza vaccines.

Müllbacher A, Lobigs M, Alsharifi M, Regner M.

Lancet Infect Dis. 2006 May;6(5):255-6. No abstract available.

PMID:
16631540
33.

NK cell-mediated immunopathology during an acute viral infection of the CNS.

Alsharifi M, Lobigs M, Simon MM, Kersten A, Müller K, Koskinen A, Lee E, Müllbacher A.

Eur J Immunol. 2006 Apr;36(4):887-96.

34.

Type I interferons trigger systemic, partial lymphocyte activation in response to viral infection.

Alsharifi M, Lobigs M, Regner M, Lee E, Koskinen A, Müllbacher A.

J Immunol. 2005 Oct 1;175(7):4635-40.

35.

Functional analysis of granzyme M and its role in immunity to infection.

Pao LI, Sumaria N, Kelly JM, van Dommelen S, Cretney E, Wallace ME, Anthony DA, Uldrich AP, Godfrey DI, Papadimitriou JM, Mullbacher A, Degli-Esposti MA, Smyth MJ.

J Immunol. 2005 Sep 1;175(5):3235-43.

36.

Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes?

Martin P, Wallich R, Pardo J, Müllbacher A, Munder M, Modolell M, Simon MM.

Blood. 2005 Oct 15;106(8):2871-8. Epub 2005 Jul 5.

37.

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis.

Pardo J, Bosque A, Brehm R, Wallich R, Naval J, Müllbacher A, Anel A, Simon MM.

J Cell Biol. 2004 Nov 8;167(3):457-68.

38.

Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection.

Rode M, Balkow S, Sobek V, Brehm R, Martin P, Kersten A, Dumrese T, Stehle T, Müllbacher A, Wallich R, Simon MM.

J Virol. 2004 Nov;78(22):12395-405.

39.

The multidrug resistance gene mdr1a influences resistance to ectromelia virus infection by mechanisms other than conventional immunity.

Xu D, Regner M, Smith D, Ruby J, Johnstone R, Müllbacher A.

Immunol Cell Biol. 2004 Oct;82(5):462-70.

PMID:
15479431
40.

Can we really learn from model pathogens?

Müllbacher A, Regner M, Wang Y, Lee E, Lobigs M, Simon M.

Trends Immunol. 2004 Oct;25(10):524-8. Review.

PMID:
15364054
41.

T-cell-mediated control of poxvirus infection in mice.

Müllbacher A, Blanden RV.

Prog Mol Subcell Biol. 2004;36:39-55. Review. No abstract available.

PMID:
15171606
42.

Evidence that a mechanism for efficient flavivirus budding upregulates MHC class I.

Lobigs M, Müllbacher A, Lee E.

Immunol Cell Biol. 2004 Apr;82(2):184-8.

PMID:
15061772
43.

Exocytosis and Fas mediated cytolytic mechanisms exert protection from West Nile virus induced encephalitis in mice.

Wang Y, Lobigs M, Lee E, Müllbacher A.

Immunol Cell Biol. 2004 Apr;82(2):170-3.

PMID:
15061770
44.

Granzymes in cytolytic lymphocytes--to kill a killer?

Regner M, Müllbacher A.

Immunol Cell Biol. 2004 Apr;82(2):161-9.

PMID:
15061769
45.

Immunobiology of mosquito-borne encephalitic flaviviruses.

Müllbacher A, Lobigs M, Lee E.

Adv Virus Res. 2003;60:87-120. No abstract available.

PMID:
14689692
46.

CD8+ T cells mediate recovery and immunopathology in West Nile virus encephalitis.

Wang Y, Lobigs M, Lee E, Müllbacher A.

J Virol. 2003 Dec;77(24):13323-34.

47.

Cell-mediated cytotoxicity in recovery from poxvirus infections.

Müllbacher A.

Rev Med Virol. 2003 Jul-Aug;13(4):223-32. Review.

PMID:
12820184
48.

MHC class I up-regulation by flaviviruses: Immune interaction with unknown advantage to host or pathogen.

Lobigs M, Müllbacher A, Regner M.

Immunol Cell Biol. 2003 Jun;81(3):217-23. Review.

PMID:
12752686
49.

Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus.

Lobigs M, Müllbacher A, Wang Y, Pavy M, Lee E.

J Gen Virol. 2003 Mar;84(Pt 3):567-72.

PMID:
12604807
50.

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