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Items: 1 to 50 of 60

1.

Editorial.

Mühlemann O, Allai F.

Chimia (Aarau). 2019 May 29;73(5):353. No abstract available.

PMID:
31174619
2.

The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence.

Contu L, Steiner S, Thiel V, Mühlemann O.

Chimia (Aarau). 2019 May 29;73(6):374-379. doi: 10.2533/chimia.2019.374. Review.

PMID:
31118119
3.

Editorial.

Mühlemann O, Allai F.

Chimia (Aarau). 2019 May 29;73(6):353. No abstract available.

PMID:
31118115
4.

The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity.

Loughlin FE, Lukavsky PJ, Kazeeva T, Reber S, Hock EM, Colombo M, Von Schroetter C, Pauli P, Cléry A, Mühlemann O, Polymenidou M, Ruepp MD, Allain FH.

Mol Cell. 2019 Feb 7;73(3):490-504.e6. doi: 10.1016/j.molcel.2018.11.012. Epub 2018 Dec 20.

PMID:
30581145
5.

Nonsense-Mediated mRNA Decay Begins Where Translation Ends.

Karousis ED, Mühlemann O.

Cold Spring Harb Perspect Biol. 2019 Feb 1;11(2). pii: a032862. doi: 10.1101/cshperspect.a032862. Review.

PMID:
29891560
6.

Dissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells.

Nicholson P, Gkratsou A, Josi C, Colombo M, Mühlemann O.

RNA. 2018 Apr;24(4):557-573. doi: 10.1261/rna.063719.117. Epub 2018 Jan 18.

7.

New functions in translation termination uncovered for NMD factor UPF3B.

Mühlemann O, Karousis ED.

EMBO J. 2017 Oct 16;36(20):2928-2930. doi: 10.15252/embj.201798063. Epub 2017 Sep 21. No abstract available.

8.

Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression.

Nasif S, Contu L, Mühlemann O.

Semin Cell Dev Biol. 2018 Mar;75:78-87. doi: 10.1016/j.semcdb.2017.08.053. Epub 2017 Sep 1. Review.

PMID:
28866327
9.

Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay.

Balistreri G, Bognanni C, Mühlemann O.

Viruses. 2017 Jan 23;9(1). pii: E24. doi: 10.3390/v9010024. Review.

10.

Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.

Colombo M, Karousis ED, Bourquin J, Bruggmann R, Mühlemann O.

RNA. 2017 Feb;23(2):189-201. doi: 10.1261/rna.059055.116. Epub 2016 Nov 18.

11.

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

Reber S, Stettler J, Filosa G, Colombo M, Jutzi D, Lenzken SC, Schweingruber C, Bruggmann R, Bachi A, Barabino SM, Mühlemann O, Ruepp MD.

EMBO J. 2016 Jul 15;35(14):1504-21. doi: 10.15252/embj.201593791. Epub 2016 Jun 1.

12.

Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact.

Karousis ED, Nasif S, Mühlemann O.

Wiley Interdiscip Rev RNA. 2016 Sep;7(5):661-82. doi: 10.1002/wrna.1357. Epub 2016 May 13. Review.

13.

Spermatogenesis Studies Reveal a Distinct Nonsense-Mediated mRNA Decay (NMD) Mechanism for mRNAs with Long 3'UTRs.

Mühlemann O.

PLoS Genet. 2016 May 5;12(5):e1005979. doi: 10.1371/journal.pgen.1005979. eCollection 2016 May. No abstract available.

14.

Identification of Interactions in the NMD Complex Using Proximity-Dependent Biotinylation (BioID).

Schweingruber C, Soffientini P, Ruepp MD, Bachi A, Mühlemann O.

PLoS One. 2016 Mar 2;11(3):e0150239. doi: 10.1371/journal.pone.0150239. eCollection 2016.

15.

The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication.

Balistreri G, Horvath P, Schweingruber C, Zünd D, McInerney G, Merits A, Mühlemann O, Azzalin C, Helenius A.

Cell Host Microbe. 2014 Sep 10;16(3):403-11. doi: 10.1016/j.chom.2014.08.007.

16.

Eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay by two genetically separable mechanisms.

Joncourt R, Eberle AB, Rufener SC, Mühlemann O.

PLoS One. 2014 Aug 22;9(8):e104391. doi: 10.1371/journal.pone.0104391. eCollection 2014.

17.

A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.

Nicholson P, Josi C, Kurosawa H, Yamashita A, Mühlemann O.

Nucleic Acids Res. 2014 Aug;42(14):9217-35. doi: 10.1093/nar/gku645. Epub 2014 Jul 22.

18.

Synthesis and characterization of photoaffinity probes that target the 5-HT3 receptor.

Jack T, Ruepp MD, Thompson AJ, Mühlemann O, Lochner M.

Chimia (Aarau). 2014;68(4):239-42. doi: 10.2533/chimia.2014.239.

PMID:
24983606
19.

Characterization of phosphorylation- and RNA-dependent UPF1 interactors by quantitative proteomics.

Flury V, Restuccia U, Bachi A, Mühlemann O.

J Proteome Res. 2014 Jun 6;13(6):3038-53. doi: 10.1021/pr5002143. Epub 2014 May 6.

PMID:
24762188
20.

Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways.

Metze S, Herzog VA, Ruepp MD, Mühlemann O.

RNA. 2013 Oct;19(10):1432-48. doi: 10.1261/rna.038893.113. Epub 2013 Aug 20.

21.

Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs.

Zünd D, Gruber AR, Zavolan M, Mühlemann O.

Nat Struct Mol Biol. 2013 Aug;20(8):936-43. doi: 10.1038/nsmb.2635. Epub 2013 Jul 7.

PMID:
23832275
22.

eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells.

Rufener SC, Mühlemann O.

Nat Struct Mol Biol. 2013 Jun;20(6):710-7. doi: 10.1038/nsmb.2576. Epub 2013 May 12.

PMID:
23665581
23.

Paraquat modulates alternative pre-mRNA splicing by modifying the intracellular distribution of SRPK2.

Vivarelli S, Lenzken SC, Ruepp MD, Ranzini F, Maffioletti A, Alvarez R, Mühlemann O, Barabino SM.

PLoS One. 2013 Apr 16;8(4):e61980. doi: 10.1371/journal.pone.0061980. Print 2013.

24.

RNA decay mechanisms: specificity through diversity.

Stoecklin G, Mühlemann O.

Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):487-90. doi: 10.1016/j.bbagrm.2013.04.002. Epub 2013 Apr 10. No abstract available.

PMID:
23583720
25.

Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells.

Schweingruber C, Rufener SC, Zünd D, Yamashita A, Mühlemann O.

Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):612-23. doi: 10.1016/j.bbagrm.2013.02.005. Epub 2013 Feb 20. Review.

PMID:
23435113
26.

Recent transcriptome-wide mapping of UPF1 binding sites reveals evidence for its recruitment to mRNA before translation.

Zünd D, Mühlemann O.

Translation (Austin). 2013 Oct 31;1(2):e26977. doi: 10.4161/trla.26977. eCollection 2013.

27.

Intimate liaison with SR proteins brings exon junction complexes to unexpected places.

Mühlemann O.

Nat Struct Mol Biol. 2012 Dec;19(12):1209-11. doi: 10.1038/nsmb.2454. No abstract available.

PMID:
23211765
28.

Analysis of nonsense-mediated mRNA decay in mammalian cells.

Nicholson P, Joncourt R, Mühlemann O.

Curr Protoc Cell Biol. 2012 Jun;Chapter 27:Unit27.4. doi: 10.1002/0471143030.cb2704s55.

PMID:
22733442
29.

mRNP quality control goes regulatory.

Mühlemann O, Jensen TH.

Trends Genet. 2012 Feb;28(2):70-7. doi: 10.1016/j.tig.2011.11.001. Epub 2011 Dec 9.

PMID:
22154474
30.

Cotranscriptional effect of a premature termination codon revealed by live-cell imaging.

de Turris V, Nicholson P, Orozco RZ, Singer RH, Mühlemann O.

RNA. 2011 Dec;17(12):2094-107. doi: 10.1261/rna.02918111. Epub 2011 Oct 25.

31.

Autoregulation of the nonsense-mediated mRNA decay pathway in human cells.

Yepiskoposyan H, Aeschimann F, Nilsson D, Okoniewski M, Mühlemann O.

RNA. 2011 Dec;17(12):2108-18. doi: 10.1261/rna.030247.111. Epub 2011 Oct 25.

32.

Cutting the nonsense: the degradation of PTC-containing mRNAs.

Nicholson P, Mühlemann O.

Biochem Soc Trans. 2010 Dec;38(6):1615-20. doi: 10.1042/BST0381615. Review.

PMID:
21118136
33.

tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans.

Aeby E, Ullu E, Yepiskoposyan H, Schimanski B, Roditi I, Mühlemann O, Schneider A.

Nucleic Acids Res. 2010 Sep;38(17):5833-43. doi: 10.1093/nar/gkq345. Epub 2010 May 5.

34.

How and where are nonsense mRNAs degraded in mammalian cells?

Mühlemann O, Lykke-Andersen J.

RNA Biol. 2010 Jan-Feb;7(1):28-32. Epub 2010 Jan 9.

35.

Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors.

Nicholson P, Yepiskoposyan H, Metze S, Zamudio Orozco R, Kleinschmidt N, Mühlemann O.

Cell Mol Life Sci. 2010 Mar;67(5):677-700. doi: 10.1007/s00018-009-0177-1. Epub 2009 Oct 27. Review.

PMID:
19859661
36.

Processing bodies are not required for mammalian nonsense-mediated mRNA decay.

Stalder L, Mühlemann O.

RNA. 2009 Jul;15(7):1265-73. doi: 10.1261/rna.1672509. Epub 2009 May 27.

37.

Equal transcription rates of productively and nonproductively rearranged immunoglobulin mu heavy chain alleles in a pro-B cell line.

Eberle AB, Herrmann K, Jäck HM, Mühlemann O.

RNA. 2009 Jun;15(6):1021-8. doi: 10.1261/rna.1516409. Epub 2009 Apr 10.

38.

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells.

Eberle AB, Lykke-Andersen S, Mühlemann O, Jensen TH.

Nat Struct Mol Biol. 2009 Jan;16(1):49-55. doi: 10.1038/nsmb.1530. Epub 2008 Dec 7.

PMID:
19060897
39.

Recognition and elimination of nonsense mRNA.

Mühlemann O, Eberle AB, Stalder L, Zamudio Orozco R.

Biochim Biophys Acta. 2008 Sep;1779(9):538-49. doi: 10.1016/j.bbagrm.2008.06.012. Epub 2008 Jul 8. Review.

PMID:
18657639
40.

The meaning of nonsense.

Stalder L, Mühlemann O.

Trends Cell Biol. 2008 Jul;18(7):315-21. doi: 10.1016/j.tcb.2008.04.005. Epub 2008 Jun 2. Review.

PMID:
18524595
41.

Recognition of nonsense mRNA: towards a unified model.

Mühlemann O.

Biochem Soc Trans. 2008 Jun;36(Pt 3):497-501. doi: 10.1042/BST0360497. Review.

PMID:
18481988
42.

Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region.

Eberle AB, Stalder L, Mathys H, Orozco RZ, Mühlemann O.

PLoS Biol. 2008 Apr 29;6(4):e92. doi: 10.1371/journal.pbio.0060092.

43.

Angiotensinergic neurons in sympathetic coeliac ganglia innervating rat and human mesenteric resistance blood vessels.

Patil J, Heiniger E, Schaffner T, Mühlemann O, Imboden H.

Regul Pept. 2008 Apr 10;147(1-3):82-7. doi: 10.1016/j.regpep.2008.01.006. Epub 2008 Jan 18.

PMID:
18308407
44.

Preparation of soluble extracts from adenovirus-infected cells for studies of RNA splicing.

Mühlemann O, Akusjärvi G.

Methods Mol Med. 2007;131:33-46.

PMID:
17656773
45.

Transcriptional silencing of nonsense codon-containing immunoglobulin micro genes requires translation of its mRNA.

Stalder L, Mühlemann O.

J Biol Chem. 2007 Jun 1;282(22):16079-85. Epub 2007 Apr 11.

46.

EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length.

Bühler M, Steiner S, Mohn F, Paillusson A, Mühlemann O.

Nat Struct Mol Biol. 2006 May;13(5):462-4. Epub 2006 Apr 23.

PMID:
16622410
47.

Turnover in the Alps: an mRNA perspective. Workshops on mechanisms and regulation of mRNA turnover.

Newbury SF, Mühlemann O, Stoecklin G.

EMBO Rep. 2006 Feb;7(2):143-8. No abstract available.

48.

Applying the brakes on gene expression.

Mühlemann O.

Nat Struct Mol Biol. 2005 Dec;12(12):1024-5. No abstract available.

PMID:
16327770
49.

Transcriptional silencing of nonsense codon-containing immunoglobulin minigenes.

Bühler M, Mohn F, Stalder L, Mühlemann O.

Mol Cell. 2005 Apr 29;18(3):307-17.

50.

A GFP-based reporter system to monitor nonsense-mediated mRNA decay.

Paillusson A, Hirschi N, Vallan C, Azzalin CM, Mühlemann O.

Nucleic Acids Res. 2005 Mar 30;33(6):e54.

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