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Items: 27

1.

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity.

Sustmann C, Dickopf S, Regula JT, Kettenberger H, Mølhøj M, Gassner C, Weininger D, Fenn S, Manigold T, Kling L, Künkele KP, Schwaiger M, Bossenmaier B, Griese JJ, Hopfner KP, Graff-Meyer A, Stahlberg H, Ringler P, Lauer ME, Brinkmann U, Schaefer W, Klein C.

MAbs. 2019 Sep 17:1-13. doi: 10.1080/19420862.2019.1661736. [Epub ahead of print]

PMID:
31526159
2.

Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics.

Tyshchuk O, Gstöttner C, Funk D, Nicolardi S, Frost S, Klostermann S, Becker T, Jolkver E, Schumacher F, Koller CF, Völger HR, Wuhrer M, Bulau P, Mølhøj M.

MAbs. 2019 Oct;11(7):1219-1232. doi: 10.1080/19420862.2019.1635865. Epub 2019 Jul 24.

3.

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.

Claus C, Ferrara C, Xu W, Sam J, Lang S, Uhlenbrock F, Albrecht R, Herter S, Schlenker R, Hüsser T, Diggelmann S, Challier J, Mössner E, Hosse RJ, Hofer T, Brünker P, Joseph C, Benz J, Ringler P, Stahlberg H, Lauer M, Perro M, Chen S, Küttel C, Bhavani Mohan PL, Nicolini V, Birk MC, Ongaro A, Prince C, Gianotti R, Dugan G, Whitlow CT, Solingapuram Sai KK, Caudell DL, Burgos-Rodriguez AG, Cline JM, Hettich M, Ceppi M, Giusti AM, Crameri F, Driessen W, Morcos PN, Freimoser-Grundschober A, Levitsky V, Amann M, Grau-Richards S, von Hirschheydt T, Tournaviti S, Mølhøj M, Fauti T, Heinzelmann-Schwarz V, Teichgräber V, Colombetti S, Bacac M, Zippelius A, Klein C, Umaña P.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaav5989. doi: 10.1126/scitranslmed.aav5989.

PMID:
31189721
4.

Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly.

Regula JT, Imhof-Jung S, Mølhøj M, Benz J, Ehler A, Bujotzek A, Schaefer W, Klein C.

Protein Eng Des Sel. 2018 Jul 1;31(7-8):289-299. doi: 10.1093/protein/gzy021.

5.

GingisKHAN™ protease cleavage allows a high-throughput antibody to Fab conversion enabling direct functional assessment during lead identification of human monoclonal and bispecific IgG1 antibodies.

Moelleken J, Endesfelder M, Gassner C, Lingke S, Tomaschek S, Tyshchuk O, Lorenz S, Reiff U, Mølhøj M.

MAbs. 2017 Oct;9(7):1076-1087. doi: 10.1080/19420862.2017.1364325. Epub 2017 Aug 14.

6.

Detection of a phosphorylated glycine-serine linker in an IgG-based fusion protein.

Tyshchuk O, Völger HR, Ferrara C, Bulau P, Koll H, Mølhøj M.

MAbs. 2017 Jan;9(1):94-103. doi: 10.1080/19420862.2016.1236165. Epub 2016 Sep 23.

7.

Applying mini-bore HPAEC-MS/MS for the characterization and quantification of Fc N-glycans from heterogeneously glycosylated IgGs.

Maier M, Reusch D, Bruggink C, Bulau P, Wuhrer M, Mølhøj M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:342-352. doi: 10.1016/j.jchromb.2016.08.001. Epub 2016 Aug 9.

8.

Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry.

Schaefer W, Völger HR, Lorenz S, Imhof-Jung S, Regula JT, Klein C, Mølhøj M.

MAbs. 2016;8(1):49-55. doi: 10.1080/19420862.2015.1111498. Epub 2015 Oct 23.

9.

Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions.

Sydow JF, Lipsmeier F, Larraillet V, Hilger M, Mautz B, Mølhøj M, Kuentzer J, Klostermann S, Schoch J, Voelger HR, Regula JT, Cramer P, Papadimitriou A, Kettenberger H.

PLoS One. 2014 Jun 24;9(6):e100736. doi: 10.1371/journal.pone.0100736. eCollection 2014.

10.

Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes.

Haberger M, Bomans K, Diepold K, Hook M, Gassner J, Schlothauer T, Zwick A, Spick C, Kepert JF, Hienz B, Wiedmann M, Beck H, Metzger P, Mølhøj M, Knoblich C, Grauschopf U, Reusch D, Bulau P.

MAbs. 2014 Mar-Apr;6(2):327-39. doi: 10.4161/mabs.27876. Epub 2014 Jan 17.

11.

Identification and monitoring of host cell proteins by mass spectrometry combined with high performance immunochemistry testing.

Bomans K, Lang A, Roedl V, Adolf L, Kyriosoglou K, Diepold K, Eberl G, Mølhøj M, Strauss U, Schmalz C, Vogel R, Reusch D, Wegele H, Wiedmann M, Bulau P.

PLoS One. 2013 Nov 27;8(11):e81639. doi: 10.1371/journal.pone.0081639. eCollection 2013.

12.

Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures.

Diepold K, Bomans K, Wiedmann M, Zimmermann B, Petzold A, Schlothauer T, Mueller R, Moritz B, Stracke JO, Mølhøj M, Reusch D, Bulau P.

PLoS One. 2012;7(1):e30295. doi: 10.1371/journal.pone.0030295. Epub 2012 Jan 17.

13.

Identification of potential sites for tryptophan oxidation in recombinant antibodies using tert-butylhydroperoxide and quantitative LC-MS.

Hensel M, Steurer R, Fichtl J, Elger C, Wedekind F, Petzold A, Schlothauer T, Molhoj M, Reusch D, Bulau P.

PLoS One. 2011 Mar 3;6(3):e17708. doi: 10.1371/journal.pone.0017708.

14.

CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis.

Mølhøj M, Crommer S, Brischwein K, Rau D, Sriskandarajah M, Hoffmann P, Kufer P, Hofmeister R, Baeuerle PA.

Mol Immunol. 2007 Mar;44(8):1935-43. Epub 2006 Nov 2.

PMID:
17083975
15.

A humanized monoclonal antibody against interleukin-2 that can inactivate the cytokine/receptor complex.

Volkland J, Lumsden J, Mølhøj M, Raum T, Hausmann S, Wissing S, Wissinger M, Hoffmann P, Sriskandarajah M, Kvesic M, Baeuerle PA, Pflanz S.

Mol Immunol. 2007 Mar;44(7):1743-53. Epub 2006 Sep 26.

PMID:
17000002
16.

A highly stable polyethylene glycol-conjugated human single-chain antibody neutralizing granulocyte-macrophage colony stimulating factor at low nanomolar concentration.

Krinner EM, Hepp J, Hoffmann P, Bruckmaier S, Petersen L, Petsch S, Parr L, Schuster I, Mangold S, Lorenczewski G, Lutterbüse P, Buziol S, Hochheim I, Volkland J, Mølhøj M, Sriskandarajah M, Strasser M, Itin C, Wolf A, Basu A, Yang K, Filpula D, Sørensen P, Kufer P, Baeuerle P, Raum T.

Protein Eng Des Sel. 2006 Oct;19(10):461-70. Epub 2006 Jul 25.

PMID:
16868004
17.

A human monoclonal IgG1 potently neutralizing the pro-inflammatory cytokine GM-CSF.

Krinner EM, Raum T, Petsch S, Bruckmaier S, Schuster I, Petersen L, Cierpka R, Abebe D, Mølhøj M, Wolf A, Sørensen P, Locher M, Baeuerle PA, Hepp J.

Mol Immunol. 2007 Feb;44(5):916-25. Epub 2006 May 11.

PMID:
16697465
18.

Leader sequences are not signal peptides.

Mølhøj M, Degan FD.

Nat Biotechnol. 2004 Dec;22(12):1502. No abstract available.

PMID:
15583649
19.
20.

Identification and characterization of a UDP-D-glucuronate 4-epimerase in Arabidopsis.

Usadel B, Schlüter U, Mølhøj M, Gipmans M, Verma R, Kossmann J, Reiter WD, Pauly M.

FEBS Lett. 2004 Jul 2;569(1-3):327-31.

21.

Molecular analysis of 10 coding regions from Arabidopsis that are homologous to the MUR3 xyloglucan galactosyltransferase.

Li X, Cordero I, Caplan J, Mølhøj M, Reiter WD.

Plant Physiol. 2004 Mar;134(3):940-50.

24.

Towards understanding the role of membrane-bound endo-beta-1,4-glucanases in cellulose biosynthesis.

Mølhøj M, Pagant S, Höfte H.

Plant Cell Physiol. 2002 Dec;43(12):1399-406. Review.

PMID:
12514237

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