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Items: 1 to 50 of 312

1.

Antimicrobial and Immunomodulatory Effect of Gum Arabic on Human and Bovine Granulocytes Against Staphylococcus aureus and Escherichia coli.

Baien SH, Seele J, Henneck T, Freibrodt C, Szura G, Moubasher H, Nau R, Brogden G, Mörgelin M, Singh M, Kietzmann M, von Köckritz-Blickwede M, de Buhr N.

Front Immunol. 2020 Jan 31;10:3119. doi: 10.3389/fimmu.2019.03119. eCollection 2019.

PMID:
32082302
2.
3.

Neutrophil Extracellular Traps in the Pathogenesis of Equine Recurrent Uveitis (ERU).

Fingerhut L, Ohnesorge B, von Borstel M, Schumski A, Strutzberg-Minder K, Mörgelin M, Deeg CA, Haagsman HP, Beineke A, von Köckritz-Blickwede M, de Buhr N.

Cells. 2019 Nov 27;8(12). pii: E1528. doi: 10.3390/cells8121528.

4.

Fasting reveals largely intact systemic lipid mobilization mechanisms in respiratory chain complex III deficient mice.

Tomašić N, Kotarsky H, de Oliveira Figueiredo R, Hansson E, Mörgelin M, Tomašić I, Kallijärvi J, Elmér E, Jauhiainen M, Eklund EA, Fellman V.

Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1;1866(1):165573. doi: 10.1016/j.bbadis.2019.165573. Epub 2019 Oct 29.

PMID:
31672551
5.

C4BP-IgM protein as a therapeutic approach to treat Neisseria gonorrhoeae infections.

Bettoni S, Shaughnessy J, Maziarz K, Ermert D, Gulati S, Zheng B, Mörgelin M, Jacobsson S, Riesbeck K, Unemo M, Ram S, Blom AM.

JCI Insight. 2019 Dec 5;4(23). pii: 131886. doi: 10.1172/jci.insight.131886.

6.

Platelet IP6K1 regulates neutrophil extracellular trap-microparticle complex formation in acute pancreatitis.

Madhi R, Rahman M, Taha D, Linders J, Merza M, Wang Y, Mörgelin M, Thorlacius H.

JCI Insight. 2019 Oct 8. pii: 129270. doi: 10.1172/jci.insight.129270. [Epub ahead of print]

7.

C-terminal proteolysis of the collagen VI α3 chain by BMP-1 and proprotein convertase(s) releases endotrophin in fragments of different sizes.

Heumüller SE, Talantikite M, Napoli M, Armengaud J, Mörgelin M, Hartmann U, Sengle G, Paulsson M, Moali C, Wagener R.

J Biol Chem. 2019 Sep 13;294(37):13769-13780. doi: 10.1074/jbc.RA119.008641. Epub 2019 Jul 25.

PMID:
31346034
8.

Antimicrobial peptides derived from the cartilage.-specific C-type Lectin Domain Family 3 Member A (CLEC3A) - potential in the prevention and treatment of septic arthritis.

Elezagic D, Mörgelin M, Hermes G, Hamprecht A, Sengle G, Lau D, Höllriegl S, Wagener R, Paulsson M, Streichert T, Klatt AR.

Osteoarthritis Cartilage. 2019 Oct;27(10):1564-1573. doi: 10.1016/j.joca.2019.06.007. Epub 2019 Jul 4.

PMID:
31279936
9.

The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus.

Ermert D, Laabei M, Weckel A, Mörgelin M, Lundqvist M, Björck L, Ram S, Linse S, Blom AM.

Front Immunol. 2019 Jun 4;10:1230. doi: 10.3389/fimmu.2019.01230. eCollection 2019.

10.

Neutrophil extracellular trap-microparticle complexes trigger neutrophil recruitment via high-mobility group protein 1 (HMGB1)-toll-like receptors(TLR2)/TLR4 signalling.

Wang Y, Du F, Hawez A, Mörgelin M, Thorlacius H.

Br J Pharmacol. 2019 Sep;176(17):3350-3363. doi: 10.1111/bph.14765. Epub 2019 Jun 17.

PMID:
31206609
11.

The heme and radical scavenger α1-microglobulin (A1M) confers early protection of the immature brain following preterm intraventricular hemorrhage.

Romantsik O, Agyemang AA, Sveinsdóttir S, Rutardóttir S, Holmqvist B, Cinthio M, Mörgelin M, Gumus G, Karlsson H, Hansson SR, Åkerström B, Ley D, Gram M.

J Neuroinflammation. 2019 Jun 7;16(1):122. doi: 10.1186/s12974-019-1486-4.

12.

c-Abl kinase regulates neutrophil extracellular trap formation, inflammation, and tissue damage in severe acute pancreatitis.

Madhi R, Rahman M, Mörgelin M, Thorlacius H.

J Leukoc Biol. 2019 Aug;106(2):455-466. doi: 10.1002/JLB.3A0618-222RR. Epub 2019 Mar 12.

PMID:
30861207
13.

Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy.

Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J.

EMBO Mol Med. 2019 Jan;11(1). pii: e9456. doi: 10.15252/emmm.201809456.

14.

Targeting peptidylarginine deiminase reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis.

Madhi R, Rahman M, Taha D, Mörgelin M, Thorlacius H.

J Cell Physiol. 2019 Jul;234(7):11850-11860. doi: 10.1002/jcp.27874. Epub 2018 Dec 4.

PMID:
30515825
15.

A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis.

Tenland E, Krishnan N, Rönnholm A, Kalsum S, Puthia M, Mörgelin M, Davoudi M, Otrocka M, Alaridah N, Glegola-Madejska I, Sturegård E, Schmidtchen A, Lerm M, Robertson BD, Godaly G.

Tuberculosis (Edinb). 2018 Dec;113:231-238. doi: 10.1016/j.tube.2018.10.008. Epub 2018 Oct 30.

16.

The Pulmonary Extracellular Matrix Is a Bactericidal Barrier Against Haemophilus influenzae in Chronic Obstructive Pulmonary Disease (COPD): Implications for an in vivo Innate Host Defense Function of Collagen VI.

Abdillahi SM, Tati R, Nordin SL, Baumgarten M, Hallgren O, Bjermer L, Erjefält J, Westergren-Thorsson G, Singh B, Riesbeck K, Mörgelin M.

Front Immunol. 2018 Aug 31;9:1988. doi: 10.3389/fimmu.2018.01988. eCollection 2018.

17.

Collagen VI Contains Multiple Host Defense Peptides with Potent In Vivo Activity.

Abdillahi SM, Maaß T, Kasetty G, Strömstedt AA, Baumgarten M, Tati R, Nordin SL, Walse B, Wagener R, Schmidtchen A, Mörgelin M.

J Immunol. 2018 Aug 1;201(3):1007-1020. doi: 10.4049/jimmunol.1700602. Epub 2018 Jun 20.

18.

Titanium granules pre-treated with hydrogen peroxide inhibit growth of bacteria associated with post-operative infections in spine surgery.

Ohlin A, Mattsson E, Mörgelin M, Davies JR, Svensäter G, Corvec S, Tengvall P, Riesbeck K.

Eur Spine J. 2018 Oct;27(10):2463-2468. doi: 10.1007/s00586-018-5619-8. Epub 2018 May 7.

PMID:
29736803
19.

Biological wound matrices with native dermis-like collagen efficiently modulate protease activity.

Tati R, Nordin S, Abdillahi SM, Mörgelin M.

J Wound Care. 2018 Apr 2;27(4):199-209. doi: 10.12968/jowc.2018.27.4.199.

PMID:
29637827
20.

Human IgG Increases Virulence of Streptococcus pyogenes through Complement Evasion.

Ermert D, Weckel A, Magda M, Mörgelin M, Shaughnessy J, Rice PA, Björck L, Ram S, Blom AM.

J Immunol. 2018 May 15;200(10):3495-3505. doi: 10.4049/jimmunol.1800090. Epub 2018 Apr 6.

21.

Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production.

Westman J, Chakrakodi B, Snäll J, Mörgelin M, Bruun Madsen M, Hyldegaard O, Neumann A, Frick IM, Norrby-Teglund A, Björck L, Herwald H.

Front Immunol. 2018 Feb 22;9:236. doi: 10.3389/fimmu.2018.00236. eCollection 2018.

22.

Neutrophil extracellular trap-microparticle complexes enhance thrombin generation via the intrinsic pathway of coagulation in mice.

Wang Y, Luo L, Braun OÖ, Westman J, Madhi R, Herwald H, Mörgelin M, Thorlacius H.

Sci Rep. 2018 Mar 5;8(1):4020. doi: 10.1038/s41598-018-22156-5.

23.

TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators.

Nüchel J, Ghatak S, Zuk AV, Illerhaus A, Mörgelin M, Schönborn K, Blumbach K, Wickström SA, Krieg T, Sengle G, Plomann M, Eckes B.

Autophagy. 2018;14(3):465-486. doi: 10.1080/15548627.2017.1422850. Epub 2018 Mar 11.

24.

The cartilage-specific lectin C-type lectin domain family 3 member A (CLEC3A) enhances tissue plasminogen activator-mediated plasminogen activation.

Lau D, Elezagic D, Hermes G, Mörgelin M, Wohl AP, Koch M, Hartmann U, Höllriegl S, Wagener R, Paulsson M, Streichert T, Klatt AR.

J Biol Chem. 2018 Jan 5;293(1):203-214. doi: 10.1074/jbc.M117.818930. Epub 2017 Nov 16.

25.

Haemophilus Protein F Orthologs of Pathogens Infecting the Airways: Exploiting Host Laminin at Heparin-Binding Sites for Maximal Adherence to Epithelial Cells.

Su YC, Halang P, Fleury C, Jalalvand F, Mörgelin M, Riesbeck K.

J Infect Dis. 2017 Dec 5;216(10):1303-1307. doi: 10.1093/infdis/jix467.

PMID:
28968674
26.

Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis.

Sonesson A, Przybyszewska K, Eriksson S, Mörgelin M, Kjellström S, Davies J, Potempa J, Schmidtchen A.

Sci Rep. 2017 Aug 18;7(1):8689. doi: 10.1038/s41598-017-08046-2.

27.

Thrombin-Derived Host-Defense Peptides Modulate Monocyte/Macrophage Inflammatory Responses to Gram-Negative Bacteria.

Hansen FC, Strömdahl AC, Mörgelin M, Schmidtchen A, van der Plas MJA.

Front Immunol. 2017 Jul 21;8:843. doi: 10.3389/fimmu.2017.00843. eCollection 2017.

28.

Syncytiotrophoblast derived extracellular vesicles transfer functional placental miRNAs to primary human endothelial cells.

Cronqvist T, Tannetta D, Mörgelin M, Belting M, Sargent I, Familari M, Hansson SR.

Sci Rep. 2017 Jul 4;7(1):4558. doi: 10.1038/s41598-017-04468-0.

29.

Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism.

Petrlova J, Hansen FC, van der Plas MJA, Huber RG, Mörgelin M, Malmsten M, Bond PJ, Schmidtchen A.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4213-E4222. doi: 10.1073/pnas.1619609114. Epub 2017 May 4.

30.

Rac1 regulates sepsis-induced formation of platelet-derived microparticles and thrombin generation.

Wang Y, Luo L, Mörgelin M, Thorlacius H.

Biochem Biophys Res Commun. 2017 Jun 10;487(4):887-891. doi: 10.1016/j.bbrc.2017.04.147. Epub 2017 Apr 29.

PMID:
28465231
31.

Ketogenic diet attenuates hepatopathy in mouse model of respiratory chain complex III deficiency caused by a Bcs1l mutation.

Purhonen J, Rajendran J, Mörgelin M, Uusi-Rauva K, Katayama S, Krjutskov K, Einarsdottir E, Velagapudi V, Kere J, Jauhiainen M, Fellman V, Kallijärvi J.

Sci Rep. 2017 Apr 19;7(1):957. doi: 10.1038/s41598-017-01109-4.

32.

Platelet-derived microparticles regulates thrombin generation via phophatidylserine in abdominal sepsis.

Wang Y, Zhang S, Luo L, Norström E, Braun OÖ, Mörgelin M, Thorlacius H.

J Cell Physiol. 2018 Feb;233(2):1051-1060. doi: 10.1002/jcp.25959. Epub 2017 Jun 6.

PMID:
28409836
33.

Heparin-Binding Protein (HBP): A Causative Marker and Potential Target for Heparin Treatment of Human Sepsis-Induced Acute Kidney Injury.

Fisher J, Russell JA, Bentzer P, Parsons D, Secchia S, Mörgelin M, Walley KR, Boyd JH, Linder A.

Shock. 2017 Sep;48(3):313-320. doi: 10.1097/SHK.0000000000000862.

PMID:
28319494
34.

Antibacterial and antibiofilm effects of sodium hypochlorite against Staphylococcus aureus isolates derived from patients with atopic dermatitis.

Eriksson S, van der Plas MJA, Mörgelin M, Sonesson A.

Br J Dermatol. 2017 Aug;177(2):513-521. doi: 10.1111/bjd.15410. Epub 2017 Jul 3.

PMID:
28238217
35.

Neutrophil Protease Cleavage of Von Willebrand Factor in Glomeruli - An Anti-thrombotic Mechanism in the Kidney.

Tati R, Kristoffersson AC, Manea Hedström M, Mörgelin M, Wieslander J, van Kooten C, Karpman D.

EBioMedicine. 2017 Feb;16:302-311. doi: 10.1016/j.ebiom.2017.01.032. Epub 2017 Jan 24.

36.

Erratum to: Heparin-binding protein is important for vascular leak in sepsis.

Bentzer P, Fisher J, Kong HJ, Mörgelin M, Boyd JH, Walley KR, Russell JA, Linder A.

Intensive Care Med Exp. 2017 Dec;5(1):6. doi: 10.1186/s40635-017-0119-4. Epub 2017 Jan 20. No abstract available.

37.

Microvesicle transfer of kinin B1-receptors is a novel inflammatory mechanism in vasculitis.

Kahn R, Mossberg M, Ståhl AL, Johansson K, Lopatko Lindman I, Heijl C, Segelmark M, Mörgelin M, Leeb-Lundberg LM, Karpman D.

Kidney Int. 2017 Jan;91(1):96-105. doi: 10.1016/j.kint.2016.09.023. Epub 2016 Dec 1.

PMID:
27914700
38.
39.

DNA-fragmentation is a source of bactericidal activity against Pseudomonas aeruginosa.

Bhongir RK, Kasetty G, Papareddy P, Mörgelin M, Herwald H, Egesten A.

Biochem J. 2017 Feb 1;474(3):411-425. doi: 10.1042/BCJ20160706. Epub 2016 Oct 26.

PMID:
27784762
40.

Heparin-binding protein is important for vascular leak in sepsis.

Bentzer P, Fisher J, Kong HJ, Mörgelin M, Boyd JH, Walley KR, Russell JA, Linder A.

Intensive Care Med Exp. 2016 Dec;4(1):33. Epub 2016 Oct 4. Erratum in: Intensive Care Med Exp. 2017 Dec;5(1):6.

41.

Biofilm in group A streptococcal necrotizing soft tissue infections.

Siemens N, Chakrakodi B, Shambat SM, Morgan M, Bergsten H, Hyldegaard O, Skrede S, Arnell P, Madsen MB, Johansson L; INFECT Study Group, Juarez J, Bosnjak L, Mörgelin M, Svensson M, Norrby-Teglund A.

JCI Insight. 2016 Jul 7;1(10):e87882. doi: 10.1172/jci.insight.87882.

42.

The Tyrosine Sulfate Domain of Fibromodulin Binds Collagen and Enhances Fibril Formation.

Tillgren V, Mörgelin M, Önnerfjord P, Kalamajski S, Aspberg A.

J Biol Chem. 2016 Nov 4;291(45):23744-23755. Epub 2016 Sep 15.

43.

High Presence of Extracellular Hemoglobin in the Periventricular White Matter Following Preterm Intraventricular Hemorrhage.

Ley D, Romantsik O, Vallius S, Sveinsdóttir K, Sveinsdóttir S, Agyemang AA, Baumgarten M, Mörgelin M, Lutay N, Bruschettini M, Holmqvist B, Gram M.

Front Physiol. 2016 Aug 3;7:330. doi: 10.3389/fphys.2016.00330. eCollection 2016.

44.

Saliva-Induced Clotting Captures Streptococci: Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion.

Wollein Waldetoft K, Mohanty T, Karlsson C, Mörgelin M, Frick IM, Malmström J, Björck L.

Infect Immun. 2016 Sep 19;84(10):2813-23. doi: 10.1128/IAI.00307-16. Print 2016 Oct.

45.

Acetic acid as a decontamination method for sink drains in a nosocomial outbreak of metallo-β-lactamase-producing Pseudomonas aeruginosa.

Stjärne Aspelund A, Sjöström K, Olsson Liljequist B, Mörgelin M, Melander E, Påhlman LI.

J Hosp Infect. 2016 Sep;94(1):13-20. doi: 10.1016/j.jhin.2016.05.009. Epub 2016 May 24.

46.

CD14 Is a Co-Receptor for TLR4 in the S100A9-Induced Pro-Inflammatory Response in Monocytes.

He Z, Riva M, Björk P, Swärd K, Mörgelin M, Leanderson T, Ivars F.

PLoS One. 2016 May 26;11(5):e0156377. doi: 10.1371/journal.pone.0156377. eCollection 2016.

47.

Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses.

van der Plas MJ, Bhongir RK, Kjellström S, Siller H, Kasetty G, Mörgelin M, Schmidtchen A.

Nat Commun. 2016 May 16;7:11567. doi: 10.1038/ncomms11567.

48.

Modulation of Hemostatic and Inflammatory Responses by Leptospira Spp.

Vieira ML, Naudin C, Mörgelin M, Romero EC, Nascimento AL, Herwald H.

PLoS Negl Trop Dis. 2016 May 11;10(5):e0004713. doi: 10.1371/journal.pntd.0004713. eCollection 2016 May.

49.

The Respiratory Pathogen Moraxella catarrhalis Targets Collagen for Maximal Adherence to Host Tissues.

Singh B, Alvarado-Kristensson M, Johansson M, Hallgren O, Westergren-Thorsson G, Mörgelin M, Riesbeck K.

mBio. 2016 Mar 22;7(2):e00066. doi: 10.1128/mBio.00066-16.

50.

The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles.

Happonen KE, Tran S, Mörgelin M, Prince R, Calzavarini S, Angelillo-Scherrer A, Dahlbäck B.

J Biol Chem. 2016 May 13;291(20):10586-601. doi: 10.1074/jbc.M115.699058. Epub 2016 Mar 22.

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