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Items: 1 to 50 of 140

1.

Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice.

Fraszczak J, Vadnais C, Rashkovan M, Ross J, Beauchemin H, Chen R, Grapton D, Khandanpour C, Möröy T.

Leukemia. 2018 Jun 20. doi: 10.1038/s41375-018-0166-1. [Epub ahead of print]

PMID:
29925903
2.

GFI1 is required for RUNX1/ETO positive acute myeloid leukemia.

Marneth AE, Botezatu L, Hönes JM, Israël JCL, Schütte J, Vassen L, Lams RF, Bergevoet SM, Groothuis L, Mandoli A, Martens JHA, Huls G, Jansen JH, Dührsen U, Berg T, Möröy T, Wichmann C, Lo MC, Zhang DE, van der Reijden BA, Khandanpour C.

Haematologica. 2018 Apr 19. pii: haematol.2017.180844. doi: 10.3324/haematol.2017.180844. [Epub ahead of print] No abstract available.

3.

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.

Vadnais C, Chen R, Fraszczak J, Yu Z, Boulais J, Pinder J, Frank D, Khandanpour C, Hébert J, Dellaire G, Côté JF, Richard S, Orthwein A, Drobetsky E, Möröy T.

Nat Commun. 2018 Apr 12;9(1):1418. doi: 10.1038/s41467-018-03817-5.

4.

Generation and characterization of human iPSC line MML-6838-Cl2 from mobilized peripheral blood derived megakaryoblasts.

Hansen M, Varga E, Wüst T, Brouwer N, Beauchemin H, Mellink C, van der Kevie-Kersemaekers AM, Möröy T, van der Reijden B, von Lindern M, van den Akker E.

Stem Cell Res. 2017 Jan;18:26-28. doi: 10.1016/j.scr.2016.12.004. Epub 2016 Dec 10.

5.

Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes.

Beauchemin H, Shooshtarizadeh P, Vadnais C, Vassen L, Pastore YD, Möröy T.

Haematologica. 2017 Mar;102(3):484-497. doi: 10.3324/haematol.2016.150375. Epub 2017 Jan 12.

6.

The role of the transcriptional repressor growth factor independent 1 in the formation of myeloid cells.

Fraszczak J, Möröy T.

Curr Opin Hematol. 2017 Jan;24(1):32-37. Review.

PMID:
27820734
7.

Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1.

Fraszczak J, Helness A, Chen R, Vadnais C, Robert F, Khandanpour C, Möröy T.

PLoS One. 2016 Jul 28;11(7):e0160344. doi: 10.1371/journal.pone.0160344. eCollection 2016.

8.

Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells.

Gaudreau MC, Grapton D, Helness A, Vadnais C, Fraszczak J, Shooshtarizadeh P, Wilhelm B, Robert F, Heyd F, Möröy T.

Sci Rep. 2016 Jun 7;6:27379. doi: 10.1038/srep27379.

9.

Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML.

Botezatu L, Michel LC, Helness A, Vadnais C, Makishima H, Hönes JM, Robert F, Vassen L, Thivakaran A, Al-Matary Y, Lams RF, Schütte J, Giebel B, Görgens A, Heuser M, Medyouf H, Maciejewski J, Dührsen U, Möröy T, Khandanpour C.

Exp Hematol. 2016 Aug;44(8):713-726.e14. doi: 10.1016/j.exphem.2016.05.004. Epub 2016 May 20.

10.

GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome.

Botezatu L, Michel LC, Makishima H, Schroeder T, Germing U, Haas R, van der Reijden B, Marneth AE, Bergevoet SM, Jansen JH, Przychodzen B, Wlodarski M, Niemeyer C, Platzbecker U, Ehninger G, Unnikrishnan A, Beck D, Pimanda J, Hellström-Lindberg E, Malcovati L, Boultwood J, Pellagatti A, Papaemmanuil E, Le Coutre P, Kaeda J, Opalka B, Möröy T, Dührsen U, Maciejewski J, Khandanpour C.

Exp Hematol. 2016 Jul;44(7):590-595.e1. doi: 10.1016/j.exphem.2016.04.001. Epub 2016 Apr 11.

11.

GFI1 as a novel prognostic and therapeutic factor for AML/MDS.

Hönes JM, Botezatu L, Helness A, Vadnais C, Vassen L, Robert F, Hergenhan SM, Thivakaran A, Schütte J, Al-Matary YS, Lams RF, Fraszscak J, Makishima H, Radivoyevitch T, Przychodzen B, da Conceição Castro SV, Görgens A, Giebel B, Klein-Hitpass L, Lennartz K, Heuser M, Thiede C, Ehninger G, Dührsen U, Maciejewski JP, Möröy T, Khandanpour C.

Leukemia. 2016 Jun;30(6):1237-45. doi: 10.1038/leu.2016.11. Epub 2016 Feb 5.

PMID:
26847026
12.

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.

Thambyrajah R, Mazan M, Patel R, Moignard V, Stefanska M, Marinopoulou E, Li Y, Lancrin C, Clapes T, Möröy T, Robin C, Miller C, Cowley S, Göttgens B, Kouskoff V, Lacaud G.

Nat Cell Biol. 2016 Jan;18(1):21-32. doi: 10.1038/ncb3276. Epub 2015 Nov 30.

PMID:
26619147
13.

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation.

Möröy T, Vassen L, Wilkes B, Khandanpour C.

Blood. 2015 Dec 10;126(24):2561-9. doi: 10.1182/blood-2015-06-655043. Epub 2015 Oct 7. Review.

14.

Neural differentiation modulates the vertebrate brain specific splicing program.

Madgwick A, Fort P, Hanson PS, Thibault P, Gaudreau MC, Lutfalla G, Möröy T, Abou Elela S, Chaudhry B, Elliott DJ, Morris CM, Venables JP.

PLoS One. 2015 May 19;10(5):e0125998. doi: 10.1371/journal.pone.0125998. eCollection 2015.

15.

Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination.

Rashkovan M, Vadnais C, Ross J, Gigoux M, Suh WK, Gu W, Kosan C, Möröy T.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5411-9. doi: 10.1073/pnas.1412107111. Epub 2014 Dec 2.

16.

The transcription factor Miz-1 is required for embryonic and stress-induced erythropoiesis but dispensable for adult erythropoiesis.

Kosan C, Rashkovan M, Ross J, Schaffer AM, Saba I, Lemsaddek W, Trudel M, Möröy T.

Am J Blood Res. 2014 Sep 5;4(1):7-19. eCollection 2014.

17.

Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice.

Preußner M, Wilhelmi I, Schultz AS, Finkernagel F, Michel M, Möröy T, Heyd F.

Mol Cell. 2014 May 22;54(4):651-62. doi: 10.1016/j.molcel.2014.04.015. Epub 2014 May 15.

18.

Growth factor independence 1b (gfi1b) is important for the maturation of erythroid cells and the regulation of embryonic globin expression.

Vassen L, Beauchemin H, Lemsaddek W, Krongold J, Trudel M, Möröy T.

PLoS One. 2014 May 6;9(5):e96636. doi: 10.1371/journal.pone.0096636. eCollection 2014.

19.

Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.

Phelan JD, Saba I, Zeng H, Kosan C, Messer MS, Olsson HA, Fraszczak J, Hildeman DA, Aronow BJ, Möröy T, Grimes HL.

PLoS Genet. 2013;9(9):e1003713. doi: 10.1371/journal.pgen.1003713. Epub 2013 Sep 12.

20.
21.

Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.

Khandanpour C, Phelan JD, Vassen L, Schütte J, Chen R, Horman SR, Gaudreau MC, Krongold J, Zhu J, Paul WE, Dührsen U, Göttgens B, Grimes HL, Möröy T.

Cancer Cell. 2013 Feb 11;23(2):200-14. doi: 10.1016/j.ccr.2013.01.011.

22.
23.

The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.

Khandanpour C, Krongold J, Schütte J, Bouwman F, Vassen L, Gaudreau MC, Chen R, Calero-Nieto FJ, Diamanti E, Hannah R, Meyer SE, Grimes HL, van der Reijden BA, Jansen JH, Patel CV, Peeters JK, Löwenberg B, Dührsen U, Göttgens B, Möröy T.

Blood. 2012 Nov 8;120(19):4006-17. doi: 10.1182/blood-2011-02-334722. Epub 2012 Aug 28.

24.

CD8 lineage-specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1.

Ligons DL, Tuncer C, Linowes BA, Akcay IM, Kurtulus S, Deniz E, Atasever Arslan B, Cevik SI, Keller HR, Luckey MA, Feigenbaum L, Möröy T, Ersahin T, Atalay R, Erman B, Park JH.

J Biol Chem. 2012 Oct 5;287(41):34386-99. doi: 10.1074/jbc.M112.378687. Epub 2012 Aug 3.

25.

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.

Lancrin C, Mazan M, Stefanska M, Patel R, Lichtinger M, Costa G, Vargel O, Wilson NK, Möröy T, Bonifer C, Göttgens B, Kouskoff V, Lacaud G.

Blood. 2012 Jul 12;120(2):314-22. doi: 10.1182/blood-2011-10-386094. Epub 2012 Jun 5.

26.

Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L regulates development, proliferation, and migration of thymic pre-T cells.

Gaudreau MC, Heyd F, Bastien R, Wilhelm B, Möröy T.

J Immunol. 2012 Jun 1;188(11):5377-88. doi: 10.4049/jimmunol.1103142. Epub 2012 Apr 20.

27.

Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1.

Schulz D, Vassen L, Chow KT, McWhirter SM, Amin RH, Möröy T, Schlissel MS.

J Exp Med. 2012 Jan 16;209(1):187-99. doi: 10.1084/jem.20110645. Epub 2011 Dec 26.

28.

Origin of the brush cell lineage in the mouse intestinal epithelium.

Bjerknes M, Khandanpour C, Möröy T, Fujiyama T, Hoshino M, Klisch TJ, Ding Q, Gan L, Wang J, Martín MG, Cheng H.

Dev Biol. 2012 Feb 15;362(2):194-218. doi: 10.1016/j.ydbio.2011.12.009. Epub 2011 Dec 13.

29.

The role of the transcription factor Miz-1 in lymphocyte development and lymphomagenesis-Binding Myc makes the difference.

Möröy T, Saba I, Kosan C.

Semin Immunol. 2011 Oct;23(5):379-87. doi: 10.1016/j.smim.2011.09.001. Epub 2011 Oct 13. Review.

PMID:
22000024
30.

Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation.

Möröy T, Khandanpour C.

Semin Immunol. 2011 Oct;23(5):368-78. doi: 10.1016/j.smim.2011.08.006. Epub 2011 Sep 14. Review.

PMID:
21920773
31.

Miz-1 is required to coordinate the expression of TCRbeta and p53 effector genes at the pre-TCR "beta-selection" checkpoint.

Saba I, Kosan C, Vassen L, Klein-Hitpass L, Möröy T.

J Immunol. 2011 Sep 15;187(6):2982-92. doi: 10.4049/jimmunol.1101451. Epub 2011 Aug 12.

32.

Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease.

Khandanpour C, Kosan C, Gaudreau MC, Dührsen U, Hébert J, Zeng H, Möröy T.

Stem Cells. 2011 Feb;29(2):376-85. doi: 10.1002/stem.575.

33.

The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1.

Heyd F, Chen R, Afshar K, Saba I, Lazure C, Fiolka K, Möröy T.

Biochim Biophys Acta. 2011 Apr-Jun;1809(4-6):255-61. doi: 10.1016/j.bbagrm.2011.04.009. Epub 2011 May 1.

PMID:
21570500
34.

IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1.

Saba I, Kosan C, Vassen L, Möröy T.

Blood. 2011 Mar 24;117(12):3370-81. doi: 10.1182/blood-2010-09-310680. Epub 2011 Jan 21.

35.

Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation.

Kosan C, Saba I, Godmann M, Herold S, Herkert B, Eilers M, Möröy T.

Immunity. 2010 Dec 14;33(6):917-28. doi: 10.1016/j.immuni.2010.11.028.

36.

Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells.

Khandanpour C, Sharif-Askari E, Vassen L, Gaudreau MC, Zhu J, Paul WE, Okayama T, Kosan C, Möröy T.

Blood. 2010 Dec 9;116(24):5149-61. doi: 10.1182/blood-2010-04-280305. Epub 2010 Sep 8.

37.

The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance.

van Riggelen J, Müller J, Otto T, Beuger V, Yetil A, Choi PS, Kosan C, Möröy T, Felsher DW, Eilers M.

Genes Dev. 2010 Jun 15;24(12):1281-94. doi: 10.1101/gad.585710.

38.

Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65.

Sharif-Askari E, Vassen L, Kosan C, Khandanpour C, Gaudreau MC, Heyd F, Okayama T, Jin J, Rojas ME, Grimes HL, Zeng H, Möröy T.

Mol Cell Biol. 2010 Aug;30(16):3929-42. doi: 10.1128/MCB.00087-10. Epub 2010 Jun 14.

39.

A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.

Khandanpour C, Thiede C, Valk PJ, Sharif-Askari E, Nückel H, Lohmann D, Horsthemke B, Siffert W, Neubauer A, Grzeschik KH, Bloomfield CD, Marcucci G, Maharry K, Slovak ML, van der Reijden BA, Jansen JH, Schackert HK, Afshar K, Schnittger S, Peeters JK, Kroschinsky F, Ehninger G, Lowenberg B, Dührsen U, Möröy T.

Blood. 2010 Mar 25;115(12):2462-72. doi: 10.1182/blood-2009-08-239822. Epub 2010 Jan 14.

40.

Gfi1 negatively regulates T(h)17 differentiation by inhibiting RORgammat activity.

Ichiyama K, Hashimoto M, Sekiya T, Nakagawa R, Wakabayashi Y, Sugiyama Y, Komai K, Saba I, Möröy T, Yoshimura A.

Int Immunol. 2009 Jul;21(7):881-9. doi: 10.1093/intimm/dxp054. Epub 2009 Jun 7.

PMID:
19505891
41.

Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia.

Vassen L, Khandanpour C, Ebeling P, van der Reijden BA, Jansen JH, Mahlmann S, Dührsen U, Möröy T.

Int J Hematol. 2009 May;89(4):422-430. doi: 10.1007/s12185-009-0286-5. Epub 2009 Apr 10.

PMID:
19360458
42.

The zinc finger protein Gfi1 is implicated in the regulation of IgG2b production and the expression of Igamma2b germline transcripts.

Igwe E, Kosan C, Khandanpour C, Sharif-Askari E, Brüne B, Möröy T.

Eur J Immunol. 2008 Nov;38(11):3004-14. doi: 10.1002/eji.200838251.

43.

Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia.

Kirjavainen A, Sulg M, Heyd F, Alitalo K, Ylä-Herttuala S, Möröy T, Petrova TV, Pirvola U.

Dev Biol. 2008 Oct 1;322(1):33-45. doi: 10.1016/j.ydbio.2008.07.004. Epub 2008 Jul 9.

44.

Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26.

Heyd F, Carmo-Fonseca M, Möröy T.

J Biol Chem. 2008 Jul 11;283(28):19636-45. doi: 10.1074/jbc.M801014200. Epub 2008 May 6.

45.

The zinc finger protein and transcriptional repressor Gfi1 as a regulator of the innate immune response.

Möröy T, Zeng H, Jin J, Schmid KW, Carpinteiro A, Gulbins E.

Immunobiology. 2008;213(3-4):341-52. doi: 10.1016/j.imbio.2007.11.004. Epub 2008 Jan 3.

PMID:
18406379
46.

Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function.

Pargmann D, Yücel R, Kosan C, Saba I, Klein-Hitpass L, Schimmer S, Heyd F, Dittmer U, Möröy T.

Eur J Immunol. 2007 Dec;37(12):3551-63.

47.

Miz1 is required for hair follicle structure and hair morphogenesis.

Gebhardt A, Kosan C, Herkert B, Möröy T, Lutz W, Eilers M, Elsässer HP.

J Cell Sci. 2007 Aug 1;120(Pt 15):2586-93. Epub 2007 Jul 17.

48.

The impact of alternative splicing in vivo: mouse models show the way.

Möröy T, Heyd F.

RNA. 2007 Aug;13(8):1155-71. Epub 2007 Jun 11. Review.

49.
50.

Regulation of pulmonary Pseudomonas aeruginosa infection by the transcriptional repressor Gfi1.

Grassmé H, Jin J, Wilker B, von Kürthy G, Wick W, Weller M, Möröy T, Gulbins E.

Cell Microbiol. 2006 Jul;8(7):1096-105.

PMID:
16819963

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