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Items: 1 to 50 of 89

1.

Synthetic sideromycins (skepticism and optimism): selective generation of either broad or narrow spectrum Gram-negative antibiotics.

Lin YM, Ghosh M, Miller PA, Möllmann U, Miller MJ.

Biometals. 2019 Mar 27. doi: 10.1007/s10534-019-00192-6. [Epub ahead of print]

PMID:
30919118
2.

Evaluation of Cervical Elastography Strain Pattern to Predict Preterm Birth.

Gesthuysen A, Hammer K, Möllers M, Braun J, Oelmeier de Murcia K, Falkenberg MK, Köster HA, Möllmann U, Fruscalzo A, Bormann E, Klockenbusch W, Schmitz R.

Ultraschall Med. 2019 Mar 25. doi: 10.1055/a-0865-1711. [Epub ahead of print]

PMID:
30909310
3.

Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.

Richter A, Rudolph I, Möllmann U, Voigt K, Chung CW, Singh OMP, Rees M, Mendoza-Losana A, Bates R, Ballell L, Batt S, Veerapen N, Fütterer K, Besra G, Imming P, Argyrou A.

Sci Rep. 2018 Sep 7;8(1):13473. doi: 10.1038/s41598-018-31316-6.

4.

Siderophore Conjugates of Daptomycin are Potent Inhibitors of Carbapenem Resistant Strains of Acinetobacter baumannii.

Ghosh M, Lin YM, Miller PA, Möllmann U, Boggess WC, Miller MJ.

ACS Infect Dis. 2018 Oct 12;4(10):1529-1535. doi: 10.1021/acsinfecdis.8b00150. Epub 2018 Aug 9.

PMID:
30043609
5.

Targeted Antibiotic Delivery: Selective Siderophore Conjugation with Daptomycin Confers Potent Activity against Multidrug Resistant Acinetobacter baumannii Both in Vitro and in Vivo.

Ghosh M, Miller PA, Möllmann U, Claypool WD, Schroeder VA, Wolter WR, Suckow M, Yu H, Li S, Huang W, Zajicek J, Miller MJ.

J Med Chem. 2017 Jun 8;60(11):4577-4583. doi: 10.1021/acs.jmedchem.7b00102. Epub 2017 Apr 1.

PMID:
28287735
6.

Assessment of cervical elastography strain pattern and its association with preterm birth.

Oturina V, Hammer K, Möllers M, Braun J, Falkenberg MK, de Murcia KO, Möllmann U, Eveslage M, Fruscalzo A, Klockenbusch W, Schmitz R.

J Perinat Med. 2017 Nov 27;45(8):925-932. doi: 10.1515/jpm-2016-0375.

PMID:
28258974
7.

Fetal thymus size in pregnant women with diabetic diseases.

Dörnemann R, Koch R, Möllmann U, Falkenberg MK, Möllers M, Klockenbusch W, Schmitz R.

J Perinat Med. 2017 Jul 26;45(5):595-601. doi: 10.1515/jpm-2016-0400.

PMID:
28195554
8.

In Vivo Dearomatization of the Potent Antituberculosis Agent BTZ043 via Meisenheimer Complex Formation.

Kloss F, Krchnak V, Krchnakova A, Schieferdecker S, Dreisbach J, Krone V, Möllmann U, Hoelscher M, Miller MJ.

Angew Chem Int Ed Engl. 2017 Feb 13;56(8):2187-2191. doi: 10.1002/anie.201609737. Epub 2017 Jan 18.

PMID:
28097740
9.

Quantification of mechanical dyssynchrony in growth restricted fetuses and normal controls using speckle tracking echocardiography (STE).

Krause K, Möllers M, Hammer K, Falkenberg MK, Möllmann U, Görlich D, Klockenbusch W, Schmitz R.

J Perinat Med. 2017 Oct 26;45(7):821-827. doi: 10.1515/jpm-2016-0280.

PMID:
28063262
10.

Importance of Transvaginal Elastography in the Diagnosis of Uterine Fibroids and Adenomyosis.

Frank ML, Schäfer SD, Möllers M, Falkenberg MK, Braun J, Möllmann U, Strube F, Fruscalzo A, Amler S, Klockenbusch W, Schmitz R.

Ultraschall Med. 2016 Aug;37(4):373-8. doi: 10.1055/s-0035-1553266. Epub 2015 Aug 14.

PMID:
26274380
11.

Heterotopic bone formation in the musculus latissimus dorsi of sheep using β-tricalcium phosphate scaffolds: evaluation of an extended prefabrication time on bone formation and matrix degeneration.

Spalthoff S, Jehn P, Zimmerer R, Möllmann U, Gellrich NC, Kokemueller H.

Int J Oral Maxillofac Surg. 2015 Jun;44(6):791-7. doi: 10.1016/j.ijom.2014.11.012. Epub 2015 Jan 22.

PMID:
25617952
12.

Design and Syntheses of Anti-Tuberculosis Agents Inspired by BTZ043 Using a Scaffold Simplification Strategy.

Tiwari R, Möllmann U, Cho S, Franzblau SG, Miller PA, Miller MJ.

ACS Med Chem Lett. 2014 Mar 3;5(5):587-91. doi: 10.1021/ml500039g. eCollection 2014 May 8.

13.

Imaging of fetal thymus in pregnant women with rheumatic diseases.

Warby AC, Amler S, Jacobi AM, Hammer K, Möllmann U, Falkenberg MK, Möllers M, Kiesel L, Klockenbusch W, Schmitz R.

J Perinat Med. 2014 Sep;42(5):635-9. doi: 10.1515/jpm-2013-0314.

PMID:
24552965
14.

Trihydroxamate siderophore-fluoroquinolone conjugates are selective sideromycin antibiotics that target Staphylococcus aureus.

Wencewicz TA, Long TE, Möllmann U, Miller MJ.

Bioconjug Chem. 2013 Mar 20;24(3):473-86. doi: 10.1021/bc300610f. Epub 2013 Feb 14.

15.

Quantitative elastography for cervical stiffness assessment during pregnancy.

Fruscalzo A, Londero AP, Fröhlich C, Möllmann U, Schmitz R.

Biomed Res Int. 2014;2014:826535. doi: 10.1155/2014/826535. Epub 2014 Mar 5.

16.

Identification of antitubercular benzothiazinone compounds by ligand-based design.

Karoli T, Becker B, Zuegg J, Möllmann U, Ramu S, Huang JX, Cooper MA.

J Med Chem. 2012 Sep 13;55(17):7940-4. doi: 10.1021/jm3008882. Epub 2012 Aug 31.

PMID:
22916795
17.

Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction.

Ji C, Lin W, Moraski GC, Thanassi JA, Pucci MJ, Franzblau SG, Möllmann U, Miller MJ.

Bioorg Med Chem. 2012 Jun 1;20(11):3422-8. doi: 10.1016/j.bmc.2012.04.026. Epub 2012 Apr 18.

18.

Structure-activity relationships of 2-benzylsulfanylbenzothiazoles: synthesis and selective antimycobacterial properties.

Klimesová V, Koci J, Palát K, Stolariková J, Dahse HM, Möllmann U.

Med Chem. 2012 Mar;8(2):281-92.

PMID:
22385183
19.

Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria.

Miller MJ, Walz AJ, Zhu H, Wu C, Moraski G, Möllmann U, Tristani EM, Crumbliss AL, Ferdig MT, Checkley L, Edwards RL, Boshoff HI.

J Am Chem Soc. 2011 Feb 23;133(7):2076-9. doi: 10.1021/ja109665t. Epub 2011 Jan 28.

20.

A note to the biological activity of benzoxazine derivatives containing the thioxo group.

Waisser K, Petrlíková E, Perina M, Klimesová V, Kunes J, Palát K Jr, Kaustová J, Dahse HM, Möllmann U.

Eur J Med Chem. 2010 Jul;45(7):2719-25. doi: 10.1016/j.ejmech.2010.02.037. Epub 2010 Feb 20.

PMID:
20226572
21.

Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters.

Moraski GC, Chang M, Villegas-Estrada A, Franzblau SG, Möllmann U, Miller MJ.

Eur J Med Chem. 2010 May;45(5):1703-16. doi: 10.1016/j.ejmech.2009.12.074. Epub 2010 Jan 14.

22.

Preparation and biological evaluation of novel leucomycin analogs derived from nitroso Diels-Alder reactions.

Yang B, Zöllner T, Gebhardt P, Möllmann U, Miller MJ.

Org Biomol Chem. 2010 Feb 7;8(3):691-7. doi: 10.1039/b922450e. Epub 2009 Dec 11.

23.

Evaluation of madurahydroxylactone as a slow release antibacterial implant coating.

Badar M, Hemmen K, Nimtz M, Stieve M, Stiesch M, Lenarz T, Hauser H, Möllmann U, Vogt S, Schnabelrauch M, Mueller PP.

Open Biomed Eng J. 2010;4:263-70. doi: 10.2174/1874120701004010263. Epub 2010 Nov 3.

24.

Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry.

Yan S, Miller MJ, Wencewicz TA, Möllmann U.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1302-5. doi: 10.1016/j.bmcl.2009.10.018. Epub 2009 Oct 8.

25.

2-amino-3-(oxirane-2,3-dicarboxamido)-propanoyl-valine, an effective peptide antibiotic from the epiphyte Pantoea agglomerans 48b/90.

Sammer UF, Völksch B, Möllmann U, Schmidtke M, Spiteller P, Spiteller M, Spiteller D.

Appl Environ Microbiol. 2009 Dec;75(24):7710-7. doi: 10.1128/AEM.01244-09. Epub 2009 Oct 9.

26.

Antimicrobial, antiproliferative, cytotoxic, and tau inhibitory activity of rubellins and caeruleoramularin produced by the phytopathogenic fungus Ramularia collo-cygni.

Miethbauer S, Gaube F, Möllmann U, Dahse HM, Schmidtke M, Gareis M, Pickhardt M, Liebermann B.

Planta Med. 2009 Nov;75(14):1523-5. doi: 10.1055/s-0029-1185835. Epub 2009 Jun 29.

PMID:
19565437
27.

Syntheses and biological activity studies of novel sterol analogs from nitroso Diels-Alder reactions of ergosterol.

Yang B, Miller PA, Möllmann U, Miller MJ.

Org Lett. 2009 Jul 2;11(13):2828-31. doi: 10.1021/ol900997t.

28.

Preparation and in-vitro evaluation of 4-benzylsulfanylpyridine-2-carbohydrazides as potential antituberculosis agents.

Herzigová P, Klimesová V, Palát K, Kaustová J, Dahse HM, Möllmann U.

Arch Pharm (Weinheim). 2009 Jul;342(7):394-404. doi: 10.1002/ardp.200800227.

PMID:
19536781
29.

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.

Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST.

Science. 2009 May 8;324(5928):801-4. doi: 10.1126/science.1171583. Epub 2009 Mar 19.

31.

Siderophores as drug delivery agents: application of the "Trojan Horse" strategy.

Möllmann U, Heinisch L, Bauernfeind A, Köhler T, Ankel-Fuchs D.

Biometals. 2009 Aug;22(4):615-24. doi: 10.1007/s10534-009-9219-2. Epub 2009 Feb 12.

PMID:
19214755
32.

Utilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents.

Miller MJ, Zhu H, Xu Y, Wu C, Walz AJ, Vergne A, Roosenberg JM, Moraski G, Minnick AA, McKee-Dolence J, Hu J, Fennell K, Kurt Dolence E, Dong L, Franzblau S, Malouin F, Möllmann U.

Biometals. 2009 Feb;22(1):61-75. doi: 10.1007/s10534-008-9185-0. Epub 2009 Jan 7. Review.

33.

NO-donors. Part 17: Synthesis and antimicrobial activity of novel ketoconazole-NO-donor hybrid compounds.

Konter J, Möllmann U, Lehmann J.

Bioorg Med Chem. 2008 Sep 1;16(17):8294-300. doi: 10.1016/j.bmc.2008.05.008. Epub 2008 May 7.

PMID:
18710813
34.

Arousing sleeping genes: shifts in secondary metabolism of metal tolerant actinobacteria under conditions of heavy metal stress.

Haferburg G, Groth I, Möllmann U, Kothe E, Sattler I.

Biometals. 2009 Apr;22(2):225-34. doi: 10.1007/s10534-008-9157-4. Epub 2008 Aug 13.

PMID:
18704271
35.

Preparation and in vitro evaluation of benzylsulfanyl benzoxazole derivatives as potential antituberculosis agents.

Klimesová V, Kocí J, Waisser K, Kaustová J, Möllmann U.

Eur J Med Chem. 2009 May;44(5):2286-93. doi: 10.1016/j.ejmech.2008.06.027. Epub 2008 Jul 5.

PMID:
18694614
36.
37.

Syntheses and biological activity of amamistatin B and analogs.

Fennell KA, Möllmann U, Miller MJ.

J Org Chem. 2008 Feb 1;73(3):1018-24. doi: 10.1021/jo7020532. Epub 2008 Jan 4.

PMID:
18173285
38.

Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.

Marchand C, Beutler JA, Wamiru A, Budihas S, Möllmann U, Heinisch L, Mellors JW, Le Grice SF, Pommier Y.

Antimicrob Agents Chemother. 2008 Jan;52(1):361-4. Epub 2007 Oct 29.

39.

Iron chelation equilibria, redox, and siderophore activity of a saccharide platform ferrichrome analogue.

Dhungana S, Harrington JM, Gebhardt P, Möllmann U, Crumbliss AL.

Inorg Chem. 2007 Oct 1;46(20):8362-71. Epub 2007 Sep 7.

PMID:
17824601
40.

Antibacterial activity of a novel series of 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives--an extended structure-activity relationship study.

Mahboobi S, Eichhorn E, Winkler M, Sellmer A, Möllmann U.

Eur J Med Chem. 2008 Mar;43(3):633-56. Epub 2007 Jun 3.

PMID:
17624634
41.

Iminonitroso Diels-Alder reactions for efficient derivatization and functionalization of complex diene-containing natural products.

Li F, Yang B, Miller MJ, Zajicek J, Noll BC, Möllmann U, Dahse HM, Miller PA.

Org Lett. 2007 Jul 19;9(15):2923-6. Epub 2007 Jun 30.

PMID:
17602642
42.

Synthesis and studies of catechol-containing mycobactin S and T analogs.

Walz AJ, Möllmann U, Miller MJ.

Org Biomol Chem. 2007 May 21;5(10):1621-8. Epub 2007 Apr 19.

PMID:
17571193
43.

A protein linkage map of the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis.

Teutschbein J, Schumann G, Möllmann U, Grabley S, Cole ST, Munder T.

Microbiol Res. 2009;164(3):253-9. Epub 2007 Apr 12.

44.

Synthesis and biological activity of saccharide based lipophilic siderophore mimetics as potential growth promoters for mycobacteria.

Gebhardt P, Crumbliss AL, Miller MJ, Möllmann U.

Biometals. 2008 Feb;21(1):41-51. Epub 2007 Mar 28.

PMID:
17390213
45.

Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities.

Adamec J, Beckert R, Weiss D, Klimesová V, Waisser K, Möllmann U, Kaustová J, Buchta V.

Bioorg Med Chem. 2007 Apr 15;15(8):2898-906. Epub 2007 Feb 13.

PMID:
17321746
46.

New C-3' hydroxamate-substituted and more lipophilic cyclic hydroxamate cephalosporin derivatives as a potential new generation of selective antimicrobial agents.

Miller MJ, Zhao G, Vakulenko S, Franzblau S, Möllmann U.

Org Biomol Chem. 2006 Nov 21;4(22):4178-85. No abstract available.

PMID:
17312974
47.

Biotechnological production and bioactivities of mollisin and two new, structurally related fungal naphthoquinone metabolites.

Johne S, Watzke R, Meusel W, Möllmann U, Härtl A, Dahse HM, Matthes B, Seifert K.

Chem Biodivers. 2005 Aug;2(8):1109-15.

PMID:
17193194
48.

The oriented development of antituberculotics: salicylanilides.

Waisser K, Matyk J, Divisová H, Husáková P, Kunes J, Klimesová V, Kaustová J, Möllmann U, Dahse HM, Miko M.

Arch Pharm (Weinheim). 2006 Nov;339(11):616-20.

PMID:
17048291
49.

Syntheses and studies of quinolone-cephalosporins as potential anti-tuberculosis agents.

Zhao G, Miller MJ, Franzblau S, Wan B, Möllmann U.

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5534-7. Epub 2006 Aug 30.

PMID:
16945530
50.

Alzheimer-like plaque formation by human macrophages is reduced by fibrillation inhibitors and lovastatin.

Gellermann GP, Ullrich K, Tannert A, Unger C, Habicht G, Sauter SR, Hortschansky P, Horn U, Möllmann U, Decker M, Lehmann J, Fändrich M.

J Mol Biol. 2006 Jul 7;360(2):251-7. Epub 2006 May 24.

PMID:
16765377

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