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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.

Bai P, Cantó C, Oudart H, Brunyánszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J.

Cell Metab. 2011 Apr 6;13(4):461-468. doi: 10.1016/j.cmet.2011.03.004.


PARP-2 regulates SIRT1 expression and whole-body energy expenditure.

Bai P, Canto C, Brunyánszki A, Huber A, Szántó M, Cen Y, Yamamoto H, Houten SM, Kiss B, Oudart H, Gergely P, Menissier-de Murcia J, Schreiber V, Sauve AA, Auwerx J.

Cell Metab. 2011 Apr 6;13(4):450-460. doi: 10.1016/j.cmet.2011.03.013.


XRCC1 interacts with the p58 subunit of DNA Pol alpha-primase and may coordinate DNA repair and replication during S phase.

Lévy N, Oehlmann M, Delalande F, Nasheuer HP, Van Dorsselaer A, Schreiber V, de Murcia G, Ménissier-de Murcia J, Maiorano D, Bresson A.

Nucleic Acids Res. 2009 Jun;37(10):3177-88. doi: 10.1093/nar/gkp144. Epub 2009 Mar 21.


PARP-1 is involved in autophagy induced by DNA damage.

Muñoz-Gámez JA, Rodríguez-Vargas JM, Quiles-Pérez R, Aguilar-Quesada R, Martín-Oliva D, de Murcia G, Menissier de Murcia J, Almendros A, Ruiz de Almodóvar M, Oliver FJ.

Autophagy. 2009 Jan;5(1):61-74. Epub 2009 Jan 27.


Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer.

Bai P, Houten SM, Huber A, Schreiber V, Watanabe M, Kiss B, de Murcia G, Auwerx J, Ménissier-de Murcia J.

J Biol Chem. 2007 Dec 28;282(52):37738-46. Epub 2007 Oct 19. Erratum in: J Biol Chem. 2008 Feb 29;283(9):5972.


Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.

Moubarak RS, Yuste VJ, Artus C, Bouharrour A, Greer PA, Menissier-de Murcia J, Susin SA.

Mol Cell Biol. 2007 Jul;27(13):4844-62. Epub 2007 Apr 30.


Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition.

Aguilar-Quesada R, Muñoz-Gámez JA, Martín-Oliva D, Peralta A, Valenzuela MT, Matínez-Romero R, Quiles-Pérez R, Menissier-de Murcia J, de Murcia G, Ruiz de Almodóvar M, Oliver FJ.

BMC Mol Biol. 2007 Apr 25;8:29.


Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis.

Dantzer F, Mark M, Quenet D, Scherthan H, Huber A, Liebe B, Monaco L, Chicheportiche A, Sassone-Corsi P, de Murcia G, Ménissier-de Murcia J.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14854-9. Epub 2006 Sep 25.


PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes.

Yélamos J, Monreal Y, Saenz L, Aguado E, Schreiber V, Mota R, Fuente T, Minguela A, Parrilla P, de Murcia G, Almarza E, Aparicio P, Ménissier-de Murcia J.

EMBO J. 2006 Sep 20;25(18):4350-60. Epub 2006 Aug 31.


Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair.

Dantzer F, Amé JC, Schreiber V, Nakamura J, Ménissier-de Murcia J, de Murcia G.

Methods Enzymol. 2006;409:493-510.


XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage.

Lévy N, Martz A, Bresson A, Spenlehauer C, de Murcia G, Ménissier-de Murcia J.

Nucleic Acids Res. 2006 Jan 5;34(1):32-41. Print 2006.


Establishment of an immortalized PARP-1-/- murine endothelial cell line: a new tool to study PARP-1 mediated endothelial cell dysfunction.

Carrillo A, Monreal Y, Ramirez P, Suarez E, Parrilla P, Menissier-de Murcia J, de Murcia G, Alvarez-Vallina L, Yélamos J.

J Cell Biochem. 2005 Apr 15;94(6):1163-74.


Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.

Espejel S, Klatt P, Ménissier-de Murcia J, Martín-Caballero J, Flores JM, Taccioli G, de Murcia G, Blasco MA.

J Cell Biol. 2004 Nov 22;167(4):627-38. Epub 2004 Nov 15.


Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.

Dantzer F, Giraud-Panis MJ, Jaco I, Amé JC, Schultz I, Blasco M, Koering CE, Gilson E, Ménissier-de Murcia J, de Murcia G, Schreiber V.

Mol Cell Biol. 2004 Feb;24(4):1595-607.


Local DNA damage by proton microbeam irradiation induces poly(ADP-ribose) synthesis in mammalian cells.

Tartier L, Spenlehauer C, Newman HC, Folkard M, Prise KM, Michael BD, Ménissier-de Murcia J, de Murcia G.

Mutagenesis. 2003 Sep;18(5):411-6.


Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1.

Marsin S, Vidal AE, Sossou M, Ménissier-de Murcia J, Le Page F, Boiteux S, de Murcia G, Radicella JP.

J Biol Chem. 2003 Nov 7;278(45):44068-74. Epub 2003 Aug 21.


Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse.

Ménissier de Murcia J, Ricoul M, Tartier L, Niedergang C, Huber A, Dantzer F, Schreiber V, Amé JC, Dierich A, LeMeur M, Sabatier L, Chambon P, de Murcia G.

EMBO J. 2003 May 1;22(9):2255-63.


PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression.

Augustin A, Spenlehauer C, Dumond H, Ménissier-De Murcia J, Piel M, Schmit AC, Apiou F, Vonesch JL, Kock M, Bornens M, De Murcia G.

J Cell Sci. 2003 Apr 15;116(Pt 8):1551-62.


Lethality in PARP-1/Ku80 double mutant mice reveals physiological synergy during early embryogenesis.

Henrie MS, Kurimasa A, Burma S, Ménissier-de Murcia J, de Murcia G, Li GC, Chen DJ.

DNA Repair (Amst). 2003 Feb 3;2(2):151-8.


Functional interaction between human papillomavirus type 18 E2 and poly(ADP-ribose) polymerase 1.

Lee D, Kim JW, Kim K, Joe CO, Schreiber V, Ménissier-De Murcia J, Choe J.

Oncogene. 2002 Aug 29;21(38):5877-85.


Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2.

Benchoua A, Couriaud C, Guégan C, Tartier L, Couvert P, Friocourt G, Chelly J, Ménissier-de Murcia J, Onténiente B.

J Biol Chem. 2002 Sep 13;277(37):34217-22. Epub 2002 Jun 13.


Unexpected sensitivity of nonobese diabetic mice with a disrupted poly(ADP-Ribose) polymerase-1 gene to streptozotocin-induced and spontaneous diabetes.

Gonzalez C, Ménissier De Murcia J, Janiak P, Bidouard JP, Beauvais C, Karray S, Garchon HJ, Lévi-Strauss M.

Diabetes. 2002 May;51(5):1470-6.


Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.

Schreiber V, Amé JC, Dollé P, Schultz I, Rinaldi B, Fraulob V, Ménissier-de Murcia J, de Murcia G.

J Biol Chem. 2002 Jun 21;277(25):23028-36. Epub 2002 Apr 10.


Optimized insect cell culture for the production of recombinant heterologous proteins and baculovirus particles.

Pereira CA, Pouliquen Y, Rodas V, Massotte D, Mortensen C, Sogayar MC, Ménissier-de Murcia J.

Biotechniques. 2001 Dec;31(6):1262, 1264, 1266, 1268. No abstract available.


Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability.

Samper E, Goytisolo FA, Ménissier-de Murcia J, González-Suárez E, Cigudosa JC, de Murcia G, Blasco MA.

J Cell Biol. 2001 Jul 9;154(1):49-60.


Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice.

Conde C, Mark M, Oliver FJ, Huber A, de Murcia G, Ménissier-de Murcia J.

EMBO J. 2001 Jul 2;20(13):3535-43.


Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation.

Fernet M, Ponette V, Deniaud-Alexandre E, Ménissier-De Murcia J, De Murcia G, Giocanti N, Megnin-Chanet F, Favaudon V.

Int J Radiat Biol. 2000 Dec;76(12):1621-9.


Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1.

Dantzer F, de La Rubia G, Ménissier-De Murcia J, Hostomsky Z, de Murcia G, Schreiber V.

Biochemistry. 2000 Jun 27;39(25):7559-69.


Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice.

Oliver FJ, Ménissier-de Murcia J, Nacci C, Decker P, Andriantsitohaina R, Muller S, de la Rubia G, Stoclet JC, de Murcia G.

EMBO J. 1999 Aug 16;18(16):4446-54.


PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase.

Amé JC, Rolli V, Schreiber V, Niedergang C, Apiou F, Decker P, Muller S, Höger T, Ménissier-de Murcia J, de Murcia G.

J Biol Chem. 1999 Jun 18;274(25):17860-8.


A dual approach in the study of poly (ADP-ribose) polymerase: in vitro random mutagenesis and generation of deficient mice.

Trucco C, Rolli V, Oliver FJ, Flatter E, Masson M, Dantzer F, Niedergang C, Dutrillaux B, Ménissier-de Murcia J, de Murcia G.

Mol Cell Biochem. 1999 Mar;193(1-2):53-60.


Involvement of poly(ADP-ribose) polymerase in base excision repair.

Dantzer F, Schreiber V, Niedergang C, Trucco C, Flatter E, De La Rubia G, Oliver J, Rolli V, Ménissier-de Murcia J, de Murcia G.

Biochimie. 1999 Jan-Feb;81(1-2):69-75. Review.


Poly(ADP-ribose) polymerase in the cellular response to DNA damage, apoptosis, and disease.

Oliver FJ, Menissier-de Murcia J, de Murcia G.

Am J Hum Genet. 1999 May;64(5):1282-8. Review. No abstract available.


Poly(ADP-ribose) polymerase activity is not affected in ataxia telangiectasia cells and knockout mice.

Dantzer F, Ménissier-de Murcia J, Barlow C, Wynshaw-Boris A, de Murcia G.

Carcinogenesis. 1999 Jan;20(1):177-80.


XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage.

Masson M, Niedergang C, Schreiber V, Muller S, Menissier-de Murcia J, de Murcia G.

Mol Cell Biol. 1998 Jun;18(6):3563-71.


Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication.

Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J.

Nucleic Acids Res. 1998 Apr 15;26(8):1891-8.


DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines.

Trucco C, Oliver FJ, de Murcia G, Ménissier-de Murcia J.

Nucleic Acids Res. 1998 Jun 1;26(11):2644-9.


Random mutagenesis of the poly(ADP-ribose) polymerase catalytic domain reveals amino acids involved in polymer branching.

Rolli V, O'Farrell M, Ménissier-de Murcia J, de Murcia G.

Biochemistry. 1997 Oct 7;36(40):12147-54.


Poly(ADP-ribose) polymerase interacts with a novel human ubiquitin conjugating enzyme: hUbc9.

Masson M, Menissier-de Murcia J, Mattei MG, de Murcia G, Niedergang CP.

Gene. 1997 May 6;190(2):287-96.


Photoaffinity labelling of human poly(ADP-ribose) polymerase catalytic domain.

Kim H, Jacobson MK, Rolli V, Ménissier-de Murcia J, Reinbolt J, Simonin F, Ruf A, Schulz G, de Murcia G.

Biochem J. 1997 Mar 1;322 ( Pt 2):469-75.


Mutations in the amino-terminal domain of the human poly(ADP-ribose) polymerase that affect its catalytic activity but not its DNA binding capacity.

Trucco C, Flatter E, Fribourg S, de Murcia G, Ménissier-de Murcia J.

FEBS Lett. 1996 Dec 16;399(3):313-6.


Efficient retroviral infection of mammalian cells is blocked by inhibition of poly(ADP-ribose) polymerase activity.

Gäken JA, Tavassoli M, Gan SU, Vallian S, Giddings I, Darling DC, Galea-Lauri J, Thomas MG, Abedi H, Schreiber V, Ménissier-de Murcia J, Collins MK, Shall S, Farzaneh F.

J Virol. 1996 Jun;70(6):3992-4000.


Kin17, a mouse nuclear zinc finger protein that binds preferentially to curved DNA.

Mazin A, Timchenko T, Ménissier-de Murcia J, Schreiber V, Angulo JF, de Murcia G, Devoret R.

Nucleic Acids Res. 1994 Oct 11;22(20):4335-41.


Structure and function of poly(ADP-ribose) polymerase.

de Murcia G, Schreiber V, Molinete M, Saulier B, Poch O, Masson M, Niedergang C, Ménissier de Murcia J.

Mol Cell Biochem. 1994 Sep;138(1-2):15-24. Review.


Poly(ADP-ribose) polymerase: a molecular nick-sensor.

de Murcia G, Ménissier de Murcia J.

Trends Biochem Sci. 1994 Apr;19(4):172-6. Review. Erratum in: Trends Biochem Sci 1994 Jun;19(6):250.


Conformational analysis of a 139 base-pair DNA fragment containing a single-stranded break and its interaction with human poly(ADP-ribose) polymerase.

Le Cam E, Fack F, Ménissier-de Murcia J, Cognet JA, Barbin A, Sarantoglou V, Révet B, Delain E, de Murcia G.

J Mol Biol. 1994 Jan 21;235(3):1062-71.


Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

Molinete M, Vermeulen W, Bürkle A, Ménissier-de Murcia J, Küpper JH, Hoeijmakers JH, de Murcia G.

EMBO J. 1993 May;12(5):2109-17.


Overproduction and large-scale purification of the human poly(ADP-ribose) polymerase using a baculovirus expression system.

Giner H, Simonin F, de Murcia G, Ménissier-de Murcia J.

Gene. 1992 May 15;114(2):279-83.


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