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Items: 22


Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate.

Jiang G, Maverakis E, Cheng MY, Elsheikh MM, Deleage C, Méndez-Lagares G, Shimoda M, Yukl SA, Hartigan-O'Connor DJ, Thompson GR 3rd, Estes JD, Wong JK, Dandekar S.

JCI Insight. 2019 Apr 4;4(7). pii: 126027. doi: 10.1172/jci.insight.126027. eCollection 2019 Apr 4.


Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade.

Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM.

Nat Med. 2019 Jan;25(1):141-151. doi: 10.1038/s41591-018-0221-5. Epub 2018 Nov 12.


Subclinical Cytomegalovirus Infection Is Associated with Altered Host Immunity, Gut Microbiota, and Vaccine Responses.

Santos Rocha C, Hirao LA, Weber MG, Méndez-Lagares G, Chang WLW, Jiang G, Deere JD, Sparger EE, Roberts J, Barry PA, Hartigan-O'Connor DJ, Dandekar S.

J Virol. 2018 Jun 13;92(13). pii: e00167-18. doi: 10.1128/JVI.00167-18. Print 2018 Jul 1.


HIV latency is reversed by ACSS2-driven histone crotonylation.

Jiang G, Nguyen D, Archin NM, Yukl SA, Méndez-Lagares G, Tang Y, Elsheikh MM, Thompson GR 3rd, Hartigan-O'Connor DJ, Margolis DM, Wong JK, Dandekar S.

J Clin Invest. 2018 Mar 1;128(3):1190-1198. doi: 10.1172/JCI98071. Epub 2018 Feb 19.


Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success.

Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ.

J Immunol. 2018 Feb 1;200(3):1124-1132. doi: 10.4049/jimmunol.1701364. Epub 2017 Dec 20.


IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8+ T Cell Responses in Acute Simian Immunodeficiency Virus Infection.

Méndez-Lagares G, Lu D, Merriam D, Baker CA, Villinger F, Van Rompay KKA, McCune JM, Hartigan-O'Connor DJ.

AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S81-S92. doi: 10.1089/aid.2017.0160.


Depletion of Gut-Resident CCR5+ Cells for HIV Cure Strategies.

Merriam D, Chen C, Méndez-Lagares G, Rogers KA, Michaels AJ, Yan J, Casaz P, Reimann KA, Villinger F, Hartigan-O'Connor DJ.

AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S70-S80. doi: 10.1089/aid.2017.0159.


Maraviroc contributes to the restoration of the homeostasis of regulatory T-cell subsets in antiretroviral-naive HIV-infected subjects.

Pozo-Balado MM, Rosado-Sánchez I, Méndez-Lagares G, Rodríguez-Méndez MM, Ruiz-Mateos E, Benhnia MR, Muñoz-Fernández MA, Leal M, Pacheco YM.

Clin Microbiol Infect. 2016 May;22(5):461.e1-5. doi: 10.1016/j.cmi.2015.12.025. Epub 2016 Jan 22.


Persistent effects of early infant diet and associated microbiota on the juvenile immune system.

Narayan NR, Méndez-Lagares G, Ardeshir A, Lu D, Van Rompay KK, Hartigan-O'Connor DJ.

Gut Microbes. 2015 Jul 4;6(4):284-9. doi: 10.1080/19490976.2015.1067743.


Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems.

Ardeshir A, Narayan NR, Méndez-Lagares G, Lu D, Rauch M, Huang Y, Van Rompay KK, Lynch SV, Hartigan-O'Connor DJ.

Sci Transl Med. 2014 Sep 3;6(252):252ra120. doi: 10.1126/scitranslmed.3008791.


Maraviroc reduces the regulatory T-cell frequency in antiretroviral-naive HIV-infected subjects.

Pozo-Balado MM, Martínez-Bonet M, Rosado I, Ruiz-Mateos E, Méndez-Lagares G, Rodríguez-Méndez MM, Vidal F, Muñoz-Fernández MA, Pacheco YM, Leal M.

J Infect Dis. 2014 Sep 15;210(6):890-8. doi: 10.1093/infdis/jiu180. Epub 2014 Mar 20.


HIV infection deregulates the balance between regulatory T cells and IL-2-producing CD4 T cells by decreasing the expression of the IL-2 receptor in Treg.

Méndez-Lagares G, Jaramillo-Ruiz D, Pion M, Leal M, Muñoz-Fernández MA, Pacheco YM, Correa-Rocha R.

J Acquir Immune Defic Syndr. 2014 Mar 1;65(3):278-82. doi: 10.1097/QAI.0000000000000092.


Long-term suppressive combined antiretroviral treatment does not normalize the serum level of soluble CD14.

Méndez-Lagares G, Romero-Sánchez MC, Ruiz-Mateos E, Genebat M, Ferrando-Martínez S, Muñoz-Fernández MÁ, Pacheco YM, Leal M.

J Infect Dis. 2013 Apr 15;207(8):1221-5. doi: 10.1093/infdis/jit025. Epub 2013 Jan 15.


High prevalence of X4/DM-tropic variants in children and adolescents infected with HIV-1 by vertical transmission.

Briz V, García D, Méndez-Lagares G, Ruiz-Mateos E, de Mulder M, Moreno-Pérez D, Navarro ML, León-Leal JA, de José MI, Ramos JT, Mellado MJ, González-Tomé MI, Leal M, Muñoz-Fernández MA.

Pediatr Infect Dis J. 2012 Oct;31(10):1048-52.


Specific patterns of CD4-associated immunosenescence in vertically HIV-infected subjects.

Méndez-Lagares G, Díaz L, Correa-Rocha R, León Leal JA, Ferrando-Martínez S, Ruiz-Mateos E, Pozo-Balado MM, Gurbindo MD, de José MI, Muñoz-Fernández MA, Leal M, Pacheco YM.

Clin Microbiol Infect. 2013 Jun;19(6):558-65. doi: 10.1111/j.1469-0691.2012.03934.x. Epub 2012 Jun 27.


Detectable viral load aggravates immunosenescence features of CD8 T-cell subsets in vertically HIV-infected children.

Díaz L, Méndez-Lagares G, Correa-Rocha R, Pacheco YM, Ferrando-Martínez S, Ruiz-Mateos E, del Mar del Pozo-Balado M, León JA, Gurbindo MD, Isabel de José M, Leal M, Muñoz-Fernández MÁ.

J Acquir Immune Defic Syndr. 2012 Aug 15;60(5):447-54.


Severe immune dysregulation affects CD4⁺CD25(hi)FoxP3⁺ regulatory T cells in HIV-infected patients with low-level CD4 T-cell repopulation despite suppressive highly active antiretroviral therapy.

Méndez-Lagares G, Pozo-Balado MM, Genebat M, García Pergañeda A, Leal M, Pacheco YM.

J Infect Dis. 2012 May 15;205(10):1501-9. doi: 10.1093/infdis/jis230. Epub 2012 Mar 28. Erratum in: J Infect Dis. 2012 Dec 15;206(12):1951. del Mar del Pozo Balado, María [corrected to Pozo-Balado, María M]; Genebat González, Miguel [corrected to Genebat, Miguel]; García Pergañeda Sánchez, Antonio [corrected to García-Pergañeda, Antonio]; Leal Noval, Manuel [corrected to Leal, Manuel];.


Differential alterations of the CD4 and CD8 T cell subsets in HIV-infected patients on highly active antiretroviral therapy with low CD4 T cell restoration.

Méndez-Lagares G, García-Pergañeda A, del Mar del Pozo-Balado M, Genebat M, Ruiz-Mateos E, García García M, Muñoz-Fernández MÁ, Pacheco YM, Leal M.

J Antimicrob Chemother. 2012 May;67(5):1228-37. doi: 10.1093/jac/dkr594. Epub 2012 Jan 27.


T-cell changes after a short-term exposure to maraviroc in HIV-infected patients are related to antiviral activity.

Pulido I, Machmach K, Romero-Sánchez MC, Genebat M, Mendez-Lagares G, Ruiz-Mateos E, Leal M.

J Infect. 2012 Apr;64(4):417-23. doi: 10.1016/j.jinf.2011.12.017. Epub 2011 Dec 29.


Increased regulatory T cell counts in HIV-infected nonresponders to hepatitis B virus vaccine.

del Pozo Balado Mdel M, Leal M, Méndez Lagares G, Mata RC, López-Cortés LF, Viciana P, Pacheco YM.

J Infect Dis. 2010 Aug 15;202(3):362-9. doi: 10.1086/653707.


Is it age or HIV that drives the regulatory T-cells expansion that occurs in older HIV-infected persons?

Méndez-Lagares G, Leal M, del Pozo-Balado MM, León JA, Pacheco YM.

Clin Immunol. 2010 Jul;136(1):157-9; author reply 160. doi: 10.1016/j.clim.2010.02.012. Epub 2010 Mar 16. No abstract available.


CD4(+)CD25(+/hi)CD127(lo) phenotype does not accurately identify regulatory T cells in all populations of HIV-infected persons.

Del Pozo-Balado Mdel M, Leal M, Méndez-Lagares G, Pacheco YM.

J Infect Dis. 2010 Feb 1;201(3):331-5. doi: 10.1086/649840.


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