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Items: 36

1.

Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers.

Talwelkar SS, Nagaraj AS, Devlin JR, Hemmes A, Potdar S, Kiss EA, Saharinen P, Salmenkivi K, Mäyränpää MI, Wennerberg K, Verschuren EW.

Mol Cancer Ther. 2019 Oct;18(10):1863-1874. doi: 10.1158/1535-7163.MCT-18-0573. Epub 2019 Jul 18.

PMID:
31320402
2.

Sudden death in cardiac sarcoidosis: an analysis of nationwide clinical and cause-of-death registries.

Ekström K, Lehtonen J, Nordenswan HK, Mäyränpää MI, Räisänen-Sokolowski A, Kandolin R, Simonen P, Pietilä-Effati P, Alatalo A, Utriainen S, Rissanen TT, Haataja P, Kokkonen J, Vihinen T, Miettinen H, Kaikkonen K, Kerola T, Kupari M.

Eur Heart J. 2019 Oct 1;40(37):3121-3128. doi: 10.1093/eurheartj/ehz428.

PMID:
31230070
3.

Morphology and histology of silent and symptom-causing atherosclerotic carotid plaques - Rationale and design of the Helsinki Carotid Endarterectomy Study 2 (the HeCES2).

Nuotio K, Ijäs P, Heikkilä HM, Koskinen SM, Saksi J, Vikatmaa P, Sorto P, Mäkitie L, Eriksson H, Kasari S, Silvennoinen H, Valanne L, Mäyränpää MI, Kovanen PT, Soinne L, Lindsberg PJ.

Ann Med. 2018 Sep;50(6):501-510. doi: 10.1080/07853890.2018.1494851. Epub 2018 Oct 1.

PMID:
30010425
4.

Human mast cell neutral proteases generate modified LDL particles with increased proteoglycan binding.

Maaninka K, Nguyen SD, Mäyränpää MI, Plihtari R, Rajamäki K, Lindsberg PJ, Kovanen PT, Öörni K.

Atherosclerosis. 2018 Aug;275:390-399. doi: 10.1016/j.atherosclerosis.2018.04.016. Epub 2018 Apr 13.

PMID:
29703634
5.

Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours.

Närhi K, Nagaraj AS, Parri E, Turkki R, van Duijn PW, Hemmes A, Lahtela J, Uotinen V, Mäyränpää MI, Salmenkivi K, Räsänen J, Linder N, Trapman J, Rannikko A, Kallioniemi O, Af Hällström TM, Lundin J, Sommergruber W, Anders S, Verschuren EW.

J Pathol. 2018 May;245(1):101-113. doi: 10.1002/path.5059. Epub 2018 Apr 2. Erratum in: J Pathol. 2019 Jan;247(1):147.

6.

TET2 mutations in B cells of patients affected by angioimmunoblastic T-cell lymphoma.

Schwartz FH, Cai Q, Fellmann E, Hartmann S, Mäyränpää MI, Karjalainen-Lindsberg ML, Sundström C, Scholtysik R, Hansmann ML, Küppers R.

J Pathol. 2017 Jun;242(2):129-133. doi: 10.1002/path.4898. Epub 2017 May 3.

PMID:
28337768
7.

Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1.

Nagaraj AS, Lahtela J, Hemmes A, Pellinen T, Blom S, Devlin JR, Salmenkivi K, Kallioniemi O, Mäyränpää MI, Närhi K, Verschuren EW.

Cell Rep. 2017 Jan 17;18(3):673-684. doi: 10.1016/j.celrep.2016.12.059.

8.

p38δ MAPK: A Novel Regulator of NLRP3 Inflammasome Activation With Increased Expression in Coronary Atherogenesis.

Rajamäki K, Mäyränpää MI, Risco A, Tuimala J, Nurmi K, Cuenda A, Eklund KK, Öörni K, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1937-46. doi: 10.1161/ATVBAHA.115.307312. Epub 2016 Jul 14.

PMID:
27417584
9.

Imatinib treatment attenuates growth and inflammation of angiotensin II induced abdominal aortic aneurysm.

Vorkapic E, Dugic E, Vikingsson S, Roy J, Mäyränpää MI, Eriksson P, Wågsäter D.

Atherosclerosis. 2016 Jun;249:101-9. doi: 10.1016/j.atherosclerosis.2016.04.006. Epub 2016 Apr 7.

10.

Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome.

Sinisalo J, Vlachopoulou E, Marchesani M, Nokelainen J, Mäyränpää MI, Lappalainen J, Paakkanen R, Wennerström A, Salli K, Niemi HJ, Männistö S, Salo P, Junttila J, Eskola M, Nikus K, Arstila TP, Perola M, Huikuri H, Karhunen PJ, Kovanen PT, Palotie A, Havulinna AS, Lluis-Ganella C, Marrugat J, Elosua R, Salomaa V, Nieminen MS, Lokki ML.

Circ Cardiovasc Genet. 2016 Feb;9(1):55-63. doi: 10.1161/CIRCGENETICS.115.001226. Epub 2015 Dec 17.

PMID:
26679868
11.

TRIF adaptor signaling is important in abdominal aortic aneurysm formation.

Vorkapic E, Lundberg AM, Mäyränpää MI, Eriksson P, Wågsäter D.

Atherosclerosis. 2015 Aug;241(2):561-8. doi: 10.1016/j.atherosclerosis.2015.06.014. Epub 2015 Jun 12.

12.

Spatial distributions of lipids in atherosclerosis of human coronary arteries studied by time-of-flight secondary ion mass spectrometry.

Lehti S, Sjövall P, Käkelä R, Mäyränpää MI, Kovanen PT, Öörni K.

Am J Pathol. 2015 May;185(5):1216-33. doi: 10.1016/j.ajpath.2015.01.026. Epub 2015 Mar 21.

PMID:
25805604
13.

Low-expression variant of fatty acid-binding protein 4 favors reduced manifestations of atherosclerotic disease and increased plaque stability.

Saksi J, Ijäs P, Mäyränpää MI, Nuotio K, Isoviita PM, Tuimala J, Lehtonen-Smeds E, Kaste M, Jula A, Sinisalo J, Nieminen MS, Lokki ML, Perola M, Havulinna AS, Salomaa V, Kettunen J, Jauhiainen M, Kovanen PT, Lindsberg PJ.

Circ Cardiovasc Genet. 2014 Oct;7(5):588-98. doi: 10.1161/CIRCGENETICS.113.000499. Epub 2014 Aug 13.

PMID:
25122052
14.

VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart.

Kivelä R, Bry M, Robciuc MR, Räsänen M, Taavitsainen M, Silvola JM, Saraste A, Hulmi JJ, Anisimov A, Mäyränpää MI, Lindeman JH, Eklund L, Hellberg S, Hlushchuk R, Zhuang ZW, Simons M, Djonov V, Knuuti J, Mervaala E, Alitalo K.

EMBO Mol Med. 2014 Mar;6(3):307-21. doi: 10.1002/emmm.201303147. Epub 2014 Jan 21.

15.

Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.

Béaslas O, Metso J, Nissilä E, Laurila PP, Kaiharju E, Batchu KC, Kaipiainen L, Mäyränpää MI, Yan D, Gylling H, Jauhiainen M, Olkkonen VM.

PLoS One. 2013;8(3):e58856. doi: 10.1371/journal.pone.0058856. Epub 2013 Mar 15.

16.

Imatinib mesylate alleviates diarrhea in a mouse model of intestinal allergy.

Vaali K, Lappalainen J, Lin AH, Mäyränpää MI, Kovanen PT, Berstad A, Eklund KK.

Neurogastroenterol Motil. 2012 Jul;24(7):e325-35. doi: 10.1111/j.1365-2982.2012.01941.x.

PMID:
22709239
17.

Serine protease inhibitor A3 in atherosclerosis and aneurysm disease.

Wågsäter D, Johansson D, Fontaine V, Vorkapic E, Bäcklund A, Razuvaev A, Mäyränpää MI, Hjerpe C, Caidahl K, Hamsten A, Franco-Cereceda A, Wilbertz J, Swedenborg J, Zhou X, Eriksson P.

Int J Mol Med. 2012 Aug;30(2):288-94. doi: 10.3892/ijmm.2012.994. Epub 2012 May 9.

PMID:
22580763
18.

Mast cells: important players in the orchestrated pathogenesis of abdominal aortic aneurysms.

Swedenborg J, Mäyränpää MI, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):734-40. doi: 10.1161/ATVBAHA.110.213157. Epub 2011 Jan 4. Review.

PMID:
21205988
19.

Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm.

Di Gennaro A, Wågsäter D, Mäyränpää MI, Gabrielsen A, Swedenborg J, Hamsten A, Samuelsson B, Eriksson P, Haeggström JZ.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21093-7. doi: 10.1073/pnas.1015166107. Epub 2010 Nov 15.

20.

OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface.

Zhou Y, Li S, Mäyränpää MI, Zhong W, Bäck N, Yan D, Olkkonen VM.

Exp Cell Res. 2010 Nov 15;316(19):3304-16. doi: 10.1016/j.yexcr.2010.06.008. Epub 2010 Jun 16.

PMID:
20599956
21.

Vascular endothelial growth factor-secreting mast cells and myofibroblasts: a novel self-perpetuating angiogenic pathway in aortic valve stenosis.

Syväranta S, Helske S, Laine M, Lappalainen J, Kupari M, Mäyränpää MI, Lindstedt KA, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1220-7. doi: 10.1161/ATVBAHA.109.198267. Epub 2010 Mar 18.

PMID:
20299690
22.

Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart.

Toivonen R, Mäyränpää MI, Kovanen PT, Savontaus M.

Histochem Cell Biol. 2010 Mar;133(3):349-57. doi: 10.1007/s00418-009-0666-1. Epub 2009 Dec 2.

PMID:
19957088
23.

Mast cells associate with neovessels in the media and adventitia of abdominal aortic aneurysms.

Mäyränpää MI, Trosien JA, Fontaine V, Folkesson M, Kazi M, Eriksson P, Swedenborg J, Hedin U.

J Vasc Surg. 2009 Aug;50(2):388-95; discussion 395-6. doi: 10.1016/j.jvs.2009.03.055. Epub 2009 Jun 10.

24.

Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages.

Linder MD, Mäyränpää MI, Peränen J, Pietilä TE, Pietiäinen VM, Uronen RL, Olkkonen VM, Kovanen PT, Ikonen E.

Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):883-8. doi: 10.1161/ATVBAHA.108.179481. Epub 2009 Mar 19.

PMID:
19304576
25.

ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model.

Simolin MA, Pedersen TX, Bro S, Mäyränpää MI, Helske S, Nielsen LB, Kovanen PT.

BMC Cardiovasc Disord. 2009 Mar 3;9:10. doi: 10.1186/1471-2261-9-10.

26.

Mast cells associate with T-cells and neointimal microvessels in giant cell arteritis.

Mäyränpää MI, Trosien JA, Nikkari ST, Kovanen PT.

Clin Exp Rheumatol. 2008 May-Jun;26(3 Suppl 49):S63-6.

PMID:
18799056
27.

The R-Ras interaction partner ORP3 regulates cell adhesion.

Lehto M, Mäyränpää MI, Pellinen T, Ihalmo P, Lehtonen S, Kovanen PT, Groop PH, Ivaska J, Olkkonen VM.

J Cell Sci. 2008 Mar 1;121(Pt 5):695-705. doi: 10.1242/jcs.016964. Epub 2008 Feb 12.

28.

OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.

Yan D, Mäyränpää MI, Wong J, Perttilä J, Lehto M, Jauhiainen M, Kovanen PT, Ehnholm C, Brown AJ, Olkkonen VM.

J Biol Chem. 2008 Jan 4;283(1):332-40. Epub 2007 Nov 8.

29.

Mast cells in vulnerable atherosclerotic plaques--a view to a kill.

Lindstedt KA, Mäyränpää MI, Kovanen PT.

J Cell Mol Med. 2007 Jul-Aug;11(4):739-58. Review.

30.

Bone densitometry in the diagnosis of vertebral fractures in children: accuracy of vertebral fracture assessment.

Mäyränpää MK, Helenius I, Valta H, Mäyränpää MI, Toiviainen-Salo S, Mäkitie O.

Bone. 2007 Sep;41(3):353-9. Epub 2007 Jun 6.

PMID:
17618848
31.

Improved identification of endothelial erosion by simultaneous detection of endothelial cells (CD31/CD34) and platelets (CD42b).

Mäyränpää MI, Reséndiz JC, Heikkilä HM, Lindstedt KA, Kovanen PT.

Endothelium. 2007 Mar-Apr;14(2):81-7.

PMID:
17497364
32.

Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques.

Oksjoki R, Laine P, Helske S, Vehmaan-Kreula P, Mäyränpää MI, Gasque P, Kovanen PT, Pentikäinen MO.

Atherosclerosis. 2007 Nov;195(1):90-9. Epub 2007 Jan 17.

PMID:
17234193
33.

Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion.

Mäyränpää MI, Heikkilä HM, Lindstedt KA, Walls AF, Kovanen PT.

Coron Artery Dis. 2006 Nov;17(7):611-21.

PMID:
17047445
34.

Endothelial apoptosis does not determine symptom status in carotid artery disease.

Nuotio K, Mäyränpää MI, Saksi J, Ijas P, Sairanen T, Carpén O, Soinne L, Saimanen E, Salonen O, Lepäntalo M, Kovanen PT, Kaste M, Lindsberg PJ.

Cerebrovasc Dis. 2007;23(1):27-34. Epub 2006 Sep 12.

PMID:
16968983
35.
36.

Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves.

Helske S, Syväranta S, Lindstedt KA, Lappalainen J, Oörni K, Mäyränpää MI, Lommi J, Turto H, Werkkala K, Kupari M, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1791-8. Epub 2006 May 25.

PMID:
16728655

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