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Best matches for Mäser P[au]:

Cherchez l'Electron. Mäser P et al. Mol Microbiol. (2017)

Inhibitors of PEX14 disrupt protein import into glycosomes and kill <i>Trypanosoma</i> parasites. Dawidowski M et al. Science. (2017)

Transporters of Trypanosoma brucei-phylogeny, physiology, pharmacology. Schmidt RS et al. FEBS J. (2018)

Search results

Items: 1 to 50 of 98

1.

Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity.

Hochegger P, Faist J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R.

Bioorg Med Chem. 2019 May 15;27(10):2052-2065. doi: 10.1016/j.bmc.2019.03.061. Epub 2019 Apr 2.

PMID:
30962114
2.

Cell Penetration, Herbicidal Activity, and in-vivo-Toxicity of Oligo-Arginine Derivatives and of Novel Guanidinium-Rich Compounds Derived from the Biopolymer Cyanophycin.

Grogg M, Hilvert D, Ebert MO, Beck AK, Seebach D, Kurth F, Dittrich PS, Sparr C, Wittlin S, Rottmann M, Mäser P.

Helv Chim Acta. 2018 Oct;101(10). pii: e1800112. doi: 10.1002/hlca.201800112.

3.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jiménez-Díaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo FJ, Mäser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. doi: 10.1073/pnas.1814685116. Epub 2019 Mar 20.

4.

Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents.

Saccoliti F, Madia VN, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet CM, Jennings GK, Podust LM, Pepe G, Cirilli R, Faggi C, Di Marco A, Battista MR, Summa V, Costi R, Di Santo R.

J Med Chem. 2019 Feb 14;62(3):1330-1347. doi: 10.1021/acs.jmedchem.8b01464. Epub 2019 Jan 23.

PMID:
30615444
5.

Host-Microbe Interactions: Parasitology Vol 46.

Mäser P.

Curr Opin Microbiol. 2018 Dec;46:vi-viii. doi: 10.1016/j.mib.2018.11.008. No abstract available.

PMID:
30553295
6.

Drug Discovery for Kinetoplastid Diseases: Future Directions.

Rao SPS, Barrett MP, Dranoff G, Faraday CJ, Gimpelewicz CR, Hailu A, Jones CL, Kelly JM, Lazdins-Helds JK, Mäser P, Mengel J, Mottram JC, Mowbray CE, Sacks DL, Scott P, Späth GF, Tarleton RL, Spector JM, Diagana TT.

ACS Infect Dis. 2019 Feb 8;5(2):152-157. doi: 10.1021/acsinfecdis.8b00298. Epub 2018 Dec 13.

7.

Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development.

Kalel VC, Mäser P, Sattler M, Erdmann R, Popowicz GM.

Curr Opin Microbiol. 2018 Dec;46:116-122. doi: 10.1016/j.mib.2018.11.003. Epub 2018 Nov 24. Review.

PMID:
30481613
8.

Antiprotozoal Activities of Tetrazole-quinolines with Aminopiperidine Linker.

Hochegger P, Faist J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R.

Med Chem. 2019;15(4):409-416. doi: 10.2174/1573406414666181015115101.

PMID:
30324885
9.

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.

Saccoliti F, Madia VN, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet CM, Jennings GK, Podust LM, Costi R, Di Santo R.

Eur J Med Chem. 2018 Aug 5;156:53-60. doi: 10.1016/j.ejmech.2018.06.063. Epub 2018 Jun 28.

PMID:
30006174
10.

Isothermal microcalorimetry - A quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time.

Gysin M, Braissant O, Gillingwater K, Brun R, Mäser P, Wenzler T.

Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):159-164. doi: 10.1016/j.ijpddr.2018.03.003. Epub 2018 Mar 16.

11.

Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria.

Subramaniam S, Schmid CD, Guan XL, Mäser P.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e01533-17. doi: 10.1128/AAC.01533-17. Print 2018 Apr.

12.

Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei.

Steinmann ME, Schmidt RS, Macêdo JP, Kunz Renggli C, Bütikofer P, Rentsch D, Mäser P, Sigel E.

PLoS One. 2017 Dec 15;12(12):e0188219. doi: 10.1371/journal.pone.0188219. eCollection 2017.

13.

Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.

Mohsin NU, Seebacher W, Faist J, Hochegger P, Kaiser M, Mäser P, Belaj F, Saf R, Kretschmer N, Alajlani M, Turek I, Brantner A, Bauer R, Bucar F, Weis R.

Eur J Med Chem. 2018 Jan 1;143:97-106. doi: 10.1016/j.ejmech.2017.11.025. Epub 2017 Nov 10.

PMID:
29172086
14.

Transporters of Trypanosoma brucei-phylogeny, physiology, pharmacology.

Schmidt RS, Macêdo JP, Steinmann ME, Salgado AG, Bütikofer P, Sigel E, Rentsch D, Mäser P.

FEBS J. 2018 Mar;285(6):1012-1023. doi: 10.1111/febs.14302. Epub 2017 Nov 13. Review.

15.
16.

Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei.

Wiedemar N, Graf FE, Zwyer M, Ndomba E, Kunz Renggli C, Cal M, Schmidt RS, Wenzler T, Mäser P.

Mol Microbiol. 2018 Jan;107(1):57-67. doi: 10.1111/mmi.13854. Epub 2017 Nov 20.

17.

Cherchez l'Electron.

Mäser P.

Mol Microbiol. 2017 Oct;106(2):183-185. doi: 10.1111/mmi.13773. Epub 2017 Sep 8.

18.

TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes.

Steinmann ME, Schmidt RS, Bütikofer P, Mäser P, Sigel E.

Sci Rep. 2017 Apr 6;7(1):656. doi: 10.1038/s41598-017-00752-1.

19.

Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.

Dawidowski M, Emmanouilidis L, Kalel VC, Tripsianes K, Schorpp K, Hadian K, Kaiser M, Mäser P, Kolonko M, Tanghe S, Rodriguez A, Schliebs W, Erdmann R, Sattler M, Popowicz GM.

Science. 2017 Mar 31;355(6332):1416-1420. doi: 10.1126/science.aal1807.

PMID:
28360328
20.

Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity.

Jeacock L, Baker N, Wiedemar N, Mäser P, Horn D.

PLoS Pathog. 2017 Mar 30;13(3):e1006307. doi: 10.1371/journal.ppat.1006307. eCollection 2017 Mar.

21.

New derivatives of quinoline-4-carboxylic acid with antiplasmodial activity.

Hochegger P, Faist J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R.

Bioorg Med Chem. 2017 Apr 1;25(7):2251-2259. doi: 10.1016/j.bmc.2017.02.043. Epub 2017 Feb 24.

PMID:
28279559
22.

In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate.

Baumgärtner F, Jourdan J, Scheurer C, Blasco B, Campo B, Mäser P, Wittlin S.

Malar J. 2017 Jan 25;16(1):45. doi: 10.1186/s12936-017-1696-0.

23.

Arginine and Lysine Transporters Are Essential for Trypanosoma brucei.

Mathieu C, Macêdo JP, Hürlimann D, Wirdnam C, Haindrich AC, Suter Grotemeyer M, González-Salgado A, Schmidt RS, Inbar E, Mäser P, Bütikofer P, Zilberstein D, Rentsch D.

PLoS One. 2017 Jan 3;12(1):e0168775. doi: 10.1371/journal.pone.0168775. eCollection 2017.

24.

New derivatives of 7-chloroquinolin-4-amine with antiprotozoal activity.

Faist J, Hinteregger C, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R.

Bioorg Med Chem. 2017 Feb 1;25(3):941-948. doi: 10.1016/j.bmc.2016.12.006. Epub 2016 Dec 18.

PMID:
28031151
25.

Assessing anti-T. cruzi candidates in vitro for sterile cidality.

Cal M, Ioset JR, Fügi MA, Mäser P, Kaiser M.

Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):165-170. doi: 10.1016/j.ijpddr.2016.08.003. Epub 2016 Aug 26.

26.

Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles.

Wang T, Mäser P, Picard D.

J Med Chem. 2016 Jul 14;59(13):6344-52. doi: 10.1021/acs.jmedchem.6b00591. Epub 2016 Jun 28.

PMID:
27312008
27.

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense.

Graf FE, Ludin P, Arquint C, Schmidt RS, Schaub N, Kunz Renggli C, Munday JC, Krezdorn J, Baker N, Horn D, Balmer O, Caccone A, de Koning HP, Mäser P.

Cell Mol Life Sci. 2016 Sep;73(17):3387-400. doi: 10.1007/s00018-016-2173-6. Epub 2016 Mar 14.

28.

A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes.

Wenzler T, Schumann Burkard G, Schmidt RS, Mäser P, Bergner A, Roditi I, Brun R.

Sci Rep. 2016 Mar 2;6:22451. doi: 10.1038/srep22451.

29.

Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel).

Jourdan J, Matile H, Reift E, Biehlmaier O, Dong Y, Wang X, Mäser P, Vennerstrom JL, Wittlin S.

ACS Infect Dis. 2016 Jan 8;2(1):54-61. Epub 2015 Sep 28.

30.

Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning.

Kaiser M, Mäser P, Tadoori LP, Ioset JR, Brun R.

PLoS One. 2015 Aug 13;10(8):e0135556. doi: 10.1371/journal.pone.0135556. eCollection 2015.

31.

Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates.

Graf FE, Baker N, Munday JC, de Koning HP, Horn D, Mäser P.

Int J Parasitol Drugs Drug Resist. 2015 May 7;5(2):65-8. doi: 10.1016/j.ijpddr.2015.04.002. eCollection 2015 Aug.

32.

An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei.

de Macêdo JP, Schumann Burkard G, Niemann M, Barrett MP, Vial H, Mäser P, Roditi I, Schneider A, Bütikofer P.

PLoS Pathog. 2015 May 6;11(5):e1004875. doi: 10.1371/journal.ppat.1004875. eCollection 2015 May.

33.

A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes.

Steinmann ME, González-Salgado A, Bütikofer P, Mäser P, Sigel E.

FASEB J. 2015 Aug;29(8):3228-37. doi: 10.1096/fj.15-271353. Epub 2015 Apr 13.

34.

Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities.

Witschel MC, Rottmann M, Schwab A, Leartsakulpanich U, Chitnumsub P, Seet M, Tonazzi S, Schwertz G, Stelzer F, Mietzner T, McNamara C, Thater F, Freymond C, Jaruwat A, Pinthong C, Riangrungroj P, Oufir M, Hamburger M, Mäser P, Sanz-Alonso LM, Charman S, Wittlin S, Yuthavong Y, Chaiyen P, Diederich F.

J Med Chem. 2015 Apr 9;58(7):3117-30. doi: 10.1021/jm501987h. Epub 2015 Mar 18.

PMID:
25785478
35.

Match-making for posaconazole through systems thinking.

Fügi MA, Kaiser M, Tanner M, Schneiter R, Mäser P, Guan XL.

Trends Parasitol. 2015 Feb;31(2):46-51. doi: 10.1016/j.pt.2014.11.004. Epub 2014 Dec 6.

PMID:
25486978
36.

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.

Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Mäser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F.

Nucleic Acids Res. 2015 Jan;43(Database issue):D637-44. doi: 10.1093/nar/gku944. Epub 2014 Oct 9.

37.

Comparative genomics reveals multiple genetic backgrounds of human pathogenicity in the Trypanosoma brucei complex.

Sistrom M, Evans B, Bjornson R, Gibson W, Balmer O, Mäser P, Aksoy S, Caccone A.

Genome Biol Evol. 2014 Oct 5;6(10):2811-9. doi: 10.1093/gbe/evu222.

38.

Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids.

Mathieu C, González Salgado A, Wirdnam C, Meier S, Grotemeyer MS, Inbar E, Mäser P, Zilberstein D, Sigel E, Bütikofer P, Rentsch D.

Biochem J. 2014 Oct 1;463(1):9-18. doi: 10.1042/BJ20140719.

PMID:
24988048
39.

Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack.

Fügi MA, Gunasekera K, Ochsenreiter T, Guan X, Wenk MR, Mäser P.

J Lipid Res. 2014 May;55(5):929-38. doi: 10.1194/jlr.M048017. Epub 2014 Mar 13.

40.

Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity.

Lüscher A, Lamprea-Burgunder E, Graf FE, de Koning HP, Mäser P.

Int J Parasitol Drugs Drug Resist. 2013 Dec 19;4(1):55-63. doi: 10.1016/j.ijpddr.2013.12.001. eCollection 2014 Apr.

41.

Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.

Wang T, Bisson WH, Mäser P, Scapozza L, Picard D.

J Med Chem. 2014 Mar 27;57(6):2524-35. doi: 10.1021/jm401801t. Epub 2014 Mar 3.

PMID:
24580531
42.

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.

Munday JC, Eze AA, Baker N, Glover L, Clucas C, Aguinaga Andrés D, Natto MJ, Teka IA, McDonald J, Lee RS, Graf FE, Ludin P, Burchmore RJ, Turner CM, Tait A, MacLeod A, Mäser P, Barrett MP, Horn D, De Koning HP.

J Antimicrob Chemother. 2014 Mar;69(3):651-63. doi: 10.1093/jac/dkt442. Epub 2013 Nov 13.

43.

Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.

Graf FE, Ludin P, Wenzler T, Kaiser M, Brun R, Pyana PP, Büscher P, de Koning HP, Horn D, Mäser P.

PLoS Negl Trop Dis. 2013 Oct 10;7(10):e2475. doi: 10.1371/journal.pntd.0002475. eCollection 2013.

44.

In silico ionomics segregates parasitic from free-living eukaryotes.

Greganova E, Steinmann M, Mäser P, Fankhauser N.

Genome Biol Evol. 2013;5(10):1902-9. doi: 10.1093/gbe/evt134.

45.

Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms.

Macêdo JP, Schmidt RS, Mäser P, Rentsch D, Vial HJ, Sigel E, Bütikofer P.

Mol Biochem Parasitol. 2013 Jul;190(1):16-22. doi: 10.1016/j.molbiopara.2013.05.007. Epub 2013 Jun 6.

PMID:
23747277
46.

Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story.

Baker N, de Koning HP, Mäser P, Horn D.

Trends Parasitol. 2013 Mar;29(3):110-8. doi: 10.1016/j.pt.2012.12.005. Epub 2013 Jan 30. Review.

47.

In silico prediction of antimalarial drug target candidates.

Ludin P, Woodcroft B, Ralph SA, Mäser P.

Int J Parasitol Drugs Drug Resist. 2012 Jul 17;2:191-9. doi: 10.1016/j.ijpddr.2012.07.002. eCollection 2012 Dec.

48.

Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines.

Ali JA, Creek DJ, Burgess K, Allison HC, Field MC, Mäser P, De Koning HP.

Mol Pharmacol. 2013 Feb;83(2):439-53. doi: 10.1124/mol.112.082321. Epub 2012 Nov 27.

49.

The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets.

Godel C, Kumar S, Koutsovoulos G, Ludin P, Nilsson D, Comandatore F, Wrobel N, Thompson M, Schmid CD, Goto S, Bringaud F, Wolstenholme A, Bandi C, Epe C, Kaminsky R, Blaxter M, Mäser P.

FASEB J. 2012 Nov;26(11):4650-61. doi: 10.1096/fj.12-205096. Epub 2012 Aug 13.

50.

Antiparasitic agents: new drugs on the horizon.

Mäser P, Wittlin S, Rottmann M, Wenzler T, Kaiser M, Brun R.

Curr Opin Pharmacol. 2012 Oct;12(5):562-6. doi: 10.1016/j.coph.2012.05.001. Epub 2012 May 29. Review.

PMID:
22652215

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