Format
Sort by
Items per page

Send to

Choose Destination

Best matches for Mäntsälä P[au]:

Structure-based engineering of angucyclinone 6-ketoreductases. Patrikainen P et al. Chem Biol. (2014)

Microbial amylolytic enzymes. Vihinen M et al. Crit Rev Biochem Mol Biol. (1989)

Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway. Oja T et al. Proc Natl Acad Sci U S A. (2013)

Search results

Items: 1 to 50 of 109

1.

Structure-based engineering of angucyclinone 6-ketoreductases.

Patrikainen P, Niiranen L, Thapa K, Paananen P, Tähtinen P, Mäntsälä P, Niemi J, Metsä-Ketelä M.

Chem Biol. 2014 Oct 23;21(10):1381-1391. doi: 10.1016/j.chembiol.2014.07.017. Epub 2014 Sep 4.

2.

Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.

Paananen P, Patrikainen P, Kallio P, Mäntsälä P, Niemi J, Niiranen L, Metsä-Ketelä M.

Biochemistry. 2013 Aug 6;52(31):5304-14. doi: 10.1021/bi400712q. Epub 2013 Jul 24.

PMID:
23848284
3.

Tracing the evolution of angucyclinone monooxygenases: structural determinants for C-12b hydroxylation and substrate inhibition in PgaE.

Kallio P, Patrikainen P, Belogurov GA, Mäntsälä P, Yang K, Niemi J, Metsä-Ketelä M.

Biochemistry. 2013 Jul 2;52(26):4507-16. doi: 10.1021/bi400381s. Epub 2013 Jun 17.

PMID:
23731237
4.

Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.

Oja T, Niiranen L, Sandalova T, Klika KD, Niemi J, Mäntsälä P, Schneider G, Metsä-Ketelä M.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1291-6. doi: 10.1073/pnas.1207407110. Epub 2013 Jan 7.

5.

Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.

Patrikainen P, Kallio P, Fan K, Klika KD, Shaaban KA, Mäntsälä P, Rohr J, Yang K, Niemi J, Metsä-Ketelä M.

Chem Biol. 2012 May 25;19(5):647-55. doi: 10.1016/j.chembiol.2012.04.010.

6.

Discovery of a two-component monooxygenase SnoaW/SnoaL2 involved in nogalamycin biosynthesis.

Siitonen V, Blauenburg B, Kallio P, Mäntsälä P, Metsä-Ketelä M.

Chem Biol. 2012 May 25;19(5):638-46. doi: 10.1016/j.chembiol.2012.04.009.

7.

Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage.

Oja T, Klika KD, Appassamy L, Sinkkonen J, Mäntsälä P, Niemi J, Metsä-Ketelä M.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6024-9. doi: 10.1073/pnas.1201530109. Epub 2012 Apr 2.

8.

Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis.

Grocholski T, Oja T, Humphrey L, Mäntsälä P, Niemi J, Metsä-Ketelä M.

J Bacteriol. 2012 Jun;194(11):2829-36. doi: 10.1128/JB.00228-12. Epub 2012 Mar 30.

9.

Identification of late-stage glycosylation steps in the biosynthetic pathway of the anthracycline nogalamycin.

Siitonen V, Claesson M, Patrikainen P, Aromaa M, Mäntsälä P, Schneider G, Metsä-Ketelä M.

Chembiochem. 2012 Jan 2;13(1):120-8. doi: 10.1002/cbic.201100637. Epub 2011 Nov 25.

PMID:
22120896
10.

Flavoprotein hydroxylase PgaE catalyzes two consecutive oxygen-dependent tailoring reactions in angucycline biosynthesis.

Kallio P, Patrikainen P, Suomela JP, Mäntsälä P, Metsä-Ketelä M, Niemi J.

Biochemistry. 2011 Jun 21;50(24):5535-43. doi: 10.1021/bi200600k. Epub 2011 May 27.

PMID:
21595438
11.

Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.

Grocholski T, Koskiniemi H, Lindqvist Y, Mäntsälä P, Niemi J, Schneider G.

Biochemistry. 2010 Feb 9;49(5):934-44. doi: 10.1021/bi901985b.

PMID:
20052967
12.

Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis.

Lindqvist Y, Koskiniemi H, Jansson A, Sandalova T, Schnell R, Liu Z, Mäntsälä P, Niemi J, Schneider G.

J Mol Biol. 2009 Nov 6;393(4):966-77. doi: 10.1016/j.jmb.2009.09.003. Epub 2009 Sep 8.

PMID:
19744497
13.

Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.

Oja T, Palmu K, Lehmussola H, Leppäranta O, Hännikäinen K, Niemi J, Mäntsälä P, Metsä-Ketelä M.

Chem Biol. 2008 Oct 20;15(10):1046-57. doi: 10.1016/j.chembiol.2008.07.022.

14.

Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C.

Kallio P, Liu Z, Mäntsälä P, Niemi J, Metsä-Ketelä M.

Chem Biol. 2008 Feb;15(2):157-66. doi: 10.1016/j.chembiol.2007.12.011.

15.

A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation.

Kallio P, Liu Z, Mäntsälä P, Niemi J, Metsä-Ketelä M.

J Mol Biol. 2008 Feb 1;375(5):1212-21. Epub 2007 Nov 22.

PMID:
18076902
16.

Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis.

Koskiniemi H, Metsä-Ketelä M, Dobritzsch D, Kallio P, Korhonen H, Mäntsälä P, Schneider G, Niemi J.

J Mol Biol. 2007 Sep 21;372(3):633-48. Epub 2007 Jul 10.

PMID:
17669423
17.

Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways.

Palmu K, Ishida K, Mäntsälä P, Hertweck C, Metsä-Ketelä M.

Chembiochem. 2007 Sep 3;8(13):1577-84.

PMID:
17654627
18.

Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.

Alexeev I, Sultana A, Mäntsälä P, Niemi J, Schneider G.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6170-5. Epub 2007 Mar 29.

19.

Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning.

Sultana A, Alexeev I, Kursula I, Mäntsälä P, Niemi J, Schneider G.

Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):149-59. Epub 2007 Jan 16.

PMID:
17242508
20.

Crystal structures of SnoaL2 and AclR: two putative hydroxylases in the biosynthesis of aromatic polyketide antibiotics.

Beinker P, Lohkamp B, Peltonen T, Niemi J, Mäntsälä P, Schneider G.

J Mol Biol. 2006 Jun 9;359(3):728-40. Epub 2006 Apr 19.

PMID:
16650858
21.

Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.

Kallio P, Sultana A, Niemi J, Mäntsälä P, Schneider G.

J Mol Biol. 2006 Mar 17;357(1):210-20. Epub 2006 Jan 6.

PMID:
16414075
22.

Mutational analysis of the Bacillus subtilis purA operator site.

Rappu P, Leppihalme M, Mäntsälä P.

Curr Microbiol. 2005 Nov;51(5):322-6. Epub 2005 Sep 16.

PMID:
16163456
23.

Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor.

Jansson A, Koskiniemi H, Erola A, Wang J, Mäntsälä P, Schneider G, Niemi J.

J Biol Chem. 2005 Feb 4;280(5):3636-44. Epub 2004 Nov 17.

24.

Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.

Metsä-Ketelä M, Ylihonko K, Mäntsälä P.

J Antibiot (Tokyo). 2004 Aug;57(8):502-10.

25.

Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products.

Jansson A, Koskiniemi H, Mäntsälä P, Niemi J, Schneider G.

J Biol Chem. 2004 Sep 24;279(39):41149-56. Epub 2004 Jul 24.

26.

Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis.

Sultana A, Kallio P, Jansson A, Niemi J, Mäntsälä P, Schneider G.

Acta Crystallogr D Biol Crystallogr. 2004 Jun;60(Pt 6):1118-20. Epub 2004 May 21.

PMID:
15159574
27.

Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation.

Sultana A, Kallio P, Jansson A, Wang JS, Niemi J, Mäntsälä P, Schneider G.

EMBO J. 2004 May 5;23(9):1911-21. Epub 2004 Apr 8.

28.
29.

In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor.

Rappu P, Pullinen T, Mäntsälä P.

J Bacteriol. 2003 Nov;185(22):6728-31.

30.

Expanding the scope of aromatic polyketides by combinatorial biosynthesis.

Kantola J, Kunnari T, Mäntsälä P, Ylihonkoa K.

Comb Chem High Throughput Screen. 2003 Sep;6(6):501-12. Review.

PMID:
14529376
31.

Crystallization and preliminary X-ray diffraction studies of aclacinomycin-10-methyl esterase and aclacinomycin-10-hydroxylase from Streptomyces purpurascens.

Jansson A, Niemi J, Mäntsälä P, Schneider G.

Acta Crystallogr D Biol Crystallogr. 2003 Sep;59(Pt 9):1637-9. Epub 2003 Aug 19.

PMID:
12925797
32.

Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.

Jansson A, Niemi J, Mäntsälä P, Schneider G.

J Biol Chem. 2003 Oct 3;278(40):39006-13. Epub 2003 Jul 23.

33.

Studies on a second and third ring cyclization in anthracycline biosynthesis.

Hautala A, Torkkell S, Räty K, Kunnari T, Kantola J, Mantsälä P, Hakala J, Ylihonko K.

J Antibiot (Tokyo). 2003 Feb;56(2):143-53.

34.

Engineering anthracycline biosynthesis toward angucyclines.

Metsä-Ketelä M, Palmu K, Kunnari T, Ylihonko K, Mäntsälä P.

Antimicrob Agents Chemother. 2003 Apr;47(4):1291-6. Erratum in: Antimicrob Agents Chemother. 2003 Jun;47(6):2063.

35.

Characterization of mutations in aclacinomycin A-non-producing Streptomyces galilaeus strains with altered glycosylation patterns.

Räty K, Hautala A, Torkkell S, Kantola J, Mäntsälä P, Hakala J, Ylihonko K.

Microbiology. 2002 Nov;148(Pt 11):3375-84.

PMID:
12427929
36.

Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species.

Metsä-Ketelä M, Halo L, Munukka E, Hakala J, Mäntsälä P, Ylihonko K.

Appl Environ Microbiol. 2002 Sep;68(9):4472-9.

37.

Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.

Räty K, Kantola J, Hautala A, Hakala J, Ylihonko K, Mäntsälä P.

Gene. 2002 Jun 26;293(1-2):115-22.

PMID:
12137949
38.

Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products.

Wang Y, Niemi J, Mäntsälä P.

FEMS Microbiol Lett. 2002 Feb 19;208(1):117-22.

39.

The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures.

Torkkell S, Kunnari T, Palmu K, Mäntsälä P, Hakala J, Ylihonko K.

Mol Genet Genomics. 2001 Oct;266(2):276-88.

PMID:
11683270
40.

A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.

Räty K, Kunnari T, Hakala J, Mäntsälä P, Ylihonko K.

Mol Gen Genet. 2000 Sep;264(1-2):164-72.

PMID:
11016846
41.

Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens.

Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mäntsälä P.

Biochim Biophys Acta. 2000 Jul 14;1480(1-2):191-200.

PMID:
11004563
42.

Hybrid anthracyclines from a genetically engineered Streptomyces galilaeus mutant.

Kunnari TJ, Ylihonko KP, Klika KD, Mäntsälä PI, Hakala JM.

J Org Chem. 2000 May 19;65(10):2851-5.

PMID:
10814169
43.

Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp.

Kantola J, Kunnari T, Hautala A, Hakala J, Ylihonko K, Mäntsälä P.

Microbiology. 2000 Jan;146 ( Pt 1):155-63.

PMID:
10658662
44.

Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.

Torkkell S, Kunnari T, Palmu K, Hakala J, Mäntsälä P, Ylihonko K.

Antimicrob Agents Chemother. 2000 Feb;44(2):396-9.

45.

Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family.

Sinha S, Rappu P, Lange SC, Mäntsälä P, Zalkin H, Smith JL.

Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13074-9.

46.

An efficient approach for screening minimal PKS genes from Streptomyces.

Metsä-Ketelä M, Salo V, Halo L, Hautala A, Hakala J, Mäntsälä P, Ylihonko K.

FEMS Microbiol Lett. 1999 Nov 1;180(1):1-6.

47.

Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants.

Kunnari T, Ylihonko K, Hautala A, Klika KD, Mäntsälä P, Hakala J.

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2639-42.

PMID:
10509907
48.
49.

Oxidation of Crocein Orange G by lignin peroxidase isoenzymes. Kinetics and effect of H2O2.

Ollikka P, Harjunpää T, Palmu K, Mäntsälä P, Suominen I.

Appl Biochem Biotechnol. 1998 Nov-Dec;75(2-3):307-21.

PMID:
10230025
50.

Characterization of aklavinone-11-hydroxylase from Streptomyces purpurascens.

Niemi J, Wang Y, Airas K, Ylihonko K, Hakala J, Mäntsälä P.

Biochim Biophys Acta. 1999 Feb 10;1430(1):57-64.

PMID:
10082933

Supplemental Content

Loading ...
Support Center