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Items: 1 to 50 of 119

1.

Increased α-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer.

Kovac B, Mäkelä TP, Vallenius T.

PLoS One. 2018 May 9;13(5):e0196986. doi: 10.1371/journal.pone.0196986. eCollection 2018.

2.

Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells.

Kuuluvainen E, Domènech-Moreno E, Niemelä EH, Mäkelä TP.

Mol Cell Biol. 2018 May 15;38(11). pii: e00573-17. doi: 10.1128/MCB.00573-17. Print 2018 Jun 1.

PMID:
29507187
3.

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway.

Ollila S, Domènech-Moreno E, Laajanen K, Wong IP, Tripathi S, Pentinmikko N, Gao Y, Yan Y, Niemelä EH, Wang TC, Viollet B, Leone G, Katajisto P, Vaahtomeri K, Mäkelä TP.

J Clin Invest. 2018 Jan 2;128(1):402-414. doi: 10.1172/JCI93597. Epub 2017 Dec 4.

4.

AMPK negatively regulates tensin-dependent integrin activity.

Georgiadou M, Lilja J, Jacquemet G, Guzmán C, Rafaeva M, Alibert C, Yan Y, Sahgal P, Lerche M, Manneville JB, Mäkelä TP, Ivaska J.

J Cell Biol. 2017 Apr 3;216(4):1107-1121. doi: 10.1083/jcb.201609066. Epub 2017 Mar 13.

5.

SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling.

Yan Y, Ollila S, Wong IP, Vallenius T, Palvimo JJ, Vaahtomeri K, Mäkelä TP.

Nat Commun. 2015 Nov 30;6:8979. doi: 10.1038/ncomms9979.

6.

Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila.

Kuuluvainen E, Hakala H, Havula E, Sahal Estimé M, Rämet M, Hietakangas V, Mäkelä TP.

J Biol Chem. 2014 Jun 6;289(23):16252-61. doi: 10.1074/jbc.M113.541904. Epub 2014 Apr 28.

7.

CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner.

Yang Y, Roine N, Mäkelä TP.

EMBO Rep. 2013 Aug;14(8):741-7. doi: 10.1038/embor.2013.80. Epub 2013 Jun 7.

8.

N-methylnitrosourea aggravates gastrointestinal polyposis in Lkb1+/- mice.

Udd L, Gao Y, Ristimäki AP, Mäkelä TP.

Carcinogenesis. 2013 Oct;34(10):2409-14. doi: 10.1093/carcin/bgt188. Epub 2013 May 30.

PMID:
23722652
9.

Assembly of non-contractile dorsal stress fibers requires α-actinin-1 and Rac1 in migrating and spreading cells.

Kovac B, Teo JL, Mäkelä TP, Vallenius T.

J Cell Sci. 2013 Jan 1;126(Pt 1):263-73. doi: 10.1242/jcs.115063. Epub 2012 Nov 6.

10.

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.

Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):E388-97. doi: 10.1073/pnas.1120421109. Epub 2012 Jan 20.

11.

Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice.

Thiel A, Narko K, Heinonen M, Hemmes A, Tomasetto C, Rio MC, Haglund C, Mäkelä TP, Ristimäki A.

Int J Cancer. 2012 Sep 1;131(5):1032-41. doi: 10.1002/ijc.27331. Epub 2011 Dec 14.

12.

The tumor suppressor kinase LKB1: lessons from mouse models.

Ollila S, Mäkelä TP.

J Mol Cell Biol. 2011 Dec;3(6):330-40. doi: 10.1093/jmcb/mjr016. Epub 2011 Sep 15. Review.

PMID:
21926085
13.

Phosphorylated β-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain.

Chilov D, Sinjushina N, Rita H, Taketo MM, Mäkelä TP, Partanen J.

Dev Biol. 2011 Sep 1;357(1):259-68. doi: 10.1016/j.ydbio.2011.06.029. Epub 2011 Jun 26.

14.

LKB1 signaling in advancing cell differentiation.

Udd L, Mäkelä TP.

Fam Cancer. 2011 Sep;10(3):425-35. doi: 10.1007/s10689-011-9441-2. Review.

PMID:
21519908
15.

Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover.

Helenius K, Yang Y, Tselykh TV, Pessa HK, Frilander MJ, Mäkelä TP.

Nucleic Acids Res. 2011 Jul;39(12):5025-35. doi: 10.1093/nar/gkr107. Epub 2011 Mar 8.

16.

An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers.

Vallenius T, Vaahtomeri K, Kovac B, Osiceanu AM, Viljanen M, Mäkelä TP.

J Cell Sci. 2011 Feb 1;124(Pt 3):384-93. doi: 10.1242/jcs.072660.

17.

Molecular mechanisms of tumor suppression by LKB1.

Vaahtomeri K, Mäkelä TP.

FEBS Lett. 2011 Apr 6;585(7):944-51. doi: 10.1016/j.febslet.2010.12.034. Epub 2010 Dec 27. Review.

18.

Impaired gastric gland differentiation in Peutz-Jeghers syndrome.

Udd L, Katajisto P, Kyyrönen M, Ristimäki AP, Mäkelä TP.

Am J Pathol. 2010 May;176(5):2467-76. doi: 10.2353/ajpath.2010.090519. Epub 2010 Apr 2.

19.

Cyclin G-associated kinase promotes microtubule outgrowth from chromosomes during spindle assembly.

Tanenbaum ME, Vallenius T, Geers EF, Greene L, Mäkelä TP, Medema RH.

Chromosoma. 2010 Aug;119(4):415-24. doi: 10.1007/s00412-010-0267-8. Epub 2010 Mar 17.

20.

Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways.

Björklund MA, Vaahtomeri K, Peltonen K, Viollet B, Mäkelä TP, Band AM, Laiho M.

Exp Cell Res. 2010 Mar 10;316(5):762-74. doi: 10.1016/j.yexcr.2009.12.014. Epub 2009 Dec 28.

PMID:
20036235
21.

PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis.

Djouder N, Tuerk RD, Suter M, Salvioni P, Thali RF, Scholz R, Vaahtomeri K, Auchli Y, Rechsteiner H, Brunisholz RA, Viollet B, Mäkelä TP, Wallimann T, Neumann D, Krek W.

EMBO J. 2010 Jan 20;29(2):469-81. doi: 10.1038/emboj.2009.339. Epub 2009 Nov 26.

22.

Integrated network analysis platform for protein-protein interactions.

Wu J, Vallenius T, Ovaska K, Westermarck J, Mäkelä TP, Hautaniemi S.

Nat Methods. 2009 Jan;6(1):75-7. doi: 10.1038/nmeth.1282. Epub 2008 Dec 14.

PMID:
19079255
23.

Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation.

Helenius K, Yang Y, Alasaari J, Mäkelä TP.

Mol Cell Biol. 2009 Jan;29(2):315-23. doi: 10.1128/MCB.00347-08. Epub 2008 Nov 3.

24.

Lkb1 is required for TGFbeta-mediated myofibroblast differentiation.

Vaahtomeri K, Ventelä E, Laajanen K, Katajisto P, Wipff PJ, Hinz B, Vallenius T, Tiainen M, Mäkelä TP.

J Cell Sci. 2008 Nov 1;121(Pt 21):3531-40. doi: 10.1242/jcs.032706. Epub 2008 Oct 7.

25.

LKB1 in endothelial cells is required for angiogenesis and TGFbeta-mediated vascular smooth muscle cell recruitment.

Londesborough A, Vaahtomeri K, Tiainen M, Katajisto P, Ekman N, Vallenius T, Mäkelä TP.

Development. 2008 Jul;135(13):2331-8. doi: 10.1242/dev.017038.

26.

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.

Katajisto P, Vaahtomeri K, Ekman N, Ventelä E, Ristimäki A, Bardeesy N, Feil R, DePinho RA, Mäkelä TP.

Nat Genet. 2008 Apr;40(4):455-9. doi: 10.1038/ng.98. Epub 2008 Mar 2.

PMID:
18311138
27.

Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization.

Partanen JI, Nieminen AI, Mäkelä TP, Klefstrom J.

Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14694-9. Epub 2007 Aug 31.

28.

Cdk8 is essential for preimplantation mouse development.

Westerling T, Kuuluvainen E, Mäkelä TP.

Mol Cell Biol. 2007 Sep;27(17):6177-82. Epub 2007 Jul 9.

29.

Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.

Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Mäkelä TP, Schneider MD.

Cell Metab. 2007 Feb;5(2):129-42.

30.

The LKB1 tumor suppressor kinase in human disease.

Katajisto P, Vallenius T, Vaahtomeri K, Ekman N, Udd L, Tiainen M, Mäkelä TP.

Biochim Biophys Acta. 2007 Jan;1775(1):63-75. Epub 2006 Aug 16. Review.

PMID:
17010524
31.

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.

Alhopuro P, Katajisto P, Lehtonen R, Ylisaukko-Oja SK, Näätsaari L, Karhu A, Westerman AM, Wilson JH, de Rooij FW, Vogel T, Moeslein G, Tomlinson IP, Aaltonen LA, Mäkelä TP, Launonen V.

Br J Cancer. 2005 Mar 28;92(6):1126-9.

32.

Mcs2 and a novel CAK subunit Pmh1 associate with Skp1 in fission yeast.

Bamps S, Westerling T, Pihlak A, Tafforeau L, Vandenhaute J, Mäkelä TP, Hermand D.

Biochem Biophys Res Commun. 2004 Dec 24;325(4):1424-32.

PMID:
15555586
33.

Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2.

Udd L, Katajisto P, Rossi DJ, Lepistö A, Lahesmaa AM, Ylikorkala A, Järvinen HJ, Ristimäki AP, Mäkelä TP.

Gastroenterology. 2004 Oct;127(4):1030-7.

PMID:
15480979
34.

KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas.

Järviluoma A, Koopal S, Räsänen S, Mäkelä TP, Ojala PM.

Blood. 2004 Nov 15;104(10):3349-54. Epub 2004 Jul 22.

35.

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR.

EMBO J. 2004 Feb 25;23(4):833-43. Epub 2004 Feb 19.

36.

The PDZ-LIM protein RIL modulates actin stress fiber turnover and enhances the association of alpha-actinin with F-actin.

Vallenius T, Scharm B, Vesikansa A, Luukko K, Schäfer R, Mäkelä TP.

Exp Cell Res. 2004 Feb 1;293(1):117-28.

PMID:
14729062
37.

Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro.

Spahr H, Khorosjutina O, Baraznenok V, Linder T, Samuelsen CO, Hermand D, Mäkela TP, Holmberg S, Gustafsson CM.

J Biol Chem. 2003 Dec 19;278(51):51301-6. Epub 2003 Oct 8.

38.

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.

Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG.

J Biol. 2003;2(4):28. doi: 10.1186/1475-4924-2-28. Epub 2003 Sep 24.

39.

The histidine triad protein Hint is not required for murine development or Cdk7 function.

Korsisaari N, Rossi DJ, Luukko K, Huebner K, Henkemeyer M, Mäkelä TP.

Mol Cell Biol. 2003 Jun;23(11):3929-35.

40.

Skp1 and the F-box protein Pof6 are essential for cell separation in fission yeast.

Hermand D, Bamps S, Tafforeau L, Vandenhaute J, Mäkelä TP.

J Biol Chem. 2003 Mar 14;278(11):9671-7. Epub 2003 Jan 2.

41.

Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells provides evidence that Mat1 is not required for general transcription.

Korsisaari N, Rossi DJ, Paetau A, Charnay P, Henkemeyer M, Mäkelä TP.

J Cell Sci. 2002 Nov 15;115(Pt 22):4275-84.

42.

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.

Rossi DJ, Ylikorkala A, Korsisaari N, Salovaara R, Luukko K, Launonen V, Henkemeyer M, Ristimaki A, Aaltonen LA, Makela TP.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12327-32. Epub 2002 Sep 6.

43.

Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.

Petrova TV, Mäkinen T, Mäkelä TP, Saarela J, Virtanen I, Ferrell RE, Finegold DN, Kerjaschki D, Ylä-Herttuala S, Alitalo K.

EMBO J. 2002 Sep 2;21(17):4593-9.

44.

Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

Tiainen M, Vaahtomeri K, Ylikorkala A, Mäkelä TP.

Hum Mol Genet. 2002 Jun 15;11(13):1497-504.

PMID:
12045203
45.

Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein.

Vallenius T, Mäkelä TP.

J Cell Sci. 2002 May 15;115(Pt 10):2067-73.

46.

Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx.

Li XD, Mäkelä TP, Guo D, Soliymani R, Koistinen V, Vapalahti O, Vaheri A, Lankinen H.

J Gen Virol. 2002 Apr;83(Pt 4):759-66.

PMID:
11907324
47.

CAK-independent activation of CDK6 by a viral cyclin.

Kaldis P, Ojala PM, Tong L, Mäkelä TP, Solomon MJ.

Mol Biol Cell. 2001 Dec;12(12):3987-99.

48.

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice.

Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, Mäkelä TP.

Science. 2001 Aug 17;293(5533):1323-6.

49.

BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.

Mäkiniemi M, Hillukkala T, Tuusa J, Reini K, Vaara M, Huang D, Pospiech H, Majuri I, Westerling T, Mäkelä TP, Syväoja JE.

J Biol Chem. 2001 Aug 10;276(32):30399-406. Epub 2001 Jun 6.

50.

Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1.

Rossi DJ, Londesborough A, Korsisaari N, Pihlak A, Lehtonen E, Henkemeyer M, Mäkelä TP.

EMBO J. 2001 Jun 1;20(11):2844-56.

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