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Items: 1 to 50 of 54

1.

Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential.

Rauscher AÁ, Gyimesi M, Kovács M, Málnási-Csizmadia A.

Trends Biochem Sci. 2018 Sep;43(9):700-713. doi: 10.1016/j.tibs.2018.06.006. Epub 2018 Jul 26. Review.

PMID:
30057142
2.

Non-blocking modulation contributes to sodium channel inhibition by a covalently attached photoreactive riluzole analog.

Lukacs P, Földi MC, Valánszki L, Casanova E, Biri-Kovács B, Nyitray L, Málnási-Csizmadia A, Mike A.

Sci Rep. 2018 May 25;8(1):8110. doi: 10.1038/s41598-018-26444-y.

3.

Sex-specific regulation of aging in Caenorhabditis elegans.

Hotzi B, Kosztelnik M, Hargitai B, Takács-Vellai K, Barna J, Bördén K, Málnási-Csizmadia A, Lippai M, Ortutay C, Bacquet C, Pasparaki A, Arányi T, Tavernarakis N, Vellai T.

Aging Cell. 2018 Jun;17(3):e12724. doi: 10.1111/acel.12724. Epub 2018 Mar 1.

4.

Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels.

Tang W, Blair CA, Walton SD, Málnási-Csizmadia A, Campbell KS, Yengo CM.

Front Physiol. 2017 Jan 9;7:659. doi: 10.3389/fphys.2016.00659. eCollection 2016.

5.

Modeling Polypharmacological Profiles by Affinity Fingerprinting.

Peragovics A, Simon Z, Malnasi-Csizmadia A, Bender A.

Curr Pharm Des. 2016;22(46):6885-6894. doi: 10.2174/1381612822666160831104718. Review.

PMID:
27587199
6.

A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative.

Várkuti BH, Képiró M, Horváth IÁ, Végner L, Ráti S, Zsigmond Á, Hegyi G, Lenkei Z, Varga M, Málnási-Csizmadia A.

Sci Rep. 2016 May 31;6:26141. doi: 10.1038/srep26141.

7.

High-Field High-Repetition-Rate Sources for the Coherent THz Control of Matter.

Green B, Kovalev S, Asgekar V, Geloni G, Lehnert U, Golz T, Kuntzsch M, Bauer C, Hauser J, Voigtlaender J, Wustmann B, Koesterke I, Schwarz M, Freitag M, Arnold A, Teichert J, Justus M, Seidel W, Ilgner C, Awari N, Nicoletti D, Kaiser S, Laplace Y, Rajasekaran S, Zhang L, Winnerl S, Schneider H, Schay G, Lorincz I, Rauscher AA, Radu I, Mährlein S, Kim TH, Lee JS, Kampfrath T, Wall S, Heberle J, Malnasi-Csizmadia A, Steiger A, Müller AS, Helm M, Schramm U, Cowan T, Michel P, Cavalleri A, Fisher AS, Stojanovic N, Gensch M.

Sci Rep. 2016 Feb 29;6:22256. doi: 10.1038/srep22256.

8.

Molecular tattoo: subcellular confinement of drug effects.

Képiró M, Várkuti BH, Rauscher AA, Kellermayer MSZ, Varga M, Málnási-Csizmadia A.

Chem Biol. 2015 Apr 23;22(4):548-558. doi: 10.1016/j.chembiol.2015.03.013. Epub 2015 Apr 16.

9.

Viscosity dependence of passage through a fluctuating bottleneck.

Orgován N, Rauscher A, Málnási-Csizmadia A, Derényi I.

J Chem Phys. 2014 Dec 7;141(21):215101. doi: 10.1063/1.4902365.

PMID:
25481170
10.

Structural model of weak binding actomyosin in the prepowerstroke state.

Várkuti BH, Yang Z, Malnasi-Csizmadia A.

J Biol Chem. 2015 Jan 16;290(3):1679-88. doi: 10.1074/jbc.M114.606665. Epub 2014 Nov 21.

11.

Magnesium modulates actin binding and ADP release in myosin motors.

Swenson AM, Trivedi DV, Rauscher AA, Wang Y, Takagi Y, Palmer BM, Málnási-Csizmadia A, Debold EP, Yengo CM.

J Biol Chem. 2014 Aug 22;289(34):23977-91. doi: 10.1074/jbc.M114.562231. Epub 2014 Jul 8.

12.

para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor.

Képiró M, Várkuti BH, Végner L, Vörös G, Hegyi G, Varga M, Málnási-Csizmadia A.

Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8211-5. doi: 10.1002/anie.201403540. Epub 2014 Jun 20.

PMID:
24954740
13.

Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching.

Végner L, Peragovics Á, Tombor L, Jelinek B, Czobor P, Bender A, Simon Z, Málnási-Csizmadia A.

J Med Chem. 2013 Nov 14;56(21):8377-88. doi: 10.1021/jm400813y. Epub 2013 Oct 23.

PMID:
24088053
14.

Identification of PPARγ ligands with One-dimensional Drug Profile Matching.

Kovács D, Simon Z, Hári P, Málnási-Csizmadia A, Hegedűs C, Drimba L, Németh J, Sári R, Szilvássy Z, Peitl B.

Drug Des Devel Ther. 2013 Sep 2;7:917-28. doi: 10.2147/DDDT.S47173. eCollection 2013.

15.

Internal friction in enzyme reactions.

Rauscher A, Derényi I, Gráf L, Málnási-Csizmadia A.

IUBMB Life. 2013 Jan;65(1):35-42. doi: 10.1002/iub.1101. Review.

16.

Virtual affinity fingerprints for target fishing: a new application of Drug Profile Matching.

Peragovics Á, Simon Z, Tombor L, Jelinek B, Hári P, Czobor P, Málnási-Csizmadia A.

J Chem Inf Model. 2013 Jan 28;53(1):103-13. doi: 10.1021/ci3004489. Epub 2012 Dec 18.

PMID:
23215025
17.

Contribution of 2D and 3D structural features of drug molecules in the prediction of Drug Profile Matching.

Peragovics A, Simon Z, Brandhuber I, Jelinek B, Hári P, Hetényi C, Czobor P, Málnási-Csizmadia A.

J Chem Inf Model. 2012 Jul 23;52(7):1733-44. doi: 10.1021/ci3001056. Epub 2012 Jun 29.

PMID:
22697495
18.

Azidoblebbistatin, a photoreactive myosin inhibitor.

Képiró M, Várkuti BH, Bodor A, Hegyi G, Drahos L, Kovács M, Málnási-Csizmadia A.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9402-7. doi: 10.1073/pnas.1202786109. Epub 2012 May 30.

19.

A novel actin binding site of myosin required for effective muscle contraction.

Várkuti BH, Yang Z, Kintses B, Erdélyi P, Bárdos-Nagy I, Kovács AL, Hári P, Kellermayer M, Vellai T, Málnási-Csizmadia A.

Nat Struct Mol Biol. 2012 Feb 12;19(3):299-306. doi: 10.1038/nsmb.2216.

PMID:
22343723
20.

Drug effect prediction by polypharmacology-based interaction profiling.

Simon Z, Peragovics A, Vigh-Smeller M, Csukly G, Tombor L, Yang Z, Zahoránszky-Kohalmi G, Végner L, Jelinek B, Hári P, Hetényi C, Bitter I, Czobor P, Málnási-Csizmadia A.

J Chem Inf Model. 2012 Jan 23;52(1):134-45. doi: 10.1021/ci2002022. Epub 2011 Dec 9.

PMID:
22098080
21.

Temperature dependence of internal friction in enzyme reactions.

Rauscher AÁ, Simon Z, Szöllosi GJ, Gráf L, Derényi I, Malnasi-Csizmadia A.

FASEB J. 2011 Aug;25(8):2804-13. doi: 10.1096/fj.11-180794. Epub 2011 May 9.

PMID:
21555355
22.

Nucleotide pocket thermodynamics measured by EPR reveal how energy partitioning relates myosin speed to efficiency.

Purcell TJ, Naber N, Franks-Skiba K, Dunn AR, Eldred CC, Berger CL, Málnási-Csizmadia A, Spudich JA, Swank DM, Pate E, Cooke R.

J Mol Biol. 2011 Mar 18;407(1):79-91. doi: 10.1016/j.jmb.2010.11.053. Epub 2010 Dec 23.

23.

Relating the shape of protein binding sites to binding affinity profiles: is there an association?

Simon Z, Vigh-Smeller M, Peragovics A, Csukly G, Zahoránszky-Kohalmi G, Rauscher AA, Jelinek B, Hári P, Bitter I, Málnási-Csizmadia A, Czobor P.

BMC Struct Biol. 2010 Oct 5;10:32. doi: 10.1186/1472-6807-10-32.

24.

Emerging complex pathways of the actomyosin powerstroke.

Málnási-Csizmadia A, Kovács M.

Trends Biochem Sci. 2010 Dec;35(12):684-90. doi: 10.1016/j.tibs.2010.07.012. Review.

25.

Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke.

Takács B, Billington N, Gyimesi M, Kintses B, Málnási-Csizmadia A, Knight PJ, Kovács M.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6799-804. doi: 10.1073/pnas.0907585107. Epub 2010 Mar 29.

26.

Combining EPR with fluorescence spectroscopy to monitor conformational changes at the myosin nucleotide pocket.

Naber N, Málnási-Csizmadia A, Purcell TJ, Cooke R, Pate E.

J Mol Biol. 2010 Mar 5;396(4):937-48. doi: 10.1016/j.jmb.2009.12.035. Epub 2009 Dec 28.

PMID:
20036250
27.

Breaking the hierarchy--a new cluster selection mechanism for hierarchical clustering methods.

Zahoránszky LA, Katona GY, Hári P, Málnási-Csizmadia A, Zweig KA, Zahoránszky-Köhalmi G.

Algorithms Mol Biol. 2009 Oct 19;4:12. doi: 10.1186/1748-7188-4-12.

28.

Experimental investigation of the seesaw mechanism of the relay region that moves the myosin lever arm.

Kintses B, Yang Z, Málnási-Csizmadia A.

J Biol Chem. 2008 Dec 5;283(49):34121-8. doi: 10.1074/jbc.M805848200. Epub 2008 Oct 14.

29.

The mechanism of the reverse recovery step, phosphate release, and actin activation of Dictyostelium myosin II.

Gyimesi M, Kintses B, Bodor A, Perczel A, Fischer S, Bagshaw CR, Málnási-Csizmadia A.

J Biol Chem. 2008 Mar 28;283(13):8153-63. doi: 10.1074/jbc.M708863200. Epub 2008 Jan 21.

30.

Probing conformational plasticity of the activation domain of trypsin: the role of glycine hinges.

Gombos L, Kardos J, Patthy A, Medveczky P, Szilágyi L, Málnási-Csizmadia A, Gráf L.

Biochemistry. 2008 Feb 12;47(6):1675-84. doi: 10.1021/bi701454e. Epub 2008 Jan 15.

PMID:
18193894
31.

Kinetic characterization of the function of myosin loop 4 in the actin-myosin interaction.

Gyimesi M, Tsaturyan AK, Kellermayer MS, Málnási-Csizmadia A.

Biochemistry. 2008 Jan 8;47(1):283-91. Epub 2007 Dec 8.

PMID:
18067324
32.

Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme.

Tóth J, Varga B, Kovács M, Málnási-Csizmadia A, Vértessy BG.

J Biol Chem. 2007 Nov 16;282(46):33572-82. Epub 2007 Sep 11.

33.

Selective perturbation of the myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release.

Málnási-Csizmadia A, Tóth J, Pearson DS, Hetényi C, Nyitray L, Geeves MA, Bagshaw CR, Kovács M.

J Biol Chem. 2007 Jun 15;282(24):17658-64. Epub 2007 Apr 21.

34.

Site directed mutagenesis at position 193 of human trypsin 4 alters the rate of conformational change during activation: role of local internal viscosity in protein dynamics.

Tóth J, Simon Z, Medveczky P, Gombos L, Jelinek B, Szilágyi L, Gráf L, Málnási-Csizmadia A.

Proteins. 2007 Jun 1;67(4):1119-27.

PMID:
17436323
35.

Reversible movement of switch 1 loop of myosin determines actin interaction.

Kintses B, Gyimesi M, Pearson DS, Geeves MA, Zeng W, Bagshaw CR, Málnási-Csizmadia A.

EMBO J. 2007 Jan 10;26(1):265-74.

36.

Enzyme kinetics above denaturation temperature: a temperature-jump/stopped-flow apparatus.

Kintses B, Simon Z, Gyimesi M, Tóth J, Jelinek B, Niedetzky C, Kovács M, Málnási-Csizmadia A.

Biophys J. 2006 Dec 15;91(12):4605-10. Epub 2006 Sep 29.

37.

Resonance energy transfer between green fluorescent protein variants: complexities revealed with myosin fusion proteins.

Zeng W, Seward HE, Málnási-Csizmadia A, Wakelin S, Woolley RJ, Cheema GS, Basran J, Patel TR, Rowe AJ, Bagshaw CR.

Biochemistry. 2006 Sep 5;45(35):10482-91.

PMID:
16939200
38.

Thermodynamic analysis reveals structural rearrangement during the acylation step in human trypsin 4 on 4-methylumbelliferyl 4-guanidinobenzoate substrate analogue.

Tóth J, Gombos L, Simon Z, Medveczky P, Szilágyi L, Gráf L, Málnási-Csizmadia A.

J Biol Chem. 2006 May 5;281(18):12596-602. Epub 2006 Feb 21.

39.

Switch movements and the myosin crossbridge stroke.

Málnási-Csizmadia A, Dickens JL, Zeng W, Bagshaw CR.

J Muscle Res Cell Motil. 2005;26(1):31-7. Epub 2005 Aug 2. Review.

PMID:
16075160
40.

Dynamics of actomyosin interactions in relation to the cross-bridge cycle.

Zeng W, Conibear PB, Dickens JL, Cowie RA, Wakelin S, Málnási-Csizmadia A, Bagshaw CR.

Philos Trans R Soc Lond B Biol Sci. 2004 Dec 29;359(1452):1843-55. Review.

41.
42.

Differential actin binding along the PEVK domain of skeletal muscle titin.

Nagy A, Cacciafesta P, Grama L, Kengyel A, Málnási-Csizmadia A, Kellermayer MS.

J Cell Sci. 2004 Nov 15;117(Pt 24):5781-9. Epub 2004 Oct 26.

43.

Characterization of f-actin tryptophan phosphorescence in the presence and absence of tryptophan-free myosin motor domain.

Bódis E, Strambini GB, Gonnelli M, Málnási-Csizmadia A, Somogyi B.

Biophys J. 2004 Aug;87(2):1146-54.

44.

Mechanism of blebbistatin inhibition of myosin II.

Kovács M, Tóth J, Hetényi C, Málnási-Csizmadia A, Sellers JR.

J Biol Chem. 2004 Aug 20;279(34):35557-63. Epub 2004 Jun 16.

45.

Engineering lysine reactivity as a conformational sensor in the Dictyostelium myosin II motor domain.

Kovács M, Tóth J, Málnási-Csizmadia A, Bagshaw CR, Nyitray L.

J Muscle Res Cell Motil. 2004;25(1):95-102.

PMID:
15160493
46.

Myosin cleft movement and its coupling to actomyosin dissociation.

Conibear PB, Bagshaw CR, Fajer PG, Kovács M, Málnási-Csizmadia A.

Nat Struct Biol. 2003 Oct;10(10):831-5. Epub 2003 Sep 21.

PMID:
14502269
47.

Engineering Dictyostelium discoideum myosin II for the introduction of site-specific fluorescence probes.

Wakelin S, Conibear PB, Woolley RJ, Floyd DN, Bagshaw CR, Kovács M, Málnási-Csizmadia A.

J Muscle Res Cell Motil. 2002;23(7-8):673-83. Review.

PMID:
12952066
48.

Localization and characterization of the inhibitory Ca2+-binding site of Physarum polycephalum myosin II.

Farkas L, Malnasi-Csizmadia A, Nakamura A, Kohama K, Nyitray L.

J Biol Chem. 2003 Jul 25;278(30):27399-405. Epub 2003 May 16.

49.

Analysis of nucleotide binding to Dictyostelium myosin II motor domains containing a single tryptophan near the active site.

Kovacs M, Malnasi-Csizmadia A, Woolley RJ, Bagshaw CR.

J Biol Chem. 2002 Aug 9;277(32):28459-67. Epub 2002 Apr 23.

50.

Kinetic resolution of a conformational transition and the ATP hydrolysis step using relaxation methods with a Dictyostelium myosin II mutant containing a single tryptophan residue.

Málnási-Csizmadia A, Pearson DS, Kovács M, Woolley RJ, Geeves MA, Bagshaw CR.

Biochemistry. 2001 Oct 23;40(42):12727-37. Erratum in: Biochemistry. 2004 Nov 9;43(44):14316.

PMID:
11601998

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