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Items: 46


Multiple Modulation of Acid-Sensing Ion Channel 1a by the Alkaloid Daurisoline.

Osmakov DI, Koshelev SG, Lyukmanova EN, Shulepko MA, Andreev YA, Illes P, Kozlov SA.

Biomolecules. 2019 Aug 2;9(8). pii: E336. doi: 10.3390/biom9080336.


CombLabel: rational design of optimized sequence-specific combinatorial labeling schemes. Application to backbone assignment of membrane proteins with low stability.

Myshkin MY, Dubinnyi MA, Kulbatskii DS, Lyukmanova EN, Kirpichnikov MP, Shenkarev ZO.

J Biomol NMR. 2019 Jul 8. doi: 10.1007/s10858-019-00259-z. [Epub ahead of print]


Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of α7 nicotinic acetylcholine receptors.

Bychkov M, Shenkarev Z, Shulepko M, Shlepova O, Kirpichnikov M, Lyukmanova E.

PLoS One. 2019 May 31;14(5):e0217339. doi: 10.1371/journal.pone.0217339. eCollection 2019.


Recombinant Production and Structure-Function Study of the Ts1 Toxin from the Brazilian Scorpion Tityus serrulatus.

Shenkarev ZO, Shulepko MA, Peigneur S, Myshkin MY, Berkut AA, Vassilevski AA, Tytgat J, Lyukmanova EN, Kirpichnikov MP.

Dokl Biochem Biophys. 2019 May;484(1):9-12. doi: 10.1134/S1607672919010034. Epub 2019 Apr 22.


Lynx1 Prevents Long-Term Potentiation Blockade and Reduction of Neuromodulator Expression Caused by Aβ1-42 and JNK Activation.

Bychkov ML, Vasilyeva NA, Shulepko MA, Balaban PM, Kirpichnikov MP, Lyukmanova EN.

Acta Naturae. 2018 Jul-Sep;10(3):57-61.


Recombinant Production, Reconstruction in Lipid-Protein Nanodiscs, and Electron Microscopy of Full-Length α-Subunit of Human Potassium Channel Kv7.1.

Shenkarev ZO, Karlova MG, Kulbatskii DS, Kirpichnikov MP, Lyukmanova EN, Sokolova OS.

Biochemistry (Mosc). 2018 May;83(5):562-573. doi: 10.1134/S0006297918050097.


Spider toxin inhibits gating pore currents underlying periodic paralysis.

Männikkö R, Shenkarev ZO, Thor MG, Berkut AA, Myshkin MY, Paramonov AS, Kulbatskii DS, Kuzmin DA, Sampedro Castañeda M, King L, Wilson ER, Lyukmanova EN, Kirpichnikov MP, Schorge S, Bosmans F, Hanna MG, Kullmann DM, Vassilevski AA.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4495-4500. doi: 10.1073/pnas.1720185115. Epub 2018 Apr 10.


Three-Finger Proteins from the Ly6/uPAR Family: Functional Diversity within One Structural Motif.

Vasilyeva NA, Loktyushov EV, Bychkov ML, Shenkarev ZO, Lyukmanova EN.

Biochemistry (Mosc). 2017 Dec;82(13):1702-1715. doi: 10.1134/S0006297917130090. Review.


Human secreted proteins SLURP-1 and SLURP-2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors.

Lyukmanova EN, Bychkov ML, Sharonov GV, Efremenko AV, Shulepko MA, Kulbatskii DS, Shenkarev ZO, Feofanov AV, Dolgikh DA, Kirpichnikov MP.

Br J Pharmacol. 2018 Jun;175(11):1973-1986. doi: 10.1111/bph.14194. Epub 2018 Apr 24.


Structural and Dynamic "Portraits" of Recombinant and Native Cytotoxin I from Naja oxiana: How Close Are They?

Dubovskii PV, Dubinnyi MA, Konshina AG, Kazakova ED, Sorokoumova GM, Ilyasova TM, Shulepko MA, Chertkova RV, Lyukmanova EN, Dolgikh DA, Arseniev AS, Efremov RG.

Biochemistry. 2017 Aug 29;56(34):4468-4477. doi: 10.1021/acs.biochem.7b00453. Epub 2017 Aug 14.


Engineering of Chimeric Protein Based on E Protein Domain III of Tick- Borne Encephalitis Virus and OmpF Porin of Yersinia pseudotuberculosis.

Stenkova AM, Chopenko NS, Davydova LA, Mazeika AN, Bystritskaya EP, Portnyagina OY, Anastyuk SD, Kulbatskii DS, Lyukmanova EN, Dolgikh DA, Kostetsky EY, Sanina NM.

Protein Pept Lett. 2017;24(10):974-981. doi: 10.2174/0929866524666170724151917.


NMR investigation of the isolated second voltage-sensing domain of human Nav1.4 channel.

Paramonov AS, Lyukmanova EN, Myshkin MY, Shulepko MA, Kulbatskii DS, Petrosian NS, Chugunov AO, Dolgikh DA, Kirpichnikov MP, Arseniev AS, Shenkarev ZO.

Biochim Biophys Acta Biomembr. 2017 Mar;1859(3):493-506. doi: 10.1016/j.bbamem.2017.01.004. Epub 2017 Jan 6.


Towards universal approach for bacterial production of three-finger Ly6/uPAR proteins: Case study of cytotoxin I from cobra N. oxiana.

Shulepko MA, Lyukmanova EN, Shenkarev ZO, Dubovskii PV, Astapova MV, Feofanov AV, Arseniev AS, Utkin YN, Kirpichnikov MP, Dolgikh DA.

Protein Expr Purif. 2017 Feb;130:13-20. doi: 10.1016/j.pep.2016.09.021. Epub 2016 Oct 1.


Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors.

Lyukmanova EN, Shulepko MA, Shenkarev ZO, Bychkov ML, Paramonov AS, Chugunov AO, Kulbatskii DS, Arvaniti M, Dolejsi E, Schaer T, Arseniev AS, Efremov RG, Thomsen MS, Dolezal V, Bertrand D, Dolgikh DA, Kirpichnikov MP.

Sci Rep. 2016 Aug 3;6:30698. doi: 10.1038/srep30698.


Lynx1 and Aβ1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes.

Thomsen MS, Arvaniti M, Jensen MM, Shulepko MA, Dolgikh DA, Pinborg LH, Härtig W, Lyukmanova EN, Mikkelsen JD.

Neurobiol Aging. 2016 Oct;46:13-21. doi: 10.1016/j.neurobiolaging.2016.06.009. Epub 2016 Jun 17.


Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models.

Faure G, Shelukhina IV, Porowinska D, Shulepko MA, Lyukmanova EN, Dolgikh DA, Spirova EN, Kasheverov IE, Utkin YN, Corringer JP, Tsetlin VI.

Dokl Biochem Biophys. 2016 May;468(1):193-6. doi: 10.1134/S1607672916030091. Epub 2016 Jul 15.


Central loop of non-conventional toxin WTX from Naja kaouthia is important for interaction with nicotinic acetylcholine receptors.

Lyukmanova EN, Shulepko MA, Shenkarev ZO, Kasheverov IE, Chugunov AO, Kulbatskii DS, Myshkin MY, Utkin YN, Efremov RG, Tsetlin VI, Arseniev AS, Kirpichnikov MP, Dolgikh DA.

Toxicon. 2016 Sep 1;119:274-9. doi: 10.1016/j.toxicon.2016.06.012. Epub 2016 Jun 23.


Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor.

Lyukmanova EN, Shulepko MA, Kudryavtsev D, Bychkov ML, Kulbatskii DS, Kasheverov IE, Astapova MV, Feofanov AV, Thomsen MS, Mikkelsen JD, Shenkarev ZO, Tsetlin VI, Dolgikh DA, Kirpichnikov MP.

PLoS One. 2016 Feb 23;11(2):e0149733. doi: 10.1371/journal.pone.0149733. eCollection 2016.


Structural Insight into Specificity of Interactions between Nonconventional Three-finger Weak Toxin from Naja kaouthia (WTX) and Muscarinic Acetylcholine Receptors.

Lyukmanova EN, Shenkarev ZO, Shulepko MA, Paramonov AS, Chugunov AO, Janickova H, Dolejsi E, Dolezal V, Utkin YN, Tsetlin VI, Arseniev AS, Efremov RG, Dolgikh DA, Kirpichnikov MP.

J Biol Chem. 2015 Sep 25;290(39):23616-30. doi: 10.1074/jbc.M115.656595. Epub 2015 Aug 4.


Neurotoxins from snake venoms and α-conotoxin ImI inhibit functionally active ionotropic γ-aminobutyric acid (GABA) receptors.

Kudryavtsev DS, Shelukhina IV, Son LV, Ojomoko LO, Kryukova EV, Lyukmanova EN, Zhmak MN, Dolgikh DA, Ivanov IA, Kasheverov IE, Starkov VG, Ramerstorfer J, Sieghart W, Tsetlin VI, Utkin YN.

J Biol Chem. 2015 Sep 11;290(37):22747-58. doi: 10.1074/jbc.M115.648824. Epub 2015 Jul 28.


Human SLURP-1 and SLURP-2 Proteins Acting on Nicotinic Acetylcholine Receptors Reduce Proliferation of Human Colorectal Adenocarcinoma HT-29 Cells.

Lyukmanova EN, Shulepko MA, Bychkov ML, Shenkarev ZO, Paramonov AS, Chugunov AO, Arseniev AS, Dolgikh DA, Kirpichnikov MP.

Acta Naturae. 2014 Oct;6(4):60-6.


Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and Mygalomorphae.

Berkut AA, Peigneur S, Myshkin MY, Paramonov AS, Lyukmanova EN, Arseniev AS, Grishin EV, Tytgat J, Shenkarev ZO, Vassilevski AA.

J Biol Chem. 2015 Jan 2;290(1):492-504. doi: 10.1074/jbc.M114.595678. Epub 2014 Oct 28.


Lipid-protein nanodiscs offer new perspectives for structural and functional studies of water-soluble membrane-active peptides.

Shenkarev ZO, Lyukmanova EN, Paramonov AS, Panteleev PV, Balandin SV, Shulepko MA, Mineev KS, Ovchinnikova TV, Kirpichnikov MP, Arseniev AS.

Acta Naturae. 2014 Apr;6(2):84-94.


Structural and functional characterization of alternative transmembrane domain conformations in VEGF receptor 2 activation.

Manni S, Mineev KS, Usmanova D, Lyukmanova EN, Shulepko MA, Kirpichnikov MP, Winter J, Matkovic M, Deupi X, Arseniev AS, Ballmer-Hofer K.

Structure. 2014 Aug 5;22(8):1077-1089. doi: 10.1016/j.str.2014.05.010. Epub 2014 Jun 26.


NMR-based approach to measure the free energy of transmembrane helix-helix interactions.

Mineev KS, Lesovoy DM, Usmanova DR, Goncharuk SA, Shulepko MA, Lyukmanova EN, Kirpichnikov MP, Bocharov EV, Arseniev AS.

Biochim Biophys Acta. 2014 Jan;1838(1 Pt B):164-72. doi: 10.1016/j.bbamem.2013.08.021. Epub 2013 Sep 10.


Structural investigation of influenza virus hemagglutinin membrane-anchoring peptide.

Mineev KS, Lyukmanova EN, Krabben L, Serebryakova MV, Shulepko MA, Arseniev AS, Kordyukova LV, Veit M.

Protein Eng Des Sel. 2013 Sep;26(9):547-52. doi: 10.1093/protein/gzt034. Epub 2013 Jul 19.


Expression of the Ly-6 family proteins Lynx1 and Ly6H in the rat brain is compartmentalized, cell-type specific, and developmentally regulated.

Thomsen MS, Cinar B, Jensen MM, Lyukmanova EN, Shulepko MA, Tsetlin V, Klein AB, Mikkelsen JD.

Brain Struct Funct. 2014 Nov;219(6):1923-34. doi: 10.1007/s00429-013-0611-x. Epub 2013 Jul 17.


Peptaibol antiamoebin I: spatial structure, backbone dynamics, interaction with bicelles and lipid-protein nanodiscs, and pore formation in context of barrel-stave model.

Shenkarev ZO, Paramonov AS, Lyukmanova EN, Gizatullina AK, Zhuravleva AV, Tagaev AA, Yakimenko ZA, Telezhinskaya IN, Kirpichnikov MP, Ovchinnikova TV, Arseniev AS.

Chem Biodivers. 2013 May;10(5):838-63. doi: 10.1002/cbdv.201200421.


Water-soluble LYNX1 residues important for interaction with muscle-type and/or neuronal nicotinic receptors.

Lyukmanova EN, Shulepko MA, Buldakova SL, Kasheverov IE, Shenkarev ZO, Reshetnikov RV, Filkin SY, Kudryavtsev DS, Ojomoko LO, Kryukova EV, Dolgikh DA, Kirpichnikov MP, Bregestovski PD, Tsetlin VI.

J Biol Chem. 2013 May 31;288(22):15888-99. doi: 10.1074/jbc.M112.436576. Epub 2013 Apr 12.


Human neuromodulator SLURP-1: bacterial expression, binding to muscle-type nicotinic acetylcholine receptor, secondary structure, and conformational heterogeneity in solution.

Shulepko MA, Lyukmanova EN, Paramonov AS, Lobas AA, Shenkarev ZO, Kasheverov IE, Dolgikh DA, Tsetlin VI, Arseniev AS, Kirpichnikov MP.

Biochemistry (Mosc). 2013 Feb;78(2):204-11. doi: 10.1134/S0006297913020090.


N-terminal fusion tags for effective production of g-protein-coupled receptors in bacterial cell-free systems.

Lyukmanova EN, Shenkarev ZO, Khabibullina NF, Kulbatskiy DS, Shulepko MA, Petrovskaya LE, Arseniev AS, Dolgikh DA, Kirpichnikov MP.

Acta Naturae. 2012 Oct;4(4):58-64.


Lipid-protein nanodiscs promote in vitro folding of transmembrane domains of multi-helical and multimeric membrane proteins.

Shenkarev ZO, Lyukmanova EN, Butenko IO, Petrovskaya LE, Paramonov AS, Shulepko MA, Nekrasova OV, Kirpichnikov MP, Arseniev AS.

Biochim Biophys Acta. 2013 Feb;1828(2):776-84. doi: 10.1016/j.bbamem.2012.11.005. Epub 2012 Nov 13.


Lipid-protein nanodiscs for cell-free production of integral membrane proteins in a soluble and folded state: comparison with detergent micelles, bicelles and liposomes.

Lyukmanova EN, Shenkarev ZO, Khabibullina NF, Kopeina GS, Shulepko MA, Paramonov AS, Mineev KS, Tikhonov RV, Shingarova LN, Petrovskaya LE, Dolgikh DA, Arseniev AS, Kirpichnikov MP.

Biochim Biophys Acta. 2012 Mar;1818(3):349-58. doi: 10.1016/j.bbamem.2011.10.020. Epub 2011 Oct 26.


Spatial structure and dimer--monomer equilibrium of the ErbB3 transmembrane domain in DPC micelles.

Mineev KS, Khabibullina NF, Lyukmanova EN, Dolgikh DA, Kirpichnikov MP, Arseniev AS.

Biochim Biophys Acta. 2011 Aug;1808(8):2081-8. doi: 10.1016/j.bbamem.2011.04.017. Epub 2011 May 6.


NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1.

Lyukmanova EN, Shenkarev ZO, Shulepko MA, Mineev KS, D'Hoedt D, Kasheverov IE, Filkin SY, Krivolapova AP, Janickova H, Dolezal V, Dolgikh DA, Arseniev AS, Bertrand D, Tsetlin VI, Kirpichnikov MP.

J Biol Chem. 2011 Mar 25;286(12):10618-27. doi: 10.1074/jbc.M110.189100. Epub 2011 Jan 20.


Predicted bacteriorhodopsin from Exiguobacterium sibiricum is a functional proton pump.

Petrovskaya LE, Lukashev EP, Chupin VV, Sychev SV, Lyukmanova EN, Kryukova EA, Ziganshin RH, Spirina EV, Rivkina EM, Khatypov RA, Erokhina LG, Gilichinsky DA, Shuvalov VA, Kirpichnikov MP.

FEBS Lett. 2010 Oct 8;584(19):4193-6. doi: 10.1016/j.febslet.2010.09.005. Epub 2010 Sep 8.


NMR structural and dynamical investigation of the isolated voltage-sensing domain of the potassium channel KvAP: implications for voltage gating.

Shenkarev ZO, Paramonov AS, Lyukmanova EN, Shingarova LN, Yakimov SA, Dubinnyi MA, Chupin VV, Kirpichnikov MP, Blommers MJ, Arseniev AS.

J Am Chem Soc. 2010 Apr 28;132(16):5630-7. doi: 10.1021/ja909752r.


Lipid-protein nanodiscs as reference medium in detergent screening for high-resolution NMR studies of integral membrane proteins.

Shenkarev ZO, Lyukmanova EN, Paramonov AS, Shingarova LN, Chupin VV, Kirpichnikov MP, Blommers MJ, Arseniev AS.

J Am Chem Soc. 2010 Apr 28;132(16):5628-9. doi: 10.1021/ja9097498.


Bacterial production and refolding from inclusion bodies of a "weak" toxin, a disulfide rich protein.

Lyukmanova EN, Shulepko MA, Tikhonov RV, Shenkarev ZO, Paramonov AS, Wulfson AN, Kasheverov IE, Ustich TL, Utkin YN, Arseniev AS, Tsetlin VI, Dolgikh DA, Kirpichnikov MP.

Biochemistry (Mosc). 2009 Oct;74(10):1142-9.


Specific membrane binding of neurotoxin II can facilitate its delivery to acetylcholine receptor.

Lesovoy DM, Bocharov EV, Lyukmanova EN, Kosinsky YA, Shulepko MA, Dolgikh DA, Kirpichnikov MP, Efremov RG, Arseniev AS.

Biophys J. 2009 Oct 7;97(7):2089-97. doi: 10.1016/j.bpj.2009.07.037.


Lipid-protein nanodiscs: possible application in high-resolution NMR investigations of membrane proteins and membrane-active peptides.

Shenkarev ZO, Lyukmanova EN, Solozhenkin OI, Gagnidze IE, Nekrasova OV, Chupin VV, Tagaev AA, Yakimenko ZA, Ovchinnikova TV, Kirpichnikov MP, Arseniev AS.

Biochemistry (Mosc). 2009 Jul;74(7):756-65.


Loop 3 of short neurotoxin II is an additional interaction site with membrane-bound nicotinic acetylcholine receptor as detected by solid-state NMR spectroscopy.

Krabben L, van Rossum BJ, Jehle S, Bocharov E, Lyukmanova EN, Schulga AA, Arseniev A, Hucho F, Oschkinat H.

J Mol Biol. 2009 Jul 24;390(4):662-71. doi: 10.1016/j.jmb.2009.05.016. Epub 2009 May 15.


Cell-free Production of the Extracellular Domain of the Nicotinic Acetylcholine Receptor.

Lyukmanova EN, Kopeina GS, Shulepko MA, Shenkarev ZO, Arseniev AS, Dolgikh DA, Kirpichnikov MP.

Acta Naturae. 2009 Apr;1(1):96-8. No abstract available.


Divalent cation coordination and mode of membrane interaction in cyclotides: NMR spatial structure of ternary complex Kalata B7/Mn2+/DPC micelle.

Shenkarev ZO, Nadezhdin KD, Lyukmanova EN, Sobol VA, Skjeldal L, Arseniev AS.

J Inorg Biochem. 2008 May-Jun;102(5-6):1246-56. doi: 10.1016/j.jinorgbio.2008.01.018. Epub 2008 Jan 21.


Lipid-protein nanoscale bilayers: a versatile medium for NMR investigations of membrane proteins and membrane-active peptides.

Lyukmanova EN, Shenkarev ZO, Paramonov AS, Sobol AG, Ovchinnikova TV, Chupin VV, Kirpichnikov MP, Blommers MJ, Arseniev AS.

J Am Chem Soc. 2008 Feb 20;130(7):2140-1. doi: 10.1021/ja0777988. Epub 2008 Jan 30. No abstract available.


Bacterial expression, NMR, and electrophysiology analysis of chimeric short/long-chain alpha-neurotoxins acting on neuronal nicotinic receptors.

Lyukmanova EN, Shenkarev ZO, Schulga AA, Ermolyuk YS, Mordvintsev DY, Utkin YN, Shoulepko MA, Hogg RC, Bertrand D, Dolgikh DA, Tsetlin VI, Kirpichnikov MP.

J Biol Chem. 2007 Aug 24;282(34):24784-91. Epub 2007 Jun 18.

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