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Items: 1 to 50 of 175

1.

Assessment of tumor redox status through (S)-4-(3-[18F]fluoropropyl)-L-glutamic acid positron emission tomography imaging of system xc- activity.

McCormick PN, Greenwood HE, Glaser M, Maddocks ODK, Gendron T, Sander K, Gowrishankar G, Hoehne A, Zhang T, Shuhendler AJ, Lewis DY, Berndt M, Koglin N, Lythgoe MF, Gambhir SS, Årstad E, Witney TH.

Cancer Res. 2018 Nov 6. pii: canres.2634.2018. doi: 10.1158/0008-5472.CAN-18-2634. [Epub ahead of print]

PMID:
30401715
2.

Non-invasive imaging of disrupted protein homeostasis induced by proteasome inhibitor treatment using chemical exchange saturation transfer MRI.

Zhu Y, Ramasawmy R, Johnson SP, Taylor V, Gibb A, Pedley RB, Chattopadhyay N, Lythgoe MF, Golay X, Bradley D, Walker-Samuel S.

Sci Rep. 2018 Oct 10;8(1):15068. doi: 10.1038/s41598-018-33549-x.

3.

Impaired brain glymphatic flow in experimental hepatic encephalopathy.

Hadjihambi A, Harrison IF, Costas-Rodríguez M, Vanhaecke F, Arias N, Gallego-Durán R, Mastitskaya S, Hosford PS, Olde Damink SWM, Davies N, Habtesion A, Lythgoe MF, Gourine AV, Jalan R.

J Hepatol. 2018 Sep 7. pii: S0168-8278(18)32367-5. doi: 10.1016/j.jhep.2018.08.021. [Epub ahead of print]

4.

Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI.

Harrison IF, Siow B, Akilo AB, Evans PG, Ismail O, Ohene Y, Nahavandi P, Thomas DL, Lythgoe MF, Wells JA.

Elife. 2018 Jul 31;7. pii: e34028. doi: 10.7554/eLife.34028.

5.

A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow.

Hosford PS, Christie IN, Niranjan A, Aziz Q, Anderson N, Ang R, Lythgoe MF, Wells JA, Tinker A, Gourine AV.

J Cereb Blood Flow Metab. 2018 Jun 4:271678X18780602. doi: 10.1177/0271678X18780602. [Epub ahead of print]

PMID:
29862863
6.

Chemically Treated 3D Printed Polymer Scaffolds for Biomineral Formation.

Jackson RJ, Patrick PS, Page K, Powell MJ, Lythgoe MF, Miodownik MA, Parkin IP, Carmalt CJ, Kalber TL, Bear JC.

ACS Omega. 2018 Apr 30;3(4):4342-4351. doi: 10.1021/acsomega.8b00219. Epub 2018 Apr 19.

7.

In vivo three-dimensional photoacoustic imaging of the renal vasculature in preclinical rodent models.

Ogunlade O, Connell JJ, Huang JL, Zhang E, Lythgoe MF, Long DA, Beard P.

Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1145-F1153. doi: 10.1152/ajprenal.00337.2017. Epub 2017 Dec 20.

8.

Investigating Low-Velocity Fluid Flow in Tumors with Convection-MRI.

Walker-Samuel S, Roberts TA, Ramasawmy R, Burrell JS, Johnson SP, Siow BM, Richardson S, Gonçalves MR, Pendse D, Robinson SP, Pedley RB, Lythgoe MF.

Cancer Res. 2018 Apr 1;78(7):1859-1872. doi: 10.1158/0008-5472.CAN-17-1546. Epub 2018 Jan 9.

PMID:
29317434
9.

Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies.

Scarfe L, Brillant N, Kumar JD, Ali N, Alrumayh A, Amali M, Barbellion S, Jones V, Niemeijer M, Potdevin S, Roussignol G, Vaganov A, Barbaric I, Barrow M, Burton NC, Connell J, Dazzi F, Edsbagge J, French NS, Holder J, Hutchinson C, Jones DR, Kalber T, Lovatt C, Lythgoe MF, Patel S, Patrick PS, Piner J, Reinhardt J, Ricci E, Sidaway J, Stacey GN, Starkey Lewis PJ, Sullivan G, Taylor A, Wilm B, Poptani H, Murray P, Goldring CEP, Park BK.

NPJ Regen Med. 2017 Oct 19;2:28. doi: 10.1038/s41536-017-0029-9. eCollection 2017. Review.

10.

In Vivo Imaging of Tau Pathology Using Magnetic Resonance Imaging Textural Analysis.

Colgan N, Ganeshan B, Harrison IF, Ismail O, Holmes HE, Wells JA, Powell NM, O'Callaghan JM, O'Neill MJ, Murray TK, Ahmed Z, Collins EC, Johnson RA, Groves A, Lythgoe MF.

Front Neurosci. 2017 Nov 6;11:599. doi: 10.3389/fnins.2017.00599. eCollection 2017.

11.

Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease.

O'Callaghan J, Holmes H, Powell N, Wells JA, Ismail O, Harrison IF, Siow B, Johnson R, Ahmed Z, Fisher A, Meftah S, O'Neill MJ, Murray TK, Collins EC, Shmueli K, Lythgoe MF.

Neuroimage. 2017 Oct 1;159:334-345. doi: 10.1016/j.neuroimage.2017.08.003. Epub 2017 Aug 4.

12.

Direct comparison of high-temporal-resolution CINE MRI with Doppler ultrasound for assessment of diastolic dysfunction in mice.

Roberts TA, Price AN, Jackson LH, Taylor V, David AL, Lythgoe MF, Stuckey DJ.

NMR Biomed. 2017 Oct;30(10). doi: 10.1002/nbm.3763. Epub 2017 Jun 23.

13.

Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance.

Dongworth RK, Campbell-Washburn AE, Cabrera-Fuentes HA, Bulluck H, Roberts T, Price AN, Hernández-Reséndiz S, Ordidge RJ, Thomas DL, Yellon DM, Lythgoe MF, Hausenloy DJ.

Sci Rep. 2017 May 23;7(1):2271. doi: 10.1038/s41598-017-02544-z.

14.

Vagal determinants of exercise capacity.

Machhada A, Trapp S, Marina N, Stephens RCM, Whittle J, Lythgoe MF, Kasparov S, Ackland GL, Gourine AV.

Nat Commun. 2017 May 18;8:15097. doi: 10.1038/ncomms15097.

15.

Comparison of In Vivo and Ex Vivo MRI for the Detection of Structural Abnormalities in a Mouse Model of Tauopathy.

Holmes HE, Powell NM, Ma D, Ismail O, Harrison IF, Wells JA, Colgan N, O'Callaghan JM, Johnson RA, Murray TK, Ahmed Z, Heggenes M, Fisher A, Cardoso MJ, Modat M, O'Neill MJ, Collins EC, Fisher EM, Ourselin S, Lythgoe MF.

Front Neuroinform. 2017 Mar 31;11:20. doi: 10.3389/fninf.2017.00020. eCollection 2017.

16.

Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemia.

Jackson LH, Vlachodimitropoulou E, Shangaris P, Roberts TA, Ryan TM, Campbell-Washburn AE, David AL, Porter JB, Lythgoe MF, Stuckey DJ.

Sci Rep. 2017 Feb 27;7:43439. doi: 10.1038/srep43439.

17.

Volumetric Spatial Correlations of Neurovascular Coupling Studied using Single Pulse Opto-fMRI.

Christie IN, Wells JA, Kasparov S, Gourine AV, Lythgoe MF.

Sci Rep. 2017 Feb 8;7:41583. doi: 10.1038/srep41583.

18.

Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.

Clayton EL, Mancuso R, Nielsen TT, Mizielinska S, Holmes H, Powell N, Norona F, Larsen JO, Milioto C, Wilson KM, Lythgoe MF, Ourselin S, Nielsen JE, Johannsen P, Holm I, Collinge J; FReJA, Oliver PL, Gomez-Nicola D, Isaacs AM.

Hum Mol Genet. 2017 Mar 1;26(5):873-887. doi: 10.1093/hmg/ddx003.

19.

Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice.

Autuori MC, Pai YJ, Stuckey DJ, Savery D, Marconi AM, Massa V, Lythgoe MF, Copp AJ, David AL, Greene ND.

Prenat Diagn. 2017 Mar;37(3):273-281. doi: 10.1002/pd.5004. Epub 2017 Feb 17.

20.

Improved hepatic arterial fraction estimation using cardiac output correction of arterial input functions for liver DCE MRI.

Chouhan MD, Bainbridge A, Atkinson D, Punwani S, Mookerjee RP, Lythgoe MF, Taylor SA.

Phys Med Biol. 2017 Feb 21;62(4):1533-1546. doi: 10.1088/1361-6560/aa553c. Epub 2016 Dec 21.

21.

Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice.

Smart N, Riegler J, Turtle CW, Lygate CA, McAndrew DJ, Gehmlich K, Dubé KN, Price AN, Muthurangu V, Taylor AM, Lythgoe MF, Redwood C, Riley PR.

J Mol Cell Cardiol. 2017 Jan;102:94-107. doi: 10.1016/j.yjmcc.2016.10.010. Epub 2016 Nov 30.

22.

Caval Subtraction 2D Phase-Contrast MRI to Measure Total Liver and Hepatic Arterial Blood Flow: Proof-of-Principle, Correlation With Portal Hypertension Severity and Validation in Patients With Chronic Liver Disease.

Chouhan MD, Mookerjee RP, Bainbridge A, Punwani S, Jones H, Davies N, Walker-Samuel S, Patch D, Jalan R, Halligan S, Lythgoe MF, Taylor SA.

Invest Radiol. 2017 Mar;52(3):170-176. doi: 10.1097/RLI.0000000000000328.

PMID:
27805917
23.

Imaging biomarker roadmap for cancer studies.

O'Connor JP, Aboagye EO, Adams JE, Aerts HJ, Barrington SF, Beer AJ, Boellaard R, Bohndiek SE, Brady M, Brown G, Buckley DL, Chenevert TL, Clarke LP, Collette S, Cook GJ, deSouza NM, Dickson JC, Dive C, Evelhoch JL, Faivre-Finn C, Gallagher FA, Gilbert FJ, Gillies RJ, Goh V, Griffiths JR, Groves AM, Halligan S, Harris AL, Hawkes DJ, Hoekstra OS, Huang EP, Hutton BF, Jackson EF, Jayson GC, Jones A, Koh DM, Lacombe D, Lambin P, Lassau N, Leach MO, Lee TY, Leen EL, Lewis JS, Liu Y, Lythgoe MF, Manoharan P, Maxwell RJ, Miles KA, Morgan B, Morris S, Ng T, Padhani AR, Parker GJ, Partridge M, Pathak AP, Peet AC, Punwani S, Reynolds AR, Robinson SP, Shankar LK, Sharma RA, Soloviev D, Stroobants S, Sullivan DC, Taylor SA, Tofts PS, Tozer GM, van Herk M, Walker-Samuel S, Wason J, Williams KJ, Workman P, Yankeelov TE, Brindle KM, McShane LM, Jackson A, Waterton JC.

Nat Rev Clin Oncol. 2017 Mar;14(3):169-186. doi: 10.1038/nrclinonc.2016.162. Epub 2016 Oct 11. Review.

24.

Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome.

Powell NM, Modat M, Cardoso MJ, Ma D, Holmes HE, Yu Y, O'Callaghan J, Cleary JO, Sinclair B, Wiseman FK, Tybulewicz VL, Fisher EM, Lythgoe MF, Ourselin S.

PLoS One. 2016 Sep 22;11(9):e0162974. doi: 10.1371/journal.pone.0162974. eCollection 2016.

25.

Estimation of contrast agent bolus arrival delays for improved reproducibility of liver DCE MRI.

Chouhan MD, Bainbridge A, Atkinson D, Punwani S, Mookerjee RP, Lythgoe MF, Taylor SA.

Phys Med Biol. 2016 Oct 7;61(19):6905-6918. Epub 2016 Sep 12.

26.

Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning.

Brzóska HŁ, d'Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA.

Kidney Int. 2016 Dec;90(6):1274-1284. doi: 10.1016/j.kint.2016.07.011. Epub 2016 Sep 2.

27.

fMRI mapping of the visual system in the mouse brain with interleaved snapshot GE-EPI.

Niranjan A, Christie IN, Solomon SG, Wells JA, Lythgoe MF.

Neuroimage. 2016 Oct 1;139:337-345. doi: 10.1016/j.neuroimage.2016.06.015. Epub 2016 Jun 10.

28.

Hyperthermia treatment of tumors by mesenchymal stem cell-delivered superparamagnetic iron oxide nanoparticles.

Kalber TL, Ordidge KL, Southern P, Loebinger MR, Kyrtatos PG, Pankhurst QA, Lythgoe MF, Janes SM.

Int J Nanomedicine. 2016 May 9;11:1973-83. doi: 10.2147/IJN.S94255. eCollection 2016.

29.

Decomposition of spontaneous fluctuations in tumour oxygenation using BOLD MRI and independent component analysis.

Gonçalves MR, Peter Johnson S, Ramasawmy R, Barbara Pedley R, Lythgoe MF, Walker-Samuel S.

Br J Cancer. 2016 Jun 14;114(12):e13. doi: 10.1038/bjc.2016.140. Epub 2016 May 26. No abstract available.

30.

Monitoring the Growth of an Orthotopic Tumour Xenograft Model: Multi-Modal Imaging Assessment with Benchtop MRI (1T), High-Field MRI (9.4T), Ultrasound and Bioluminescence.

Ramasawmy R, Johnson SP, Roberts TA, Stuckey DJ, David AL, Pedley RB, Lythgoe MF, Siow B, Walker-Samuel S.

PLoS One. 2016 May 25;11(5):e0156162. doi: 10.1371/journal.pone.0156162. eCollection 2016.

31.

Use of Caval Subtraction 2D Phase-Contrast MR Imaging to Measure Total Liver and Hepatic Arterial Blood Flow: Preclinical Validation and Initial Clinical Translation.

Chouhan MD, Mookerjee RP, Bainbridge A, Walker-Samuel S, Davies N, Halligan S, Lythgoe MF, Taylor SA.

Radiology. 2016 Sep;280(3):916-23. doi: 10.1148/radiol.2016151832. Epub 2016 May 12.

32.

Vascular assessment of liver disease-towards a new frontier in MRI.

Chouhan MD, Lythgoe MF, Mookerjee RP, Taylor SA.

Br J Radiol. 2016 May 16:20150675. [Epub ahead of print]

33.

Acute changes in liver tumour perfusion measured non-invasively with arterial spin labelling.

Johnson SP, Ramasawmy R, Campbell-Washburn AE, Wells JA, Robson M, Rajkumar V, Lythgoe MF, Pedley RB, Walker-Samuel S.

Br J Cancer. 2016 Apr 12;114(8):897-904. doi: 10.1038/bjc.2016.51. Epub 2016 Mar 31.

34.

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.

Castillo SD, Tzouanacou E, Zaw-Thin M, Berenjeno IM, Parker VE, Chivite I, Milà-Guasch M, Pearce W, Solomon I, Angulo-Urarte A, Figueiredo AM, Dewhurst RE, Knox RG, Clark GR, Scudamore CL, Badar A, Kalber TL, Foster J, Stuckey DJ, David AL, Phillips WA, Lythgoe MF, Wilson V, Semple RK, Sebire NJ, Kinsler VA, Graupera M, Vanhaesebroeck B.

Sci Transl Med. 2016 Mar 30;8(332):332ra43. doi: 10.1126/scitranslmed.aad9982.

35.

Origins of the vagal drive controlling left ventricular contractility.

Machhada A, Marina N, Korsak A, Stuckey DJ, Lythgoe MF, Gourine AV.

J Physiol. 2016 Jul 15;594(14):4017-30. doi: 10.1113/JP270984. Epub 2016 Apr 28.

36.

Imaging the accumulation and suppression of tau pathology using multiparametric MRI.

Holmes HE, Colgan N, Ismail O, Ma D, Powell NM, O'Callaghan JM, Harrison IF, Johnson RA, Murray TK, Ahmed Z, Heggenes M, Fisher A, Cardoso MJ, Modat M, Walker-Samuel S, Fisher EM, Ourselin S, O'Neill MJ, Wells JA, Collins EC, Lythgoe MF.

Neurobiol Aging. 2016 Mar;39:184-94. doi: 10.1016/j.neurobiolaging.2015.12.001. Epub 2015 Dec 15.

37.

Characterization of tau positron emission tomography tracer [18F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias.

Sander K, Lashley T, Gami P, Gendron T, Lythgoe MF, Rohrer JD, Schott JM, Revesz T, Fox NC, Årstad E.

Alzheimers Dement. 2016 Nov;12(11):1116-1124. doi: 10.1016/j.jalz.2016.01.003. Epub 2016 Feb 15.

PMID:
26892233
38.

Hydroxychloroquine Protects against Cardiac Ischaemia/Reperfusion Injury In Vivo via Enhancement of ERK1/2 Phosphorylation.

Bourke L, McCormick J, Taylor V, Pericleous C, Blanchet B, Costedoat-Chalumeau N, Stuckey D, Lythgoe MF, Stephanou A, Ioannou Y.

PLoS One. 2015 Dec 4;10(12):e0143771. doi: 10.1371/journal.pone.0143771. eCollection 2015.

39.

Correction: Mutation of the Diamond-Blackfan Anemia Gene Rps7 in Mouse Results in Morphological and Neuroanatomical Phenotypes.

Watkins-Chow DE, Cooke J, Pidsley R, Edwards A, Slotkin R, Leeds KE, Mullen R, Baxter LL, Campbell TG, Salzer MC, Biondini L, Gibney G, Tuy FP, Chelly J, Morris HD, Riegler J, Lythgoe MF, Arkell RM, Loreni F, Flint J, Pavan WJ, Keays DA.

PLoS Genet. 2015 Nov 19;11(11):e1005682. doi: 10.1371/journal.pgen.1005682. eCollection 2015 Nov. No abstract available.

40.

Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease.

Colgan N, Siow B, O'Callaghan JM, Harrison IF, Wells JA, Holmes HE, Ismail O, Richardson S, Alexander DC, Collins EC, Fisher EM, Johnson R, Schwarz AJ, Ahmed Z, O'Neill MJ, Murray TK, Zhang H, Lythgoe MF.

Neuroimage. 2016 Jan 15;125:739-744. doi: 10.1016/j.neuroimage.2015.10.043. Epub 2015 Oct 23.

41.

Decomposition of spontaneous fluctuations in tumour oxygenation using BOLD MRI and independent component analysis.

Gonçalves MR, Johnson SP, Ramasawmy R, Pedley RB, Lythgoe MF, Walker-Samuel S.

Br J Cancer. 2015 Oct 20;113(8):1168-77. doi: 10.1038/bjc.2015.270. Erratum in: Br J Cancer. 2016 Jun 14;114(12):e13.

42.

Advanced cell therapies: targeting, tracking and actuation of cells with magnetic particles.

Connell JJ, Patrick PS, Yu Y, Lythgoe MF, Kalber TL.

Regen Med. 2015;10(6):757-72. doi: 10.2217/rme.15.36. Epub 2015 Sep 21. Review.

43.

Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting.

Muthana M, Kennerley AJ, Hughes R, Fagnano E, Richardson J, Paul M, Murdoch C, Wright F, Payne C, Lythgoe MF, Farrow N, Dobson J, Conner J, Wild JM, Lewis C.

Nat Commun. 2015 Aug 18;6:8009. doi: 10.1038/ncomms9009.

44.

Quantification of light attenuation in optically cleared mouse brains.

d'Esposito A, Nikitichev D, Desjardins A, Walker-Samuel S, Lythgoe MF.

J Biomed Opt. 2015 Aug;20(8):80503. doi: 10.1117/1.JBO.20.8.080503.

45.

Bimodal Imaging of Inflammation with SPECT/CT and MRI Using Iodine-125 Labeled VCAM-1 Targeting Microparticle Conjugates.

Patel N, Duffy BA, Badar A, Lythgoe MF, Årstad E.

Bioconjug Chem. 2015 Aug 19;26(8):1542-9. doi: 10.1021/acs.bioconjchem.5b00380. Epub 2015 Aug 11.

46.

Using the robust principal component analysis algorithm to remove RF spike artifacts from MR images.

Campbell-Washburn AE, Atkinson D, Nagy Z, Chan RW, Josephs O, Lythgoe MF, Ordidge RJ, Thomas DL.

Magn Reson Med. 2016 Jun;75(6):2517-25. doi: 10.1002/mrm.25851. Epub 2015 Jul 20.

47.

Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography.

Sander K, Galante E, Gendron T, Yiannaki E, Patel N, Kalber TL, Badar A, Robson M, Johnson SP, Bauer F, Mairinger S, Stanek J, Wanek T, Kuntner C, Kottke T, Weizel L, Dickens D, Erlandsson K, Hutton BF, Lythgoe MF, Stark H, Langer O, Koepp M, Årstad E.

J Med Chem. 2015 Aug 13;58(15):6058-80. doi: 10.1021/acs.jmedchem.5b00652. Epub 2015 Jul 24.

PMID:
26161456
48.

Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve.

Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A, Marina N, Gourine AV.

Heart Rhythm. 2015 Nov;12(11):2285-93. doi: 10.1016/j.hrthm.2015.06.005. Epub 2015 Jun 5.

49.

Significant Therapeutic Efficacy with Combined Radioimmunotherapy and Cetuximab in Preclinical Models of Colorectal Cancer.

Vassileva V, Rajkumar V, Mazzantini M, Robson M, Badar A, Sharma S, Årstad E, Hochhauser D, Lythgoe MF, Kinghorn J, Boxer GM, Pedley RB.

J Nucl Med. 2015 Aug;56(8):1239-45. doi: 10.2967/jnumed.115.157362. Epub 2015 Jun 4. Erratum in: J Nucl Med. 2015 Nov;56(11):1807. Kinghorn, Jane [added].

50.

Sulfonium salts as leaving groups for aromatic labelling of drug-like small molecules with fluorine-18.

Sander K, Gendron T, Yiannaki E, Cybulska K, Kalber TL, Lythgoe MF, Årstad E.

Sci Rep. 2015 Apr 21;5:9941. doi: 10.1038/srep09941.

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