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Items: 25


On the diverse and opposing effects of nutrition on pathogen virulence.

Pike VL, Lythgoe KA, King KC.

Proc Biol Sci. 2019 Jul 10;286(1906):20191220. doi: 10.1098/rspb.2019.1220. Epub 2019 Jul 10.


Link between the numbers of particles and variants founding new HIV-1 infections depends on the timing of transmission.

Thompson RN, Wymant C, Spriggs RA, Raghwani J, Fraser C, Lythgoe KA.

Virus Evol. 2019 Jan 30;5(1):vey038. doi: 10.1093/ve/vey038. eCollection 2019 Jan.


High-Resolution Evolutionary Analysis of Within-Host Hepatitis C Virus Infection.

Raghwani J, Wu CH, Ho CKY, De Jong M, Molenkamp R, Schinkel J, Pybus OG, Lythgoe KA.

J Infect Dis. 2019 May 5;219(11):1722-1729. doi: 10.1093/infdis/jiy747.


Structure-Guided Identification of a Nonhuman Morbillivirus with Zoonotic Potential.

Abdullah N, Kelly JT, Graham SC, Birch J, Gonçalves-Carneiro D, Mitchell T, Thompson RN, Lythgoe KA, Logan N, Hosie MJ, Bavro VN, Willett BJ, Heaton MP, Bailey D.

J Virol. 2018 Nov 12;92(23). pii: e01248-18. doi: 10.1128/JVI.01248-18. Print 2018 Dec 1.


Hepatitis B Virus Adaptation to the CD8+ T Cell Response: Consequences for Host and Pathogen.

Lumley SF, McNaughton AL, Klenerman P, Lythgoe KA, Matthews PC.

Front Immunol. 2018 Jul 16;9:1561. doi: 10.3389/fimmu.2018.01561. eCollection 2018. Review.


Evolution of HIV-1 within untreated individuals and at the population scale in Uganda.

Raghwani J, Redd AD, Longosz AF, Wu CH, Serwadda D, Martens C, Kagaayi J, Sewankambo N, Porcella SF, Grabowski MK, Quinn TC, Eller MA, Eller LA, Wabwire-Mangen F, Robb ML, Fraser C, Lythgoe KA.

PLoS Pathog. 2018 Jul 27;14(7):e1007167. doi: 10.1371/journal.ppat.1007167. eCollection 2018 Jul.


Short-Sighted Virus Evolution and a Germline Hypothesis for Chronic Viral Infections.

Lythgoe KA, Gardner A, Pybus OG, Grove J.

Trends Microbiol. 2017 May;25(5):336-348. doi: 10.1016/j.tim.2017.03.003. Epub 2017 Apr 1. Review.


Effect of the Latent Reservoir on the Evolution of HIV at the Within- and Between-Host Levels.

Doekes HM, Fraser C, Lythgoe KA.

PLoS Comput Biol. 2017 Jan 19;13(1):e1005228. doi: 10.1371/journal.pcbi.1005228. eCollection 2017 Jan.


A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda.

Blanquart F, Grabowski MK, Herbeck J, Nalugoda F, Serwadda D, Eller MA, Robb ML, Gray R, Kigozi G, Laeyendecker O, Lythgoe KA, Nakigozi G, Quinn TC, Reynolds SJ, Wawer MJ, Fraser C.

Elife. 2016 Nov 5;5. pii: e20492. doi: 10.7554/eLife.20492.


Large Variations in HIV-1 Viral Load Explained by Shifting-Mosaic Metapopulation Dynamics.

Lythgoe KA, Blanquart F, Pellis L, Fraser C.

PLoS Biol. 2016 Oct 5;14(10):e1002567. doi: 10.1371/journal.pbio.1002567. eCollection 2016 Oct.


Virulence and pathogenesis of HIV-1 infection: an evolutionary perspective.

Fraser C, Lythgoe K, Leventhal GE, Shirreff G, Hollingsworth TD, Alizon S, Bonhoeffer S.

Science. 2014 Mar 21;343(6177):1243727. doi: 10.1126/science.1243727. Review.


Is HIV short-sighted? Insights from a multistrain nested model.

Lythgoe KA, Pellis L, Fraser C.

Evolution. 2013 Oct;67(10):2769-82. doi: 10.1111/evo.12166. Epub 2013 Jun 13.


Preexposure prophylaxis will have a limited impact on HIV-1 drug resistance in sub-Saharan Africa: a comparison of mathematical models.

van de Vijver DA, Nichols BE, Abbas UL, Boucher CA, Cambiano V, Eaton JW, Glaubius R, Lythgoe K, Mellors J, Phillips A, Sigaloff KC, Hallett TB.

AIDS. 2013 Nov 28;27(18):2943-51. doi: 10.1097/01.aids.0000433237.63560.20.


New insights into the evolutionary rate of HIV-1 at the within-host and epidemiological levels.

Lythgoe KA, Fraser C.

Proc Biol Sci. 2012 Aug 22;279(1741):3367-75. doi: 10.1098/rspb.2012.0595. Epub 2012 May 16.


Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.

Hitosugi T, Fan J, Chung TW, Lythgoe K, Wang X, Xie J, Ge Q, Gu TL, Polakiewicz RD, Roesel JL, Chen GZ, Boggon TJ, Lonial S, Fu H, Khuri FR, Kang S, Chen J.

Mol Cell. 2011 Dec 23;44(6):864-77. doi: 10.1016/j.molcel.2011.10.015.


p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.

Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Fan S, Sun SY, Marcus AI, Gu TL, Polakiewicz RD, Chen ZG, Khuri FR, Shin DM, Chen J.

J Clin Invest. 2010 Apr;120(4):1165-77. doi: 10.1172/JCI40582. Epub 2010 Mar 15.


Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.

Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, Khuri FR, Gilliland DG, Cantley LC, Kaufman J, Chen J.

Sci Signal. 2009 Nov 17;2(97):ra73. doi: 10.1126/scisignal.2000431.


Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.

Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, Ruan H, Lonial S, Khoury HJ, Williams IR, Lee BH, Roesel JL, Karsenty G, Hanauer A, Taunton J, Boggon TJ, Gu TL, Chen J.

Mol Cell Biol. 2009 Apr;29(8):2105-17. doi: 10.1128/MCB.00998-08. Epub 2009 Feb 17.


Effects of acquired immunity and mating strategy on the genetic structure of parasite populations.

Lythgoe KA.

Am Nat. 2002 May;159(5):519-29. doi: 10.1086/339462.


Parasite-intrinsic factors can explain ordered progression of trypanosome antigenic variation.

Lythgoe KA, Morrison LJ, Read AF, Barry JD.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):8095-100. Epub 2007 Apr 26.


What the genome sequence is revealing about trypanosome antigenic variation.

Barry JD, Marcello L, Morrison LJ, Read AF, Lythgoe K, Jones N, Carrington M, Blandin G, Böhme U, Caler E, Hertz-Fowler C, Renauld H, El-Sayed N, Berriman M.

Biochem Soc Trans. 2005 Nov;33(Pt 5):986-9.


Catching the Red Queen? The advice of the Rose.

Lythgoe KA, Read AF.

Trends Ecol Evol. 1998 Dec 1;13(12):473-4. No abstract available.


Isobolographic assessment of the interaction between adriamycin and photodynamic therapy with meso-chlorin e6 monoethylene diamine in human epithelial ovarian carcinoma (OVCAR-3) in vitro.

Peterson CM, Lu JM, Gu ZW, Shiah JG, Lythgoe K, Peterson CA, Straight RC, Kopecek J.

J Soc Gynecol Investig. 1995 Nov-Dec;2(6):772-7.


Multiple endocrine neoplasia presenting as primary amenorrhea: a case report.

Lythgoe K, Dotson R, Peterson CM.

Obstet Gynecol. 1995 Oct;86(4 Pt 2):683-6.


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