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Items: 1 to 50 of 76

1.

Bacillus anthracis Overcomes an Amino Acid Auxotrophy by Cleaving Host Serum Proteins.

Terwilliger A, Swick MC, Pflughoeft KJ, Pomerantsev A, Lyons CR, Koehler TM, Maresso A.

J Bacteriol. 2015 Jul;197(14):2400-11. doi: 10.1128/JB.00073-15. Epub 2015 May 11.

2.

Live attenuated Francisella novicida vaccine protects against Francisella tularensis pulmonary challenge in rats and non-human primates.

Chu P, Cunningham AL, Yu JJ, Nguyen JQ, Barker JR, Lyons CR, Wilder J, Valderas M, Sherwood RL, Arulanandam BP, Klose KE.

PLoS Pathog. 2014 Oct 23;10(10):e1004439. doi: 10.1371/journal.ppat.1004439. eCollection 2014 Oct.

3.

Lethal factor, but not edema factor, is required to cause fatal anthrax in cynomolgus macaques after pulmonary spore challenge.

Hutt JA, Lovchik JA, Drysdale M, Sherwood RL, Brasel T, Lipscomb MF, Lyons CR.

Am J Pathol. 2014 Dec;184(12):3205-16. doi: 10.1016/j.ajpath.2014.08.008. Epub 2014 Oct 5.

4.

Serologic evidence of human Rickettsia infection found in three locations in Panamá.

Bermúdez SE, Lyons CR, García GG, Zaldíva YL, Gabster A, Arteaga GB.

Biomedica. 2013 Sep;33 Suppl 1:31-7.

PMID:
24652247
5.

IgG subclass and heavy chain domains contribute to binding and protection by mAbs to the poly γ-D-glutamic acid capsular antigen of Bacillus anthracis.

Hovenden M, Hubbard MA, Aucoin DP, Thorkildson P, Reed DE, Welch WH, Lyons CR, Lovchik JA, Kozel TR.

PLoS Pathog. 2013;9(4):e1003306. doi: 10.1371/journal.ppat.1003306. Epub 2013 Apr 18.

6.

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation.

Castillo EF, Dekonenko A, Arko-Mensah J, Mandell MA, Dupont N, Jiang S, Delgado-Vargas M, Timmins GS, Bhattacharya D, Yang H, Hutt J, Lyons CR, Dobos KM, Deretic V.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3168-76. doi: 10.1073/pnas.1210500109. Epub 2012 Oct 23.

7.

Expression of either lethal toxin or edema toxin by Bacillus anthracis is sufficient for virulence in a rabbit model of inhalational anthrax.

Lovchik JA, Drysdale M, Koehler TM, Hutt JA, Lyons CR.

Infect Immun. 2012 Jul;80(7):2414-25. doi: 10.1128/IAI.06340-11. Epub 2012 Apr 23.

8.

Identification of circulating bacterial antigens by in vivo microbial antigen discovery.

Nuti DE, Crump RB, Dwi Handayani F, Chantratita N, Peacock SJ, Bowen R, Felgner PL, Davies DH, Wu T, Lyons CR, Brett PJ, Burtnick MN, Kozel TR, AuCoin DP.

MBio. 2011 Aug 16;2(4). pii: e00136-11. doi: 10.1128/mBio.00136-11. Print 2011.

9.

Cowpox virus inhibits human dendritic cell immune function by nonlethal, nonproductive infection.

Hansen SJ, Rushton J, Dekonenko A, Chand HS, Olson GK, Hutt JA, Pickup D, Lyons CR, Lipscomb MF.

Virology. 2011 Apr 10;412(2):411-25. doi: 10.1016/j.virol.2011.01.024. Epub 2011 Feb 21.

10.

Antibodies contribute to effective vaccination against respiratory infection by type A Francisella tularensis strains.

Mara-Koosham G, Hutt JA, Lyons CR, Wu TH.

Infect Immun. 2011 Apr;79(4):1770-8. doi: 10.1128/IAI.00605-10. Epub 2011 Jan 31.

11.

Pre- and postexposure protection against virulent anthrax infection in mice by humanized monoclonal antibodies to Bacillus anthracis capsule.

Chen Z, Schneerson R, Lovchik J, Lyons CR, Zhao H, Dai Z, Kubler-Kielb J, Leppla SH, Purcell RH.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):739-44. doi: 10.1073/pnas.1017677108. Epub 2010 Dec 27.

12.

Milestones in progression of primary pneumonic plague in cynomolgus macaques.

Koster F, Perlin DS, Park S, Brasel T, Gigliotti A, Barr E, Myers L, Layton RC, Sherwood R, Lyons CR.

Infect Immun. 2010 Jul;78(7):2946-55. doi: 10.1128/IAI.01296-09. Epub 2010 Apr 12.

13.

The Fischer 344 rat reflects human susceptibility to francisella pulmonary challenge and provides a new platform for virulence and protection studies.

Ray HJ, Chu P, Wu TH, Lyons CR, Murthy AK, Guentzel MN, Klose KE, Arulanandam BP.

PLoS One. 2010 Apr 1;5(4):e9952. doi: 10.1371/journal.pone.0009952.

14.

Regulatory interactions of a virulence-associated serine/threonine phosphatase-kinase pair in Bacillus anthracis.

Shakir SM, Bryant KM, Larabee JL, Hamm EE, Lovchik J, Lyons CR, Ballard JD.

J Bacteriol. 2010 Jan;192(2):400-9. doi: 10.1128/JB.01221-09. Epub 2009 Nov 13.

15.

The pathogenesis of acute pulmonary viral and bacterial infections: investigations in animal models.

Lipscomb MF, Hutt J, Lovchik J, Wu T, Lyons CR.

Annu Rev Pathol. 2010;5:223-52. doi: 10.1146/annurev-pathol-121808-102153. Review.

PMID:
19824827
16.

New classes of orthopoxvirus vaccine candidates by functionally screening a synthetic library for protective antigens.

Borovkov A, Magee DM, Loskutov A, Cano JA, Selinsky C, Zsemlye J, Lyons CR, Sykes K.

Virology. 2009 Dec 5;395(1):97-113. doi: 10.1016/j.virol.2009.09.008. Epub 2009 Oct 2.

17.

Vaccination of Fischer 344 rats against pulmonary infections by Francisella tularensis type A strains.

Wu TH, Zsemlye JL, Statom GL, Hutt JA, Schrader RM, Scrymgeour AA, Lyons CR.

Vaccine. 2009 Jul 23;27(34):4684-93. doi: 10.1016/j.vaccine.2009.05.060. Epub 2009 Jun 9.

18.

Rapid detection of the poly-gamma-D-glutamic acid capsular antigen of Bacillus anthracis by latex agglutination.

AuCoin DP, Sutherland MD, Percival AL, Lyons CR, Lovchik JA, Kozel TR.

Diagn Microbiol Infect Dis. 2009 Jun;64(2):229-32. doi: 10.1016/j.diagmicrobio.2009.02.001. Epub 2009 Apr 2.

19.

T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria.

Collazo CM, Meierovics AI, De Pascalis R, Wu TH, Lyons CR, Elkins KL.

Infect Immun. 2009 May;77(5):2010-21. doi: 10.1128/IAI.01322-08. Epub 2009 Feb 23.

20.

Killed but metabolically active Bacillus anthracis vaccines induce broad and protective immunity against anthrax.

Skoble J, Beaber JW, Gao Y, Lovchik JA, Sower LE, Liu W, Luckett W, Peterson JW, Calendar R, Portnoy DA, Lyons CR, Dubensky TW Jr.

Infect Immun. 2009 Apr;77(4):1649-63. doi: 10.1128/IAI.00530-08. Epub 2009 Jan 21.

21.

Characterization of BBB permeability in a preclinical model of cryptococcal meningoencephalitis using magnetic resonance imaging.

Pai MP, Sakoglu U, Peterson SL, Lyons CR, Sood R.

J Cereb Blood Flow Metab. 2009 Mar;29(3):545-53. doi: 10.1038/jcbfm.2008.144. Epub 2008 Dec 10.

PMID:
19066614
22.

Discriminating virulence mechanisms among Bacillus anthracis strains by using a murine subcutaneous infection model.

Chand HS, Drysdale M, Lovchik J, Koehler TM, Lipscomb MF, Lyons CR.

Infect Immun. 2009 Jan;77(1):429-35. doi: 10.1128/IAI.00647-08. Epub 2008 Nov 3.

23.

Effect of Bacillus anthracis virulence factors on human dendritic cell activation.

Hahn AC, Lyons CR, Lipscomb MF.

Hum Immunol. 2008 Sep;69(9):552-61. doi: 10.1016/j.humimm.2008.06.012. Epub 2008 Jul 26.

24.

A dual-purpose protein ligand for effective therapy and sensitive diagnosis of anthrax.

Vuyisich M, Gnanakaran S, Lovchik JA, Lyons CR, Gupta G.

Protein J. 2008 Aug;27(5):292-302. doi: 10.1007/s10930-008-9137-0.

PMID:
18649128
25.

Application of in vivo induced antigen technology (IVIAT) to Bacillus anthracis.

Rollins SM, Peppercorn A, Young JS, Drysdale M, Baresch A, Bikowski MV, Ashford DA, Quinn CP, Handfield M, Hillman JD, Lyons CR, Koehler TM, Calderwood SB, Ryan ET.

PLoS One. 2008 Mar 19;3(3):e1824. doi: 10.1371/journal.pone.0001824.

26.

Clinical and pathologic features of cynomolgus macaques (Macaca fascicularis) infected with aerosolized Yersinia pestis.

Van Andel R, Sherwood R, Gennings C, Lyons CR, Hutt J, Gigliotti A, Barr E.

Comp Med. 2008 Feb;58(1):68-75.

27.

Effects of endogenous D-alanine synthesis and autoinhibition of Bacillus anthracis germination on in vitro and in vivo infections.

McKevitt MT, Bryant KM, Shakir SM, Larabee JL, Blanke SR, Lovchik J, Lyons CR, Ballard JD.

Infect Immun. 2007 Dec;75(12):5726-34. Epub 2007 Oct 8.

28.

Novel semisynthetic derivative of antibiotic Eremomycin active against drug-resistant gram-positive pathogens including Bacillus anthracis.

Maples KR, Wheeler C, Ip E, Plattner JJ, Chu D, Zhang YK, Preobrazhenskaya MN, Printsevskaya SS, Solovieva SE, Olsufyeva EN, Heine H, Lovchik J, Lyons CR.

J Med Chem. 2007 Jul 26;50(15):3681-5. Epub 2007 Jul 3.

PMID:
17608397
29.

Learning and modeling biosignatures from tissue images.

Gilfeather F, Hamine V, Helman P, Hutt J, Loring T, Lyons CR, Veroff R.

Comput Biol Med. 2007 Nov;37(11):1539-52. Epub 2007 Apr 11.

PMID:
17433283
30.
31.

Murine innate immune response to virulent toxigenic and nontoxigenic Bacillus anthracis strains.

Drysdale M, Olson G, Koehler TM, Lipscomb MF, Lyons CR.

Infect Immun. 2007 Apr;75(4):1757-64. Epub 2007 Jan 22.

32.

Expression profiling of Yersinia pestis during mouse pulmonary infection.

Lawson JN, Lyons CR, Johnston SA.

DNA Cell Biol. 2006 Nov;25(11):608-16.

PMID:
17132091
33.

Protective and immunochemical activities of monoclonal antibodies reactive with the Bacillus anthracis polypeptide capsule.

Kozel TR, Thorkildson P, Brandt S, Welch WH, Lovchik JA, AuCoin DP, Vilai J, Lyons CR.

Infect Immun. 2007 Jan;75(1):152-63. Epub 2006 Oct 23.

34.

Toxin-deficient mutants of Bacillus anthracis are lethal in a murine model for pulmonary anthrax.

Heninger S, Drysdale M, Lovchik J, Hutt J, Lipscomb MF, Koehler TM, Lyons CR.

Infect Immun. 2006 Nov;74(11):6067-74. Epub 2006 Aug 21.

35.

Passive immunotherapy of Bacillus anthracis pulmonary infection in mice with antisera produced by DNA immunization.

Herrmann JE, Wang S, Zhang C, Panchal RG, Bavari S, Lyons CR, Lovchik JA, Golding B, Shiloach J, Lu S.

Vaccine. 2006 Jul 26;24(31-32):5872-80. Epub 2006 May 15.

PMID:
16790303
36.
37.

Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells.

Stanley KP, Chicoine LG, Young TL, Reber KM, Lyons CR, Liu Y, Nelin LD.

Am J Physiol Lung Cell Mol Physiol. 2006 Feb;290(2):L298-306. Epub 2005 Sep 9.

38.

Intranasal vaccination induces protective immunity against intranasal infection with virulent Francisella tularensis biovar A.

Wu TH, Hutt JA, Garrison KA, Berliba LS, Zhou Y, Lyons CR.

Infect Immun. 2005 May;73(5):2644-54.

39.

Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthrax.

Drysdale M, Heninger S, Hutt J, Chen Y, Lyons CR, Koehler TM.

EMBO J. 2005 Jan 12;24(1):221-7. Epub 2004 Dec 16.

40.

Organism identification using a genome sequence-independent universal microarray probe set.

Belosludtsev YY, Bowerman D, Weil R, Marthandan N, Balog R, Luebke K, Lawson J, Johnston SA, Lyons CR, Obrien K, Garner HR, Powdrill TF.

Biotechniques. 2004 Oct;37(4):654-8, 660.

41.

Murine model of pulmonary anthrax: kinetics of dissemination, histopathology, and mouse strain susceptibility.

Lyons CR, Lovchik J, Hutt J, Lipscomb MF, Wang E, Heninger S, Berliba L, Garrison K.

Infect Immun. 2004 Aug;72(8):4801-9.

42.

Intratracheal adenoviral-mediated delivery of iNOS decreases pulmonary vasoconstrictor responses in rats.

Chicoine LG, Tzeng E, Bryan R, Saenz S, Paffett ML, Jones J, Lyons CR, Resta TC, Nelin LD, Walker BR.

J Appl Physiol (1985). 2004 Nov;97(5):1814-22. Epub 2004 Jul 16.

43.

mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemia.

Kozel TR, Murphy WJ, Brandt S, Blazar BR, Lovchik JA, Thorkildson P, Percival A, Lyons CR.

Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5042-7. Epub 2004 Mar 29.

44.

A polymorphic region in Mycobacterium abscessus contains a novel insertion sequence element.

Howard ST, Byrd TF, Lyons CR.

Microbiology. 2002 Oct;148(Pt 10):2987-96.

PMID:
12368432
45.

Genetic vaccines protect against Sin Nombre hantavirus challenge in the deer mouse (Peromyscus maniculatus).

Bharadwaj M, Mirowsky K, Ye C, Botten J, Masten B, Yee J, Lyons CR, Hjelle B.

J Gen Virol. 2002 Jul;83(Pt 7):1745-51.

PMID:
12075094
46.

Ultraviolet light induces reactivation in a murine model of cutaneous herpes simplex virus-1 infection.

Goade DE, Nofchissey RA, Kusewitt DF, Hjelle B, Kreisel J, Moore J, Lyons CR.

Photochem Photobiol. 2001 Jul;74(1):108-14.

PMID:
11460531
47.

Ovalbumin aerosols induce airway hyperreactivity in naïve DO11.10 T cell receptor transgenic mice without pulmonary eosinophilia or OVA-specific antibody.

Wilder JA, Collie DD, Bice DE, Tesfaigzi Y, Lyons CR, Lipscomb MF.

J Leukoc Biol. 2001 Apr;69(4):538-47.

PMID:
11310839
48.

Ig heavy chain complex-linked genes influence the immune response in a murine cryptococcal infection.

Lovchik JA, Wilder JA, Huffnagle GB, Riblet R, Lyons CR, Lipscomb MF.

J Immunol. 1999 Oct 1;163(7):3907-13.

49.
50.

Intramuscular inoculation of Sin Nombre hantavirus cDNAs induces cellular and humoral immune responses in BALB/c mice.

Bharadwaj M, Lyons CR, Wortman IA, Hjelle B.

Vaccine. 1999 Jul 16;17(22):2836-43.

PMID:
10438054

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