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Items: 1 to 50 of 89

1.

A coiled-coil masking domain for selective activation of therapeutic antibodies.

Trang VH, Zhang X, Yumul RC, Zeng W, Stone IJ, Wo SW, Dominguez MM, Cochran JH, Simmons JK, Ryan MC, Lyon RP, Senter PD, Levengood MR.

Nat Biotechnol. 2019 Jul;37(7):761-765. doi: 10.1038/s41587-019-0135-x. Epub 2019 May 27.

PMID:
31133742
2.

Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates.

Neumann CS, Olivas KC, Anderson ME, Cochran JH, Jin S, Li F, Loftus LV, Meyer DW, Neale J, Nix JC, Pittman PG, Simmons JK, Ulrich ML, Waight AB, Wong A, Zaval MC, Zeng W, Lyon RP, Senter PD.

Mol Cancer Ther. 2018 Dec;17(12):2633-2642. doi: 10.1158/1535-7163.MCT-18-0643. Epub 2018 Sep 21.

PMID:
30242091
3.

Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR+ and Heterogeneous Tumor Models.

Burke PJ, Hamilton JZ, Pires TA, Lai HWH, Leiske CI, Emmerton KK, Waight AB, Senter PD, Lyon RP, Jeffrey SC.

Mol Cancer Ther. 2018 Aug;17(8):1752-1760. doi: 10.1158/1535-7163.MCT-18-0073. Epub 2018 Jun 4.

4.

Oyster toadfish (Opsanus tau) boatwhistle call detection and patterns within a large-scale oyster restoration site.

Ricci SW, Bohnenstiehl DR, Eggleston DB, Kellogg ML, Lyon RP.

PLoS One. 2017 Aug 8;12(8):e0182757. doi: 10.1371/journal.pone.0182757. eCollection 2017.

5.

Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody-Drug Conjugates.

Burke PJ, Hamilton JZ, Jeffrey SC, Hunter JH, Doronina SO, Okeley NM, Miyamoto JB, Anderson ME, Stone IJ, Ulrich ML, Simmons JK, McKinney EE, Senter PD, Lyon RP.

Mol Cancer Ther. 2017 Jan;16(1):116-123. doi: 10.1158/1535-7163.MCT-16-0343. Epub 2016 Nov 9.

6.

The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates.

Kolakowski RV, Haelsig KT, Emmerton KK, Leiske CI, Miyamoto JB, Cochran JH, Lyon RP, Senter PD, Jeffrey SC.

Angew Chem Int Ed Engl. 2016 Jul 4;55(28):7948-51. doi: 10.1002/anie.201601506. Epub 2016 May 20.

PMID:
27198854
7.

Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates.

Burke PJ, Hamilton JZ, Pires TA, Setter JR, Hunter JH, Cochran JH, Waight AB, Gordon KA, Toki BE, Emmerton KK, Zeng W, Stone IJ, Senter PD, Lyon RP, Jeffrey SC.

Mol Cancer Ther. 2016 May;15(5):938-45. doi: 10.1158/1535-7163.MCT-16-0038. Epub 2016 Mar 4.

8.

Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models.

Li F, Emmerton KK, Jonas M, Zhang X, Miyamoto JB, Setter JR, Nicholas ND, Okeley NM, Lyon RP, Benjamin DR, Law CL.

Cancer Res. 2016 May 1;76(9):2710-9. doi: 10.1158/0008-5472.CAN-15-1795. Epub 2016 Feb 26.

9.

Antibody-conjugated drug assay for protease-cleavable antibody-drug conjugates.

Sanderson RJ, Nicholas ND, Baker Lee C, Hengel SM, Lyon RP, Benjamin DR, Alley SC.

Bioanalysis. 2016;8(1):55-63. doi: 10.4155/bio.15.230. Epub 2015 Dec 9.

PMID:
26647801
10.

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index.

Lyon RP, Bovee TD, Doronina SO, Burke PJ, Hunter JH, Neff-LaFord HD, Jonas M, Anderson ME, Setter JR, Senter PD.

Nat Biotechnol. 2015 Jul;33(7):733-5. doi: 10.1038/nbt.3212. Epub 2015 Jun 15.

PMID:
26076429
11.

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates.

Lyon RP, Setter JR, Bovee TD, Doronina SO, Hunter JH, Anderson ME, Balasubramanian CL, Duniho SM, Leiske CI, Li F, Senter PD.

Nat Biotechnol. 2014 Oct;32(10):1059-62. doi: 10.1038/nbt.2968. Epub 2014 Sep 7.

PMID:
25194818
12.

Sounds and Charrière: the rest of the story.

Bowen DK, Wan J, Engel R, Lyon RP, Dielubanza E, Bloom DA.

J Pediatr Urol. 2014 Dec;10(6):1106-10. doi: 10.1016/j.jpurol.2014.04.010. Epub 2014 May 21.

PMID:
24942595
13.

A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology.

Jeffrey SC, Burke PJ, Lyon RP, Meyer DW, Sussman D, Anderson M, Hunter JH, Leiske CI, Miyamoto JB, Nicholas ND, Okeley NM, Sanderson RJ, Stone IJ, Zeng W, Gregson SJ, Masterson L, Tiberghien AC, Howard PW, Thurston DE, Law CL, Senter PD.

Bioconjug Chem. 2013 Jul 17;24(7):1256-63. doi: 10.1021/bc400217g. Epub 2013 Jun 28.

PMID:
23808985
14.

SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.

Kung Sutherland MS, Walter RB, Jeffrey SC, Burke PJ, Yu C, Kostner H, Stone I, Ryan MC, Sussman D, Lyon RP, Zeng W, Harrington KH, Klussman K, Westendorf L, Meyer D, Bernstein ID, Senter PD, Benjamin DR, Drachman JG, McEarchern JA.

Blood. 2013 Aug 22;122(8):1455-63. doi: 10.1182/blood-2013-03-491506. Epub 2013 Jun 14.

PMID:
23770776
15.

Conjugation of anticancer drugs through endogenous monoclonal antibody cysteine residues.

Lyon RP, Meyer DL, Setter JR, Senter PD.

Methods Enzymol. 2012;502:123-38. doi: 10.1016/B978-0-12-416039-2.00006-9.

PMID:
22208984
16.

Snap-to-it probes: chelate-constrained nucleobase oligomers with enhanced binding specificity.

Morgan JR, Lyon RP, Maeda DY, Zebala JA.

Nucleic Acids Res. 2008 Jun;36(11):3522-30. doi: 10.1093/nar/gkn219. Epub 2008 Apr 29.

17.

A glutathione-based hydrogel and its site-selective interactions with water.

Mahajan SS, Paranji R, Mehta R, Lyon RP, Atkins WM.

Bioconjug Chem. 2005 Jul-Aug;16(4):1019-26.

PMID:
16029045
18.

Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.

Abel EL, Lyon RP, Bammler TK, Verlinde CL, Lau SS, Monks TJ, Eaton DL.

Chem Biol Interact. 2004 Dec 30;151(1):21-32.

PMID:
15607759
19.

Novel class of bivalent glutathione S-transferase inhibitors.

Lyon RP, Hill JJ, Atkins WM.

Biochemistry. 2003 Sep 9;42(35):10418-28.

PMID:
12950168
21.

Re: the treatment of post-urethrotomy incontinence in pediatric and adolescent females.

Lyon RP.

J Urol. 2001 Nov;166(5):1838. No abstract available.

PMID:
11586187
22.

Self-assembly and gelation of oxidized glutathione in organic solvents.

Lyon RP, Atkins WM.

J Am Chem Soc. 2001 May 16;123(19):4408-13.

PMID:
11457225
23.

Periurethral haematomas in a child following urethral dilation for dysfunctional voiding.

Lyon RP, Marshall S.

BJU Int. 1999 Feb;83(3):364. No abstract available.

PMID:
10375285
24.
25.
26.

Re: floating kidneys: a century of nephroptosis and nephropexy.

Harrison RH 3rd, Lyon RP.

J Urol. 1998 May;159(5):1645. No abstract available.

PMID:
9554376
27.

Fluid balance during transurethral resection of the prostate.

Lyon RP.

Br J Urol. 1996 Apr;77(4):617. No abstract available.

PMID:
8777640
28.

Monitoring of body weight during transurethral resection of the prostate: preliminary report.

Lyon RP, St Lezin M, Thomas C, Narayan P.

J Endourol. 1994 Apr;8(2):161-3.

PMID:
8061677
29.

Hyponatremic encephalopathy after endometrial ablation.

Lyon RP.

JAMA. 1994 Feb 2;271(5):343; author reply 345. No abstract available.

PMID:
8283574
30.

Absorption of irrigating fluid during turp.

Lyon RP.

Urology. 1992 Apr;39(4):396. No abstract available.

PMID:
1557860
32.

Suprapubic cystotomy: a new device.

Lyon RP.

Urology. 1988 Oct;32(4):350-1. No abstract available.

PMID:
3176225
33.

Re: The surgical management of acute bacterial epididymitis with emphasis on epididymotomy.

Lyon RP.

J Urol. 1983 Aug;130(2):371. No abstract available.

PMID:
6876300
34.

Varicocele in youth.

Lyon RP, Marshall S, Scott MP.

West J Med. 1983 Jun;138(6):832-4.

35.

Internal urethrotomy and recurrent urinary tract infection.

Lyon RP.

Urology. 1983 Apr;21(4):435. No abstract available.

PMID:
6682270
36.

A conservative approach to testicular tumors in children: 12 cases and their management.

Marshall S, Lyon RP, Scott MP.

J Urol. 1983 Feb;129(2):350-1.

PMID:
6834506
37.

Varicocele in childhood and adolescence: implication in adulthood infertility?

Lyon RP, Marshall S, Scott MP.

Urology. 1982 Jun;19(6):641-4.

PMID:
7090115
38.

Treatment of vesicoureteral reflux: point system based on twenty years of experience.

Lyon RP, Marshall SK, Scott MP.

Urology. 1980 Jul;16(1):38-46.

PMID:
7395010
39.

Treatment of vesicoureteral reflux: point system based on 20 years of experience.

Lyon RP.

Trans Am Assoc Genitourin Surg. 1979;71:146-53.

PMID:
575683
40.

Further simplifications for coagulum pyelolithotomy.

Marshall S, Lyon RP, Scott MP Jr.

J Urol. 1978 May;119(5):588. No abstract available.

PMID:
660724
41.

Ureterovesicoplasty: selection of patients, incidence and avoidance of complications. A review of 3,527 cases.

Marshall S, Guthrie T, Jeffs R, Politano V, Lyon RP.

J Urol. 1977 Nov;118(5):829-31.

PMID:
916109
42.

What does urethral dilation really do?

Lyon RP.

Birth Defects Orig Artic Ser. 1977;13(5):439-41. No abstract available.

PMID:
563252
43.

Intermittent catheterization rather than urinary diversion in children with meningomyelocele.

Lyon RP, Scott MP, Marshall S.

J Urol. 1975 Mar;113(3):409-17.

PMID:
1090762
44.

Prostatic acid phosphatase levels. Significance in serum and bone marrow.

Marshall S, Lyon RP, Scott MP Jr.

Urology. 1974 Oct;4(4):435-8. No abstract available.

PMID:
4424449
45.

Bladder rupture following formalin therapy for hemorrhage secondary to cyclophosphamide therapy.

Scott MP Jr, Marshall S, Lyon RP.

Urology. 1974 Mar;3(3):364-5. No abstract available.

PMID:
4819702
46.

Enuresis: an analysis of various therapeutic approaches.

Marshall S, Marshall HH, Lyon RP.

Pediatrics. 1973 Dec;52(6):813-7. No abstract available.

PMID:
4768999
47.

Renal arrest.

Lyon RP.

J Urol. 1973 Apr;109(4):707-10. No abstract available.

PMID:
4695116
48.

Balanoposthitis secondary to tetracycline therapy.

Marshall S, Lyon RP, Scott MP Jr.

JAMA. 1973 Jan 29;223(5):559. No abstract available.

PMID:
4739150
49.

Variability of sperm disappearance from the ejaculate after vasectomy.

Marshall S, Lyon RP.

J Urol. 1972 May;107(5):815-7. No abstract available.

PMID:
5022549
50.

Transient reappearance of sperm after vasectomy.

Marshall S, Lyon RP.

JAMA. 1972 Mar 27;219(13):1753-4. No abstract available.

PMID:
5067241

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