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Influx rate of 18F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts.

Pitman KE, Alluri SR, Kristian A, Aarnes EK, Lyng H, Riss PJ, Malinen E.

Eur J Nucl Med Mol Imaging. 2019 Sep;46(10):2190-2198. doi: 10.1007/s00259-019-04375-8. Epub 2019 Jul 1.


PTEN Expression in Prostate Cancer: Relationship With Clinicopathologic Features and Multiparametric MRI Findings.

Switlyk MD, Salberg UB, Geier OM, Vlatkovic L, Lilleby W, Lyng H, Seierstad T.

AJR Am J Roentgenol. 2019 Mar 19:1-9. doi: 10.2214/AJR.18.20743. [Epub ahead of print]


Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer.

Jonsson M, Fjeldbo CS, Holm R, Stokke T, Kristensen GB, Lyng H.

Neoplasia. 2019 Apr;21(4):353-362. doi: 10.1016/j.neo.2019.01.002. Epub 2019 Mar 8.


Reference MicroRNAs for RT-qPCR Assays in Cervical Cancer Patients and Their Application to Studies of HPV16 and Hypoxia Biomarkers.

Nilsen A, Jonsson M, Aarnes EK, Kristensen GB, Lyng H.

Transl Oncol. 2019 Mar;12(3):576-584. doi: 10.1016/j.tranon.2018.12.010. Epub 2019 Jan 17.


Potentials and challenges of diffusion-weighted magnetic resonance imaging in radiotherapy.

Leibfarth S, Winter RM, Lyng H, Zips D, Thorwarth D.

Clin Transl Radiat Oncol. 2018 Sep 20;13:29-37. doi: 10.1016/j.ctro.2018.09.002. eCollection 2018 Nov. Review.


Transkingdom network reveals bacterial players associated with cervical cancer gene expression program.

Lam KC, Vyshenska D, Hu J, Rodrigues RR, Nilsen A, Zielke RA, Brown NS, Aarnes EK, Sikora AE, Shulzhenko N, Lyng H, Morgun A.

PeerJ. 2018 Sep 19;6:e5590. doi: 10.7717/peerj.5590. eCollection 2018.


Combined MR Imaging of Oxygen Consumption and Supply Reveals Tumor Hypoxia and Aggressiveness in Prostate Cancer Patients.

Hompland T, Hole KH, Ragnum HB, Aarnes EK, Vlatkovic L, Lie AK, Patzke S, Brennhovd B, Seierstad T, Lyng H.

Cancer Res. 2018 Aug 15;78(16):4774-4785. doi: 10.1158/0008-5472.CAN-17-3806. Epub 2018 Jun 26.


Low dose-rate irradiation with [3H]-labelled valine to selectively target hypoxic cells in a human colorectal cancer xenograft model.

Mikalsen SG, Mikalsen LTG, Sandvik JA, Aarnes EK, Fenne S, Flatmark K, Lyng H, Edin NFJ, Pettersen EO.

Acta Oncol. 2018 Sep;57(9):1216-1224. doi: 10.1080/0284186X.2018.1457223. Epub 2018 Apr 9.


Hypoxia in cervical cancer: from biology to imaging.

Lyng H, Malinen E.

Clin Transl Imaging. 2017;5(4):373-388. doi: 10.1007/s40336-017-0238-7. Epub 2017 Jul 10. Review.


Autodelineation of cervical cancers using multiparametric magnetic resonance imaging and machine learning.

Torheim T, Malinen E, Hole KH, Lund KV, Indahl UG, Lyng H, Kvaal K, Futsaether CM.

Acta Oncol. 2017 Jun;56(6):806-812. doi: 10.1080/0284186X.2017.1285499. Epub 2017 Feb 8.


Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition.

Jonsson M, Ragnum HB, Julin CH, Yeramian A, Clancy T, Frikstad KM, Seierstad T, Stokke T, Matias-Guiu X, Ree AH, Flatmark K, Lyng H.

Br J Cancer. 2016 Oct 11;115(8):929-939. doi: 10.1038/bjc.2016.278. Epub 2016 Sep 6.


Cluster analysis of dynamic contrast enhanced MRI reveals tumor subregions related to locoregional relapse for cervical cancer patients.

Torheim T, Groendahl AR, Andersen EK, Lyng H, Malinen E, Kvaal K, Futsaether CM.

Acta Oncol. 2016 Nov;55(11):1294-1298. Epub 2016 Aug 26.


Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence.

Wilting SM, Miok V, Jaspers A, Boon D, Sørgård H, Lando M, Snoek BC, van Wieringen WN, Meijer CJ, Lyng H, Snijders PJ, Steenbergen RD.

Oncotarget. 2016 Jul 12;7(28):43805-43819. doi: 10.18632/oncotarget.9698.


Identification and Validation of Reference Genes for RT-qPCR Studies of Hypoxia in Squamous Cervical Cancer Patients.

Fjeldbo CS, Aarnes EK, Malinen E, Kristensen GB, Lyng H.

PLoS One. 2016 May 31;11(5):e0156259. doi: 10.1371/journal.pone.0156259. eCollection 2016.


Integrative Analysis of DCE-MRI and Gene Expression Profiles in Construction of a Gene Classifier for Assessment of Hypoxia-Related Risk of Chemoradiotherapy Failure in Cervical Cancer.

Fjeldbo CS, Julin CH, Lando M, Forsberg MF, Aarnes EK, Alsner J, Kristensen GB, Malinen E, Lyng H.

Clin Cancer Res. 2016 Aug 15;22(16):4067-76. doi: 10.1158/1078-0432.CCR-15-2322. Epub 2016 Mar 24.


Hypoxia-induced alterations of G2 checkpoint regulators.

Hasvold G, Lund-Andersen C, Lando M, Patzke S, Hauge S, Suo Z, Lyng H, Syljuåsen RG.

Mol Oncol. 2016 May;10(5):764-73. doi: 10.1016/j.molonc.2015.12.015. Epub 2016 Jan 8.


Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer.

Lando M, Fjeldbo CS, Wilting SM, C Snoek B, Aarnes EK, Forsberg MF, Kristensen GB, Steenbergen RD, Lyng H.

Epigenetics. 2015;10(10):970-80. doi: 10.1080/15592294.2015.1085140.


The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer.

Ragnum HB, Vlatkovic L, Lie AK, Axcrona K, Julin CH, Frikstad KM, Hole KH, Seierstad T, Lyng H.

Br J Cancer. 2015 Jan 20;112(2):382-90. doi: 10.1038/bjc.2014.604. Epub 2014 Dec 2.


Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.

Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL, Scozzafava A, Supuran CT, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop KM, Wouters BG, Koritzinsky M, Mujcic H, Cojocari D.

J Enzyme Inhib Med Chem. 2015;30(5):689-721. doi: 10.3109/14756366.2014.966704. Epub 2014 Oct 27. Review.


Classification of dynamic contrast enhanced MR images of cervical cancers using texture analysis and support vector machines.

Torheim T, Malinen E, Kvaal K, Lyng H, Indahl UG, Andersen EK, Futsaether CM.

IEEE Trans Med Imaging. 2014 Aug;33(8):1648-56. doi: 10.1109/TMI.2014.2321024. Epub 2014 Apr 29.


Ménage à trois: an evolutionary interplay between human papillomavirus, a tumor, and a woman.

Shulzhenko N, Lyng H, Sanson GF, Morgun A.

Trends Microbiol. 2014 Jun;22(6):345-53. doi: 10.1016/j.tim.2014.02.009. Epub 2014 Mar 24. Review.


Hypoxia-independent downregulation of hypoxia-inducible factor 1 targets by androgen deprivation therapy in prostate cancer.

Ragnum HB, Røe K, Holm R, Vlatkovic L, Nesland JM, Aarnes EK, Ree AH, Flatmark K, Seierstad T, Lilleby W, Lyng H.

Int J Radiat Oncol Biol Phys. 2013 Nov 15;87(4):753-60. doi: 10.1016/j.ijrobp.2013.07.023. Epub 2013 Sep 10.


Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer.

Mine KL, Shulzhenko N, Yambartsev A, Rochman M, Sanson GF, Lando M, Varma S, Skinner J, Volfovsky N, Deng T, Brenna SM, Carvalho CR, Ribalta JC, Bustin M, Matzinger P, Silva ID, Lyng H, Gerbase-DeLima M, Morgun A.

Nat Commun. 2013;4:1806. doi: 10.1038/ncomms2693.


Identification of eight candidate target genes of the recurrent 3p12-p14 loss in cervical cancer by integrative genomic profiling.

Lando M, Wilting SM, Snipstad K, Clancy T, Bierkens M, Aarnes EK, Holden M, Stokke T, Sundfør K, Holm R, Kristensen GB, Steenbergen RD, Lyng H.

J Pathol. 2013 May;230(1):59-69. doi: 10.1002/path.4168. Epub 2013 Mar 14.


Pharmacokinetic parameters derived from dynamic contrast enhanced MRI of cervical cancers predict chemoradiotherapy outcome.

Andersen EK, Hole KH, Lund KV, Sundfør K, Kristensen GB, Lyng H, Malinen E.

Radiother Oncol. 2013 Apr;107(1):117-22. doi: 10.1016/j.radonc.2012.11.007. Epub 2013 Jan 17.


Hypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrast-enhanced MRI.

Halle C, Andersen E, Lando M, Aarnes EK, Hasvold G, Holden M, Syljuåsen RG, Sundfør K, Kristensen GB, Holm R, Malinen E, Lyng H.

Cancer Res. 2012 Oct 15;72(20):5285-95. doi: 10.1158/0008-5472.CAN-12-1085. Epub 2012 Aug 13.


Vascular responses to radiotherapy and androgen-deprivation therapy in experimental prostate cancer.

Røe K, Mikalsen LT, van der Kogel AJ, Bussink J, Lyng H, Ree AH, Marignol L, Olsen DR.

Radiat Oncol. 2012 May 23;7:75. doi: 10.1186/1748-717X-7-75.


Dynamic contrast-enhanced MRI of cervical cancers: temporal percentile screening of contrast enhancement identifies parameters for prediction of chemoradioresistance.

Andersen EK, Hole KH, Lund KV, Sundfør K, Kristensen GB, Lyng H, Malinen E.

Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):e485-92. doi: 10.1016/j.ijrobp.2011.05.050. Epub 2011 Oct 17.


Pharmacokinetic analysis and k-means clustering of DCEMR images for radiotherapy outcome prediction of advanced cervical cancers.

Andersen EK, Kristensen GB, Lyng H, Malinen E.

Acta Oncol. 2011 Aug;50(6):859-65. doi: 10.3109/0284186X.2011.578586.


Membranous expression of ectodomain isoforms of the epidermal growth factor receptor predicts outcome after chemoradiotherapy of lymph node-negative cervical cancer.

Halle C, Lando M, Svendsrud DH, Clancy T, Holden M, Sundfør K, Kristensen GB, Holm R, Lyng H.

Clin Cancer Res. 2011 Aug 15;17(16):5501-12. doi: 10.1158/1078-0432.CCR-11-0297. Epub 2011 Jul 7.


Phosphorylation of EGFR measured with in situ proximity ligation assay: relationship to EGFR protein level and gene dosage in cervical cancer.

Halle C, Lando M, Sundfør K, Kristensen GB, Holm R, Lyng H.

Radiother Oncol. 2011 Oct;101(1):152-7. doi: 10.1016/j.radonc.2011.05.052. Epub 2011 Jun 15.


Three independent mechanisms for arrest in G2 after ionizing radiation.

Landsverk KS, Patzke S, Rein ID, Stokke C, Lyng H, De Angelis PM, Stokke T.

Cell Cycle. 2011 Mar 1;10(5):819-29. Epub 2011 Mar 1.


Weighted lasso with data integration.

Bergersen LC, Glad IK, Lyng H.

Stat Appl Genet Mol Biol. 2011 Aug 29;10(1). pii: /j/sagmb.2011.10.issue-1/sagmb.2011.10.1.1703/sagmb.2011.10.1.1703.xml. doi: 10.2202/1544-6115.1703.


Gene dosage, expression, and ontology analysis identifies driver genes in the carcinogenesis and chemoradioresistance of cervical cancer.

Lando M, Holden M, Bergersen LC, Svendsrud DH, Stokke T, Sundfør K, Glad IK, Kristensen GB, Lyng H.

PLoS Genet. 2009 Nov;5(11):e1000719. doi: 10.1371/journal.pgen.1000719. Epub 2009 Nov 13.


Expression of 14-3-3sigma in cervical squamous cell carcinomas: relationship with clinical outcome.

Holm R, Ali T, Svendsrud DH, Nesland JM, Kristensen GB, Lyng H.

Oncol Rep. 2009 Jul;22(1):11-5.


Validation of oligoarrays for quantitative exploration of the transcriptome.

Nygaard V, Liu F, Holden M, Kuo WP, Trimarchi J, Ohno-Machado L, Cepko CL, Frigessi A, Glad IK, Wiel MA, Hovig E, Lyng H.

BMC Genomics. 2008 May 30;9:258. doi: 10.1186/1471-2164-9-258.


GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data.

Lyng H, Lando M, Brøvig RS, Svendsrud DH, Johansen M, Galteland E, Brustugun OT, Meza-Zepeda LA, Myklebost O, Kristensen GB, Hovig E, Stokke T.

Genome Biol. 2008;9(5):R86. doi: 10.1186/gb-2008-9-5-r86. Epub 2008 May 23.


Indirect genomic effects on survival from gene expression data.

Ferkingstad E, Frigessi A, Lyng H.

Genome Biol. 2008;9(3):R58. doi: 10.1186/gb-2008-9-3-r58. Epub 2008 Mar 22.


Human papillomavirus DNA and e6/e7 mRNA status in relation to survival of patients treated for cervical squamous cell carcinoma.

Holm R, Kraus I, Skomedal H, Langerød A, Kristensen GB, Lyng H.

Open Virol J. 2008;2:74-81. doi: 10.2174/1874357900802010074. Epub 2008 Oct 24.


Metabolic mapping by use of high-resolution magic angle spinning 1H MR spectroscopy for assessment of apoptosis in cervical carcinomas.

Lyng H, Sitter B, Bathen TF, Jensen LR, Sundfør K, Kristensen GB, Gribbestad IS.

BMC Cancer. 2007 Jan 17;7:11.


Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer.

Lyng H, Brøvig RS, Svendsrud DH, Holm R, Kaalhus O, Knutstad K, Oksefjell H, Sundfør K, Kristensen GB, Stokke T.

BMC Genomics. 2006 Oct 20;7:268.


The influence of missing value imputation on detection of differentially expressed genes from microarray data.

Scheel I, Aldrin M, Glad IK, Sørum R, Lyng H, Frigessi A.

Bioinformatics. 2005 Dec 1;21(23):4272-9. Epub 2005 Oct 10.


Genome-wide estimation of transcript concentrations from spotted cDNA microarray data.

Frigessi A, van de Wiel MA, Holden M, Svendsrud DH, Glad IK, Lyng H.

Nucleic Acids Res. 2005 Oct 4;33(17):e143.


Response of malignant B lymphocytes to ionizing radiation: gene expression and genotype.

Lyng H, Landsverk KS, Kristiansen E, DeAngelis PM, Ree AH, Myklebost O, Hovig E, Stokke T.

Int J Cancer. 2005 Jul 20;115(6):935-42.


Intratumor chromosomal heterogeneity in advanced carcinomas of the uterine cervix.

Lyng H, Beigi M, Svendsrud DH, Brustugun OT, Stokke T, Kristensen GB, Sundfør K, Skjønsberg A, De Angelis PM.

Int J Cancer. 2004 Sep 1;111(3):358-66.


Profound influence of microarray scanner characteristics on gene expression ratios: analysis and procedure for correction.

Lyng H, Badiee A, Svendsrud DH, Hovig E, Myklebost O, Stokke T.

BMC Genomics. 2004 Feb 3;5(1):10.


Assessment of tumor oxygenation in human cervical carcinoma by use of dynamic Gd-DTPA-enhanced MR imaging.

Lyng H, Vorren AO, Sundfør K, Taksdal I, Lien HH, Kaalhus O, Rofstad EK.

J Magn Reson Imaging. 2001 Dec;14(6):750-6.


Intra- and intertumor heterogeneity in blood perfusion of human cervical cancer before treatment and after radiotherapy.

Lyng H, Vorren AO, Sundfør K, Taksdal I, Lien HH, Kaalhus O, Rofstad EK.

Int J Cancer. 2001 Jun 20;96(3):182-90.


Microvessel oxyhemoglobin saturation does not reflect tissue oxygen tension in human melanoma xenografts.

Måseide K, Lyng H, Rofstad EK.

Microvasc Res. 2001 Mar;61(2):199-202. No abstract available.


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