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Items: 1 to 50 of 332

1.

Heterogeneity of Pulmonary Stem Cells.

Lynch TJ, Ievlev V, Parekh KR.

Adv Exp Med Biol. 2019;1169:95-117. doi: 10.1007/978-3-030-24108-7_6. Review.

PMID:
31487021
2.

Virtual Standardized Patient Simulation: Case Development and Pilot Application to High-Value Care.

Bond WF, Lynch TJ, Mischler MJ, Fish JL, McGarvey JS, Taylor JT, Kumar DM, Mou KM, Ebert-Allen RA, Mahale DN, Talbot TB, Aiyer M.

Simul Healthc. 2019 Aug;14(4):241-250. doi: 10.1097/SIH.0000000000000373.

PMID:
31116172
3.

Highly Efficient Transgenesis in Ferrets Using CRISPR/Cas9-Mediated Homology-Independent Insertion at the ROSA26 Locus.

Yu M, Sun X, Tyler SR, Liang B, Swatek AM, Lynch TJ, He N, Yuan F, Feng Z, Rotti PG, Choi SH, Shahin W, Liu X, Yan Z, Engelhardt JF.

Sci Rep. 2019 Feb 13;9(1):1971. doi: 10.1038/s41598-018-37192-4.

4.

A Trust Initiative in Health Care: Why and Why Now?

Lynch TJ, Wolfson DB, Baron RJ.

Acad Med. 2019 Apr;94(4):463-465. doi: 10.1097/ACM.0000000000002599.

PMID:
30649020
5.

Lung transplantation: chronic rejection and stem cell depletion.

Lynch TJ, Ahlers BA, Parekh KR.

J Thorac Dis. 2018 Aug;10(8):E666-E668. doi: 10.21037/jtd.2018.07.70. No abstract available.

6.

Adipose and Liver Function in Primate Offspring with Insulin Resistance Induced by Estrogen Deprivation in Utero.

Kim SO, Aberdeen G, Lynch TJ, Albrecht ED, Pepe GJ.

Endocrinol Diabetes Metab J. 2017 Aug;1(3). pii: http://researchopenworld.com/wp-content/uploads/2017/10/EDMJ-2017-109-Gerald-J.-Pepe-USA.pdf. Epub 2017 Sep 12.

7.

Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium.

Lynch TJ, Anderson PJ, Rotti PG, Tyler SR, Crooke AK, Choi SH, Montoro DT, Silverman CL, Shahin W, Zhao R, Jensen-Cody CW, Adamcakova-Dodd A, Evans TIA, Xie W, Zhang Y, Mou H, Herring BP, Thorne PS, Rajagopal J, Yeaman C, Parekh KR, Engelhardt JF.

Cell Stem Cell. 2018 May 3;22(5):779. doi: 10.1016/j.stem.2018.04.007. No abstract available.

8.

Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up.

Kadara H, Choi M, Zhang J, Parra ER, Rodriguez-Canales J, Gaffney SG, Zhao Z, Behrens C, Fujimoto J, Chow C, Yoo Y, Kalhor N, Moran C, Rimm D, Swisher S, Gibbons DL, Heymach J, Kaftan E, Townsend JP, Lynch TJ, Schlessinger J, Lee J, Lifton RP, Wistuba II, Herbst RS.

Ann Oncol. 2018 Apr 1;29(4):1072. doi: 10.1093/annonc/mdx062. No abstract available.

PMID:
29688333
9.

Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium.

Lynch TJ, Anderson PJ, Rotti PG, Tyler SR, Crooke AK, Choi SH, Montoro DT, Silverman CL, Shahin W, Zhao R, Jensen-Cody CW, Adamcakova-Dodd A, Evans TIA, Xie W, Zhang Y, Mou H, Herring BP, Thorne PS, Rajagopal J, Yeaman C, Parekh KR, Engelhardt JF.

Cell Stem Cell. 2018 May 3;22(5):653-667.e5. doi: 10.1016/j.stem.2018.03.017. Epub 2018 Apr 12. Erratum in: Cell Stem Cell. 2018 May 3;22(5):779.

10.

Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis.

Swatek AM, Lynch TJ, Crooke AK, Anderson PJ, Tyler SR, Brooks L, Ivanovic M, Klesney-Tait JA, Eberlein M, Pena T, Meyerholz DK, Engelhardt JF, Parekh KR.

Am J Respir Crit Care Med. 2018 Apr 15;197(8):1045-1057. doi: 10.1164/rccm.201707-1368OC.

11.

Abdominal pain with a twist: a rare presentation of acute gastric volvulus.

Chen DP, Walayat S, Balouch IL, Martin DK, Lynch TJ.

J Community Hosp Intern Med Perspect. 2017 Oct 18;7(5):325-328. doi: 10.1080/20009666.2017.1379853. eCollection 2017.

12.

Developing the Storyline for an Advance Care Planning Video for Surgery Patients: Patient-Centered Outcomes Research Engagement from Stakeholder Summit to State Fair.

Aslakson RA, Schuster ALR, Lynch TJ, Weiss MJ, Gregg L, Miller J, Isenberg SR, Crossnohere NL, Conca-Cheng AM, Volandes AE, Smith TJ, Bridges JFP.

J Palliat Med. 2018 Jan;21(1):89-94. doi: 10.1089/jpm.2017.0106. Epub 2017 Aug 17.

PMID:
28817359
13.

Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function.

Choi M, Kadara H, Zhang J, Parra ER, Rodriguez-Canales J, Gaffney SG, Zhao Z, Behrens C, Fujimoto J, Chow C, Kim K, Kalhor N, Moran C, Rimm D, Swisher S, Gibbons DL, Heymach J, Kaftan E, Townsend JP, Lynch TJ, Schlessinger J, Lee J, Lifton RP, Herbst RS, Wistuba II.

Ann Oncol. 2017 Jan 1;28(1):83-89. doi: 10.1093/annonc/mdw437.

14.

Multipotent Myoepithelial Progenitor Cells Are Born Early during Airway Submucosal Gland Development.

Anderson PJ, Lynch TJ, Engelhardt JF.

Am J Respir Cell Mol Biol. 2017 Jun;56(6):716-726. doi: 10.1165/rcmb.2016-0304OC.

15.

ABI5-binding proteins (AFPs) alter transcription of ABA-induced genes via a variety of interactions with chromatin modifiers.

Lynch TJ, Erickson BJ, Miller DR, Finkelstein RR.

Plant Mol Biol. 2017 Mar;93(4-5):403-418. doi: 10.1007/s11103-016-0569-1. Epub 2016 Dec 9.

16.

Insulin resistance elicited in postpubertal primate offspring deprived of estrogen in utero.

Pepe GJ, Maniu A, Aberdeen G, Lynch TJ, Kim SO, Nadler J, Albrecht ED.

Endocrine. 2016 Dec;54(3):788-797. doi: 10.1007/s12020-016-1145-9. Epub 2016 Oct 21.

17.

Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up.

Kadara H, Choi M, Zhang J, Parra ER, Rodriguez-Canales J, Gaffney SG, Zhao Z, Behrens C, Fujimoto J, Chow C, Yoo Y, Kalhor N, Moran C, Rimm D, Swisher S, Gibbons DL, Heymach J, Kaftan E, Townsend JP, Lynch TJ, Schlessinger J, Lee J, Lifton RP, Wistuba II, Herbst RS.

Ann Oncol. 2017 Jan 1;28(1):75-82. doi: 10.1093/annonc/mdw436. Erratum in: Ann Oncol. 2018 Apr 1;29(4):1072.

18.

A Case Report of Delayed Return of Spontaneous Circulation: Lazarus Phenomenon.

Meeker JW, Kelkar AH, Loc BL, Lynch TJ.

Am J Med. 2016 Dec;129(12):e343-e344. doi: 10.1016/j.amjmed.2016.07.009. Epub 2016 Aug 1. No abstract available.

PMID:
27491467
19.

Wnt Signaling Regulates Airway Epithelial Stem Cells in Adult Murine Submucosal Glands.

Lynch TJ, Anderson PJ, Xie W, Crooke AK, Liu X, Tyler SR, Luo M, Kusner DM, Zhang Y, Neff T, Burnette DC, Walters KS, Goodheart MJ, Parekh KR, Engelhardt JF.

Stem Cells. 2016 Nov;34(11):2758-2771. doi: 10.1002/stem.2443. Epub 2016 Jul 11.

20.

Estrogen deprivation in primate pregnancy leads to insulin resistance in offspring.

Maniu A, Aberdeen GW, Lynch TJ, Nadler JL, Kim SO, Quon MJ, Pepe GJ, Albrecht ED.

J Endocrinol. 2016 Aug;230(2):171-83. doi: 10.1530/JOE-15-0530. Epub 2016 May 20.

21.

Estrogen Regulation of Fetal Adrenal Cortical Zone-Specific Development in the Nonhuman Primate Impacts Adrenal Production of Androgen and Cortisol and Response to ACTH in Females in Adulthood.

Pepe GJ, Maniu A, Aberdeen G, Lynch TJ, Albrecht ED.

Endocrinology. 2016 May;157(5):1905-13. doi: 10.1210/en.2015-2087. Epub 2016 Mar 18.

22.

Perceived Barriers and Potential Strategies to Improve Self-Management Among Adults with Type 2 Diabetes: A Community-Engaged Research Approach.

Purnell TS, Lynch TJ, Bone L, Segal JB, Evans C, Longo DR, Bridges JF.

Patient. 2016 Aug;9(4):349-58. doi: 10.1007/s40271-016-0162-3.

PMID:
26939674
23.

Effectiveness of bevacizumab exposure beyond disease progression in patients with non-small-cell lung cancer: analyses of the ARIES observational cohort study.

Leon L, Kosty M, Jahanzeb M, Spigel D, Wozniak AJ, Brahmer J, Fish S, Flick ED, Hazard SJ, Lynch TJ.

Pharmacoepidemiol Drug Saf. 2016 May;25(5):569-77. doi: 10.1002/pds.3948. Epub 2016 Jan 8.

PMID:
26748833
24.

Palliative Care Medical Education in European Universities: A Descriptive Study and Numerical Scoring System Proposal for Assessing Educational Development.

Carrasco JM, Lynch TJ, Garralda E, Woitha K, Elsner F, Filbet M, Ellershaw JE, Clark D, Centeno C.

J Pain Symptom Manage. 2015 Oct;50(4):516-23.e2. doi: 10.1016/j.jpainsymman.2015.04.019. Epub 2015 May 27.

25.

CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice.

Xie W, Fisher JT, Lynch TJ, Luo M, Evans TI, Neff TL, Zhou W, Zhang Y, Ou Y, Bunnett NW, Russo AF, Goodheart MJ, Parekh KR, Liu X, Engelhardt JF.

J Clin Invest. 2015 May;125(5):2179. doi: 10.1172/JCI82138. Epub 2015 May 1. No abstract available.

26.

May-Thurner syndrome: High output cardiac failure as a result of iatrogenic iliac fistula.

Singh S, Singh S, Jyothimallika J, Lynch TJ.

World J Clin Cases. 2015 Mar 16;3(3):318-21. doi: 10.12998/wjcc.v3.i3.318.

27.

A phase I trial of high dose gefitinib for patients with leptomeningeal metastases from non-small cell lung cancer.

Jackman DM, Cioffredi LA, Jacobs L, Sharmeen F, Morse LK, Lucca J, Plotkin SR, Marcoux PJ, Rabin MS, Lynch TJ, Johnson BE, Kesari S.

Oncotarget. 2015 Feb 28;6(6):4527-36.

28.

Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer.

Heist RS, Duda DG, Sahani DV, Ancukiewicz M, Fidias P, Sequist LV, Temel JS, Shaw AT, Pennell NA, Neal JW, Gandhi L, Lynch TJ, Engelman JA, Jain RK.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1547-52. doi: 10.1073/pnas.1424024112. Epub 2015 Jan 20.

29.

Clinical outcomes in elderly patients with advanced non-small cell lung cancer: results from ARIES, a bevacizumab observational cohort study.

Wozniak AJ, Kosty MP, Jahanzeb M, Brahmer JR, Spigel DR, Leon L, Fish S, Flick ED, Hazard SJ, Lynch TJ Jr.

Clin Oncol (R Coll Radiol). 2015 Apr;27(4):187-96. doi: 10.1016/j.clon.2014.12.002. Epub 2015 Jan 7.

PMID:
25576353
30.

Effectiveness and safety of post-induction phase bevacizumab treatment for patients with non-small-cell lung cancer: results from the ARIES observational cohort study.

Kosty MP, Wozniak AJ, Jahanzeb M, Leon L, Fish S, Hazard SJ, Lynch TJ Jr.

Target Oncol. 2015 Dec;10(4):509-16. doi: 10.1007/s11523-014-0355-4. Epub 2015 Jan 6.

PMID:
25559289
31.

Safety and effectiveness of bevacizumab-containing treatment for non-small-cell lung cancer: final results of the ARIES observational cohort study.

Lynch TJ Jr, Spigel DR, Brahmer J, Fischbach N, Garst J, Jahanzeb M, Kumar P, Vidaver RM, Wozniak AJ, Fish S, Flick ED, Leon L, Hazard SJ, Kosty MP; ARIES Study Investigators.

J Thorac Oncol. 2014 Sep;9(9):1332-9. doi: 10.1097/JTO.0000000000000257.

32.

Progenitor cells in proximal airway epithelial development and regeneration.

Lynch TJ, Engelhardt JF.

J Cell Biochem. 2014 Oct;115(10):1637-45. doi: 10.1002/jcb.24834. Review.

33.

Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets.

Sun X, Olivier AK, Yi Y, Pope CE, Hayden HS, Liang B, Sui H, Zhou W, Hager KR, Zhang Y, Liu X, Yan Z, Fisher JT, Keiser NW, Song Y, Tyler SR, Goeken JA, Kinyon JM, Radey MC, Fligg D, Wang X, Xie W, Lynch TJ, Kaminsky PM, Brittnacher MJ, Miller SI, Parekh K, Meyerholz DK, Hoffman LR, Frana T, Stewart ZA, Engelhardt JF.

Am J Pathol. 2014 May;184(5):1309-22. doi: 10.1016/j.ajpath.2014.01.035. Epub 2014 Mar 15.

34.

Sox2 modulates Lef-1 expression during airway submucosal gland development.

Xie W, Lynch TJ, Liu X, Tyler SR, Yu S, Zhou X, Luo M, Kusner DM, Sun X, Yi Y, Zhang Y, Goodheart MJ, Parekh KR, Wells JM, Xue HH, Pevny LH, Engelhardt JF.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L645-60. doi: 10.1152/ajplung.00157.2013. Epub 2014 Jan 31.

35.

Meta-analysis of individual patient data from randomized trials of chemotherapy plus cetuximab as first-line treatment for advanced non-small cell lung cancer.

Pujol JL, Pirker R, Lynch TJ, Butts CA, Rosell R, Shepherd FA, Vansteenkiste J, O'Byrne KJ, de Blas B, Heighway J, von Heydebreck A, Thatcher N.

Lung Cancer. 2014 Feb;83(2):211-8. doi: 10.1016/j.lungcan.2013.11.006. Epub 2013 Nov 16.

PMID:
24332319
36.

Regulation of baboon fetal ovarian development by placental estrogen: onset of puberty is delayed in offspring deprived of estrogen in utero.

Pepe GJ, Lynch TJ, Albrecht ED.

Biol Reprod. 2013 Dec 5;89(6):132. doi: 10.1095/biolreprod.112.107318. Print 2013 Dec.

37.

The COX-2 inhibitor meloxicam prevents pregnancy when administered as an emergency contraceptive to nonhuman primates.

McCann NC, Lynch TJ, Kim SO, Duffy DM.

Contraception. 2013 Dec;88(6):744-8. doi: 10.1016/j.contraception.2013.09.006. Epub 2013 Sep 13.

PMID:
24120248
38.

Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets.

Sun X, Olivier AK, Liang B, Yi Y, Sui H, Evans TI, Zhang Y, Zhou W, Tyler SR, Fisher JT, Keiser NW, Liu X, Yan Z, Song Y, Goeken JA, Kinyon JM, Fligg D, Wang X, Xie W, Lynch TJ, Kaminsky PM, Stewart ZA, Pope RM, Frana T, Meyerholz DK, Parekh K, Engelhardt JF.

Am J Respir Cell Mol Biol. 2014 Mar;50(3):502-12. doi: 10.1165/rcmb.2013-0261OC.

39.

A review on cylindrospermopsin: the global occurrence, detection, toxicity and degradation of a potent cyanotoxin.

de la Cruz AA, Hiskia A, Kaloudis T, Chernoff N, Hill D, Antoniou MG, He X, Loftin K, O'Shea K, Zhao C, Pelaez M, Han C, Lynch TJ, Dionysiou DD.

Environ Sci Process Impacts. 2013 Oct;15(11):1979-2003. doi: 10.1039/c3em00353a. Review.

PMID:
24056894
40.

Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner.

Spencer NY, Zhou W, Li Q, Zhang Y, Luo M, Yan Z, Lynch TJ, Abbott D, Banfi B, Engelhardt JF.

Am J Physiol Gastrointest Liver Physiol. 2013 Jul 1;305(1):G84-94. doi: 10.1152/ajpgi.00430.2012. Epub 2013 May 2.

41.

Potential of 18F-FDG PET toward personalized radiotherapy or chemoradiotherapy in lung cancer.

Choi NC, Chun TT, Niemierko A, Ancukiewicz M, Fidias PM, Kradin RL, Mathisen DJ, Lynch TJ, Fischman AJ.

Eur J Nucl Med Mol Imaging. 2013 Jun;40(6):832-41. doi: 10.1007/s00259-013-2348-4. Epub 2013 Feb 12.

42.

Choosing optimal antimicrobial therapies.

Lynch TJ.

Med Clin North Am. 2012 Nov;96(6):1079-94. doi: 10.1016/j.mcna.2012.08.006. Epub 2012 Sep 27. Review.

PMID:
23102478
43.

A phase I study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer.

Goldberg SB, Supko JG, Neal JW, Muzikansky A, Digumarthy S, Fidias P, Temel JS, Heist RS, Shaw AT, McCarthy PO, Lynch TJ, Sharma S, Settleman JE, Sequist LV.

J Thorac Oncol. 2012 Oct;7(10):1602-8. doi: 10.1097/JTO.0b013e318262de4a.

44.

Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial.

Reck M, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Lu H, Cuillerot JM, Lynch TJ.

Ann Oncol. 2013 Jan;24(1):75-83. doi: 10.1093/annonc/mds213. Epub 2012 Aug 2.

PMID:
22858559
45.

Phase II study of the multitargeted tyrosine kinase inhibitor XL647 in patients with non-small-cell lung cancer.

Pietanza MC, Gadgeel SM, Dowlati A, Lynch TJ, Salgia R, Rowland KM Jr, Wertheim MS, Price KA, Riely GJ, Azzoli CG, Miller VA, Krug LM, Kris MG, Beumer JH, Tonda M, Mitchell B, Rizvi NA.

J Thorac Oncol. 2012 May;7(5):856-65. doi: 10.1097/JTO.0b013e31824c943f.

46.

Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study.

Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Neal J, Lu H, Cuillerot JM, Reck M.

J Clin Oncol. 2012 Jun 10;30(17):2046-54. doi: 10.1200/JCO.2011.38.4032. Epub 2012 Apr 30. Erratum in: J Clin Oncol. 2012 Oct 10;30(29):3654.

PMID:
22547592
47.

Two sides of the same coin: EGFR exon 19 deletions and insertions in lung cancer.

Politi K, Lynch TJ.

Clin Cancer Res. 2012 Mar 15;18(6):1490-2. doi: 10.1158/1078-0432.CCR-11-3282. Epub 2012 Feb 8.

48.

Unmet challenges in the use of novel agents in locally advanced non-small-cell lung cancer.

Decker RH, Lynch TJ.

J Clin Oncol. 2012 Feb 20;30(6):582-4. doi: 10.1200/JCO.2011.40.1471. Epub 2012 Jan 23. No abstract available.

PMID:
22271476
49.

Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice.

Sequist LV, Heist RS, Shaw AT, Fidias P, Rosovsky R, Temel JS, Lennes IT, Digumarthy S, Waltman BA, Bast E, Tammireddy S, Morrissey L, Muzikansky A, Goldberg SB, Gainor J, Channick CL, Wain JC, Gaissert H, Donahue DM, Muniappan A, Wright C, Willers H, Mathisen DJ, Choi NC, Baselga J, Lynch TJ, Ellisen LW, Mino-Kenudson M, Lanuti M, Borger DR, Iafrate AJ, Engelman JA, Dias-Santagata D.

Ann Oncol. 2011 Dec;22(12):2616-24. doi: 10.1093/annonc/mdr489. Epub 2011 Nov 9.

50.

XL647--a multitargeted tyrosine kinase inhibitor: results of a phase II study in subjects with non-small cell lung cancer who have progressed after responding to treatment with either gefitinib or erlotinib.

Pietanza MC, Lynch TJ Jr, Lara PN Jr, Cho J, Yanagihara RH, Vrindavanam N, Chowhan NM, Gadgeel SM, Pennell NA, Funke R, Mitchell B, Wakelee HA, Miller VA.

J Thorac Oncol. 2012 Jan;7(1):219-26. doi: 10.1097/JTO.0b013e31822eebf9.

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