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Items: 1 to 50 of 136

1.

Accurate Prediction for Antibody Resistance of Clinical HIV-1 Isolates.

Rawi R, Mall R, Shen CH, Farney SK, Shiakolas A, Zhou J, Bensmail H, Chun TW, Doria-Rose NA, Lynch RM, Mascola JR, Kwong PD, Chuang GY.

Sci Rep. 2019 Oct 11;9(1):14696. doi: 10.1038/s41598-019-50635-w.

2.

Permeability of Epithelial/Endothelial Barriers in Transwells and Microfluidic Bilayer Devices.

Frost TS, Jiang L, Lynch RM, Zohar Y.

Micromachines (Basel). 2019 Aug 13;10(8). pii: E533. doi: 10.3390/mi10080533.

3.

Simian-Human Immunodeficiency Virus SHIV.CH505 Infection of Rhesus Macaques Results in Persistent Viral Replication and Induces Intestinal Immunopathology.

Bar KJ, Coronado E, Hensley-McBain T, O'Connor MA, Osborn JM, Miller C, Gott TM, Wangari S, Iwayama N, Ahrens CY, Smedley J, Moats C, Lynch RM, Haddad EK, Haigwood NL, Fuller DH, Shaw GM, Klatt NR, Manuzak JA.

J Virol. 2019 Aug 28;93(18). pii: e00372-19. doi: 10.1128/JVI.00372-19. Print 2019 Sep 15.

PMID:
31217249
4.
5.

Establishment of a Novel Humanized Mouse Model To Investigate In Vivo Activation and Depletion of Patient-Derived HIV Latent Reservoirs.

Flerin NC, Bardhi A, Zheng JH, Korom M, Folkvord J, Kovacs C, Benko E, Truong R, Mota T, Connick E, Jones RB, Lynch RM, Goldstein H.

J Virol. 2019 Mar 5;93(6). pii: e02051-18. doi: 10.1128/JVI.02051-18. Print 2019 Mar 15.

6.

Multivalent activation of GLP-1 and sulfonylurea receptors modulates β-cell second-messenger signaling and insulin secretion.

Hart NJ, Weber C, Papas KK, Limesand SW, Vagner J, Lynch RM.

Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C48-C56. doi: 10.1152/ajpcell.00209.2018. Epub 2018 Nov 7.

PMID:
30404557
7.

Susceptibility to Neutralization by Broadly Neutralizing Antibodies Generally Correlates with Infected Cell Binding for a Panel of Clade B HIV Reactivated from Latent Reservoirs.

Ren Y, Korom M, Truong R, Chan D, Huang SH, Kovacs CC, Benko E, Safrit JT, Lee J, Garbán H, Apps R, Goldstein H, Lynch RM, Jones RB.

J Virol. 2018 Nov 12;92(23). pii: e00895-18. doi: 10.1128/JVI.00895-18. Print 2018 Dec 1.

8.

Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome.

Lynch RM, Mantus G, Encinales L, Pacheco N, Li G, Porras A, Mendoza AR, Peng J, Rengifo-Pardo M, Cruz MM, Harris E, Bethony JM, Simon GL, Chang AY.

J Infect Dis. 2019 Jan 1;219(1):26-30. doi: 10.1093/infdis/jiy466.

9.

Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling.

Kelly AC, Smith KE, Purvis WG, Min CG, Weber CS, Cooksey AM, Hasilo C, Paraskevas S, Suszynski TM, Weegman BP, Anderson MJ, Camacho LE, Harland RC, Loudovaris T, Jandova J, Molano DS, Price ND, Georgiev IG, Scott WE 3rd, Manas DMD, Shaw JAM, OʼGorman D, Kin T, McCarthy FM, Szot GL, Posselt AM, Stock PG, Karatzas T, Shapiro AMJ, Lynch RM, Limesand SW, Papas KK.

Transplantation. 2019 Jan;103(1):160-167. doi: 10.1097/TP.0000000000002400.

PMID:
30095738
10.

In vitro characterization of neonatal, juvenile, and adult porcine islet oxygen demand, β-cell function, and transcriptomes.

Smith KE, Purvis WG, Davis MA, Min CG, Cooksey AM, Weber CS, Jandova J, Price ND, Molano DS, Stanton JB, Kelly AC, Steyn LV, Lynch RM, Limesand SW, Alexander M, Lakey JRT, Seeberger K, Korbutt GS, Mueller KR, Hering BJ, McCarthy FM, Papas KK.

Xenotransplantation. 2018 Nov;25(6):e12432. doi: 10.1111/xen.12432. Epub 2018 Jul 27.

PMID:
30052287
11.

Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors.

González N, McKee K, Lynch RM, Georgiev IS, Jimenez L, Grau E, Yuste E, Kwong PD, Mascola JR, Alcamí J.

PLoS One. 2018 Mar 20;13(3):e0193773. doi: 10.1371/journal.pone.0193773. eCollection 2018.

12.

Adrenergic receptor stimulation suppresses oxidative metabolism in isolated rat islets and Min6 cells.

Kelly AC, Camacho LE, Pendarvis K, Davenport HM, Steffens NR, Smith KE, Weber CS, Lynch RM, Papas KK, Limesand SW.

Mol Cell Endocrinol. 2018 Sep 15;473:136-145. doi: 10.1016/j.mce.2018.01.012. Epub 2018 Jan 31.

13.

Artefact mimicking torsades: treat the patient not the ECG.

Bergin U, Lynch RM.

Practitioner. 2017 Feb;261(1801):23-6.

PMID:
29020721
14.

Comment on "Identification of Novel G Protein-Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism".

McKay BS, Lynch RM, Stamer WD.

Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4733-4734. doi: 10.1167/iovs.17-22660. No abstract available.

15.

Broadly Neutralizing Antibodies as Treatment: Effects on Virus and Immune System.

Bhiman JN, Lynch RM.

Curr HIV/AIDS Rep. 2017 Apr;14(2):54-62. doi: 10.1007/s11904-017-0352-1. Review.

16.

Longitudinal dynamics of the HIV-specific B cell response during intermittent treatment of primary HIV infection.

de Bree GJ, Wheatley AK, Lynch RM, Prabhakaran M, Grijsen ML, Prins JM, Schmidt SD, Koup RA, Mascola JR, McDermott AB.

PLoS One. 2017 Mar 15;12(3):e0173577. doi: 10.1371/journal.pone.0173577. eCollection 2017.

17.

Acute Ischemia Induced by High-Density Culture Increases Cytokine Expression and Diminishes the Function and Viability of Highly Purified Human Islets of Langerhans.

Smith KE, Kelly AC, Min CG, Weber CS, McCarthy FM, Steyn LV, Badarinarayana V, Stanton JB, Kitzmann JP, Strop P, Gruessner AC, Lynch RM, Limesand SW, Papas KK.

Transplantation. 2017 Nov;101(11):2705-2712. doi: 10.1097/TP.0000000000001714.

18.

Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption.

Bar KJ, Sneller MC, Harrison LJ, Justement JS, Overton ET, Petrone ME, Salantes DB, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Blazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden K, O'Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli EV, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun TW.

N Engl J Med. 2016 Nov 24;375(21):2037-2050. Epub 2016 Nov 9.

19.

Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine.

Chen X, Kelly AC, Yates DT, Macko AR, Lynch RM, Limesand SW.

J Endocrinol. 2017 Feb;232(2):285-295. Epub 2016 Nov 25.

20.

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection.

Lynch RM, Boritz E, Coates EE, DeZure A, Madden P, Costner P, Enama ME, Plummer S, Holman L, Hendel CS, Gordon I, Casazza J, Conan-Cibotti M, Migueles SA, Tressler R, Bailer RT, McDermott A, Narpala S, O'Dell S, Wolf G, Lifson JD, Freemire BA, Gorelick RJ, Pandey JP, Mohan S, Chomont N, Fromentin R, Chun TW, Fauci AS, Schwartz RM, Koup RA, Douek DC, Hu Z, Capparelli E, Graham BS, Mascola JR, Ledgerwood JE; VRC 601 Study Team.

Sci Transl Med. 2015 Dec 23;7(319):319ra206. doi: 10.1126/scitranslmed.aad5752.

PMID:
26702094
21.

B cells in HIV pathogenesis.

de Bree GJ, Lynch RM.

Curr Opin Infect Dis. 2016 Feb;29(1):23-30. doi: 10.1097/QCO.0000000000000225. Review.

PMID:
26658653
22.

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency.

Doria-Rose NA, Bhiman JN, Roark RS, Schramm CA, Gorman J, Chuang GY, Pancera M, Cale EM, Ernandes MJ, Louder MK, Asokan M, Bailer RT, Druz A, Fraschilla IR, Garrett NJ, Jarosinski M, Lynch RM, McKee K, O'Dell S, Pegu A, Schmidt SD, Staupe RP, Sutton MS, Wang K, Wibmer CK, Haynes BF, Abdool-Karim S, Shapiro L, Kwong PD, Moore PL, Morris L, Mascola JR.

J Virol. 2015 Oct 14;90(1):76-91. doi: 10.1128/JVI.01791-15. Print 2016 Jan 1.

23.

Linear scaffolds for multivalent targeting of melanocortin receptors.

Dehigaspitiya DC, Anglin BL, Smith KR, Weber CS, Lynch RM, Mash EA.

Org Biomol Chem. 2015 Dec 21;13(47):11507-17. doi: 10.1039/c5ob01779c. Epub 2015 Oct 13.

PMID:
26461460
24.

Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults.

Ledgerwood JE, Coates EE, Yamshchikov G, Saunders JG, Holman L, Enama ME, DeZure A, Lynch RM, Gordon I, Plummer S, Hendel CS, Pegu A, Conan-Cibotti M, Sitar S, Bailer RT, Narpala S, McDermott A, Louder M, O'Dell S, Mohan S, Pandey JP, Schwartz RM, Hu Z, Koup RA, Capparelli E, Mascola JR, Graham BS; VRC 602 Study Team.

Clin Exp Immunol. 2015 Dec;182(3):289-301. doi: 10.1111/cei.12692. Epub 2015 Sep 24.

25.

Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection.

Yamamoto T, Lynch RM, Gautam R, Matus-Nicodemos R, Schmidt SD, Boswell KL, Darko S, Wong P, Sheng Z, Petrovas C, McDermott AB, Seder RA, Keele BF, Shapiro L, Douek DC, Nishimura Y, Mascola JR, Martin MA, Koup RA.

Sci Transl Med. 2015 Jul 29;7(298):298ra120. doi: 10.1126/scitranslmed.aab3964.

PMID:
26223303
26.

Synthesis and bioactivity of MSH4 oligomers prepared by an A2 + B2 strategy.

Dehigaspitiya DC, Navath S, Weber CS, Lynch RM, Mash EA.

Tetrahedron Lett. 2015 Jun 3;56(23):3060-3065.

27.

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.

Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, Lingwood D, Soto C, Bailer RT, Ernandes MJ, Kong R, Longo NS, Louder MK, McKee K, O'Dell S, Schmidt SD, Tran L, Yang Z, Druz A, Luongo TS, Moquin S, Srivatsan S, Yang Y, Zhang B, Zheng A, Pancera M, Kirys T, Georgiev IS, Gindin T, Peng HP, Yang AS; NISC Comparative Sequencing Program, Mullikin JC, Gray MD, Stamatatos L, Burton DR, Koff WC, Cohen MS, Haynes BF, Casazza JP, Connors M, Corti D, Lanzavecchia A, Sattentau QJ, Weiss RA, West AP Jr, Bjorkman PJ, Scheid JF, Nussenzweig MC, Shapiro L, Mascola JR, Kwong PD.

Cell. 2015 Jun 4;161(6):1280-92. doi: 10.1016/j.cell.2015.05.007. Epub 2015 May 21.

28.

Bestrophin-1 influences transepithelial electrical properties and Ca2+ signaling in human retinal pigment epithelium.

Marmorstein AD, Kinnick TR, Stanton JB, Johnson AA, Lynch RM, Marmorstein LY.

Mol Vis. 2015 Apr 1;21:347-59. eCollection 2015.

29.

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.

Wu X, Zhang Z, Schramm CA, Joyce MG, Kwon YD, Zhou T, Sheng Z, Zhang B, O'Dell S, McKee K, Georgiev IS, Chuang GY, Longo NS, Lynch RM, Saunders KO, Soto C, Srivatsan S, Yang Y, Bailer RT, Louder MK; NISC Comparative Sequencing Program, Mullikin JC, Connors M, Kwong PD, Mascola JR, Shapiro L.

Cell. 2015 Apr 23;161(3):470-485. doi: 10.1016/j.cell.2015.03.004. Epub 2015 Apr 9.

30.

Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization.

Francica JR, Sheng Z, Zhang Z, Nishimura Y, Shingai M, Ramesh A, Keele BF, Schmidt SD, Flynn BJ, Darko S, Lynch RM, Yamamoto T, Matus-Nicodemos R, Wolinsky D; NISC Comparative Sequencing Program, Nason M, Valiante NM, Malyala P, De Gregorio E, Barnett SW, Singh M, O'Hagan DT, Koup RA, Mascola JR, Martin MA, Kepler TB, Douek DC, Shapiro L, Seder RA.

Nat Commun. 2015 Apr 10;6:6565. doi: 10.1038/ncomms7565.

31.

Development of a time-resolved fluorescence probe for evaluation of competitive binding to the cholecystokinin 2 receptor.

Elshan NG, Jayasundera T, Weber CS, Lynch RM, Mash EA.

Bioorg Med Chem. 2015 Apr 15;23(8):1841-8. doi: 10.1016/j.bmc.2015.02.028. Epub 2015 Feb 26.

32.

G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets.

Insel PA, Wilderman A, Zambon AC, Snead AN, Murray F, Aroonsakool N, McDonald DS, Zhou S, McCann T, Zhang L, Sriram K, Chinn AM, Michkov AV, Lynch RM, Overland AC, Corriden R.

Mol Pharmacol. 2015 Jul;88(1):181-7. doi: 10.1124/mol.115.098129. Epub 2015 Mar 3. Review.

33.

Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302.

Wojtkowiak JW, Cornnell HC, Matsumoto S, Saito K, Takakusagi Y, Dutta P, Kim M, Zhang X, Leos R, Bailey KM, Martinez G, Lloyd MC, Weber C, Mitchell JB, Lynch RM, Baker AF, Gatenby RA, Rejniak KA, Hart C, Krishna MC, Gillies RJ.

Cancer Metab. 2015 Jan 29;3(1):2. doi: 10.1186/s40170-014-0026-z. eCollection 2015.

34.

HIV-1 fitness cost associated with escape from the VRC01 class of CD4 binding site neutralizing antibodies.

Lynch RM, Wong P, Tran L, O'Dell S, Nason MC, Li Y, Wu X, Mascola JR.

J Virol. 2015 Apr;89(8):4201-13. doi: 10.1128/JVI.03608-14. Epub 2015 Jan 28.

35.

A Synthetic Heterobivalent Ligand Composed of Glucagon-Like Peptide 1 and Yohimbine Specifically Targets β Cells Within the Pancreas.

Steyn LV, Ananthakrishnan K, Anderson MJ, Patek R, Kelly A, Vagner J, Lynch RM, Limesand SW.

Mol Imaging Biol. 2015 Aug;17(4):461-70. doi: 10.1007/s11307-014-0817-1. Epub 2015 Jan 21.

36.

Trigonal scaffolds for multivalent targeting of melanocortin receptors.

Elshan NG, Jayasundera T, Anglin BL, Weber CS, Lynch RM, Mash EA.

Org Biomol Chem. 2015 Feb 14;13(6):1778-91. doi: 10.1039/c4ob02094d.

37.

Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.

Gao F, Bonsignori M, Liao HX, Kumar A, Xia SM, Lu X, Cai F, Hwang KK, Song H, Zhou T, Lynch RM, Alam SM, Moody MA, Ferrari G, Berrong M, Kelsoe G, Shaw GM, Hahn BH, Montefiori DC, Kamanga G, Cohen MS, Hraber P, Kwong PD, Korber BT, Mascola JR, Kepler TB, Haynes BF.

Cell. 2014 Jul 31;158(3):481-91. doi: 10.1016/j.cell.2014.06.022. Epub 2014 Jul 24.

38.

Function and expression of sulfonylurea, adrenergic, and glucagon-like peptide 1 receptors in isolated porcine islets.

Kelly AC, Steyn LV, Kitzmann JP, Anderson MJ, Mueller KR, Hart NJ, Lynch RM, Papas KK, Limesand SW.

Xenotransplantation. 2014 Jul-Aug;21(4):385-91. doi: 10.1111/xen.12101. Epub 2014 May 7.

39.

Hetero-bivalent GLP-1/glibenclamide for targeting pancreatic β-cells.

Hart NJ, Chung WJ, Weber C, Ananthakrishnan K, Anderson M, Patek R, Zhang Z, Limesand SW, Vagner J, Lynch RM.

Chembiochem. 2014 Jan 3;15(1):135-45. doi: 10.1002/cbic.201300375. Epub 2013 Nov 20.

40.

Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors.

Alleti R, Vagner J, Dehigaspitiya DC, Moberg VE, Elshan NG, Tafreshi NK, Brabez N, Weber CS, Lynch RM, Hruby VJ, Gillies RJ, Morse DL, Mash EA.

Bioorg Med Chem. 2013 Sep 1;21(17):5029-38. doi: 10.1016/j.bmc.2013.06.052. Epub 2013 Jul 2.

41.

HIV vaccine research and discovery in the nonhuman primates model: a unified theory in acquisition prevention and control of SIV infection.

Lynch RM, Yamamoto T, McDermott AB.

Curr Opin HIV AIDS. 2013 Jul;8(4):288-94. doi: 10.1097/COH.0b013e328361cfe8. Review.

42.

Increased redox-sensitive green fluorescent protein reduction potential in the endoplasmic reticulum following glutathione-mediated dimerization.

Sarkar DD, Edwards SK, Mauser JA, Suarez AM, Serowoky MA, Hudok NL, Hudok PL, Nuñez M, Weber CS, Lynch RM, Miyashita O, Tsao TS.

Biochemistry. 2013 May 14;52(19):3332-45. doi: 10.1021/bi400052u. Epub 2013 Apr 30.

PMID:
23594148
43.

Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo.

Escalante AM, McGrath RT, Karolak MR, Dorr RT, Lynch RM, Landowski TH.

Cancer Chemother Pharmacol. 2013 Jun;71(6):1567-76. doi: 10.1007/s00280-013-2156-3. Epub 2013 Apr 10.

44.

Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting.

Brabez N, Saunders K, Nguyen KL, Jayasundera TB, Weber C, Lynch RM, Chassaing G, Lavielle S, Hruby VJ.

ACS Med Chem Lett. 2013 Jan 1;4(1):98-102. Epub 2012 Nov 24.

45.

Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment.

Brabez N, Nguyen KL, Saunders K, Lacy R, Xu L, Gillies RJ, Lynch RM, Chassaing G, Lavielle S, Hruby VJ.

Bioorg Med Chem Lett. 2013 Apr 15;23(8):2422-5. doi: 10.1016/j.bmcl.2013.02.022. Epub 2013 Feb 13.

46.

Heterobivalent ligands target cell-surface receptor combinations in vivo.

Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21295-300. doi: 10.1073/pnas.1211762109. Epub 2012 Dec 10.

47.

Keeping the beat. Focus on "enrichment of neonatal rat cardiomyocytes in primary culture facilitates long-term maintenance of contractility in vitro".

Konhilas JP, Behunin SM, Lynch RM.

Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1218-9. doi: 10.1152/ajpcell.00310.2012. Epub 2012 Sep 26. No abstract available.

48.

Simultaneous analysis of intracellular pH and Ca²⁺ from cell populations.

Martinez-Zaguilan R, Tompkins LS, Gillies RJ, Lynch RM.

Methods Mol Biol. 2013;937:253-71.

PMID:
23007592
49.

The development of CD4 binding site antibodies during HIV-1 infection.

Lynch RM, Tran L, Louder MK, Schmidt SD, Cohen M; CHAVI 001 Clinical Team Members, Dersimonian R, Euler Z, Gray ES, Abdool Karim S, Kirchherr J, Montefiori DC, Sibeko S, Soderberg K, Tomaras G, Yang ZY, Nabel GJ, Schuitemaker H, Morris L, Haynes BF, Mascola JR.

J Virol. 2012 Jul;86(14):7588-95. doi: 10.1128/JVI.00734-12. Epub 2012 May 9.

50.

Chronic pulsatile hyperglycemia reduces insulin secretion and increases accumulation of reactive oxygen species in fetal sheep islets.

Green AS, Chen X, Macko AR, Anderson MJ, Kelly AC, Hart NJ, Lynch RM, Limesand SW.

J Endocrinol. 2012 Mar;212(3):327-42. doi: 10.1530/JOE-11-0300. Epub 2011 Dec 19.

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