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Items: 1 to 50 of 290

1.

Can the emerging field of immunometabolism provide insights into neuroinflammation?

Lynch MA.

Prog Neurobiol. 2019 Nov 6:101719. doi: 10.1016/j.pneurobio.2019.101719. [Epub ahead of print] Review.

PMID:
31704314
2.

The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages.

Finucane OM, Sugrue J, Rubio-Araiz A, Guillot-Sestier MV, Lynch MA.

Sci Rep. 2019 Mar 11;9(1):4034. doi: 10.1038/s41598-019-40619-1.

3.

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice.

McIntosh A, Mela V, Harty C, Minogue AM, Costello DA, Kerskens C, Lynch MA.

Brain Pathol. 2019 Sep;29(5):606-621. doi: 10.1111/bpa.12704. Epub 2019 Feb 17.

PMID:
30661261
4.

Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming.

Wolfe H, Mela V, Minogue AM, Miller AM, McGuigan C, Williams L, Lohan D, Lawlor BA, Lynch MA.

Neurosci Res. 2019 Nov;148:54-60. doi: 10.1016/j.neures.2019.01.001. Epub 2019 Jan 12.

PMID:
30641113
5.

Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid.

Rubio-Araiz A, Finucane OM, Keogh S, Lynch MA.

J Neuroinflammation. 2018 Aug 31;15(1):247. doi: 10.1186/s12974-018-1281-7.

6.

Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice.

Wolfe H, Minogue AM, Rooney S, Lynch MA.

Mech Ageing Dev. 2018 Jul;173:84-91. doi: 10.1016/j.mad.2018.05.003.

PMID:
29758231
7.

Comparing disciplinary methods used by mothers in Palestine and Qatar.

Kamal M, Halileh S, Dargham S, Alyafei KA, Giacaman R, Imseeh S, Eldeeb N, Nasr S, Korayem M, Abu-Rmeileh N, Mahfoud Z, Tawfik H, Mahmoud MH, Mian M, Lynch MA.

Child Abuse Negl. 2018 Jul;81:118-127. doi: 10.1016/j.chiabu.2018.04.018. Epub 2018 May 3.

PMID:
29730312
8.

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice.

Holland R, McIntosh AL, Finucane OM, Mela V, Rubio-Araiz A, Timmons G, McCarthy SA, Gun'ko YK, Lynch MA.

Brain Behav Immun. 2018 Feb;68:183-196. doi: 10.1016/j.bbi.2017.10.017. Epub 2017 Oct 20.

PMID:
29061364
9.

FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation.

McManus RM, Finucane OM, Wilk MM, Mills KHG, Lynch MA.

J Neuroimmune Pharmacol. 2017 Dec;12(4):670-681. doi: 10.1007/s11481-017-9753-6. Epub 2017 Jun 15.

PMID:
28620801
10.

Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis.

Wilk MM, Misiak A, McManus RM, Allen AC, Lynch MA, Mills KHG.

J Immunol. 2017 Jul 1;199(1):233-243. doi: 10.4049/jimmunol.1602051. Epub 2017 May 22.

11.

Hunter and New England HealthPathways: a 4-year journey of integrated care.

Gray JS, Swan JR, Lynch MA, Tay TM, Mackenzie MJ, Wiggers JH, Harrison KA, McDonald RC, O'Dea IP, Harrigan LM, Fitzgerald SM; Hunter and New England HealthPathways Steering Committee .

Aust Health Rev. 2018 Feb;42(1):66-71. doi: 10.1071/AH16197.

PMID:
28214475
12.

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.

Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AAB, Cooper MA, O'Neill LAJ, Lynch MA.

Brain Behav Immun. 2017 Mar;61:306-316. doi: 10.1016/j.bbi.2016.12.014. Epub 2016 Dec 18.

PMID:
28003153
13.

Analysis of the Impact of CD200 on Phagocytosis.

Lyons A, Minogue AM, Jones RS, Fitzpatrick O, Noonan J, Campbell VA, Lynch MA.

Mol Neurobiol. 2017 Sep;54(7):5730-5739. doi: 10.1007/s12035-016-0223-6. Epub 2016 Nov 9.

PMID:
27830533
14.

Child discipline in Qatar and Palestine: A comparative study of ICAST-R.

Eldeeb N, Halileh S, Alyafei KA, Ghandour R, Dargham S, Giacaman R, Kamal M, Imseeh S, Korayem M, Nasr S, Mahfoud Z, Abu-Rmeileh N, Mahmoud MH, Tawfik H, Lynch MA, Mian M.

Child Abuse Negl. 2016 Nov;61:63-72. doi: 10.1016/j.chiabu.2016.10.006. Epub 2016 Oct 17.

PMID:
27760709
15.

With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions.

Drechsler S, Lynch MA, Novella S, González-Navarro H, Hecimovic S, Barini E, Tucci V, Castro RE, Vandenbroucke RE, Osuchowski M, Potter PK.

Mech Ageing Dev. 2016 Dec;160:54-68. doi: 10.1016/j.mad.2016.07.005. Epub 2016 Jul 21. Review.

16.

Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer's disease.

McDonald CL, Hennessy E, Rubio-Araiz A, Keogh B, McCormack W, McGuirk P, Reilly M, Lynch MA.

Brain Behav Immun. 2016 Nov;58:191-200. doi: 10.1016/j.bbi.2016.07.143. Epub 2016 Jul 12.

PMID:
27422717
17.

The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function.

Costello DA, Keenan K, McManus RM, Falvey A, Lynch MA.

Neurobiol Aging. 2016 Jul;43:140-8. doi: 10.1016/j.neurobiolaging.2016.04.001. Epub 2016 Apr 13.

PMID:
27255823
18.

Targeting innate immunity for neurodegenerative disorders of the central nervous system.

Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, Russek-Blum N, Sandusky LA, Selenica ML, Takata K, Teeling J, Town T, Van Eldik LJ.

J Neurochem. 2016 Sep;138(5):653-93. doi: 10.1111/jnc.13667. Review. Erratum in: J Neurochem. 2017 Apr;141(1):151.

19.

Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair.

Bryson KJ, Lynch MA.

Curr Opin Pharmacol. 2016 Feb;26:67-73. doi: 10.1016/j.coph.2015.10.003. Epub 2015 Oct 27. Review.

PMID:
26516722
20.

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice.

Jones RS, Minogue AM, Fitzpatrick O, Lynch MA.

Neurobiol Aging. 2015 Oct;36(10):2716-24. doi: 10.1016/j.neurobiolaging.2015.04.018. Epub 2015 Jul 11.

PMID:
26227742
21.

Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages.

Barrett JP, Minogue AM, Falvey A, Lynch MA.

Exp Cell Res. 2015 Jul 15;335(2):258-68. doi: 10.1016/j.yexcr.2015.05.015. Epub 2015 May 28.

PMID:
26022664
22.

T Cells-Protective or Pathogenic in Alzheimer's Disease?

McManus RM, Mills KH, Lynch MA.

J Neuroimmune Pharmacol. 2015 Dec;10(4):547-60. doi: 10.1007/s11481-015-9612-2. Epub 2015 May 10. Review.

PMID:
25957956
23.

Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli.

Barrett JP, Costello DA, O'Sullivan J, Cowley TR, Lynch MA.

J Neuroinflammation. 2015 Apr 9;12:67. doi: 10.1186/s12974-015-0287-7.

24.

α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.

Costello DA, Carney DG, Lynch MA.

Brain Behav Immun. 2015 May;46:70-9. doi: 10.1016/j.bbi.2015.01.005. Epub 2015 Jan 22.

PMID:
25620736
25.

Bone marrow-derived macrophages from AβPP/PS1 mice are sensitized to the effects of inflammatory stimuli.

Barrett JP, Minogue AM, Jones RS, Ribeiro C, Kelly RJ, Lynch MA.

J Alzheimers Dis. 2015;44(3):949-62. doi: 10.3233/JAD-142076.

PMID:
25374107
26.

Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP.

Distrutti E, O'Reilly JA, McDonald C, Cipriani S, Renga B, Lynch MA, Fiorucci S.

PLoS One. 2014 Sep 9;9(9):e106503. doi: 10.1371/journal.pone.0106503. eCollection 2014.

27.

Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β.

Lynch MA.

Brain Res. 2015 Sep 24;1621:197-204. doi: 10.1016/j.brainres.2014.08.040. Epub 2014 Sep 2. Review.

PMID:
25193603
28.

How dependent is synaptic plasticity on microglial phenotype?

Jones RS, Lynch MA.

Neuropharmacology. 2015 Sep;96(Pt A):3-10. doi: 10.1016/j.neuropharm.2014.08.012. Epub 2014 Aug 27. Review.

PMID:
25168262
29.

Innate IFN-γ promotes development of experimental autoimmune encephalomyelitis: a role for NK cells and M1 macrophages.

Dungan LS, McGuinness NC, Boon L, Lynch MA, Mills KH.

Eur J Immunol. 2014 Oct;44(10):2903-17. doi: 10.1002/eji.201444612. Epub 2014 Aug 19.

30.

Age-associated dysregulation of microglial activation is coupled with enhanced blood-brain barrier permeability and pathology in APP/PS1 mice.

Minogue AM, Jones RS, Kelly RJ, McDonald CL, Connor TJ, Lynch MA.

Neurobiol Aging. 2014 Jun;35(6):1442-52. doi: 10.1016/j.neurobiolaging.2013.12.026. Epub 2013 Dec 27.

PMID:
24439957
31.

Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10.

Murphy N, Grehan B, Lynch MA.

Neuromolecular Med. 2014 Mar;16(1):205-15. doi: 10.1007/s12017-013-8274-6. Epub 2013 Nov 7.

PMID:
24197756
32.

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice.

McManus RM, Higgins SC, Mills KH, Lynch MA.

Neurobiol Aging. 2014 Jan;35(1):109-21. doi: 10.1016/j.neurobiolaging.2013.07.025. Epub 2013 Aug 29.

PMID:
23993702
33.

Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells.

Denieffe S, Kelly RJ, McDonald C, Lyons A, Lynch MA.

Brain Behav Immun. 2013 Nov;34:86-97. doi: 10.1016/j.bbi.2013.07.174. Epub 2013 Aug 2.

PMID:
23916893
34.

The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.

Lynch MA.

Immunology. 2014 Mar;141(3):292-301. doi: 10.1111/imm.12156. Review.

35.

Glial Activation in AβPP/PS1 Mice is Associated with Infiltration of IFNγ-Producing Cells.

Kelly RJ, Minogue AM, Lyons A, Jones RS, Browne TC, Costello DA, Denieffe S, O'Sullivan C, Connor TJ, Lynch MA.

J Alzheimers Dis. 2013;37(1):63-75. Epub 2013 Jun 18.

PMID:
23780663
36.

Identifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory.

Downer EJ, Jones RS, McDonald CL, Greco E, Brennan S, Connor TJ, Robertson IH, Lynch MA.

PLoS One. 2013 May 6;8(5):e63194. doi: 10.1371/journal.pone.0063194. Print 2013.

37.

Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia.

Downer EJ, Johnston DG, Lynch MA.

Mol Cell Neurosci. 2013 Sep;56:148-58. doi: 10.1016/j.mcn.2013.04.007. Epub 2013 May 7.

PMID:
23659921
38.

Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β.

Costello DA, Lynch MA.

Hippocampus. 2013 Aug;23(8):696-707. doi: 10.1002/hipo.22129. Epub 2013 Jun 3.

PMID:
23554175
39.

Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction.

McGuckin CP, Jurga M, Miller AM, Sarnowska A, Wiedner M, Boyle NT, Lynch MA, Jablonska A, Drela K, Lukomska B, Domanska-Janik K, Kenner L, Moriggl R, Degoul O, Perruisseau-Carrier C, Forraz N.

Arch Biochem Biophys. 2013 Jun;534(1-2):88-97. doi: 10.1016/j.abb.2013.02.005. Epub 2013 Mar 4.

PMID:
23466243
40.

IFN-γ Production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease.

Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA.

J Immunol. 2013 Mar 1;190(5):2241-51. doi: 10.4049/jimmunol.1200947. Epub 2013 Jan 30.

41.

The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner.

Cox FF, Berezin V, Bock E, Lynch MA.

Neuroscience. 2013 Apr 3;235:141-8. doi: 10.1016/j.neuroscience.2012.12.030. Epub 2013 Jan 18.

PMID:
23337536
42.

Amyloid-β-induced astrocytic phagocytosis is mediated by CD36, CD47 and RAGE.

Jones RS, Minogue AM, Connor TJ, Lynch MA.

J Neuroimmune Pharmacol. 2013 Mar;8(1):301-11. doi: 10.1007/s11481-012-9427-3. Epub 2012 Dec 14.

PMID:
23238794
43.

An NCAM mimetic, FGL, alters hippocampal cellular morphometry in young adult (4 month-old) rats.

Ojo B, Gabbott PL, Rezaie P, Corbett N, Medvedev NI, Cowley TR, Lynch MA, Stewart MG.

Neurochem Res. 2013 Jun;38(6):1208-18. doi: 10.1007/s11064-012-0908-9. Epub 2012 Oct 18.

PMID:
23076631
44.
45.

The age-related gliosis and accompanying deficit in spatial learning are unaffected by dimebon.

Cowley TR, González-Reyes RE, Richardson JC, Virley D, Upton N, Lynch MA.

Neurochem Res. 2013 Jun;38(6):1190-5. doi: 10.1007/s11064-012-0884-0. Epub 2012 Sep 26.

PMID:
23011205
46.

LPS-induced release of IL-6 from glia modulates production of IL-1β in a JAK2-dependent manner.

Minogue AM, Barrett JP, Lynch MA.

J Neuroinflammation. 2012 Jun 14;9:126. doi: 10.1186/1742-2094-9-126.

47.

Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia.

Lyons A, Downer EJ, Costello DA, Murphy N, Lynch MA.

J Neuroinflammation. 2012 May 29;9:107. doi: 10.1186/1742-2094-9-107.

48.

Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased Aβ accumulation and microglial activation.

Gallagher JJ, Minogue AM, Lynch MA.

Neurodegener Dis. 2013;11(1):33-41. Epub 2012 May 24.

PMID:
22627185
49.

The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation.

Murphy N, Cowley TR, Blau CW, Dempsey CN, Noonan J, Gowran A, Tanveer R, Olango WM, Finn DP, Campbell VA, Lynch MA.

J Neuroinflammation. 2012 Apr 26;9:79. doi: 10.1186/1742-2094-9-79.

50.

Tibial loading increases osteogenic gene expression and cortical bone volume in mature and middle-aged mice.

Silva MJ, Brodt MD, Lynch MA, Stephens AL, Wood DJ, Civitelli R.

PLoS One. 2012;7(4):e34980. doi: 10.1371/journal.pone.0034980. Epub 2012 Apr 13.

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