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Glycine Protects Muscle Cells From Wasting in vitro via mTORC1 Signaling.

Caldow MK, Ham DJ, Trieu J, Chung JD, Lynch GS, Koopman R.

Front Nutr. 2019 Nov 13;6:172. doi: 10.3389/fnut.2019.00172. eCollection 2019.


The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation.

Nguyen JH, Chung JD, Lynch GS, Ryall JG.

Front Cell Dev Biol. 2019 Oct 29;7:254. doi: 10.3389/fcell.2019.00254. eCollection 2019. Review.


Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation.

Swiderski K, Bindon R, Trieu J, Naim T, Schokman S, Swaminathan M, Leembruggen AJL, Hill-Yardin EL, Koopman R, Bornstein JC, Lynch GS.

J Neurogastroenterol Motil. 2020 Jan 30;26(1):133-146. doi: 10.5056/jnm19029.


Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice.

Ham DJ, Gardner A, Kennedy TL, Trieu J, Naim T, Chee A, Alves FM, Caldow MK, Lynch GS, Koopman R.

Sci Rep. 2019 Sep 10;9(1):12982. doi: 10.1038/s41598-019-49140-x.


Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry.

Nelson ME, Parker BL, Burchfield JG, Hoffman NJ, Needham EJ, Cooke KC, Naim T, Sylow L, Ling NX, Francis D, Norris DM, Chaudhuri R, Oakhill JS, Richter EA, Lynch GS, Stöckli J, James DE.

EMBO J. 2019 Dec 16;38(24):e102578. doi: 10.15252/embj.2019102578. Epub 2019 Aug 5.


Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities.

Lauterborn JC, Schultz MN, Le AA, Amani M, Friedman AE, Leach PT, Gall CM, Lynch GS, Crawley JN.

Transl Psychiatry. 2019 Jun 10;9(1):166. doi: 10.1038/s41398-019-0495-5.


Current pharmacotherapies for sarcopenia.

Hardee JP, Lynch GS.

Expert Opin Pharmacother. 2019 Sep;20(13):1645-1657. doi: 10.1080/14656566.2019.1622093. Epub 2019 May 23. Review.


Expression and localization of heat-shock proteins during skeletal muscle cell proliferation and differentiation and the impact of heat stress.

Thakur SS, James JL, Cranna NJ, Chhen VL, Swiderski K, Ryall JG, Lynch GS.

Cell Stress Chaperones. 2019 Jul;24(4):749-761. doi: 10.1007/s12192-019-01001-2. Epub 2019 May 16.


Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury.

Swiderski K, Caldow MK, Naim T, Trieu J, Chee A, Koopman R, Lynch GS.

PLoS One. 2019 Feb 27;14(2):e0212880. doi: 10.1371/journal.pone.0212880. eCollection 2019.


Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer.

Murphy KT, Hossain MI, Swiderski K, Chee A, Naim T, Trieu J, Haynes V, Read SJ, Stapleton DI, Judge SM, Trevino JG, Judge AR, Lynch GS.

Cancer Res. 2019 Feb 15;79(4):706-719. doi: 10.1158/0008-5472.CAN-18-1207. Epub 2018 Nov 12.


Dietary meat and protection against sarcopenia.

Lynch GS, Koopman R.

Meat Sci. 2018 Oct;144:180-185. doi: 10.1016/j.meatsci.2018.06.023. Epub 2018 Jun 19.


The molecular signature of muscle stem cells is driven by nutrient availability and innate cell metabolism.

Ryall JG, Lynch GS.

Curr Opin Clin Nutr Metab Care. 2018 Jul;21(4):240-245. doi: 10.1097/MCO.0000000000000472. Review.


Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditions.

Thakur SS, Swiderski K, Ryall JG, Lynch GS.

Philos Trans R Soc Lond B Biol Sci. 2018 Jan 19;373(1738). pii: 20160528. doi: 10.1098/rstb.2016.0528. Review.


Corrigendum: G-CSF does not influence C2C12 myogenesis despite receptor expression in healthy and dystrophic skeletal muscle.

Wright CR, Brown EL, Della-Gatta PA, Ward AC, Lynch GS, Russell AP.

Front Physiol. 2017 Oct 30;8:886. doi: 10.3389/fphys.2017.00886. eCollection 2017.


Muscle-specific deletion of SOCS3 does not reduce the anabolic response to leucine in a mouse model of acute inflammation.

Caldow MK, Ham DJ, Chee A, Trieu J, Naim T, Stapleton DI, Swiderski K, Lynch GS, Koopman R.

Cytokine. 2017 Aug;96:274-278. doi: 10.1016/j.cyto.2017.05.016. Epub 2017 May 26.


Glycine metabolism in skeletal muscle: implications for metabolic homeostasis.

Koopman R, Caldow MK, Ham DJ, Lynch GS.

Curr Opin Clin Nutr Metab Care. 2017 Jul;20(4):237-242. doi: 10.1097/MCO.0000000000000383. Review.


Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice.

Gaur V, Connor T, Venardos K, Henstridge DC, Martin SD, Swinton C, Morrison S, Aston-Mourney K, Gehrig SM, van Ewijk R, Lynch GS, Febbraio MA, Steinberg GR, Hargreaves M, Walder KR, McGee SL.

Diabetes Obes Metab. 2017 Jul;19(7):936-943. doi: 10.1111/dom.12896. Epub 2017 Mar 3.


Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle.

Lee-Young RS, Hoffman NJ, Murphy KT, Henstridge DC, Samocha-Bonet D, Siebel AL, Iliades P, Zivanovic B, Hong YH, Colgan TD, Kraakman MJ, Bruce CR, Gregorevic P, McConell GK, Lynch GS, Drummond GR, Kingwell BA, Greenfield JR, Febbraio MA.

Mol Metab. 2016 Sep 9;5(11):1083-1091. doi: 10.1016/j.molmet.2016.09.002. eCollection 2016 Nov.


Muscle-specific deletion of SOCS3 increases the early inflammatory response but does not affect regeneration after myotoxic injury.

Swiderski K, Thakur SS, Naim T, Trieu J, Chee A, Stapleton DI, Koopman R, Lynch GS.

Skelet Muscle. 2016 Oct 24;6:36. eCollection 2016.


Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology.

Swiderski K, Martins KJ, Chee A, Trieu J, Naim T, Gehrig SM, Baum DM, Brenmoehl J, Chau L, Koopman R, Gregorevic P, Metzger F, Hoeflich A, Lynch GS.

Growth Horm IGF Res. 2016 Oct - Dec;30-31:1-10. doi: 10.1016/j.ghir.2016.07.002. Epub 2016 Jul 29.


Disease-Induced Skeletal Muscle Atrophy and Fatigue.

Powers SK, Lynch GS, Murphy KT, Reid MB, Zijdewind I.

Med Sci Sports Exerc. 2016 Nov;48(11):2307-2319. Review.


BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle.

Kennedy TL, Swiderski K, Murphy KT, Gehrig SM, Curl CL, Chandramouli C, Febbraio MA, Delbridge LM, Koopman R, Lynch GS.

Am J Pathol. 2016 Dec;186(12):3246-3260. doi: 10.1016/j.ajpath.2016.08.008. Epub 2016 Oct 14. Erratum in: Am J Pathol. 2017 Apr;187(4):937-938. Am J Pathol. 2017 Sep;187(9):2128.


Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice.

Winbanks CE, Murphy KT, Bernardo BC, Qian H, Liu Y, Sepulveda PV, Beyer C, Hagg A, Thomson RE, Chen JL, Walton KL, Loveland KL, McMullen JR, Rodgers BD, Harrison CA, Lynch GS, Gregorevic P.

Sci Transl Med. 2016 Jul 20;8(348):348ra98. doi: 10.1126/scitranslmed.aac4976.


Review: Leon N. Cooper's Science and Human Experience: Values, Culture, and the Mind.

Lynch GS.

Cerebrum. 2015 Jul 1;2015. pii: cer-09-15. eCollection 2015 Jul-Aug.


Glycine restores the anabolic response to leucine in a mouse model of acute inflammation.

Ham DJ, Caldow MK, Chhen V, Chee A, Wang X, Proud CG, Lynch GS, Koopman R.

Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E970-81. doi: 10.1152/ajpendo.00468.2015. Epub 2016 Apr 19.


Skeletal effects of the alteration of masseter muscle function.

Mayne RJ, van der Poel C, Woods MG, Lynch GS.

Aust Orthod J. 2015 Nov;31(2):184-94.


Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size.

Hagg A, Colgan TD, Thomson RE, Qian H, Lynch GS, Gregorevic P.

Sci Rep. 2016 Mar 14;6:23042. doi: 10.1038/srep23042.


Amino acid sensing and activation of mechanistic target of rapamycin complex 1: implications for skeletal muscle.

Ham DJ, Lynch GS, Koopman R.

Curr Opin Clin Nutr Metab Care. 2016 Jan;19(1):67-73. doi: 10.1097/MCO.0000000000000240. Review.


L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism.

Ham DJ, Gleeson BG, Chee A, Baum DM, Caldow MK, Lynch GS, Koopman R.

PLoS One. 2015 Oct 29;10(10):e0141572. doi: 10.1371/journal.pone.0141572. eCollection 2015.


Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice.

Caldow MK, Ham DJ, Godeassi DP, Chee A, Lynch GS, Koopman R.

Clin Nutr. 2016 Oct;35(5):1118-26. doi: 10.1016/j.clnu.2015.08.013. Epub 2015 Sep 25.


Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.

Johnston AJ, Murphy KT, Jenkinson L, Laine D, Emmrich K, Faou P, Weston R, Jayatilleke KM, Schloegel J, Talbo G, Casey JL, Levina V, Wong WW, Dillon H, Sahay T, Hoogenraad J, Anderton H, Hall C, Schneider P, Tanzer M, Foley M, Scott AM, Gregorevic P, Liu SY, Burkly LC, Lynch GS, Silke J, Hoogenraad NJ.

Cell. 2015 Sep 10;162(6):1365-78. doi: 10.1016/j.cell.2015.08.031.


Glucose uptake during contraction in isolated skeletal muscles from neuronal nitric oxide synthase μ knockout mice.

Hong YH, Frugier T, Zhang X, Murphy RM, Lynch GS, Betik AC, Rattigan S, McConell GK.

J Appl Physiol (1985). 2015 May 1;118(9):1113-21. doi: 10.1152/japplphysiol.00056.2015. Epub 2015 Mar 6.


Citrulline does not prevent skeletal muscle wasting or weakness in limb-casted mice.

Ham DJ, Kennedy TL, Caldow MK, Chee A, Lynch GS, Koopman R.

J Nutr. 2015 May;145(5):900-6. doi: 10.3945/jn.114.203737. Epub 2015 Mar 4.


FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1).

Feeney SJ, McGrath MJ, Sriratana A, Gehrig SM, Lynch GS, D'Arcy CE, Price JT, McLean CA, Tupler R, Mitchell CA.

PLoS One. 2015 Feb 19;10(2):e0117665. doi: 10.1371/journal.pone.0117665. eCollection 2015.


Leucine as a treatment for muscle wasting: a critical review.

Ham DJ, Caldow MK, Lynch GS, Koopman R.

Clin Nutr. 2014 Dec;33(6):937-45. doi: 10.1016/j.clnu.2014.09.016. Review.


Arginine protects muscle cells from wasting in vitro in an mTORC1-dependent and NO-independent manner.

Ham DJ, Caldow MK, Lynch GS, Koopman R.

Amino Acids. 2014 Dec;46(12):2643-52. doi: 10.1007/s00726-014-1815-y. Epub 2014 Aug 6.


Phosphorylation within the cysteine-rich region of dystrophin enhances its association with β-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting.

Swiderski K, Shaffer SA, Gallis B, Odom GL, Arnett AL, Scott Edgar J, Baum DM, Chee A, Naim T, Gregorevic P, Murphy KT, Moody J, Goodlett DR, Lynch GS, Chamberlain JS.

Hum Mol Genet. 2014 Dec 20;23(25):6697-711. doi: 10.1093/hmg/ddu388. Epub 2014 Jul 31.


Functional β-adrenoceptors are important for early muscle regeneration in mice through effects on myoblast proliferation and differentiation.

Church JE, Trieu J, Sheorey R, Chee AY, Naim T, Baum DM, Ryall JG, Gregorevic P, Lynch GS.

PLoS One. 2014 Jul 7;9(7):e101379. doi: 10.1371/journal.pone.0101379. eCollection 2014.


G-CSF does not influence C2C12 myogenesis despite receptor expression in healthy and dystrophic skeletal muscle.

Wright CR, Brown EL, Della-Gatta PA, Ward AC, Lynch GS, Russell AP.

Front Physiol. 2014 May 1;5:170. doi: 10.3389/fphys.2014.00170. eCollection 2014. Erratum in: Front Physiol. 2017 Oct 30;8:886.


Dysfunctional muscle and liver glycogen metabolism in mdx dystrophic mice.

Stapleton DI, Lau X, Flores M, Trieu J, Gehrig SM, Chee A, Naim T, Lynch GS, Koopman R.

PLoS One. 2014 Mar 13;9(3):e91514. doi: 10.1371/journal.pone.0091514. eCollection 2014.


Tranilast administration reduces fibrosis and improves fatigue resistance in muscles of mdx dystrophic mice.

Swiderski K, Todorov M, Gehrig SM, Naim T, Chee A, Stapleton DI, Koopman R, Lynch GS.

Fibrogenesis Tissue Repair. 2014 Jan 30;7(1):1. doi: 10.1186/1755-1536-7-1.


Alterations in Notch signalling in skeletal muscles from mdx and dko dystrophic mice and patients with Duchenne muscular dystrophy.

Church JE, Trieu J, Chee A, Naim T, Gehrig SM, Lamon S, Angelini C, Russell AP, Lynch GS.

Exp Physiol. 2014 Apr;99(4):675-87. doi: 10.1113/expphysiol.2013.077255. Epub 2014 Jan 17.


Elevated expression of activins promotes muscle wasting and cachexia.

Chen JL, Walton KL, Winbanks CE, Murphy KT, Thomson RE, Makanji Y, Qian H, Lynch GS, Harrison CA, Gregorevic P.

FASEB J. 2014 Apr;28(4):1711-23. doi: 10.1096/fj.13-245894. Epub 2013 Dec 30.


Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy.

D'Arcy CE, Feeney SJ, McLean CA, Gehrig SM, Lynch GS, Smith JE, Cowling BS, Mitchell CA, McGrath MJ.

Hum Mol Genet. 2014 Feb 1;23(3):618-36. doi: 10.1093/hmg/ddt449. Epub 2013 Sep 18.


Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia.

Ham DJ, Murphy KT, Chee A, Lynch GS, Koopman R.

Clin Nutr. 2014 Jun;33(3):448-58. doi: 10.1016/j.clnu.2013.06.013. Epub 2013 Jun 26.


Intramuscular administration of PEGylated IGF-I improves skeletal muscle regeneration after myotoxic injury.

Martins KJ, Gehrig SM, Naim T, Saenger S, Baum D, Metzger F, Lynch GS.

Growth Horm IGF Res. 2013 Aug;23(4):128-33. doi: 10.1016/j.ghir.2013.03.002. Epub 2013 Apr 19.


Physiological characterization of a mouse model of cachexia in colorectal liver metastases.

Murphy KT, Struk A, Malcontenti-Wilson C, Christophi C, Lynch GS.

Am J Physiol Regul Integr Comp Physiol. 2013 May 15;304(10):R854-64. doi: 10.1152/ajpregu.00057.2013. Epub 2013 Mar 13.


Inhibition of the renin-angiotensin system improves physiological outcomes in mice with mild or severe cancer cachexia.

Murphy KT, Chee A, Trieu J, Naim T, Lynch GS.

Int J Cancer. 2013 Sep 1;133(5):1234-46. doi: 10.1002/ijc.28128. Epub 2013 Mar 16.


Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity.

Jorgensen SB, O'Neill HM, Sylow L, Honeyman J, Hewitt KA, Palanivel R, Fullerton MD, Öberg L, Balendran A, Galic S, van der Poel C, Trounce IA, Lynch GS, Schertzer JD, Steinberg GR.

Diabetes. 2013 Jan;62(1):56-64. doi: 10.2337/db12-0443. Epub 2012 Sep 6.


Disruption of muscle renin-angiotensin system in AT1a-/- mice enhances muscle function despite reducing muscle mass but compromises repair after injury.

Murphy KT, Allen AM, Chee A, Naim T, Lynch GS.

Am J Physiol Regul Integr Comp Physiol. 2012 Aug 1;303(3):R321-31. doi: 10.1152/ajpregu.00007.2012. Epub 2012 Jun 6.

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