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Items: 13

1.

Novel inhibitors of the Pseudomonas aeruginosa virulence factor LasB: a potential therapeutic approach for the attenuation of virulence mechanisms in pseudomonal infection.

Cathcart GR, Quinn D, Greer B, Harriott P, Lynas JF, Gilmore BF, Walker B.

Antimicrob Agents Chemother. 2011 Jun;55(6):2670-8. doi: 10.1128/AAC.00776-10. Epub 2011 Mar 28.

2.

Peptides containing acylated C-terminal gem diamines: novel irreversible inactivators of the cysteine and serine proteinases.

Gilmore BF, Lynas JF, Harriott P, Healy A, Walker B.

Chem Biol Drug Des. 2006 May;67(5):364-9.

PMID:
16784461
3.

Dipeptide proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha).

Gilmore BF, Lynas JF, Scott CJ, McGoohan C, Martin L, Walker B.

Biochem Biophys Res Commun. 2006 Jul 28;346(2):436-46.

PMID:
16769036
4.

Irreversible inhibition of the bacterial cysteine protease-transpeptidase sortase (SrtA) by substrate-derived affinity labels.

Scott CJ, McDowell A, Martin SL, Lynas JF, Vandenbroeck K, Walker B.

Biochem J. 2002 Sep 15;366(Pt 3):953-8.

5.

Strategies for the inhibition of serine proteases.

Walker B, Lynas JF.

Cell Mol Life Sci. 2001 Apr;58(4):596-624. Review.

PMID:
11361094
6.
7.

A study of the anti-invasive properties of N-alpha-phthalimidomethyl-ketomethylene tripeptide-based metalloprotease inhibitors.

Martin SL, McDowell A, Lynas JF, Nelson J, Walker B.

J Pharm Pharmacol. 2001 Mar;53(3):333-43.

PMID:
11291748
8.

Inhibition of Escherichia coli glucosamine synthetase by novel electrophilic analogues of glutamine--comparison with 6-diazo-5-oxo-norleucine.

Walker B, Brown MF, Lynas JF, Martin SL, McDowell A, Badet B, Hill AJ.

Bioorg Med Chem Lett. 2000 Dec 18;10(24):2795-8.

PMID:
11133094
9.

Evaluation of dipeptide alpha-keto-beta-aldehydes as new inhibitors of cathepsin S.

Walker B, Lynas JF, Meighan MA, Brömme D.

Biochem Biophys Res Commun. 2000 Aug 28;275(2):401-5.

PMID:
10964677
10.
11.

Potent new leucine aminopeptidase inhibitor of novel structure synthesised by a modified Wadsworth-Emmons (Horner) Wittig procedure.

Walker B, Darkins PA, McKervey MA, Moncrieff HM, Lynas JF.

Bioorg Med Chem Lett. 2000 Jul 3;10(13):1481-2.

PMID:
10888337
12.

Solid-phase synthesis and biological screening of N-alpha-mercaptoamide template-based matrix metalloprotease inhibitors.

Lynas JF, Martin SL, Walker B, Baxter AD, Bird J, Bhogal R, Montana JG, Owen DA.

Comb Chem High Throughput Screen. 2000 Feb;3(1):37-41.

PMID:
10702612
13.

Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl alpha-keto aldehydes (glyoxals).

Lynas JF, Harriott P, Healy A, McKervey MA, Walker B.

Bioorg Med Chem Lett. 1998 Feb 17;8(4):373-8.

PMID:
9871688

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