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Items: 1 to 50 of 134

1.

The importance of non-histone protein methylation in cancer therapy.

Rodríguez-Paredes M, Lyko F.

Nat Rev Mol Cell Biol. 2019 Oct;20(10):569-570. doi: 10.1038/s41580-019-0147-x. No abstract available.

PMID:
31270441
2.

DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries.

Wiehle L, Thorn GJ, Raddatz G, Clarkson CT, Rippe K, Lyko F, Breiling A, Teif VB.

Genome Res. 2019 May;29(5):750-761. doi: 10.1101/gr.239707.118. Epub 2019 Apr 4.

3.

Ecological plasticity and commercial impact of invasive marbled crayfish populations in Madagascar.

Andriantsoa R, Tönges S, Panteleit J, Theissinger K, Carneiro VC, Rasamy J, Lyko F.

BMC Ecol. 2019 Feb 6;19(1):8. doi: 10.1186/s12898-019-0224-1.

4.

Queuine links translational control in eukaryotes to a micronutrient from bacteria.

Müller M, Legrand C, Tuorto F, Kelly VP, Atlasi Y, Lyko F, Ehrenhofer-Murray AE.

Nucleic Acids Res. 2019 Apr 23;47(7):3711-3727. doi: 10.1093/nar/gkz063.

5.

Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast.

Müller M, Samel-Pommerencke A, Legrand C, Tuorto F, Lyko F, Ehrenhofer-Murray AE.

RNA Biol. 2019 Mar;16(3):249-256. doi: 10.1080/15476286.2019.1568819. Epub 2019 Feb 1.

6.

Whole-Genome Bisulfite Sequencing for the Methylation Analysis of Insect Genomes.

Gatzmann F, Lyko F.

Methods Mol Biol. 2019;1858:141-156. doi: 10.1007/978-1-4939-8775-7_11.

PMID:
30414116
7.

Dnmt1 has an essential function despite the absence of CpG DNA methylation in the red flour beetle Tribolium castaneum.

Schulz NKE, Wagner CI, Ebeling J, Raddatz G, Diddens-de Buhr MF, Lyko F, Kurtz J.

Sci Rep. 2018 Nov 7;8(1):16462. doi: 10.1038/s41598-018-34701-3.

8.

BisAMP: A web-based pipeline for targeted RNA cytosine-5 methylation analysis.

Bormann F, Tuorto F, Cirzi C, Lyko F, Legrand C.

Methods. 2019 Mar 1;156:121-127. doi: 10.1016/j.ymeth.2018.10.013. Epub 2018 Oct 24.

PMID:
30366099
9.

The methylome of the marbled crayfish links gene body methylation to stable expression of poorly accessible genes.

Gatzmann F, Falckenhayn C, Gutekunst J, Hanna K, Raddatz G, Carneiro VC, Lyko F.

Epigenetics Chromatin. 2018 Oct 4;11(1):57. doi: 10.1186/s13072-018-0229-6.

10.

Queuosine-modified tRNAs confer nutritional control of protein translation.

Tuorto F, Legrand C, Cirzi C, Federico G, Liebers R, Müller M, Ehrenhofer-Murray AE, Dittmar G, Gröne HJ, Lyko F.

EMBO J. 2018 Sep 14;37(18). pii: e99777. doi: 10.15252/embj.201899777. Epub 2018 Aug 9.

11.

Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis.

Bormann F, Rodríguez-Paredes M, Lasitschka F, Edelmann D, Musch T, Benner A, Bergman Y, Dieter SM, Ball CR, Glimm H, Linhart HG, Lyko F.

Cell Rep. 2018 Jun 12;23(11):3407-3418. doi: 10.1016/j.celrep.2018.05.045.

12.

Transforming growth factor β1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia.

Geyh S, Rodríguez-Paredes M, Jäger P, Koch A, Bormann F, Gutekunst J, Zilkens C, Germing U, Kobbe G, Lyko F, Haas R, Schroeder T.

Haematologica. 2018 Sep;103(9):1462-1471. doi: 10.3324/haematol.2017.186734. Epub 2018 May 17.

13.

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.

Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q.

Nat Cell Biol. 2018 May;20(5):535-540. doi: 10.1038/s41556-018-0087-2. Epub 2018 Apr 25.

14.

Positioning Europe for the EPITRANSCRIPTOMICS challenge.

Jantsch MF, Quattrone A, O'Connell M, Helm M, Frye M, Macias-Gonzales M, Ohman M, Ameres S, Willems L, Fuks F, Oulas A, Vanacova S, Nielsen H, Bousquet-Antonelli C, Motorin Y, Roignant JY, Balatsos N, Dinnyes A, Baranov P, Kelly V, Lamm A, Rechavi G, Pelizzola M, Liepins J, Holodnuka Kholodnyuk I, Zammit V, Ayers D, Drablos F, Dahl JA, Bujnicki J, Jeronimo C, Almeida R, Neagu M, Costache M, Bankovic J, Banovic B, Kyselovic J, Valor LM, Selbert S, Pir P, Demircan T, Cowling V, Schäfer M, Rossmanith W, Lafontaine D, David A, Carre C, Lyko F, Schaffrath R, Schwartz S, Verdel A, Klungland A, Purta E, Timotijevic G, Cardona F, Davalos A, Ballana E, O Carroll D, Ule J, Fray R.

RNA Biol. 2018;15(6):829-831. doi: 10.1080/15476286.2018.1460996. Epub 2018 May 9.

15.

Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats.

Genenncher B, Durdevic Z, Hanna K, Zinkl D, Mobin MB, Senturk N, Da Silva B, Legrand C, Carré C, Lyko F, Schaefer M.

Cell Rep. 2018 Feb 13;22(7):1861-1874. doi: 10.1016/j.celrep.2018.01.061.

16.

Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin.

Rodríguez-Paredes M, Bormann F, Raddatz G, Gutekunst J, Lucena-Porcel C, Köhler F, Wurzer E, Schmidt K, Gallinat S, Wenck H, Röwert-Huber J, Denisova E, Feuerbach L, Park J, Brors B, Herpel E, Nindl I, Hofmann TG, Winnefeld M, Lyko F.

Nat Commun. 2018 Feb 8;9(1):577. doi: 10.1038/s41467-018-03025-1.

17.

Clonal genome evolution and rapid invasive spread of the marbled crayfish.

Gutekunst J, Andriantsoa R, Falckenhayn C, Hanna K, Stein W, Rasamy J, Lyko F.

Nat Ecol Evol. 2018 Mar;2(3):567-573. doi: 10.1038/s41559-018-0467-9. Epub 2018 Feb 5.

PMID:
29403072
18.

The marbled crayfish (Decapoda: Cambaridae) represents an independent new species.

Lyko F.

Zootaxa. 2017 Dec 12;4363(4):544-552. doi: 10.11646/zootaxa.4363.4.6.

PMID:
29245391
19.

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation.

Lyko F.

Nat Rev Genet. 2018 Feb;19(2):81-92. doi: 10.1038/nrg.2017.80. Epub 2017 Oct 16. Review.

PMID:
29033456
20.

mIDH-associated DNA hypermethylation in acute myeloid leukemia reflects differentiation blockage rather than inhibition of TET-mediated demethylation.

Wiehle L, Raddatz G, Pusch S, Gutekunst J, von Deimling A, Rodríguez-Paredes M, Lyko F.

Cell Stress. 2017 Sep 20;1(1):55-67. doi: 10.15698/cst2017.10.106.

21.

Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs.

Legrand C, Tuorto F, Hartmann M, Liebers R, Jacob D, Helm M, Lyko F.

Genome Res. 2017 Sep;27(9):1589-1596. doi: 10.1101/gr.210666.116. Epub 2017 Jul 6.

22.

Genetic and epigenetic profiling of a solitary Peutz-Jeghers colon polyp.

Linhart H, Bormann F, Hutter B, Brors B, Lyko F.

Cold Spring Harb Mol Case Stud. 2017 May;3(3):a001610. doi: 10.1101/mcs.a001610.

23.

Genome recoding by tRNA modifications.

Tuorto F, Lyko F.

Open Biol. 2016 Dec;6(12). pii: 160287. Review.

24.

Transcriptional programs that control expression of the autoimmune regulator gene Aire.

Herzig Y, Nevo S, Bornstein C, Brezis MR, Ben-Hur S, Shkedy A, Eisenberg-Bord M, Levi B, Delacher M, Goldfarb Y, David E, Weinberger L, Viukov S, Ben-Dor S, Giraud M, Hanna JH, Breiling A, Lyko F, Amit I, Feuerer M, Abramson J.

Nat Immunol. 2017 Feb;18(2):161-172. doi: 10.1038/ni.3638. Epub 2016 Dec 12.

PMID:
27941786
25.

Comprehensive DNA methylation analysis of the Aedes aegypti genome.

Falckenhayn C, Carneiro VC, de Mendonça Amarante A, Schmid K, Hanna K, Kang S, Helm M, Dimopoulos G, Fantappié MR, Lyko F.

Sci Rep. 2016 Nov 2;6:36444. doi: 10.1038/srep36444.

26.

Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation.

Jeltsch A, Ehrenhofer-Murray A, Jurkowski TP, Lyko F, Reuter G, Ankri S, Nellen W, Schaefer M, Helm M.

RNA Biol. 2017 Sep 2;14(9):1108-1123. doi: 10.1080/15476286.2016.1191737. Epub 2016 May 27. Review.

27.

Reduced DNA methylation patterning and transcriptional connectivity define human skin aging.

Bormann F, Rodríguez-Paredes M, Hagemann S, Manchanda H, Kristof B, Gutekunst J, Raddatz G, Haas R, Terstegen L, Wenck H, Kaderali L, Winnefeld M, Lyko F.

Aging Cell. 2016 Jun;15(3):563-71. doi: 10.1111/acel.12470. Epub 2016 Mar 23.

28.

De Novo assembly and annotation of the freshwater crayfish Astacus astacus transcriptome.

Theissinger K, Falckenhayn C, Blande D, Toljamo A, Gutekunst J, Makkonen J, Jussila J, Lyko F, Schrimpf A, Schulz R, Kokko H.

Mar Genomics. 2016 Aug;28:7-10. doi: 10.1016/j.margen.2016.02.006. Epub 2016 Mar 14.

PMID:
26988698
29.

Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia.

Geyh S, Rodríguez-Paredes M, Jäger P, Khandanpour C, Cadeddu RP, Gutekunst J, Wilk CM, Fenk R, Zilkens C, Hermsen D, Germing U, Kobbe G, Lyko F, Haas R, Schroeder T.

Leukemia. 2016 Mar;30(3):683-91. doi: 10.1038/leu.2015.325. Epub 2015 Nov 25.

PMID:
26601782
30.

Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation.

Wiehle L, Raddatz G, Musch T, Dawlaty MM, Jaenisch R, Lyko F, Breiling A.

Mol Cell Biol. 2015 Nov 23;36(3):452-61. doi: 10.1128/MCB.00587-15. Print 2016 Feb 1.

31.

The marbled crayfish as a paradigm for saltational speciation by autopolyploidy and parthenogenesis in animals.

Vogt G, Falckenhayn C, Schrimpf A, Schmid K, Hanna K, Panteleit J, Helm M, Schulz R, Lyko F.

Biol Open. 2015 Oct 30;4(11):1583-94. doi: 10.1242/bio.014241.

32.

Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine.

Müller M, Hartmann M, Schuster I, Bender S, Thüring KL, Helm M, Katze JR, Nellen W, Lyko F, Ehrenhofer-Murray AE.

Nucleic Acids Res. 2015 Dec 15;43(22):10952-62. doi: 10.1093/nar/gkv980. Epub 2015 Sep 30.

33.

The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis.

Tuorto F, Herbst F, Alerasool N, Bender S, Popp O, Federico G, Reitter S, Liebers R, Stoecklin G, Gröne HJ, Dittmar G, Glimm H, Lyko F.

EMBO J. 2015 Sep 14;34(18):2350-62. doi: 10.15252/embj.201591382. Epub 2015 Aug 13.

34.

Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond.

Breiling A, Lyko F.

Epigenetics Chromatin. 2015 Jul 21;8:24. doi: 10.1186/s13072-015-0016-6. eCollection 2015. Review.

35.

Chronic inflammation induces a novel epigenetic program that is conserved in intestinal adenomas and in colorectal cancer.

Abu-Remaileh M, Bender S, Raddatz G, Ansari I, Cohen D, Gutekunst J, Musch T, Linhart H, Breiling A, Pikarsky E, Bergman Y, Lyko F.

Cancer Res. 2015 May 15;75(10):2120-30. doi: 10.1158/0008-5472.CAN-14-3295. Epub 2015 Mar 25.

36.

Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells.

Öz S, Raddatz G, Rius M, Blagitko-Dorfs N, Lübbert M, Maercker C, Lyko F.

Nucleic Acids Res. 2014 Oct 29;42(19):e152. doi: 10.1093/nar/gku775. Epub 2014 Aug 26.

37.

Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a.

Weis B, Schmidt J, Maamar H, Raj A, Lin H, Tóth C, Riedmann K, Raddatz G, Seitz HK, Ho AD, Lyko F, Linhart HG.

Oncogene. 2015 Apr 2;34(14):1822-30. doi: 10.1038/onc.2014.114. Epub 2014 May 19.

PMID:
24837369
38.

Epigenetic regulation by heritable RNA.

Liebers R, Rassoulzadegan M, Lyko F.

PLoS Genet. 2014 Apr 17;10(4):e1004296. doi: 10.1371/journal.pgen.1004296. eCollection 2014 Apr. Review.

39.

Loss of Tet enzymes compromises proper differentiation of embryonic stem cells.

Dawlaty MM, Breiling A, Le T, Barrasa MI, Raddatz G, Gao Q, Powell BE, Cheng AW, Faull KF, Lyko F, Jaenisch R.

Dev Cell. 2014 Apr 14;29(1):102-11. doi: 10.1016/j.devcel.2014.03.003.

40.

Aging is associated with highly defined epigenetic changes in the human epidermis.

Raddatz G, Hagemann S, Aran D, Söhle J, Kulkarni PP, Kaderali L, Hellman A, Winnefeld M, Lyko F.

Epigenetics Chromatin. 2013 Oct 31;6(1):36. doi: 10.1186/1756-8935-6-36.

41.

The RNA methyltransferase Dnmt2 is required for efficient Dicer-2-dependent siRNA pathway activity in Drosophila.

Durdevic Z, Mobin MB, Hanna K, Lyko F, Schaefer M.

Cell Rep. 2013 Sep 12;4(5):931-7. doi: 10.1016/j.celrep.2013.07.046. Epub 2013 Sep 5.

42.

The role of human equilibrative nucleoside transporter 1 on the cellular transport of the DNA methyltransferase inhibitors 5-azacytidine and CP-4200 in human leukemia cells.

Hummel-Eisenbeiss J, Hascher A, Hals PA, Sandvold ML, Müller-Tidow C, Lyko F, Rius M.

Mol Pharmacol. 2013 Sep;84(3):438-50. doi: 10.1124/mol.113.086801. Epub 2013 Jun 28.

PMID:
23814180
43.

Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells.

Geyh S, Oz S, Cadeddu RP, Fröbel J, Brückner B, Kündgen A, Fenk R, Bruns I, Zilkens C, Hermsen D, Gattermann N, Kobbe G, Germing U, Lyko F, Haas R, Schroeder T.

Leukemia. 2013 Sep;27(9):1841-51. doi: 10.1038/leu.2013.193. Epub 2013 Mar 29.

PMID:
23797473
44.

RNA-mediated epigenetic heredity requires the cytosine methyltransferase Dnmt2.

Kiani J, Grandjean V, Liebers R, Tuorto F, Ghanbarian H, Lyko F, Cuzin F, Rassoulzadegan M.

PLoS Genet. 2013 May;9(5):e1003498. doi: 10.1371/journal.pgen.1003498. Epub 2013 May 23.

45.

Dnmt2-dependent methylomes lack defined DNA methylation patterns.

Raddatz G, Guzzardo PM, Olova N, Fantappié MR, Rampp M, Schaefer M, Reik W, Hannon GJ, Lyko F.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8627-31. doi: 10.1073/pnas.1306723110. Epub 2013 May 2.

46.

The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation.

Hussain S, Tuorto F, Menon S, Blanco S, Cox C, Flores JV, Watt S, Kudo NR, Lyko F, Frye M.

Mol Cell Biol. 2013 Apr;33(8):1561-70. doi: 10.1128/MCB.01523-12. Epub 2013 Feb 11.

47.

Efficient RNA virus control in Drosophila requires the RNA methyltransferase Dnmt2.

Durdevic Z, Hanna K, Gold B, Pollex T, Cherry S, Lyko F, Schaefer M.

EMBO Rep. 2013 Mar 1;14(3):269-75. doi: 10.1038/embor.2013.3. Epub 2013 Feb 1.

48.

Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development.

Dawlaty MM, Breiling A, Le T, Raddatz G, Barrasa MI, Cheng AW, Gao Q, Powell BE, Li Z, Xu M, Faull KF, Lyko F, Jaenisch R.

Dev Cell. 2013 Feb 11;24(3):310-23. doi: 10.1016/j.devcel.2012.12.015. Epub 2013 Jan 24.

49.

Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.

Raddatz G, Gao Q, Bender S, Jaenisch R, Lyko F.

PLoS Genet. 2012;8(12):e1003146. doi: 10.1371/journal.pgen.1003146. Epub 2012 Dec 20.

50.

Characterization of genome methylation patterns in the desert locust Schistocerca gregaria.

Falckenhayn C, Boerjan B, Raddatz G, Frohme M, Schoofs L, Lyko F.

J Exp Biol. 2013 Apr 15;216(Pt 8):1423-9. doi: 10.1242/jeb.080754. Epub 2012 Dec 21.

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