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Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet-induced obesity.

Gradel AKJ, Porsgaard T, Brockhoff PB, Seested T, Lykkesfeldt J, Refsgaard HHF.

Obes Sci Pract. 2019 Mar 18;5(3):281-288. doi: 10.1002/osp4.326. eCollection 2019 Jun.


An ELISA for detection of complement-bound circulating immune complexes in mice.

Boysen L, Lauritzen B, Viuff BM, Lykkesfeldt J, Landsy LH.

J Immunotoxicol. 2019 Dec;16(1):82-86. doi: 10.1080/1547691X.2019.1599471.


Generic immune complex assay for detection of murine anti-drug-antibodies in complex with human IgG.

Boysen L, Sprinkel AME, Lauritzen B, Breinholt J, Lykkesfeldt J, Viuff BM, Landsy LH.

Biologicals. 2019 Jul;60:42-48. doi: 10.1016/j.biologicals.2019.05.008. Epub 2019 Jun 11.


Glycemic Control during Pregnancy-A Predictor of Vitamin C Status at Labor in Type 1 Diabetic Women?

Juhl B, Lauszus FF, Lykkesfeldt J.

Antioxidants (Basel). 2019 May 31;8(6). pii: E153. doi: 10.3390/antiox8060153.


Telomere length and genotoxicity in the lung of rats following intragastric exposure to food-grade titanium dioxide and vegetable carbon particles.

Jensen DM, Løhr M, Sheykhzade M, Lykkesfeldt J, Wils RS, Loft S, Møller P.

Mutagenesis. 2019 May 29;34(2):203-214. doi: 10.1093/mutage/gez003.


Expression of endothelin type B receptors in uterine artery smooth muscle cells from pregnant Guinea pigs.

Skovsted GF, Tveden-Nyborg P, Lykkesfeldt J.

Placenta. 2019 Feb;77:8-15. doi: 10.1016/j.placenta.2019.01.015. Epub 2019 Jan 22.


Molecular drivers of non-alcoholic steatohepatitis are sustained in mild-to-late fibrosis progression in a guinea pig model.

Ipsen DH, Skat-Rørdam J, Tsamouri MM, Latta M, Lykkesfeldt J, Tveden-Nyborg P.

Mol Genet Genomics. 2019 Jun;294(3):649-661. doi: 10.1007/s00438-019-01537-z. Epub 2019 Feb 13.


A role of peroxisome proliferator-activated receptor γ in non-alcoholic fatty liver disease.

Skat-Rørdam J, Højland Ipsen D, Lykkesfeldt J, Tveden-Nyborg P.

Basic Clin Pharmacol Toxicol. 2019 May;124(5):528-537. doi: 10.1111/bcpt.13190. Epub 2019 Jan 22. Review.


Peri-operative endothelial dysfunction in patients undergoing minor abdominal surgery: An observational study.

Ekeloef S, Godthaab C, Schou-Pedersen AMV, Lykkesfeldt J, Gögenur I.

Eur J Anaesthesiol. 2019 Feb;36(2):130-134. doi: 10.1097/EJA.0000000000000935.


Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability.

Gradel AKJ, Porsgaard T, Lykkesfeldt J, Seested T, Gram-Nielsen S, Kristensen NR, Refsgaard HHF.

J Diabetes Res. 2018 Jul 4;2018:1205121. doi: 10.1155/2018/1205121. eCollection 2018. Review.


Subcutaneous Administration of Insulin is Associated With Regional Differences in Injection Depot Variability and Kinetics in The Rat.

Gradel AKJ, Porsgaard T, Lykkesfeldt J, Brockhoff PB, Seested T, Refsgaard HHF.

Exp Clin Endocrinol Diabetes. 2018 Aug 3. doi: 10.1055/a-0658-1089. [Epub ahead of print]


Pharmacological modulation of colorectal distension evoked potentials in conscious rats.

Nissen TD, Brock C, Lykkesfeldt J, Lindström E, Hultin L.

Neuropharmacology. 2018 Sep 15;140:193-200. doi: 10.1016/j.neuropharm.2018.07.028. Epub 2018 Jul 27.


Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide.

Jensen DM, Skovsted GF, Lykkesfeldt J, Dreier R, Berg JO, Jeppesen JL, Sheykhzade M, Loft S, Møller P.

Food Chem Toxicol. 2018 Oct;120:321-327. doi: 10.1016/j.fct.2018.07.015. Epub 2018 Jul 7.


Spatial Memory Dysfunction Induced by Vitamin C Deficiency Is Associated with Changes in Monoaminergic Neurotransmitters and Aberrant Synapse Formation.

Hansen SN, Schou-Pedersen AMV, Lykkesfeldt J, Tveden-Nyborg P.

Antioxidants (Basel). 2018 Jun 29;7(7). pii: E82. doi: 10.3390/antiox7070082.


Liraglutide Decreases Hepatic Inflammation and Injury in Advanced Lean Non-Alcoholic Steatohepatitis.

Ipsen DH, Rolin B, Rakipovski G, Skovsted GF, Madsen A, Kolstrup S, Schou-Pedersen AM, Skat-Rørdam J, Lykkesfeldt J, Tveden-Nyborg P.

Basic Clin Pharmacol Toxicol. 2018 Dec;123(6):704-713. doi: 10.1111/bcpt.13082. Epub 2018 Jul 30.


High-fat feeding induces mobilization of vitamin C in obese prone rats.

Tranberg B, Hellgren LI, Lykkesfeldt J, Hansen AK.

Res Vet Sci. 2018 Aug;119:167-169. doi: 10.1016/j.rvsc.2018.06.011. Epub 2018 Jun 12.


Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease.

Ipsen DH, Lykkesfeldt J, Tveden-Nyborg P.

Cell Mol Life Sci. 2018 Sep;75(18):3313-3327. doi: 10.1007/s00018-018-2860-6. Epub 2018 Jun 23. Review.


Basic & Clinical Pharmacology & Toxicology Policy for Experimental and Clinical studies.

Tveden-Nyborg P, Bergmann TK, Lykkesfeldt J.

Basic Clin Pharmacol Toxicol. 2018 Sep;123(3):233-235. doi: 10.1111/bcpt.13059. Epub 2018 Jul 20. No abstract available.


Early Life Vitamin C Deficiency Does Not Alter Morphology of Hippocampal CA1 Pyramidal Neurons or Markers of Synaptic Plasticity in a Guinea Pig Model.

Hansen SN, Jørgensen JMB, Nyengaard JR, Lykkesfeldt J, Tveden-Nyborg P.

Nutrients. 2018 Jun 8;10(6). pii: E749. doi: 10.3390/nu10060749.


Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner.

Højland A, Richner M, Mølgaard S, Dieu RS, Eskelund A, Nykjær A, Nyengaard JR, Lykkesfeldt J, Glerup S, Nielsen MS.

Behav Brain Res. 2018 Aug 1;348:90-100. doi: 10.1016/j.bbr.2018.04.017. Epub 2018 Apr 13.


Long term Westernized diet leads to region-specific changes in brain signaling mechanisms.

Hansen SN, Ipsen DH, Schou-Pedersen AM, Lykkesfeldt J, Tveden-Nyborg P.

Neurosci Lett. 2018 May 29;676:85-91. doi: 10.1016/j.neulet.2018.04.014. Epub 2018 Apr 12.


Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics.

Rune I, Rolin B, Lykkesfeldt J, Nielsen DS, Krych Ł, Kanter JE, Bornfeldt KE, Kihl P, Buschard K, Josefsen K, Fels JJ, Mortensen A, Christoffersen B, Kirk RK, Hansen AK.

Sci Rep. 2018 Apr 3;8(1):5416. doi: 10.1038/s41598-018-23835-z.


Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles.

Jensen DM, Christophersen DV, Sheykhzade M, Skovsted GF, Lykkesfeldt J, Münter R, Roursgaard M, Loft S, Møller P.

Part Fibre Toxicol. 2018 Feb 26;15(1):12. doi: 10.1186/s12989-018-0248-2.


Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.

Nasser A, Møller AT, Hellmund V, Thorborg SS, Jespersgaard C, Bjerrum OJ, Dupont E, Nachman G, Lykkesfeldt J, Jensen TS, Møller LB.

Pain. 2018 Jun;159(6):1012-1024. doi: 10.1097/j.pain.0000000000001175.


Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague-Dawley rats.

Jensen VS, Hvid H, Damgaard J, Nygaard H, Ingvorsen C, Wulff EM, Lykkesfeldt J, Fledelius C.

Diabetol Metab Syndr. 2018 Jan 24;10:4. doi: 10.1186/s13098-018-0307-8. eCollection 2018.


Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat.

Jensen VFH, Mølck AM, Lykkesfeldt J, Bøgh IB.

Reprod Toxicol. 2018 Apr;77:1-24. doi: 10.1016/j.reprotox.2018.01.007. Epub 2018 Feb 3. Review.


Effect of High Inspiratory Oxygen Fraction on Endothelial Function in Healthy Volunteers: A Randomized Controlled Crossover Pilot Study.

Larsen MHH, Ekeloef S, Kokotovic D, Schou-Pedersen AM, Lykkesfeldt J, Gögenür I.

Anesth Analg. 2017 Nov;125(5):1793-1796. doi: 10.1213/ANE.0000000000002357.


Proximal Neuropathy and Associated Skeletal Muscle Changes Resembling Denervation Atrophy in Hindlimbs of Chronic Hypoglycaemic Rats.

Jensen VFH, Molck AM, Soeborg H, Nowak J, Chapman M, Lykkesfeldt J, Bogh IB.

Basic Clin Pharmacol Toxicol. 2018 Jan;122(1):165-175. doi: 10.1111/bcpt.12870. Epub 2017 Sep 6.


Weekly ascorbic acid infusion in castration-resistant prostate cancer patients: a single-arm phase II trial.

Nielsen TK, Højgaard M, Andersen JT, Jørgensen NR, Zerahn B, Kristensen B, Henriksen T, Lykkesfeldt J, Mikines KJ, Poulsen HE.

Transl Androl Urol. 2017 Jun;6(3):517-528. doi: 10.21037/tau.2017.04.42.


Vitamin C Deficiency Reduces Muscarinic Receptor Coronary Artery Vasoconstriction and Plasma Tetrahydrobiopterin Concentration in Guinea Pigs.

Skovsted GF, Tveden-Nyborg P, Lindblad MM, Hansen SN, Lykkesfeldt J.

Nutrients. 2017 Jul 3;9(7). pii: E691. doi: 10.3390/nu9070691.


Chronic Hyperinsulinaemic Hypoglycaemia in Rats Is Accompanied by Increased Body Weight, Hyperleptinaemia, and Decreased Neuronal Glucose Transporter Levels in the Brain.

Jensen VFH, Mølck AM, Chapman M, Alifrangis L, Andersen L, Lykkesfeldt J, Bøgh IB.

Int J Endocrinol. 2017;2017:7861236. doi: 10.1155/2017/7861236. Epub 2017 Mar 21.


Pasteurization Procedures for Donor Human Milk Affect Body Growth, Intestinal Structure, and Resistance against Bacterial Infections in Preterm Pigs.

Li Y, Nguyen DN, de Waard M, Christensen L, Zhou P, Jiang P, Sun J, Bojesen AM, Lauridsen C, Lykkesfeldt J, Dalsgaard TK, Bering SB, Sangild PT.

J Nutr. 2017 Jun;147(6):1121-1130. doi: 10.3945/jn.116.244822. Epub 2017 Mar 15.


Toxicological Effects during and following Persistent Insulin-Induced Hypoglycaemia in Healthy Euglycaemic Rats.

Jensen VFH, Mølck AM, Berthelsen LO, Alifrangis L, Andersen L, Chapman M, Lykkesfeldt J, Bøgh IB.

Basic Clin Pharmacol Toxicol. 2017 Jul;121(1):53-66. doi: 10.1111/bcpt.12769. Epub 2017 May 3.


Is Diabetes Associated with Lower Vitamin C Status in Pregnant Women? A Prospective Study.

Juhl B, Lauszus FF, Lykkesfeldt J.

Int J Vitam Nutr Res. 2016 Jun;86(3-4):184-189. doi: 10.1024/0300-9831/a000407. Epub 2017 Feb 16.


Clarithromycin, trimethoprim, and penicillin and oxidative nucleic acid modifications in humans: randomised, controlled trials.

Larsen EL, Cejvanovic V, Kjaer LK, Pedersen MT, Popik SD, Hansen LK, Andersen JT, Jimenez-Solem E, Broedbaek K, Petersen M, Weimann A, Henriksen T, Lykkesfeldt J, Torp-Pedersen C, Poulsen HE.

Br J Clin Pharmacol. 2017 Aug;83(8):1643-1653. doi: 10.1111/bcp.13261. Epub 2017 Mar 17.


Markers of Oxidative Stress in Dogs with Myxomatous Mitral Valve Disease are Influenced by Sex, Neuter Status, and Serum Cholesterol Concentration.

Reimann MJ, Häggström J, Møller JE, Lykkesfeldt J, Falk T, Olsen LH.

J Vet Intern Med. 2017 Mar;31(2):295-302. doi: 10.1111/jvim.14647. Epub 2017 Jan 29.


Endothelial dysfunction in the early postoperative period after major colon cancer surgery.

Ekeloef S, Larsen MH, Schou-Pedersen AM, Lykkesfeldt J, Rosenberg J, Gögenür I.

Br J Anaesth. 2017 Feb;118(2):200-206. doi: 10.1093/bja/aew410.


Brief Communication: Plasma lipid oxidation predicts atherosclerotic status better than cholesterol in diabetic apolipoprotein E deficient mice.

Petersen KE, Lykkesfeldt J, Raun K, Rakipovski G.

Exp Biol Med (Maywood). 2017 Jan;242(1):88-91. doi: 10.1177/1535370216650520. Epub 2016 Jul 24.


Oxidative costs of reproduction in mouse strains selected for different levels of food intake and which differ in reproductive performance.

Jothery AH, Vaanholt LM, Mody N, Arnous A, Lykkesfeldt J, Bünger L, Hill WG, Mitchell SE, Allison DB, Speakman JR.

Sci Rep. 2016 Nov 14;6:36353. doi: 10.1038/srep36353.


Simvastatin and oxidative stress in humans: A randomized, double-blinded, placebo-controlled clinical trial.

Rasmussen ST, Andersen JT, Nielsen TK, Cejvanovic V, Petersen KM, Henriksen T, Weimann A, Lykkesfeldt J, Poulsen HE.

Redox Biol. 2016 Oct;9:32-38. doi: 10.1016/j.redox.2016.05.007. Epub 2016 May 30.


Cardiovascular health effects of oral and pulmonary exposure to multi-walled carbon nanotubes in ApoE-deficient mice.

Christophersen DV, Jacobsen NR, Andersen MH, Connell SP, Barfod KK, Thomsen MB, Miller MR, Duffin R, Lykkesfeldt J, Vogel U, Wallin H, Loft S, Roursgaard M, Møller P.

Toxicology. 2016 Sep 14;371:29-40. doi: 10.1016/j.tox.2016.10.003. Epub 2016 Oct 8.


Dyslipidemia: Obese or Not Obese-That Is Not the Question.

Ipsen DH, Tveden-Nyborg P, Lykkesfeldt J.

Curr Obes Rep. 2016 Dec;5(4):405-412. Review.


Rodent model choice has major impact on variability of standard preclinical readouts associated with diabetes and obesity research.

Jensen VS, Porsgaard T, Lykkesfeldt J, Hvid H.

Am J Transl Res. 2016 Aug 15;8(8):3574-84. eCollection 2016.


High-fat but not sucrose intake is essential for induction of dyslipidemia and non-alcoholic steatohepatitis in guinea pigs.

Ipsen DH, Tveden-Nyborg P, Rolin B, Rakipovski G, Beck M, Mortensen LW, Færk L, Heegaard PM, Møller P, Lykkesfeldt J.

Nutr Metab (Lond). 2016 Aug 9;13:51. doi: 10.1186/s12986-016-0110-1. eCollection 2016.


In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines.

Roursgaard M, Knudsen KB, Northeved H, Persson M, Christensen T, Kumar PEK, Permin A, Andresen TL, Gjetting T, Lykkesfeldt J, Vesterdal LK, Loft S, Møller P.

Toxicol In Vitro. 2016 Oct;36:164-171. doi: 10.1016/j.tiv.2016.08.002. Epub 2016 Aug 3.


Assessment of implantable infusion pumps for continuous infusion of human insulin in rats: potential for group housing.

Jensen VFH, Mølck AM, Mårtensson M, Strid MA, Chapman M, Lykkesfeldt J, Bøgh IB.

Lab Anim. 2017 Jun;51(3):273-283. doi: 10.1177/0023677216660740. Epub 2016 Jul 27.


Simultaneous quantification of monoamine neurotransmitters and their biogenic metabolites intracellularly and extracellularly in primary neuronal cell cultures and in sub-regions of guinea pig brain.

Schou-Pedersen AMV, Hansen SN, Tveden-Nyborg P, Lykkesfeldt J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Aug 15;1028:222-230. doi: 10.1016/j.jchromb.2016.05.048. Epub 2016 Jun 16.


Maternal vitamin C deficiency does not reduce hippocampal volume and β-tubulin III intensity in prenatal Guinea pigs.

Hansen SN, Schjoldager JG, Paidi MD, Lykkesfeldt J, Tveden-Nyborg P.

Nutr Res. 2016 Jul;36(7):696-702. doi: 10.1016/j.nutres.2016.03.004. Epub 2016 Mar 6.


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