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GemC1 is a critical switch for neural stem cell generation in the postnatal brain.

Lalioti ME, Kaplani K, Lokka G, Georgomanolis T, Kyrousi C, Dong W, Dunbar A, Parlapani E, Damianidou E, Spassky N, Kahle KT, Papantonis A, Lygerou Z, Taraviras S.

Glia. 2019 Dec;67(12):2360-2373. doi: 10.1002/glia.23690. Epub 2019 Jul 22.


Replication Licensing Aberrations, Replication Stress, and Genomic Instability.

Petropoulos M, Champeris Tsaniras S, Taraviras S, Lygerou Z.

Trends Biochem Sci. 2019 Sep;44(9):752-764. doi: 10.1016/j.tibs.2019.03.011. Epub 2019 May 1. Review.


GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73.

Lalioti ME, Arbi M, Loukas I, Kaplani K, Kalogeropoulou A, Lokka G, Kyrousi C, Mizi A, Georgomanolis T, Josipovic N, Gkikas D, Benes V, Politis PK, Papantonis A, Lygerou Z, Taraviras S.

J Cell Sci. 2019 Jun 3;132(11). pii: jcs228684. doi: 10.1242/jcs.228684.


Cortical Development and Brain Malformations: Insights From the Differential Regulation of Early Events of DNA Replication.

Kalogeropoulou A, Lygerou Z, Taraviras S.

Front Cell Dev Biol. 2019 Mar 11;7:29. doi: 10.3389/fcell.2019.00029. eCollection 2019. Review.


Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1.

Hayashi A, Giakoumakis NN, Heidebrecht T, Ishii T, Panagopoulos A, Caillat C, Takahara M, Hibbert RG, Suenaga N, Stadnik-Spiewak M, Takahashi T, Shiomi Y, Taraviras S, von Castelmur E, Lygerou Z, Perrakis A, Nishitani H.

Life Sci Alliance. 2018 Dec 31;1(6):e201800238. doi: 10.26508/lsa.201800238. eCollection 2018 Dec.


Visualizing the dynamics of histone variants in the S-phase nucleus.

Maxouri S, Taraviras S, Lygerou Z.

Genome Biol. 2018 Oct 31;19(1):182. doi: 10.1186/s13059-018-1556-4.


Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.

Champeris Tsaniras S, Villiou M, Giannou AD, Nikou S, Petropoulos M, Pateras IS, Tserou P, Karousi F, Lalioti ME, Gorgoulis VG, Patmanidi AL, Stathopoulos GT, Bravou V, Lygerou Z, Taraviras S.

J Pathol. 2018 Oct;246(2):134-140. doi: 10.1002/path.5128. Epub 2018 Aug 21.


EasyFRAP-web: a web-based tool for the analysis of fluorescence recovery after photobleaching data.

Koulouras G, Panagopoulos A, Rapsomaniki MA, Giakoumakis NN, Taraviras S, Lygerou Z.

Nucleic Acids Res. 2018 Jul 2;46(W1):W467-W472. doi: 10.1093/nar/gky508.


Expression of α-Defensins, CD20+ B-lymphocytes, and Intraepithelial CD3+ T-lymphocytes in the Intestinal Mucosa of Patients with Liver Cirrhosis: Emerging Mediators of Intestinal Barrier Function.

Tsiaoussis GI, Papaioannou EC, Kourea EP, Assimakopoulos SF, Theocharis GI, Petropoulos M, Theopistos VI, Diamantopoulou GG, Lygerou Z, Spiliopoulou I, Thomopoulos KC.

Dig Dis Sci. 2018 Oct;63(10):2582-2592. doi: 10.1007/s10620-018-5146-9. Epub 2018 Jun 7.


Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG.

Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.


Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis.

Arbi M, Pefani DE, Taraviras S, Lygerou Z.

Chromosoma. 2018 Jun;127(2):151-174. doi: 10.1007/s00412-017-0652-7. Epub 2017 Dec 14. Review.


Geminin Participates in Differentiation Decisions of Adult Neural Stem Cells Transplanted in the Hemiparkinsonian Mouse Brain.

Taouki I, Tasiudi E, Lalioti ME, Kyrousi C, Skavatsou E, Kaplani K, Lygerou Z, Kouvelas ED, Mitsacos A, Giompres P, Taraviras S.

Stem Cells Dev. 2017 Aug 15;26(16):1214-1222. doi: 10.1089/scd.2016.0335. Epub 2017 Jun 30.


Mismatch repair regulates Cdt1 after UV damage.

Panagopoulos A, Taraviras S, Lygerou Z.

Cell Cycle. 2017 Jun 18;16(12):1143-1144. doi: 10.1080/15384101.2017.1319687. No abstract available.


Analysis of Protein Kinetics Using Fluorescence Recovery After Photobleaching (FRAP).

Giakoumakis NN, Rapsomaniki MA, Lygerou Z.

Methods Mol Biol. 2017;1563:243-267. doi: 10.1007/978-1-4939-6810-7_16.


How a radial glial cell decides to become a multiciliated ependymal cell.

Kyrousi C, Lygerou Z, Taraviras S.

Glia. 2017 Jul;65(7):1032-1042. doi: 10.1002/glia.23118. Epub 2017 Feb 7. Review.


Concise Review: Geminin-A Tale of Two Tails: DNA Replication and Transcriptional/Epigenetic Regulation in Stem Cells.

Patmanidi AL, Champeris Tsaniras S, Karamitros D, Kyrousi C, Lygerou Z, Taraviras S.

Stem Cells. 2017 Feb;35(2):299-310. doi: 10.1002/stem.2529. Epub 2016 Nov 11. Review.


Mcidas and GemC1/Lynkeas specify embryonic radial glial cells.

Kyrousi C, Lalioti ME, Skavatsou E, Lygerou Z, Taraviras S.

Neurogenesis (Austin). 2016 Apr 27;3(1):e1172747. doi: 10.1080/23262133.2016.1172747. eCollection 2016.


IPP Complex Reinforces Adhesion by Relaying Tension-Dependent Signals to Inhibit Integrin Turnover.

Vakaloglou KM, Chrysanthis G, Rapsomaniki MA, Lygerou Z, Zervas CG.

Cell Rep. 2016 Jul 12;16(2):596. doi: 10.1016/j.celrep.2016.06.079. Epub 2016 Jul 12. No abstract available.


Whole transcriptome data analysis of mouse embryonic hematopoietic stem and progenitor cells that lack Geminin expression.

Patmanidi AL, Kanellakis NI, Karamitros D, Papadimitriou C, Lygerou Z, Taraviras S.

Data Brief. 2016 Mar 12;7:889-93. doi: 10.1016/j.dib.2016.03.028. eCollection 2016 Jun.


IPP Complex Reinforces Adhesion by Relaying Tension-Dependent Signals to Inhibit Integrin Turnover.

Vakaloglou KM, Chrysanthis G, Rapsomaniki MA, Lygerou Z, Zervas CG.

Cell Rep. 2016 Mar 22;14(11):2668-82. doi: 10.1016/j.celrep.2016.02.052. Epub 2016 Mar 10. Erratum in: Cell Rep. 2016 Jul 12;16(2):596.


GemC1 controls multiciliogenesis in the airway epithelium.

Arbi M, Pefani DE, Kyrousi C, Lalioti ME, Kalogeropoulou A, Papanastasiou AD, Taraviras S, Lygerou Z.

EMBO Rep. 2016 Mar;17(3):400-13. doi: 10.15252/embr.201540882. Epub 2016 Feb 4.


Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis.

Stathopoulou A, Natarajan D, Nikolopoulou P, Patmanidi AL, Lygerou Z, Pachnis V, Taraviras S.

Dev Biol. 2016 Jan 15;409(2):392-405. doi: 10.1016/j.ydbio.2015.11.023. Epub 2015 Dec 3.


The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins.

Caillat C, Fish A, Pefani DE, Taraviras S, Lygerou Z, Perrakis A.

Acta Crystallogr D Biol Crystallogr. 2015 Nov;71(Pt 11):2278-86. doi: 10.1107/S1399004715016892. Epub 2015 Oct 31.


Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche.

Kyrousi C, Arbi M, Pilz GA, Pefani DE, Lalioti ME, Ninkovic J, Götz M, Lygerou Z, Taraviras S.

Development. 2015 Nov 1;142(21):3661-74. doi: 10.1242/dev.126342. Epub 2015 Sep 22.


CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation.

Kourti M, Ikonomou G, Giakoumakis NN, Rapsomaniki MA, Landegren U, Siniossoglou S, Lygerou Z, Simos G, Mylonis I.

Cell Signal. 2015 Jun;27(6):1129-40. doi: 10.1016/j.cellsig.2015.02.017. Epub 2015 Mar 3.


Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors.

Karamitros D, Patmanidi AL, Kotantaki P, Potocnik AJ, Bähr-Ivacevic T, Benes V, Lygerou Z, Kioussis D, Taraviras S.

Development. 2015 Jan 1;142(1):70-81. doi: 10.1242/dev.109454.


Inference of protein kinetics by stochastic modeling and simulation of fluorescence recovery after photobleaching experiments.

Rapsomaniki MA, Cinquemani E, Giakoumakis NN, Kotsantis P, Lygeros J, Lygerou Z.

Bioinformatics. 2015 Feb 1;31(3):355-62. doi: 10.1093/bioinformatics/btu619. Epub 2014 Sep 30.


Licensing of DNA replication, cancer, pluripotency and differentiation: an interlinked world?

Champeris Tsaniras S, Kanellakis N, Symeonidou IE, Nikolopoulou P, Lygerou Z, Taraviras S.

Semin Cell Dev Biol. 2014 Jun;30:174-80. doi: 10.1016/j.semcdb.2014.03.013. Epub 2014 Mar 15. Review.


Multi-step loading of human minichromosome maintenance proteins in live human cells.

Symeonidou IE, Kotsantis P, Roukos V, Rapsomaniki MA, Grecco HE, Bastiaens P, Taraviras S, Lygerou Z.

J Biol Chem. 2013 Dec 13;288(50):35852-67. doi: 10.1074/jbc.M113.474825. Epub 2013 Oct 24.


The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing.

Caillat C, Pefani DE, Gillespie PJ, Taraviras S, Blow JJ, Lygerou Z, Perrakis A.

J Biol Chem. 2013 Nov 1;288(44):31624-34. doi: 10.1074/jbc.M113.491928. Epub 2013 Sep 24.


Cell cycle-dependent subcellular translocation of the human DNA licensing inhibitor geminin.

Dimaki M, Xouri G, Symeonidou IE, Sirinian C, Nishitani H, Taraviras S, Lygerou Z.

J Biol Chem. 2013 Aug 16;288(33):23953-63. doi: 10.1074/jbc.M113.453092. Epub 2013 Jun 29.


Reduced Geminin levels promote cellular senescence.

Iliou MS, Kotantaki P, Karamitros D, Spella M, Taraviras S, Lygerou Z.

Mech Ageing Dev. 2013 Jan-Feb;134(1-2):10-23. doi: 10.1016/j.mad.2012.10.001. Epub 2012 Nov 8.


Control over DNA replication in time and space.

Symeonidou IE, Taraviras S, Lygerou Z.

FEBS Lett. 2012 Aug 31;586(18):2803-12. doi: 10.1016/j.febslet.2012.07.042. Epub 2012 Jul 25. Review.


easyFRAP: an interactive, easy-to-use tool for qualitative and quantitative analysis of FRAP data.

Rapsomaniki MA, Kotsantis P, Symeonidou IE, Giakoumakis NN, Taraviras S, Lygerou Z.

Bioinformatics. 2012 Jul 1;28(13):1800-1. doi: 10.1093/bioinformatics/bts241. Epub 2012 Apr 27.


Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs.

Stathopoulou A, Roukos V, Petropoulou C, Kotsantis P, Karantzelis N, Nishitani H, Lygerou Z, Taraviras S.

PLoS One. 2012;7(3):e34621. doi: 10.1371/journal.pone.0034621. Epub 2012 Mar 30.


T cell proliferation and homeostasis: an emerging role for the cell cycle inhibitor geminin.

Karamitros D, Kotantaki P, Lygerou Z, Kioussis D, Taraviras S.

Crit Rev Immunol. 2011;31(3):209-31. Review.


Geminin regulates cortical progenitor proliferation and differentiation.

Spella M, Kyrousi C, Kritikou E, Stathopoulou A, Guillemot F, Kioussis D, Pachnis V, Lygerou Z, Taraviras S.

Stem Cells. 2011 Aug;29(8):1269-82. doi: 10.1002/stem.678.


Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression.

Pefani DE, Dimaki M, Spella M, Karantzelis N, Mitsiki E, Kyrousi C, Symeonidou IE, Perrakis A, Taraviras S, Lygerou Z.

J Biol Chem. 2011 Jul 1;286(26):23234-46. doi: 10.1074/jbc.M110.207688. Epub 2011 May 4.


Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage.

Roukos V, Kinkhabwala A, Colombelli J, Kotsantis P, Taraviras S, Nishitani H, Stelzer E, Bastiaens P, Lygerou Z.

J Cell Sci. 2011 Feb 1;124(Pt 3):422-34. doi: 10.1242/jcs.074229. Epub 2011 Jan 11.


Life without geminin.

Karamitros D, Kotantaki P, Lygerou Z, Veiga-Fernandes H, Pachnis V, Kioussis D, Taraviras S.

Cell Cycle. 2010 Aug 15;9(16):3181-5. doi: 10.4161/cc.9.16.12554. Epub 2010 Aug 28.


Differential geminin requirement for proliferation of thymocytes and mature T cells.

Karamitros D, Kotantaki P, Lygerou Z, Veiga-Fernandes H, Pachnis V, Kioussis D, Taraviras S.

J Immunol. 2010 Mar 1;184(5):2432-41. doi: 10.4049/jimmunol.0901983. Epub 2010 Jan 27.


Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.

De Marco V, Gillespie PJ, Li A, Karantzelis N, Christodoulou E, Klompmaker R, van Gerwen S, Fish A, Petoukhov MV, Iliou MS, Lygerou Z, Medema RH, Blow JJ, Svergun DI, Taraviras S, Perrakis A.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19807-12. doi: 10.1073/pnas.0905281106. Epub 2009 Nov 11.


Stochastic hybrid modeling of DNA replication across a complete genome.

Lygeros J, Koutroumpas K, Dimopoulos S, Legouras I, Kouretas P, Heichinger C, Nurse P, Lygerou Z.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12295-300. doi: 10.1073/pnas.0805549105. Epub 2008 Aug 19.


Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.

Liontos M, Koutsami M, Sideridou M, Evangelou K, Kletsas D, Levy B, Kotsinas A, Nahum O, Zoumpourlis V, Kouloukoussa M, Lygerou Z, Taraviras S, Kittas C, Bartkova J, Papavassiliou AG, Bartek J, Halazonetis TD, Gorgoulis VG.

Cancer Res. 2007 Nov 15;67(22):10899-909.


Cdt1 interactions in the licensing process: a model for dynamic spatiotemporal control of licensing.

Xouri G, Dimaki M, Bastiaens PI, Lygerou Z.

Cell Cycle. 2007 Jul 1;6(13):1549-52. Epub 2007 May 22. Review.


Licensing regulators Geminin and Cdt1 identify progenitor cells of the mouse CNS in a specific phase of the cell cycle.

Spella M, Britz O, Kotantaki P, Lygerou Z, Nishitani H, Ramsay RG, Flordellis C, Guillemot F, Mantamadiotis T, Taraviras S.

Neuroscience. 2007 Jun 29;147(2):373-87. Epub 2007 May 29.


Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin.

Xouri G, Squire A, Dimaki M, Geverts B, Verveer PJ, Taraviras S, Nishitani H, Houtsmuller AB, Bastiaens PI, Lygerou Z.

EMBO J. 2007 Mar 7;26(5):1303-14. Epub 2007 Feb 22.


Geminin cleavage during apoptosis by caspase-3 alters its binding ability to the SWI/SNF subunit Brahma.

Roukos V, Iliou MS, Nishitani H, Gentzel M, Wilm M, Taraviras S, Lygerou Z.

J Biol Chem. 2007 Mar 30;282(13):9346-57. Epub 2007 Jan 29.


DNA replication in the fission yeast: robustness in the face of uncertainty.

Legouras I, Xouri G, Dimopoulos S, Lygeros J, Lygerou Z.

Yeast. 2006 Oct 15;23(13):951-62. Review.


Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

Nishitani H, Sugimoto N, Roukos V, Nakanishi Y, Saijo M, Obuse C, Tsurimoto T, Nakayama KI, Nakayama K, Fujita M, Lygerou Z, Nishimoto T.

EMBO J. 2006 Mar 8;25(5):1126-36. Epub 2006 Feb 16.

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