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Localized rest and stress human cardiac creatine kinase reaction kinetics at 3 T.

Clarke WT, Peterzan MA, Rayner JJ, Sayeed RA, Petrou M, Krasopoulos G, Lake HA, Raman B, Watson WD, Cox P, Hundertmark MJ, Apps AP, Lygate CA, Neubauer S, Rider OJ, Rodgers CT.

NMR Biomed. 2019 Jun;32(6):e4085. doi: 10.1002/nbm.4085. Epub 2019 Mar 28.


Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism.

Valli A, Morotti M, Zois CE, Albers PK, Soga T, Feldinger K, Fischer R, Frejno M, McIntyre A, Bridges E, Haider S, Buffa FM, Baban D, Rodriguez M, Yanes O, Whittington HJ, Lake HA, Zervou S, Lygate CA, Kessler BM, Harris AL.

Mol Cancer Res. 2019 Jul;17(7):1531-1544. doi: 10.1158/1541-7786.MCR-18-0315. Epub 2019 Mar 18.


The creatine kinase system as a therapeutic target for myocardial ischaemia-reperfusion injury.

Cao F, Zervou S, Lygate CA.

Biochem Soc Trans. 2018 Oct 19;46(5):1119-1127. doi: 10.1042/BST20170504. Epub 2018 Sep 20. Review.


A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism.

Stockebrand M, Sasani A, Das D, Hornig S, Hermans-Borgmeyer I, Lake HA, Isbrandt D, Lygate CA, Heerschap A, Neu A, Choe CU.

Front Physiol. 2018 Jun 22;9:773. doi: 10.3389/fphys.2018.00773. eCollection 2018.


Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.

Chuaiphichai S, Rashbrook VS, Hale AB, Trelfa L, Patel J, McNeill E, Lygate CA, Channon KM, Douglas G.

Hypertension. 2018 Jul;72(1):128-138. doi: 10.1161/HYPERTENSIONAHA.118.11144. Epub 2018 May 29.


Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion.

Whittington HJ, Ostrowski PJ, McAndrew DJ, Cao F, Shaw A, Eykyn TR, Lake HA, Tyler J, Schneider JE, Neubauer S, Zervou S, Lygate CA.

Cardiovasc Res. 2018 May 1;114(6):858-869. doi: 10.1093/cvr/cvy054.


Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine.

Faller KME, Atzler D, McAndrew DJ, Zervou S, Whittington HJ, Simon JN, Aksentijevic D, Ten Hove M, Choe CU, Isbrandt D, Casadei B, Schneider JE, Neubauer S, Lygate CA.

Cardiovasc Res. 2018 Mar 1;114(3):417-430. doi: 10.1093/cvr/cvx242.


Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.

Zervou S, Whittington HJ, Ostrowski PJ, Cao F, Tyler J, Lake HA, Neubauer S, Lygate CA.

PLoS One. 2017 Aug 14;12(8):e0182994. doi: 10.1371/journal.pone.0182994. eCollection 2017.


Metabolic remodeling in hypertrophied and failing myocardium: a review.

Peterzan MA, Lygate CA, Neubauer S, Rider OJ.

Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H597-H616. doi: 10.1152/ajpheart.00731.2016. Epub 2017 Jun 23. Review.


Metabolic arithmetic: do two wrongs make a right?

Lygate CA.

Cardiovasc Res. 2017 Aug 1;113(10):1093-1095. doi: 10.1093/cvr/cvx121. No abstract available.


Validation of diffusion tensor MRI measurements of cardiac microstructure with structure tensor synchrotron radiation imaging.

Teh I, McClymont D, Zdora MC, Whittington HJ, Davidoiu V, Lee J, Lygate CA, Rau C, Zanette I, Schneider JE.

J Cardiovasc Magn Reson. 2017 Mar 10;19(1):31. doi: 10.1186/s12968-017-0342-x.


The Subcellular Localisation of Neuronal Nitric Oxide Synthase Determines the Downstream Effects of NO on Myocardial Function.

Carnicer R, Suffredini S, Liu X, Reilly S, Simon JN, Surdo NC, Zhang YH, Lygate CA, Channon KM, Casadei B.

Cardiovasc Res. 2017 Feb 1. doi: 10.1093/cvr/cvx002. [Epub ahead of print] No abstract available.


Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure.

Atzler D, McAndrew DJ, Cordts K, Schneider JE, Zervou S, Schwedhelm E, Neubauer S, Lygate CA.

Circulation. 2017 Jan 24;135(4):400-402. doi: 10.1161/CIRCULATIONAHA.116.025673. No abstract available.


Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice.

Smart N, Riegler J, Turtle CW, Lygate CA, McAndrew DJ, Gehmlich K, Dubé KN, Price AN, Muthurangu V, Taylor AM, Lythgoe MF, Redwood C, Riley PR.

J Mol Cell Cardiol. 2017 Jan;102:94-107. doi: 10.1016/j.yjmcc.2016.10.010. Epub 2016 Nov 30.


Resolving Fine Cardiac Structures in Rats with High-Resolution Diffusion Tensor Imaging.

Teh I, McClymont D, Burton RA, Maguire ML, Whittington HJ, Lygate CA, Kohl P, Schneider JE.

Sci Rep. 2016 Jul 28;6:30573. doi: 10.1038/srep30573.


ASPP2 deficiency causes features of 1q41q42 microdeletion syndrome.

Zak J, Vives V, Szumska D, Vernet A, Schneider JE, Miller P, Slee EA, Joss S, Lacassie Y, Chen E, Escobar LF, Tucker M, Aylsworth AS, Dubbs HA, Collins AT, Andrieux J, Dieux-Coeslier A, Haberlandt E, Kotzot D, Scott DA, Parker MJ, Zakaria Z, Choy YS, Wieczorek D, Innes AM, Jun KR, Zinner S, Prin F, Lygate CA, Pretorius P, Rosenfeld JA, Mohun TJ, Lu X.

Cell Death Differ. 2016 Dec;23(12):1973-1984. doi: 10.1038/cdd.2016.76. Epub 2016 Jul 22.


Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.

Zervou S, Yin X, Nabeebaccus AA, O'Brien BA, Cross RL, McAndrew DJ, Atkinson RA, Eykyn TR, Mayr M, Neubauer S, Lygate CA.

Amino Acids. 2016 Aug;48(8):1969-81. doi: 10.1007/s00726-016-2236-x. Epub 2016 May 3.


Protective Effect of Creatine Elevation against Ischaemia Reperfusion Injury Is Retained in the Presence of Co-Morbidities and during Cardioplegia.

Whittington HJ, McAndrew DJ, Cross RL, Neubauer S, Lygate CA.

PLoS One. 2016 Jan 14;11(1):e0146429. doi: 10.1371/journal.pone.0146429. eCollection 2016.


Augmentation of Creatine in the Heart.

Zervou S, Whittington HJ, Russell AJ, Lygate CA.

Mini Rev Med Chem. 2016;16(1):19-28. Review.


Compressed sensing to accelerate magnetic resonance spectroscopic imaging: evaluation and application to 23Na-imaging of mouse hearts.

Maguire ML, Geethanath S, Lygate CA, Kodibagkar VD, Schneider JE.

J Cardiovasc Magn Reson. 2015 Jun 15;17:45. doi: 10.1186/s12968-015-0149-6.


Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans.

Ruparelia N, Godec J, Lee R, Chai JT, Dall'Armellina E, McAndrew D, Digby JE, Forfar JC, Prendergast BD, Kharbanda RK, Banning AP, Neubauer S, Lygate CA, Channon KM, Haining NW, Choudhury RP.

Eur Heart J. 2015 Aug 1;36(29):1923-34. doi: 10.1093/eurheartj/ehv195. Epub 2015 May 16.


A requirement for Gch1 and tetrahydrobiopterin in embryonic development.

Douglas G, Hale AB, Crabtree MJ, Ryan BJ, Hansler A, Watschinger K, Gross SS, Lygate CA, Alp NJ, Channon KM.

Dev Biol. 2015 Mar 1;399(1):129-138. doi: 10.1016/j.ydbio.2014.12.025. Epub 2014 Dec 31.


Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale.

Faller KM, McAndrew DJ, Schneider JE, Lygate CA.

Exp Physiol. 2015 Feb 1;100(2):164-72. doi: 10.1113/expphysiol.2014.083139. Epub 2015 Jan 14.


Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart.

Aksentijević D, Zervou S, Faller KM, McAndrew DJ, Schneider JE, Neubauer S, Lygate CA.

PLoS One. 2014 Oct 1;9(10):e109021. doi: 10.1371/journal.pone.0109021. eCollection 2014.


Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.

Aksentijević D, McAndrew DJ, Karlstädt A, Zervou S, Sebag-Montefiore L, Cross R, Douglas G, Regitz-Zagrosek V, Lopaschuk GD, Neubauer S, Lygate CA.

J Mol Cell Cardiol. 2014 Oct;75:76-87. doi: 10.1016/j.yjmcc.2014.07.008. Epub 2014 Jul 24.


Metabolic flux as a predictor of heart failure prognosis.

Lygate CA, Neubauer S.

Circ Res. 2014 Apr 11;114(8):1228-30. doi: 10.1161/CIRCRESAHA.114.303551.


Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation.

Masoud WG, Ussher JR, Wang W, Jaswal JS, Wagg CS, Dyck JR, Lygate CA, Neubauer S, Clanachan AS, Lopaschuk GD.

Cardiovasc Res. 2014 Jan 1;101(1):30-8. doi: 10.1093/cvr/cvt216. Epub 2013 Sep 17.


Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart.

Faller KM, Medway DJ, Aksentijevic D, Sebag-Montefiore L, Schneider JE, Lygate CA, Neubauer S.

PLoS One. 2013 Jun 18;8(6):e66461. doi: 10.1371/journal.pone.0066461. Print 2013.


Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts.

Branovets J, Sepp M, Kotlyarova S, Jepihhina N, Sokolova N, Aksentijevic D, Lygate CA, Neubauer S, Vendelin M, Birkedal R.

Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H506-20. doi: 10.1152/ajpheart.00919.2012. Epub 2013 Jun 21.


A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.

Zervou S, Ray T, Sahgal N, Sebag-Montefiore L, Cross R, Medway DJ, Ostrowski PJ, Neubauer S, Lygate CA.

Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E263-70. doi: 10.1152/ajpendo.00637.2012. Epub 2013 May 28.


Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus.

Ruparelia N, Digby JE, Jefferson A, Medway DJ, Neubauer S, Lygate CA, Choudhury RP.

Inflamm Res. 2013 May;62(5):515-25. doi: 10.1007/s00011-013-0605-4. Epub 2013 Mar 8.


Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.

Lygate CA, Aksentijevic D, Dawson D, ten Hove M, Phillips D, de Bono JP, Medway DJ, Sebag-Montefiore L, Hunyor I, Channon KM, Clarke K, Zervou S, Watkins H, Balaban RS, Neubauer S.

Circ Res. 2013 Mar 15;112(6):945-55. doi: 10.1161/CIRCRESAHA.112.300725. Epub 2013 Jan 16.


Investigating cardiac energetics in heart failure.

Lygate CA, Schneider JE, Neubauer S.

Exp Physiol. 2013 Mar;98(3):601-5. doi: 10.1113/expphysiol.2012.064709. Epub 2012 Sep 14. Review.


(1)H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism.

Faller KM, Lygate CA, Neubauer S, Schneider JE.

Heart Fail Rev. 2013 Sep;18(5):657-68. doi: 10.1007/s10741-012-9341-z. Review.


Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.

Lygate CA, Bohl S, ten Hove M, Faller KM, Ostrowski PJ, Zervou S, Medway DJ, Aksentijevic D, Sebag-Montefiore L, Wallis J, Clarke K, Watkins H, Schneider JE, Neubauer S.

Cardiovasc Res. 2012 Dec 1;96(3):466-75. doi: 10.1093/cvr/cvs272. Epub 2012 Aug 21.


Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age.

Lygate CA, Medway DJ, Ostrowski PJ, Aksentijevic D, Sebag-Montefiore L, Hunyor I, Zervou S, Schneider JE, Neubauer S.

Basic Res Cardiol. 2012 Sep;107(5):276. doi: 10.1007/s00395-012-0276-2. Epub 2012 Jul 4.


Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

Ashrafian H, Czibik G, Bellahcene M, Aksentijević D, Smith AC, Mitchell SJ, Dodd MS, Kirwan J, Byrne JJ, Ludwig C, Isackson H, Yavari A, Støttrup NB, Contractor H, Cahill TJ, Sahgal N, Ball DR, Birkler RI, Hargreaves I, Tennant DA, Land J, Lygate CA, Johannsen M, Kharbanda RK, Neubauer S, Redwood C, de Cabo R, Ahmet I, Talan M, Günther UL, Robinson AJ, Viant MR, Pollard PJ, Tyler DJ, Watkins H.

Cell Metab. 2012 Mar 7;15(3):361-71. doi: 10.1016/j.cmet.2012.01.017.


Accelerating cine-MR imaging in mouse hearts using compressed sensing.

Wech T, Lemke A, Medway D, Stork LA, Lygate CA, Neubauer S, Köstler H, Schneider JE.

J Magn Reson Imaging. 2011 Nov;34(5):1072-9. doi: 10.1002/jmri.22718. Epub 2011 Sep 19.


Accelerating global left-ventricular function assessment in mice using reduced slice acquisition and three-dimensional guide-point modelling.

Young AA, Medway DJ, Lygate CA, Neubauer S, Schneider JE.

J Cardiovasc Magn Reson. 2011 Sep 14;13:49. doi: 10.1186/1532-429X-13-49.


Improved method for quantification of regional cardiac function in mice using phase-contrast MRI.

Dall'Armellina E, Jung BA, Lygate CA, Neubauer S, Markl M, Schneider JE.

Magn Reson Med. 2012 Feb;67(2):541-51. doi: 10.1002/mrm.23022. Epub 2011 Jun 14.


High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes.

Aksentijević D, Lygate CA, Makinen K, Zervou S, Sebag-Montefiore L, Medway D, Barnes H, Schneider JE, Neubauer S.

Eur J Heart Fail. 2010 Dec;12(12):1282-9. doi: 10.1093/eurjhf/hfq174. Epub 2010 Oct 12.


Accelerated cardiac magnetic resonance imaging in the mouse using an eight-channel array at 9.4 Tesla.

Schneider JE, Lanz T, Barnes H, Stork LA, Bohl S, Lygate CA, Ordidge RJ, Neubauer S.

Magn Reson Med. 2011 Jan;65(1):60-70. doi: 10.1002/mrm.22605.


A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.

Ashrafian H, Docherty L, Leo V, Towlson C, Neilan M, Steeples V, Lygate CA, Hough T, Townsend S, Williams D, Wells S, Norris D, Glyn-Jones S, Land J, Barbaric I, Lalanne Z, Denny P, Szumska D, Bhattacharya S, Griffin JL, Hargreaves I, Fernandez-Fuentes N, Cheeseman M, Watkins H, Dear TN.

PLoS Genet. 2010 Jun 24;6(6):e1001000. doi: 10.1371/journal.pgen.1001000.


Changes in creatine transporter function during cardiac maturation in the rat.

Fischer A, Ten Hove M, Sebag-Montefiore L, Wagner H, Clarke K, Watkins H, Lygate CA, Neubauer S.

BMC Dev Biol. 2010 Jun 22;10:70. doi: 10.1186/1471-213X-10-70.


Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.

Phillips D, Ten Hove M, Schneider JE, Wu CO, Sebag-Montefiore L, Aponte AM, Lygate CA, Wallis J, Clarke K, Watkins H, Balaban RS, Neubauer S.

J Mol Cell Cardiol. 2010 Apr;48(4):582-90. doi: 10.1016/j.yjmcc.2009.10.033. Epub 2009 Nov 11.


Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heart.

Bohl S, Medway DJ, Schulz-Menger J, Schneider JE, Neubauer S, Lygate CA.

Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2054-8. doi: 10.1152/ajpheart.00836.2009. Epub 2009 Oct 9.


Advanced methods for quantification of infarct size in mice using three-dimensional high-field late gadolinium enhancement MRI.

Bohl S, Lygate CA, Barnes H, Medway D, Stork LA, Schulz-Menger J, Neubauer S, Schneider JE.

Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1200-8. doi: 10.1152/ajpheart.01294.2008. Epub 2009 Feb 13.


Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background.

Lygate CA, Hunyor I, Medway D, de Bono JP, Dawson D, Wallis J, Sebag-Montefiore L, Neubauer S.

J Mol Cell Cardiol. 2009 Jan;46(1):93-9. doi: 10.1016/j.yjmcc.2008.09.710. Epub 2008 Oct 4.


Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.

Bishop T, Gallagher D, Pascual A, Lygate CA, de Bono JP, Nicholls LG, Ortega-Saenz P, Oster H, Wijeyekoon B, Sutherland AI, Grosfeld A, Aragones J, Schneider M, van Geyte K, Teixeira D, Diez-Juan A, Lopez-Barneo J, Channon KM, Maxwell PH, Pugh CW, Davies AM, Carmeliet P, Ratcliffe PJ.

Mol Cell Biol. 2008 May;28(10):3386-400. doi: 10.1128/MCB.02041-07. Epub 2008 Mar 10.


Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart.

Murray AJ, Cole MA, Lygate CA, Carr CA, Stuckey DJ, Little SE, Neubauer S, Clarke K.

J Mol Cell Cardiol. 2008 Apr;44(4):694-700. doi: 10.1016/j.yjmcc.2008.01.008. Epub 2008 Feb 9.


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