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Short-term RANKL exposure initiates a neoplastic transcriptional program in the basal epithelium of the murine salivary gland.

Hai L, Szwarc MM, Lonard DM, Rajapakshe K, Perera D, Coarfa C, Ittmann M, Fernandez-Valdivia R, Lydon JP.

Cytokine. 2019 Nov;123:154745. doi: 10.1016/j.cyto.2019.154745. Epub 2019 Jun 18.


The histone methyltransferase EZH2 is required for normal uterine development and function in mice†.

Nanjappa MK, Mesa AM, Medrano TI, Jefferson WN, DeMayo FJ, Williams CJ, Lydon JP, Levin ER, Cooke PS.

Biol Reprod. 2019 Aug 1;101(2):306-317. doi: 10.1093/biolre/ioz097.


Uterine Gαq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse.

de Oliveira V, Schaefer J, Calder M, Lydon JP, DeMayo FJ, Bhattacharya M, Radovick S, Babwah AV.

FASEB J. 2019 Aug;33(8):9374-9387. doi: 10.1096/fj.201900026R. Epub 2019 May 15.


A distal super enhancer mediates estrogen-dependent mouse uterine-specific gene transcription of Igf1 (insulin-like growth factor 1).

Hewitt SC, Lierz SL, Garcia M, Hamilton KJ, Gruzdev A, Grimm SA, Lydon JP, Demayo FJ, Korach KS.

J Biol Chem. 2019 Jun 21;294(25):9746-9759. doi: 10.1074/jbc.RA119.008759. Epub 2019 May 9.


Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity.

Fang X, Ni N, Lydon JP, Ivanov I, Bayless KJ, Rijnkels M, Li Q.

Am J Pathol. 2019 Jun;189(6):1212-1225. doi: 10.1016/j.ajpath.2019.02.016. Epub 2019 Apr 5.


Impaired Progesterone-Responsiveness of CD11c+ Dendritic Cells Affects the Generation of CD4+ Regulatory T Cells and Is Associated With Intrauterine Growth Restriction in Mice.

Thiele K, Hierweger AM, Riquelme JIA, Solano ME, Lydon JP, Arck PC.

Front Endocrinol (Lausanne). 2019 Feb 25;10:96. doi: 10.3389/fendo.2019.00096. eCollection 2019.


Early growth response 1 transcriptionally primes the human endometrial stromal cell for decidualization.

Szwarc MM, Hai L, Gibbons WE, Mo Q, Lanz RB, DeMayo FJ, Lydon JP.

J Steroid Biochem Mol Biol. 2019 May;189:283-290. doi: 10.1016/j.jsbmb.2019.01.021. Epub 2019 Jan 31.


Using CRISPR/Cas9 engineering to generate a mouse with a conditional knockout allele for the promyelocytic leukemia zinc finger transcription factor.

Hai L, Szwarc MM, Lanza DG, Heaney JD, Lydon JP.

Genesis. 2019 Mar;57(3):e23281. doi: 10.1002/dvg.23281. Epub 2019 Jan 23.


Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment.

Ni N, Gao Y, Fang X, Melgar M, Vincent DF, Lydon JP, Bartholin L, Li Q.

PLoS One. 2018 Dec 14;13(12):e0209417. doi: 10.1371/journal.pone.0209417. eCollection 2018.


FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation.

Vasquez YM, Wang X, Wetendorf M, Franco HL, Mo Q, Wang T, Lanz RB, Young SL, Lessey BA, Spencer TE, Lydon JP, DeMayo FJ.

PLoS Genet. 2018 Nov 19;14(11):e1007787. doi: 10.1371/journal.pgen.1007787. eCollection 2018 Nov.


SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh.

Wang X, Li X, Wang T, Wu SP, Jeong JW, Kim TH, Young SL, Lessey BA, Lanz RB, Lydon JP, DeMayo FJ.

Nat Commun. 2018 Oct 24;9(1):4421. doi: 10.1038/s41467-018-06652-w.


Negative elongation factor is essential for endometrial function.

Hewitt SC, Li R, Adams N, Winuthayanon W, Hamilton KJ, Donoghue LJ, Lierz SL, Garcia M, Lydon JP, DeMayo FJ, Adelman K, Korach KS.

FASEB J. 2019 Feb;33(2):3010-3023. doi: 10.1096/fj.201801752. Epub 2018 Oct 17.


Retinoid signaling controlled by SRC-2 in decidualization revealed by transcriptomics

Szwarc MM, Hai L, Gibbons WE, White LD, Mo Q, Kommagani R, Lanz RB, DeMayo FJ, O’Malley BW, Lydon JP.

Reproduction. 2018 Oct 16;156(5):387-395. doi: 10.1530/REP-18-0282.


Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells.

Szwarc MM, Kommagani R, Putluri V, Dubrulle J, Stossi F, Mancini MA, Coarfa C, Lanz RB, Putluri N, DeMayo FJ, Lydon JP, O'Malley BW.

Sci Rep. 2018 Sep 3;8(1):13134. doi: 10.1038/s41598-018-31372-y.


A mouse model engineered to conditionally express the progesterone receptor-B isoform.

Hai L, Szwarc MM, Wetendorf M, Wu SP, Peavey MC, Grimm SL, Edwards DP, DeMayo FJ, Lydon JP.

Genesis. 2018 Aug;56(8):e23223. doi: 10.1002/dvg.23223. Epub 2018 Aug 10.


Uterine function in the mouse requires speckle-type poz protein.

Hai L, Szwarc MM, He B, Lonard DM, Kommagani R, DeMayo FJ, Lydon JP.

Biol Reprod. 2018 Jun 1;98(6):856-869. doi: 10.1093/biolre/ioy060.


Human endometrial stromal cell decidualization requires transcriptional reprogramming by PLZF.

Szwarc MM, Hai L, Gibbons WE, Peavey MC, White LD, Mo Q, Lonard DM, Kommagani R, Lanz RB, DeMayo FJ, Lydon JP.

Biol Reprod. 2018 Jan 1;98(1):15-27. doi: 10.1093/biolre/iox161.


A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse.

Peavey MC, Reynolds CL, Szwarc MM, Gibbons WE, Valdes CT, DeMayo FJ, Lydon JP.

J Vis Exp. 2017 Oct 24;(128). doi: 10.3791/56207.


Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization.

Camden AJ, Szwarc MM, Chadchan SB, DeMayo FJ, O'Malley BW, Lydon JP, Kommagani R.

Mol Hum Reprod. 2017 Sep 1;23(9):646-653. doi: 10.1093/molehr/gax045.


PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice.

Cui T, He B, Kong S, Zhou C, Zhang H, Ni Z, Bao H, Qiu J, Xin Q, Reinberg D, Lydon JP, Lu J, Wang H.

Cell Death Differ. 2017 Dec;24(12):2013-2021. doi: 10.1038/cdd.2017.120. Epub 2017 Jul 21.


Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice.

El Zowalaty AE, Li R, Zheng Y, Lydon JP, DeMayo FJ, Ye X.

Endocrinology. 2017 Jul 1;158(7):2168-2178. doi: 10.1210/en.2016-1796.


Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase.

Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z, Wang C, Wang H.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4816-4821. doi: 10.1073/pnas.1700978114. Epub 2017 Apr 19.


CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy.

Mapes J, Li Q, Kannan A, Anandan L, Laws M, Lydon JP, Bagchi IC, Bagchi MK.

PLoS Genet. 2017 Mar 9;13(3):e1006654. doi: 10.1371/journal.pgen.1006654. eCollection 2017 Mar.


A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin.

Szwarc MM, Kommagani R, Peavey MC, Hai L, Lonard DM, Lydon JP.

PLoS One. 2017 Mar 2;12(3):e0173014. doi: 10.1371/journal.pone.0173014. eCollection 2017.


Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment.

Wetendorf M, Wu SP, Wang X, Creighton CJ, Wang T, Lanz RB, Blok L, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJ.

Biol Reprod. 2017 Feb 1;96(2):313-326. doi: 10.1095/biolreprod.116.144410.


Three-Dimensional High-Frequency Ultrasonography for Early Detection and Characterization of Embryo Implantation Site Development in the Mouse.

Peavey MC, Reynolds CL, Szwarc MM, Gibbons WE, Valdes CT, DeMayo FJ, Lydon JP.

PLoS One. 2017 Jan 3;12(1):e0169312. doi: 10.1371/journal.pone.0169312. eCollection 2017.


Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence.

Clark NC, Pru CA, Yee SP, Lydon JP, Peluso JJ, Pru JK.

Endocrinology. 2017 Mar 1;158(3):640-651. doi: 10.1210/en.2016-1701.


A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function.

Rubel CA, Wu SP, Lin L, Wang T, Lanz RB, Li X, Kommagani R, Franco HL, Camper SA, Tong Q, Jeong JW, Lydon JP, DeMayo FJ.

Cell Rep. 2016 Oct 25;17(5):1414-1425. doi: 10.1016/j.celrep.2016.09.093.


Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice.

Gal A, Lin PC, Cacioppo JA, Hannon PR, Mahoney MM, Wolfe A, Fernandez-Valdivia R, Lydon JP, Elias CF, Ko C.

PLoS One. 2016 Jul 21;11(7):e0159534. doi: 10.1371/journal.pone.0159534. eCollection 2016.


The essential role of GATA transcription factors in adult murine prostate.

Xiao L, Feng Q, Zhang Z, Wang F, Lydon JP, Ittmann MM, Xin L, Mitsiades N, He B.

Oncotarget. 2016 Jul 26;7(30):47891-47903. doi: 10.18632/oncotarget.10294.


Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts.

McCallum ML, Pru CA, Niikura Y, Yee SP, Lydon JP, Peluso JJ, Pru JK.

Endocrinology. 2016 Sep;157(9):3309-19. doi: 10.1210/en.2016-1081. Epub 2016 Jun 16.


The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker.

Xiao L, Lanz RB, Frolov A, Castro PD, Zhang Z, Dong B, Xue W, Jung SY, Lydon JP, Edwards DP, Mancini MA, Feng Q, Ittmann MM, He B.

Prostate. 2016 Oct;76(14):1271-84. doi: 10.1002/pros.23213. Epub 2016 Jun 8.


The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization.

Kommagani R, Szwarc MM, Vasquez YM, Peavey MC, Mazur EC, Gibbons WE, Lanz RB, DeMayo FJ, Lydon JP.

PLoS Genet. 2016 Apr 1;12(4):e1005937. doi: 10.1371/journal.pgen.1005937. eCollection 2016 Apr.


Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.

Vasquez YM, Wu SP, Anderson ML, Hawkins SM, Creighton CJ, Ray M, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJ.

Mol Endocrinol. 2016 May;30(5):518-32. doi: 10.1210/me.2015-1215. Epub 2016 Mar 28.


Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus.

Mehta FF, Son J, Hewitt SC, Jang E, Lydon JP, Korach KS, Chung SH.

Oncotarget. 2016 Apr 5;7(14):17455-67. doi: 10.18632/oncotarget.8159.


Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells.

Lee II, Maniar K, Lydon JP, Kim JJ.

Oncogene. 2016 Sep 29;35(39):5191-201. doi: 10.1038/onc.2016.56. Epub 2016 Mar 21.


Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development.

Shen J, Yao L, Lin YG, DeMayo FJ, Lydon JP, Dubeau L, Lee AS.

Oncotarget. 2016 Mar 22;7(12):14885-97. doi: 10.18632/oncotarget.7450.


Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.

Kim YS, Kim HR, Kim H, Yang SC, Park M, Yoon JA, Lim HJ, Hong SH, DeMayo FJ, Lydon JP, Choi Y, Lee DR, Song H.

Sci Rep. 2016 Feb 2;6:20242. doi: 10.1038/srep20242.


Uterine ALK3 is essential during the window of implantation.

Monsivais D, Clementi C, Peng J, Titus MM, Barrish JP, Creighton CJ, Lydon JP, DeMayo FJ, Matzuk MM.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E387-95. doi: 10.1073/pnas.1523758113. Epub 2015 Dec 31.


Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization.

Whirledge SD, Oakley RH, Myers PH, Lydon JP, DeMayo F, Cidlowski JA.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15166-71. doi: 10.1073/pnas.1508056112. Epub 2015 Nov 23.


Correction: Perturbing the Cellular Levels of Steroid Receptor Coactivator-2 Impairs Murine Endometrial Function.

Szwarc MM, Kommagani R, Jeong JW, Wu SP, Tsai SY, Tsai MJ, O'Malley BW, DeMayo FJ, Lydon JP.

PLoS One. 2015 Nov 18;10(11):e0143652. doi: 10.1371/journal.pone.0143652. eCollection 2015. No abstract available.


Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis.

Han SJ, Jung SY, Wu SP, Hawkins SM, Park MJ, Kyo S, Qin J, Lydon JP, Tsai SY, Tsai MJ, DeMayo FJ, O'Malley BW.

Cell. 2015 Nov 5;163(4):960-74. doi: 10.1016/j.cell.2015.10.034.


GATA4 and GATA6 Knockdown During Luteinization Inhibits Progesterone Production and Gonadotropin Responsiveness in the Corpus Luteum of Female Mice.

Convissar SM, Bennett J, Baumgarten SC, Lydon JP, DeMayo FJ, Stocco C.

Biol Reprod. 2015 Dec;93(6):133. doi: 10.1095/biolreprod.115.132969. Epub 2015 Oct 28.


Application of (13) C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation.

Bhowmik SK, Putluri V, Kommagani R, Konde SA, Lydon JP, Sreekumar A, Putluri N.

J Mass Spectrom. 2015 Oct;50(10):1180. doi: 10.1002/jms.3645. No abstract available.


Correction: Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization.

Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW.

PLoS Genet. 2015 Sep 29;11(9):e1005515. doi: 10.1371/journal.pgen.1005515. eCollection 2015 Sep. No abstract available.


ARID1A Is Essential for Endometrial Function during Early Pregnancy.

Kim TH, Yoo JY, Wang Z, Lydon JP, Khatri S, Hawkins SM, Leach RE, Fazleabas AT, Young SL, Lessey BA, Ku BJ, Jeong JW.

PLoS Genet. 2015 Sep 17;11(9):e1005537. doi: 10.1371/journal.pgen.1005537. eCollection 2015 Sep.


Reprint of "Steroid receptor coactivators as therapeutic targets in the female reproductive system".

Szwarc MM, Lydon JP, O'Malley BW.

J Steroid Biochem Mol Biol. 2015 Sep;153:144-50. doi: 10.1016/j.jsbmb.2015.08.012. Epub 2015 Aug 19.


Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice.

Tu Z, Wang Q, Cui T, Wang J, Ran H, Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S, Wu X, Wang H.

Cell Death Differ. 2016 Jan;23(1):169-81. doi: 10.1038/cdd.2015.98. Epub 2015 Jul 17.


Steroid receptor coactivators as therapeutic targets in the female reproductive system.

Szwarc MM, Lydon JP, O'Malley BW.

J Steroid Biochem Mol Biol. 2015 Nov;154:32-8. doi: 10.1016/j.jsbmb.2015.06.010. Epub 2015 Jul 4. Review.

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