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Items: 1 to 50 of 199

1.

Neuron-generated thrombin induces a protective astrocyte response via protease activated receptors.

Rajput PS, Lamb J, Kothari S, Pereira B, Soetkamp D, Wang Y, Tang J, Van Eyk JE, Mullins ES, Lyden PD.

Glia. 2020 Feb;68(2):246-262. doi: 10.1002/glia.23714. Epub 2019 Aug 27.

PMID:
31453648
2.

Thrombolytic Therapy for Acute Ischemic Stroke.

Lyden PD.

Stroke. 2019 Sep;50(9):2597-2603. doi: 10.1161/STROKEAHA.119.025699. Epub 2019 Jul 22. No abstract available.

PMID:
31327316
3.

Neuroprotection and vasculoprotection using genetically targeted protease-ligands.

Rajput PS, Lamb JA, Fernández JÁ, Bai J, Pereira BR, Lei IF, Leung J, Griffin JH, Lyden PD.

Brain Res. 2019 Jul 15;1715:13-20. doi: 10.1016/j.brainres.2019.03.010. Epub 2019 Mar 14.

PMID:
30880117
4.

Acute neuropathological consequences of short-term mechanical ventilation in wild-type and Alzheimer's disease mice.

Lahiri S, Regis GC, Koronyo Y, Fuchs DT, Sheyn J, Kim EH, Mastali M, Van Eyk JE, Rajput PS, Lyden PD, Black KL, Ely EW, D Jones H, Koronyo-Hamaoui M.

Crit Care. 2019 Feb 22;23(1):63. doi: 10.1186/s13054-019-2356-2.

5.

Differential effects of hypothermia on neurovascular unit determine protective or toxic results: Toward optimized therapeutic hypothermia.

Lyden PD, Lamb J, Kothari S, Toossi S, Boitano P, Rajput PS.

J Cereb Blood Flow Metab. 2019 Sep;39(9):1693-1709. doi: 10.1177/0271678X18814614. Epub 2018 Nov 21.

PMID:
30461327
6.

Differential Expression of Vascular Endothelial Growth Factor-A165 Isoforms Between Intracranial Atherosclerosis and Moyamoya Disease.

Jiang H, Toscano JF, Schiraldi M, Song SS, Schlick KH, Dumitrascu OM, Liou R, Lyden PD, Pan J, Zhan R, Saver JL, Gonzalez NR.

J Stroke Cerebrovasc Dis. 2019 Feb;28(2):360-368. doi: 10.1016/j.jstrokecerebrovasdis.2018.10.004. Epub 2018 Nov 2.

PMID:
30392834
7.

Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data.

Al-Shahi Salman R, Frantzias J, Lee RJ, Lyden PD, Battey TWK, Ayres AM, Goldstein JN, Mayer SA, Steiner T, Wang X, Arima H, Hasegawa H, Oishi M, Godoy DA, Masotti L, Dowlatshahi D, Rodriguez-Luna D, Molina CA, Jang DK, Davalos A, Castillo J, Yao X, Claassen J, Volbers B, Kazui S, Okada Y, Fujimoto S, Toyoda K, Li Q, Khoury J, Delgado P, Sabín JÁ, Hernández-Guillamon M, Prats-Sánchez L, Cai C, Kate MP, McCourt R, Venkatasubramanian C, Diringer MN, Ikeda Y, Worthmann H, Ziai WC, d'Esterre CD, Aviv RI, Raab P, Murai Y, Zazulia AR, Butcher KS, Seyedsaadat SM, Grotta JC, Martí-Fàbregas J, Montaner J, Broderick J, Yamamoto H, Staykov D, Connolly ES, Selim M, Leira R, Moon BH, Demchuk AM, Di Napoli M, Fujii Y, Anderson CS, Rosand J; VISTA-ICH Collaboration; ICH Growth Individual Patient Data Meta-analysis Collaborators.

Lancet Neurol. 2018 Oct;17(10):885-894. doi: 10.1016/S1474-4422(18)30253-9. Epub 2018 Aug 14. Erratum in: Lancet Neurol. 2018 Sep 19;:.

8.

Can an anticoagulant reduce brain hemorrhage: Invited comment on "Dabigatran reduces endothelial permeability through inhibition of thrombin-induced cytoskeleton reorganization".

Lyden PD.

Thromb Res. 2018 Jun 12. pii: S0049-3848(18)30379-7. doi: 10.1016/j.thromres.2018.06.005. [Epub ahead of print] No abstract available.

PMID:
29935770
9.

Retinal Microvascular Abnormalities as Surrogate Markers of Cerebrovascular Ischemic Disease: A Meta-Analysis.

Dumitrascu OM, Demaerschalk BM, Valencia Sanchez C, Almader-Douglas D, O'Carroll CB, Aguilar MI, Lyden PD, Kumar G.

J Stroke Cerebrovasc Dis. 2018 Jul;27(7):1960-1968. doi: 10.1016/j.jstrokecerebrovasdis.2018.02.041. Epub 2018 Mar 20. Review.

PMID:
29571764
10.

When less is more (brain)-comment on "Rivaroxaban plasma levels in acute ischemic stroke and intracerebral hemorrhage".

Lyden PD.

Ann Neurol. 2018 Mar;83(3):446-448. doi: 10.1002/ana.25163. Epub 2018 Mar 3. No abstract available.

11.

Translational Stroke Research: Vision and Opportunities.

Bosetti F, Koenig JI, Ayata C, Back SA, Becker K, Broderick JP, Carmichael ST, Cho S, Cipolla MJ, Corbett D, Corriveau RA, Cramer SC, Ferguson AR, Finklestein SP, Ford BD, Furie KL, Hemmen TM, Iadecola C, Jakeman LB, Janis S, Jauch EC, Johnston KC, Kochanek PM, Kohn H, Lo EH, Lyden PD, Mallard C, McCullough LD, McGavern LM, Meschia JF, Moy CS, Perez-Pinzon MA, Ramadan I, Savitz SI, Schwamm LH, Steinberg GK, Stenzel-Poore MP, Tymianski M, Warach S, Wechsler LR, Zhang JH, Koroshetz W.

Stroke. 2017 Sep;48(9):2632-2637. doi: 10.1161/STROKEAHA.117.017112. Epub 2017 Jul 27. Review. No abstract available.

12.

Cerebral Pulsatility Index Is Elevated in Patients with Elevated Right Atrial Pressure.

Lahiri S, Schlick KH, Padrick MM, Rinsky B, Gonzalez N, Jones H, Mayer SA, Lyden PD.

J Neuroimaging. 2018 Jan;28(1):95-98. doi: 10.1111/jon.12456. Epub 2017 Jul 3.

PMID:
28670797
13.

Paradoxical cerebrovascular hemodynamic changes with nicardipine.

Lahiri S, Nezhad M, Schlick KH, Rinsky B, Rosengart A, Mayer SA, Lyden PD.

J Neurosurg. 2018 Apr;128(4):1015-1019. doi: 10.3171/2016.11.JNS161992. Epub 2017 Apr 21.

PMID:
28430036
14.

Migraine and the Risk of Carotid Artery Dissection in the IPSYS Registry: Are They Related?

Lyden PD.

JAMA Neurol. 2017 May 1;74(5):503-504. doi: 10.1001/jamaneurol.2016.6008. No abstract available.

PMID:
28264078
15.

Clinical Studies Targeting Stroke and Ischemic Insults.

Lundbye J, Lyden PD, Polderman KH, Schwab S.

Ther Hypothermia Temp Manag. 2017 Mar;7(1):12-15. doi: 10.1089/ther.2016.29022.jjl. No abstract available.

PMID:
28253089
16.

Clinical Studies Targeting Stroke and Ischemic Insults.

Lundbye J, Lyden PD, Polderman KH, Schwab S.

Ther Hypothermia Temp Manag. 2017 Jan 20. doi: 10.1089/ther.2016.29022.jjl.rev. [Epub ahead of print] No abstract available.

PMID:
28106522
17.

Meta-Analysis of Pre-Clinical Trials of Therapeutic Hypothermia for Intracerebral Hemorrhage.

Melmed KR, Lyden PD.

Ther Hypothermia Temp Manag. 2017 Sep;7(3):141-146. doi: 10.1089/ther.2016.0033. Epub 2016 Dec 1. Review.

18.

In Response.

Lahiri S, Lyden PD.

J Stroke Cerebrovasc Dis. 2017 Feb;26(2):454. doi: 10.1016/j.jstrokecerebrovasdis.2016.10.022. Epub 2016 Nov 22. No abstract available.

PMID:
27887790
19.

Transcranial Doppler Changes in Patients Treated with Extracorporeal Membrane Oxygenation.

Kavi T, Esch M, Rinsky B, Rosengart A, Lahiri S, Lyden PD.

J Stroke Cerebrovasc Dis. 2016 Dec;25(12):2882-2885. doi: 10.1016/j.jstrokecerebrovasdis.2016.07.050. Epub 2016 Aug 26.

PMID:
27576213
20.

Optimizing Outcomes for Mechanically Ventilated Patients in an Era of Endovascular Acute Ischemic Stroke Therapy.

Lahiri S, Schlick K, Kavi T, Song S, Moheet AM, Yusufali T, Rosengart A, Alexander MJ, Lyden PD.

J Intensive Care Med. 2017 Sep;32(8):467-472. doi: 10.1177/0885066616663168. Epub 2016 Aug 19. Review.

PMID:
27543141
21.

Activated protein C promotes neuroprotection: mechanisms and translation to the clinic.

Griffin JH, Fernández JA, Lyden PD, Zlokovic BV.

Thromb Res. 2016 May;141 Suppl 2:S62-4. doi: 10.1016/S0049-3848(16)30368-1. Review.

22.

Novel method for inducing rapid, controllable therapeutic hypothermia in rats using a perivascular implanted closed-loop cooling circuit.

Lamb JA, Rajput PS, Lyden PD.

J Neurosci Methods. 2016 Jul 15;267:55-61. doi: 10.1016/j.jneumeth.2016.04.011. Epub 2016 Apr 21.

PMID:
27090948
23.

Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke.

Dumitrascu OM, Lamb J, Lyden PD.

J Cereb Blood Flow Metab. 2016 Jul;36(7):1157-64. doi: 10.1177/0271678X16645112. Epub 2016 Apr 18. Review.

24.

Current Advances in the Use of Therapeutic Hypothermia.

Lyden PD, Lopez-de-Sa E, Nichol G, Kiragu AW.

Ther Hypothermia Temp Manag. 2016 Mar;6(1):2-5. doi: 10.1089/ther.2016.29010.pdl. Epub 2016 Feb 1. No abstract available.

PMID:
26829471
25.

Clinical Studies Targeting Stroke and In-Hospital Cardiac Arrest.

Kurz M, Lundbye J, Lyden PD.

Ther Hypothermia Temp Manag. 2016 Mar;6(1):6-8. doi: 10.1089/ther.2016.29008.mjk. Epub 2016 Jan 22. No abstract available.

PMID:
26799665
26.

Online Tool to Improve Stratification of Adverse Events in Stroke Clinical Trials.

Hesse K, MacIsaac RL, Abdul-Rahim AH, Lyden PD, Bluhmki E, Lees KR; VISTA Collaborators.

Stroke. 2016 Mar;47(3):882-5. doi: 10.1161/STROKEAHA.115.011930. Epub 2016 Jan 7.

PMID:
26742798
27.

Letter by Lahiri et al Regarding Article, "Endovascular Thrombectomy for Anterior Circulation Stroke: Systematic Review and Meta-Analysis".

Lahiri S, Nuño M, Lyden PD.

Stroke. 2015 Dec;46(12):e258. doi: 10.1161/STROKEAHA.115.011677. Epub 2015 Nov 3. No abstract available.

PMID:
26534970
28.

Arabic cross cultural adaptation and validation of the National Institutes of Health Stroke Scale.

Hussein HM, Abdel Moneim A, Emara T, Abd-Elhamid YA, Salem HH, Abd-Allah F, Farrag MA, Tork MA, Shalash AS, Ezz El Dein KH, Osman G, Georgy SS, Ghali PG, Lyden PD, Moustafa RR.

J Neurol Sci. 2015 Oct 15;357(1-2):152-6. doi: 10.1016/j.jns.2015.07.022. Epub 2015 Jul 16.

PMID:
26210056
29.

Seizures and Meperidine: Overstated and Underutilized.

Schlick KH, Hemmen TM, Lyden PD.

Ther Hypothermia Temp Manag. 2015 Dec;5(4):223-7. doi: 10.1089/ther.2015.0013. Epub 2015 Jun 18. Review.

30.

Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture.

Shih AY, Rühlmann C, Blinder P, Devor A, Drew PJ, Friedman B, Knutsen PM, Lyden PD, Mateo C, Mellander L, Nishimura N, Schaffer CB, Tsai PS, Kleinfeld D.

Microcirculation. 2015 Apr;22(3):204-218. doi: 10.1111/micc.12195. Review.

31.

Clinical studies targeting stroke.

Lyden PD, Rincon F, Staykov D, Lyden PD.

Ther Hypothermia Temp Manag. 2015 Mar;5(1):4-8. doi: 10.1089/ther.2015.1501. No abstract available.

PMID:
25692220
32.

Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema.

Bai J, Lyden PD.

Int J Stroke. 2015 Feb;10(2):143-52. doi: 10.1111/ijs.12434. Review.

PMID:
25598025
33.

Protease activated receptor-1 mediates cytotoxicity during ischemia using in vivo and in vitro models.

Rajput PS, Lyden PD, Chen B, Lamb JA, Pereira B, Lamb A, Zhao L, Lei IF, Bai J.

Neuroscience. 2014 Dec 5;281:229-40. doi: 10.1016/j.neuroscience.2014.09.038. Epub 2014 Sep 28.

34.

Mild hypothermia reduces tissue plasminogen activator-related hemorrhage and blood brain barrier disruption after experimental stroke: editorial commentary on tang et Al., 2013.

Lyden PD.

Ther Hypothermia Temp Manag. 2013 Dec;3(4):171-2. doi: 10.1089/ther.2013.0014. Epub 2013 Aug 28. No abstract available.

PMID:
24834949
35.

Preclinical and clinical studies targeting stroke.

Lyden MP, Gupta PR, Kollmar R, Lyden PD.

Ther Hypothermia Temp Manag. 2013 Sep;3(3):114-9. doi: 10.1089/ther.2013.1512. No abstract available.

PMID:
24834840
36.

Challenges of decision making regarding futility in a randomized trial: the Interventional Management of Stroke III experience.

Yeatts SD, Martin RH, Coffey CS, Lyden PD, Foster LD, Woolson RF, Broderick JP, Di Tullio MR, Jungreis CA, Palesch YY; IMS III Investigators.

Stroke. 2014 May;45(5):1408-14. doi: 10.1161/STROKEAHA.113.003925. Epub 2014 Apr 3.

37.

Optically induced occlusion of single blood vessels in rodent neocortex.

Shih AY, Nishimura N, Nguyen J, Friedman B, Lyden PD, Schaffer CB, Kleinfeld D.

Cold Spring Harb Protoc. 2013 Dec 1;2013(12):1153-60. doi: 10.1101/pdb.prot079509.

PMID:
24298038
38.

Endovascular therapeutic hypothermia for acute ischemic stroke: ICTuS 2/3 protocol.

Lyden PD, Hemmen TM, Grotta J, Rapp K, Raman R.

Int J Stroke. 2014 Jan;9(1):117-25. doi: 10.1111/ijs.12151. Epub 2013 Nov 10.

PMID:
24206528
39.

Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats.

Wang Y, Zhao Z, Chow N, Rajput PS, Griffin JH, Lyden PD, Zlokovic BV.

Stroke. 2013 Dec;44(12):3529-36. doi: 10.1161/STROKEAHA.113.003350. Epub 2013 Oct 24.

40.

Correlations among impairment, daily activities and thinking operations after stroke.

Akbari S, Lyden PD, Kamali M, Fahimi MA.

NeuroRehabilitation. 2013;33(1):153-60. doi: 10.3233/NRE-130940.

PMID:
23949044
41.

Pooled assessment of computed tomography interpretation by vascular neurologists in the STRokE DOC telestroke network.

Spokoyny I, Raman R, Ernstrom K, Demaerschalk BM, Lyden PD, Hemmen TM, Guzik AK, Chen JY, Meyer BC.

J Stroke Cerebrovasc Dis. 2014 Mar;23(3):511-5. doi: 10.1016/j.jstrokecerebrovasdis.2013.04.023. Epub 2013 May 19.

42.

Representation of people with aphasia in randomized controlled trials of acute stroke interventions.

Ali M, Bath PM, Lyden PD, Bernhardt J, Brady M; VISTA Collaboration.

Int J Stroke. 2014 Feb;9(2):174-82. doi: 10.1111/ijs.12043. Epub 2013 Mar 19.

PMID:
23506193
43.

Type of admission is associated with outcome of spontaneous subarachnoid hemorrhage.

Drazin D, Rosner J, Nuño M, Alexander MJ, Schievink WI, Palestrant D, Lyden PD, Miller C.

Int J Stroke. 2015 Jun;10(4):529-33. doi: 10.1111/ijs.12005. Epub 2013 Mar 12.

PMID:
23489935
44.

Hemorrhagic transformation during thrombolytic therapy and reperfusion: effects of age, blood pressure, and matrix metalloproteinases.

Lyden PD.

J Stroke Cerebrovasc Dis. 2013 May;22(4):532-8. doi: 10.1016/j.jstrokecerebrovasdis.2013.02.001. Epub 2013 Mar 1.

PMID:
23453556
45.

Concurrent middle cerebral artery occlusion and intra-arterial drug infusion via ipsilateral common carotid artery catheter in the rat.

Van Winkle JA, Chen B, Lei IF, Pereira B, Rajput PS, Lyden PD.

J Neurosci Methods. 2013 Feb 15;213(1):63-9. doi: 10.1016/j.jneumeth.2012.12.004. Epub 2012 Dec 20.

46.

Clinical use of computed tomographic perfusion for the diagnosis and prediction of lesion growth in acute ischemic stroke.

Huisa BN, Neil WP, Schrader R, Maya M, Pereira B, Bruce NT, Lyden PD.

J Stroke Cerebrovasc Dis. 2014 Jan;23(1):114-22. doi: 10.1016/j.jstrokecerebrovasdis.2012.10.020. Epub 2012 Dec 14.

47.

The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit.

Shih AY, Blinder P, Tsai PS, Friedman B, Stanley G, Lyden PD, Kleinfeld D.

Nat Neurosci. 2013 Jan;16(1):55-63. doi: 10.1038/nn.3278. Epub 2012 Dec 16.

48.

PHLPP1 gene deletion protects the brain from ischemic injury.

Chen B, Van Winkle JA, Lyden PD, Brown JH, Purcell NH.

J Cereb Blood Flow Metab. 2013 Feb;33(2):196-204. doi: 10.1038/jcbfm.2012.150. Epub 2012 Oct 17.

49.

Overview of therapeutic hypothermia.

Song SS, Lyden PD.

Curr Treat Options Neurol. 2012 Dec;14(6):541-8. doi: 10.1007/s11940-012-0201-x.

50.

β-adrenergic receptor inhibition affects cerebral glucose metabolism, motor performance, and inflammatory response after traumatic brain injury.

Ley EJ, Clond MA, Bukur M, Park R, Chervonski M, Dagliyan G, Margulies DR, Lyden PD, Conti PS, Salim A.

J Trauma Acute Care Surg. 2012 Jul;73(1):33-40. doi: 10.1097/TA.0b013e31825a769b.

PMID:
22743370

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